Details for: AOAH

Gene ID: 313

Symbol: AOAH

Ensembl ID: ENSG00000136250

Description: acyloxyacyl hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.4934
    Cell Significance Index: -18.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.4532
    Cell Significance Index: -17.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.1807
    Cell Significance Index: -19.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.4281
    Cell Significance Index: -21.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9376
    Cell Significance Index: -19.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7369
    Cell Significance Index: -18.1700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 9.6533
    Cell Significance Index: 25.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6266
    Cell Significance Index: -18.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6604
    Cell Significance Index: -18.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.1648
    Cell Significance Index: 54.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9299
    Cell Significance Index: -5.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4094
    Cell Significance Index: 26.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8260
    Cell Significance Index: 31.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8155
    Cell Significance Index: 36.0700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.6510
    Cell Significance Index: 7.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5333
    Cell Significance Index: 52.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4164
    Cell Significance Index: 83.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3705
    Cell Significance Index: 334.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3361
    Cell Significance Index: 20.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2561
    Cell Significance Index: 41.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2095
    Cell Significance Index: 75.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1593
    Cell Significance Index: 31.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1428
    Cell Significance Index: 3.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1282
    Cell Significance Index: 5.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1221
    Cell Significance Index: 13.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1146
    Cell Significance Index: 2.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0517
    Cell Significance Index: 9.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0298
    Cell Significance Index: 0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0269
    Cell Significance Index: 36.6200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0259
    Cell Significance Index: 0.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0028
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0090
    Cell Significance Index: -0.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0099
    Cell Significance Index: -6.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0207
    Cell Significance Index: -3.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0243
    Cell Significance Index: -18.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0252
    Cell Significance Index: -16.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0293
    Cell Significance Index: -21.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0312
    Cell Significance Index: -14.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0333
    Cell Significance Index: -18.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0358
    Cell Significance Index: -20.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0493
    Cell Significance Index: -14.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0519
    Cell Significance Index: -22.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0617
    Cell Significance Index: -6.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0631
    Cell Significance Index: -4.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0654
    Cell Significance Index: -9.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0716
    Cell Significance Index: -1.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0808
    Cell Significance Index: -1.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0898
    Cell Significance Index: -11.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0903
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0953
    Cell Significance Index: -20.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1069
    Cell Significance Index: -18.2500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1124
    Cell Significance Index: -1.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1177
    Cell Significance Index: -2.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1267
    Cell Significance Index: -1.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1304
    Cell Significance Index: -17.9100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1325
    Cell Significance Index: -1.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1501
    Cell Significance Index: -11.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1508
    Cell Significance Index: -19.4900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1508
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1653
    Cell Significance Index: -3.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1681
    Cell Significance Index: -19.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1685
    Cell Significance Index: -17.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1691
    Cell Significance Index: -19.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1802
    Cell Significance Index: -20.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1874
    Cell Significance Index: -24.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2095
    Cell Significance Index: -9.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2104
    Cell Significance Index: -9.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2225
    Cell Significance Index: -14.9600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2301
    Cell Significance Index: -3.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2451
    Cell Significance Index: -7.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2460
    Cell Significance Index: -5.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2588
    Cell Significance Index: -19.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2621
    Cell Significance Index: -3.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2678
    Cell Significance Index: -17.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3092
    Cell Significance Index: -17.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3163
    Cell Significance Index: -10.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3245
    Cell Significance Index: -16.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3269
    Cell Significance Index: -23.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3428
    Cell Significance Index: -17.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3435
    Cell Significance Index: -18.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3464
    Cell Significance Index: -6.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3629
    Cell Significance Index: -11.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3670
    Cell Significance Index: -12.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3764
    Cell Significance Index: -7.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3939
    Cell Significance Index: -11.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4246
    Cell Significance Index: -12.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4335
    Cell Significance Index: -5.7600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4499
    Cell Significance Index: -5.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4512
    Cell Significance Index: -10.9300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4538
    Cell Significance Index: -4.0400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4569
    Cell Significance Index: -7.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4707
    Cell Significance Index: -21.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4843
    Cell Significance Index: -5.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AOAH is a hydrolase enzyme that catalyzes the hydrolysis of acyloxyacyl esters, which are key components of bacterial LPS. This enzyme is characterized by its ability to bind calcium ions, which is essential for its catalytic activity. AOAH is also known to be involved in the negative regulation of inflammatory responses, suggesting that it may play a role in modulating immune cell function and preventing excessive inflammation. **Pathways and Functions:** AOAH is involved in several key pathways, including: 1. **Fatty acid metabolic process:** AOAH is involved in the degradation of fatty acids, which are essential energy sources for immune cells. 2. **Lipopolysaccharide catabolic process:** AOAH is responsible for the breakdown of LPS, which is a key component of bacterial cell walls. 3. **Negative regulation of inflammatory response:** AOAH has been shown to inhibit inflammatory responses by regulating the activity of immune cells. 4. **Calcium ion binding:** AOAH binds calcium ions, which is essential for its catalytic activity. AOAH's functions are diverse and include: 1. **Immune cell regulation:** AOAH regulates the function of immune cells, including macrophages, microglia, and dendritic cells. 2. **Inflammation modulation:** AOAH modulates inflammatory responses by regulating the activity of immune cells. 3. **Lipid metabolism:** AOAH is involved in the degradation of fatty acids, which are essential energy sources for immune cells. **Clinical Significance:** AOAH has been implicated in various immune-related disorders, including: 1. **Inflammatory bowel disease (IBD):** AOAH has been shown to be overexpressed in patients with IBD, suggesting that it may play a role in the pathogenesis of this disease. 2. **Autoimmune disorders:** AOAH has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus, where it may contribute to the regulation of immune cell function and inflammation. 3. **Neurological disorders:** AOAH has been shown to be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the regulation of neuroinflammation. In conclusion, AOAH is a critical enzyme involved in the regulation of inflammatory responses and immune cell function. Its involvement in various immune-related disorders highlights the importance of further research into the mechanisms of AOAH and its potential therapeutic applications.

Genular Protein ID: 1157093180

Symbol: AOAH_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1883828

Title: Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides.

PubMed ID: 1883828

DOI: 10.1021/bi00098a020

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8089145

Title: A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase.

PubMed ID: 8089145

DOI: 10.1016/s0021-9258(17)31577-6

PubMed ID: 29343645

Title: Crystal structure of the mammalian lipopolysaccharide detoxifier.

PubMed ID: 29343645

DOI: 10.1073/pnas.1719834115

Sequence Information:

  • Length: 575
  • Mass: 65105
  • Checksum: E3B3853DBD308AF7
  • Sequence:
  • MQSPWKILTV APLFLLLSLQ SSASPANDDQ SRPSLSNGHT CVGCVLVVSV IEQLAQVHNS 
    TVQASMERLC SYLPEKLFLK TTCYLVIDKF GSDIIKLLSA DMNADVVCHT LEFCKQNTGQ 
    PLCHLYPLPK ETWKFTLQKA RQIVKKSPIL KYSRSGSDIC SLPVLAKICQ KIKLAMEQSV 
    PFKDVDSDKY SVFPTLRGYH WRGRDCNDSD ESVYPGRRPN NWDVHQDSNC NGIWGVDPKD 
    GVPYEKKFCE GSQPRGIILL GDSAGAHFHI SPEWITASQM SLNSFINLPT ALTNELDWPQ 
    LSGATGFLDS TVGIKEKSIY LRLWKRNHCN HRDYQNISRN GASSRNLKKF IESLSRNKVL 
    DYPAIVIYAM IGNDVCSGKS DPVPAMTTPE KLYSNVMQTL KHLNSHLPNG SHVILYGLPD 
    GTFLWDNLHN RYHPLGQLNK DMTYAQLYSF LNCLQVSPCH GWMSSNKTLR TLTSERAEQL 
    SNTLKKIAAS EKFTNFNLFY MDFAFHEIIQ EWQKRGGQPW QLIEPVDGFH PNEVALLLLA 
    DHFWKKVQLQ WPQILGKENP FNPQIKQVFG DQGGH

Genular Protein ID: 3653024140

Symbol: A0A087WVT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 688
  • Mass: 77933
  • Checksum: B2FD4DC74D815E39
  • Sequence:
  • MQSPWKILTV APLFLLLSLQ SSASPANDDQ SRPSLSNGHT CVGCVLVVSV IEQLAQVHNS 
    TVQASMERLC SYLPEKLFLK TTCYLVIDKF GSDIIKLLSA DMNADVVCHT LEFCKQNTGQ 
    PLCHLYPLPK ETWKFTLQKA RQIVKKSPIL KYSRSGSDIC SLPVLAKICQ KIKLAMEQSV 
    PFKDVDSDKY SVFPTLRGYH WRGRDCNDSD ESVYPGRRPN NWDVHQDSNC NGIWGVDPKD 
    GVPYEKKFCE GSQPRGIILL GDSAGAHFHI SPEWITASQM SLNSFINLPT ALTNELDWPQ 
    LSGATGFLDS TVGIKEKSIY LRLWKRNHCN HRDYQNISRN GASSRNLKKF IESLSRNKVL 
    DYPAIVIYAM IGNDVCSGKS DPVPAMTTPE KLYSNVMQTL KHLNSHLPNG SHVILYGLPD 
    GTFLWDNLHN RYHPLGQLNK DMTYAQLYSF LNCLQVSPCH GWMSSNKTLR TLTSERAEQL 
    SNTLKKIAAS EKFTNFNLFY MDFAFHEIIQ EWQKRGGQPW QLIEPVDGFH PNERKSILLK 
    GILMTSQTLD NQEWTQLTSW IKGNLTCDSR TREWLCCCWR IISGKRCSSS GPKSWERRIR 
    STPRLNRCLE TKAGTEPLRS MHPWGAQGGR GLGKLIPQTL WGLPRHRPKG LFFSSIFAKC 
    LSLNEEHIWT TVQCCVLPGS VTLPLFLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.