Other Information
Genular Protein ID: 857558242
Symbol: NOTCH_DROME
Name: Neurogenic locus Notch protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3935325
Title: Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.
PubMed ID: 3935325
PubMed ID: 3097517
Title: Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.
PubMed ID: 3097517
PubMed ID: 10731132
Title: The genome sequence of Drosophila melanogaster.
PubMed ID: 10731132
PubMed ID: 12537572
Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
PubMed ID: 12537572
PubMed ID: 10731137
Title: From sequence to chromosome: the tip of the X chromosome of D. melanogaster.
PubMed ID: 10731137
PubMed ID: 3037327
Title: Restriction of P-element insertions at the Notch locus of Drosophila melanogaster.
PubMed ID: 3037327
PubMed ID: 2981631
Title: opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.
PubMed ID: 2981631
PubMed ID: 2780284
Title: Hypervariability of simple sequences as a general source for polymorphic DNA markers.
PubMed ID: 2780284
PubMed ID: 8162848
Title: Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
PubMed ID: 8162848
PubMed ID: 7671825
Title: Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.
PubMed ID: 7671825
PubMed ID: 10206646
Title: Presenilin is required for activity and nuclear access of Notch in Drosophila.
PubMed ID: 10206646
DOI: 10.1038/19091
PubMed ID: 10206647
Title: Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.
PubMed ID: 10206647
DOI: 10.1038/19096
PubMed ID: 10935637
Title: Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.
PubMed ID: 10935637
DOI: 10.1038/35019075
PubMed ID: 11719214
Title: Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.
PubMed ID: 11719214
PubMed ID: 11799064
PubMed ID: 12369105
Title: General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review.
PubMed ID: 12369105
PubMed ID: 12909620
Title: Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.
PubMed ID: 12909620
PubMed ID: 15620649
Title: Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation.
PubMed ID: 15620649
PubMed ID: 15620650
Title: Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.
PubMed ID: 15620650
PubMed ID: 17329366
Title: The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.
PubMed ID: 17329366
DOI: 10.1242/dev.02811
PubMed ID: 18243100
Title: Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
PubMed ID: 18243100
PubMed ID: 18342578
Title: The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.
PubMed ID: 18342578
PubMed ID: 18327897
Title: Phosphoproteome analysis of Drosophila melanogaster embryos.
PubMed ID: 18327897
DOI: 10.1021/pr700696a
PubMed ID: 20152183
Title: dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.
PubMed ID: 20152183
PubMed ID: 21262215
Title: The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.
PubMed ID: 21262215
PubMed ID: 23056424
Title: The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch.
PubMed ID: 23056424
PubMed ID: 27268051
Title: Mapping sites of O-glycosylation and fringe elongation on Drosophila Notch.
PubMed ID: 27268051
PubMed ID: 27151950
Title: Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff.
PubMed ID: 27151950
DOI: 10.1242/dev.136184
PubMed ID: 28899667
Title: bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression.
PubMed ID: 28899667
PubMed ID: 29309414
Title: AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster.
PubMed ID: 29309414
PubMed ID: 14573873
Title: Structure and stability of the ankyrin domain of the Drosophila Notch receptor.
PubMed ID: 14573873
DOI: 10.1110/ps.03279003
Sequence Information:
- Length: 2703
- Mass: 288853
- Checksum: 0EAE23F426FECD7B
- Sequence:
MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV RGTDTALVAA SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC NSMRCQNGGT CQVTFRNGRP GISCKCPLGF DESLCEIAVP NACDHVTCLN GGTCQLKTLE EYTCACANGY TGERCETKNL CASSPCRNGA TCTALAGSSS FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ CMCPTGYTGK DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT NTHGSYSCIC VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK GKTGLLCHLD DACTSNPCHA DAICDTSPIN GSYACSCATG YKGVDCSEDI DECDQGSPCE HNGICVNTPG SYRCNCSQGF TGPRCETNIN ECESHPCQNE GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT CHDKINGFKC SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF DGHCQDRVGS YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK CQCVPGFTGQ HCEKNVDECI SSPCANNGVC IDQVNGYKCE CPRGFYDAHC LSDVDECASN PCVNEGRCED GINEFICHCP PGYTGKRCEL DIDECSSNPC QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN GGTCIDKVNG YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC ASFPCQNGGT CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS QYVNSYTCTC PLGFSGINCQ TNDEDCTESS CLNGGSCIDG INGYNCSCLA GYSGANCQYK LNKCDSNPCL NGATCHEQNN EYTCHCPSGF TGKQCSEYVD WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC QDAADRKGLS LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG TMGIICEINK DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE CLSNPCSNAG TLDCVQLVNN YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG NCNIRQSGHH CICNNGFYGK NCELSGQDCD SNPCRVGNCV VADEGFGYRC ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL CPSKWKGKRC DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH DCERKLKSCD SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV LAEGAMSVVM LMNVEAFREI QAQFLRNMSH MLRTTVRLKK DALGHDIIIN WKDNVRVPEI EDTDFARKNK ILYTQQVHQT GIQIYLEIDN RKCTECFTHA VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP ANVKYVITGI ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY ASDHTMVSEY EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP CGLTPLMIAA VRGGGLDTGE DIENNEDSTA QVISDLLAQG AELNATMDKT GETSLHLAAR FARADAAKRL LDAGADANCQ DNTGRTPLHA AVAADAMGVF QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA DADINAADNS GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT PQAMIGSPPP GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA AKKAKLIEGS PDNGLDATGS LRRKASSKKT SAASKKAANL NGLNPGQLTG GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH ELEGSPVGVG MGGNLPSPYD TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS LQGNGLDMIK LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT SPTHIQAMRH ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ NSPVSLGIIS PTGSDMGIML APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD LNGFCGSPDS FHSGQMNPPS IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH TPQHLVQTLD SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA IYI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.