Details for: AOX1

Gene ID: 316

Symbol: AOX1

Ensembl ID: ENSG00000138356

Description: aldehyde oxidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.6693
    Cell Significance Index: -11.7700
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 49.0630
    Cell Significance Index: 24.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.0095
    Cell Significance Index: -11.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 9.3104
    Cell Significance Index: 63.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.4610
    Cell Significance Index: 142.5300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 6.8917
    Cell Significance Index: 18.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.0111
    Cell Significance Index: 161.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.5639
    Cell Significance Index: 160.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.7880
    Cell Significance Index: 73.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9878
    Cell Significance Index: -11.7900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.3237
    Cell Significance Index: 29.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9003
    Cell Significance Index: 60.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8559
    Cell Significance Index: 368.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7611
    Cell Significance Index: 107.9700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.1869
    Cell Significance Index: 4.4700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1756
    Cell Significance Index: 6.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.1277
    Cell Significance Index: 56.9900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.0337
    Cell Significance Index: 16.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6881
    Cell Significance Index: 100.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6239
    Cell Significance Index: 118.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4743
    Cell Significance Index: 7.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3982
    Cell Significance Index: 68.0000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3948
    Cell Significance Index: 5.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3453
    Cell Significance Index: 34.1600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3078
    Cell Significance Index: 1.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2892
    Cell Significance Index: 6.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2762
    Cell Significance Index: 249.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2013
    Cell Significance Index: 21.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2009
    Cell Significance Index: 12.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1957
    Cell Significance Index: 4.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1885
    Cell Significance Index: 30.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1520
    Cell Significance Index: 4.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1454
    Cell Significance Index: 90.7700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1073
    Cell Significance Index: 0.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0957
    Cell Significance Index: 1.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0872
    Cell Significance Index: 6.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0566
    Cell Significance Index: 10.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0538
    Cell Significance Index: 6.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0525
    Cell Significance Index: 98.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0366
    Cell Significance Index: 23.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0176
    Cell Significance Index: 27.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0041
    Cell Significance Index: 1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0004
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0049
    Cell Significance Index: -2.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0086
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0144
    Cell Significance Index: -10.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0192
    Cell Significance Index: -8.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0219
    Cell Significance Index: -11.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0229
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0300
    Cell Significance Index: -6.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0328
    Cell Significance Index: -6.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0375
    Cell Significance Index: -10.7800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0394
    Cell Significance Index: -0.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0442
    Cell Significance Index: -4.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0475
    Cell Significance Index: -1.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0479
    Cell Significance Index: -0.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0594
    Cell Significance Index: -4.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0675
    Cell Significance Index: -8.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0710
    Cell Significance Index: -8.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0764
    Cell Significance Index: -3.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0845
    Cell Significance Index: -3.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0924
    Cell Significance Index: -7.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0937
    Cell Significance Index: -12.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1006
    Cell Significance Index: -10.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1203
    Cell Significance Index: -8.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1366
    Cell Significance Index: -3.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1393
    Cell Significance Index: -8.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1566
    Cell Significance Index: -12.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1567
    Cell Significance Index: -11.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1841
    Cell Significance Index: -4.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1968
    Cell Significance Index: -5.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1970
    Cell Significance Index: -12.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2035
    Cell Significance Index: -5.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2095
    Cell Significance Index: -10.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2124
    Cell Significance Index: -11.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2232
    Cell Significance Index: -10.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2336
    Cell Significance Index: -4.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2465
    Cell Significance Index: -5.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2512
    Cell Significance Index: -7.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2549
    Cell Significance Index: -3.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2571
    Cell Significance Index: -13.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2603
    Cell Significance Index: -13.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2608
    Cell Significance Index: -8.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2641
    Cell Significance Index: -3.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2650
    Cell Significance Index: -11.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2889
    Cell Significance Index: -2.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3098
    Cell Significance Index: -8.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3169
    Cell Significance Index: -12.0000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3248
    Cell Significance Index: -4.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3288
    Cell Significance Index: -11.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3533
    Cell Significance Index: -12.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3537
    Cell Significance Index: -12.2900
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3548
    Cell Significance Index: -3.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AOX1 is a flavoprotein enzyme that belongs to the aldehyde oxidase family, characterized by the presence of two iron and two sulfur clusters. This unique structure enables the enzyme to catalyze the oxidation of various aldehydes, resulting in the production of carboxylic acids and other metabolites. AOX1 is predominantly expressed in various tissues, including skeletal muscle, kidney, liver, pancreas, and colon, suggesting its widespread involvement in human metabolism. **Pathways and Functions:** AOX1 plays a crucial role in various metabolic pathways, including lipid metabolism, vitamin B6 activation to pyridoxal phosphate, and xenobiotic metabolism. The enzyme's ability to oxidize aldehydes has been implicated in the regulation of glucose and lipid metabolism, as well as the production of reactive oxygen species (ROS). AOX1 has also been shown to interact with various proteins, including flavin adenine dinucleotide (FAD), nicotinamide adenine dinucleotide (NAD), and molybdopterin, highlighting its complex role in energy metabolism and redox homeostasis. **Clinical Significance:** AOX1 has been implicated in various diseases, including metabolic disorders, such as insulin resistance, type 2 diabetes, and obesity. The enzyme's expression in skeletal muscle and adipose tissue suggests its potential role in regulating glucose and lipid metabolism. Additionally, AOX1 has been linked to cancer development, with its expression observed in various types of tumors, including colorectal, pancreatic, and prostate cancer. The enzyme's ability to metabolize xenobiotics has also raised concerns about its potential role in the development of antibiotic resistance and other toxicological effects. **Implications for Immunology:** While AOX1 is not traditionally considered an immunoglobulin, its expression in various immune-privileged tissues, such as the eye and brain, suggests its potential role in modulating immune responses. The enzyme's ability to produce ROS and interact with various proteins has also led to speculation about its involvement in immune cell function and regulation. Further research is needed to fully elucidate the immunological implications of AOX1 and its potential role in modulating immune responses in various diseases. **Conclusion:** AOX1 is a multifaceted enzyme with far-reaching implications for human metabolism and disease. Its unique structure and expression patterns suggest its potential role in regulating various biological processes, including lipid metabolism, vitamin B6 activation, and xenobiotic metabolism. Further research is needed to fully elucidate the mechanisms by which AOX1 influences human health and disease, with potential implications for the development of novel therapeutic strategies for metabolic disorders and cancer.

Genular Protein ID: 3932043198

Symbol: AOXA_HUMAN

Name: Aldehyde oxidase 1

UniProtKB Accession Codes:

Q06278 O14765 Q53RR8 Q53TV3 Q9BYF0 Q9UPG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 36 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 23 DrugCentral 1 EC 1 EMBL 43 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 21 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SMART 2 SMR 1 STRING 1 SUPFAM 6 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248161

Title: cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.

PubMed ID: 8248161

DOI: 10.1073/pnas.90.22.10690

PubMed ID: 11302742

Title: Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II.

PubMed ID: 11302742

DOI: 10.1006/bbrc.2001.4719

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7786031

Title: Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon.

PubMed ID: 7786031

DOI: 10.1006/abbi.1995.1320

PubMed ID: 9224775

Title: In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

PubMed ID: 9224775

PubMed ID: 17022944

Title: Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is down-regulated by adiponectin and fenofibric acid in hepatocytes in vitro.

PubMed ID: 17022944

DOI: 10.1016/j.bbrc.2006.09.101

PubMed ID: 18066686

Title: Mammalian aldehyde oxidases: genetics, evolution and biochemistry.

PubMed ID: 18066686

DOI: 10.1007/s00018-007-7398-y

PubMed ID: 18671973

Title: Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release.

PubMed ID: 18671973

DOI: 10.1016/j.febslet.2008.07.034

PubMed ID: 20444863

Title: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.

PubMed ID: 20444863

DOI: 10.1124/dmd.110.033555

PubMed ID: 22031625

Title: Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes.

PubMed ID: 22031625

DOI: 10.1124/dmd.111.042861

PubMed ID: 22522748

Title: Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.

PubMed ID: 22522748

DOI: 10.1124/dmd.112.045195

PubMed ID: 22335465

Title: The role of aldehyde oxidase in drug metabolism.

PubMed ID: 22335465

DOI: 10.1517/17425255.2012.663352

PubMed ID: 22996261

Title: Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase.

PubMed ID: 22996261

DOI: 10.1124/dmd.112.048546

PubMed ID: 23857892

Title: Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.

PubMed ID: 23857892

DOI: 10.1124/dmd.113.053082

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26322824

Title: Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.

PubMed ID: 26322824

DOI: 10.1038/nchembio.1895

PubMed ID: 26842593

Title: Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.

PubMed ID: 26842593

DOI: 10.1124/dmd.115.068395

PubMed ID: 22279051

Title: The impact of single nucleotide polymorphisms on human aldehyde oxidase.

PubMed ID: 22279051

DOI: 10.1124/dmd.111.043828

Sequence Information:

  • Length: 1338
  • Mass: 147918
  • Checksum: 2AB5E543F18C9261
  • Sequence:
    • MDRASELLFY VNGRKVIEKN VDPETMLLPY LRKKLRLTGT KYGCGGGGCG ACTVMISRYN 
PITKRIRHHP ANACLIPICS LYGAAVTTVE GIGSTHTRIH PVQERIAKCH GTQCGFCTPG 
MVMSIYTLLR NHPEPTLDQL TDALGGNLCR CTGYRPIIDA CKTFCKTSGC CQSKENGVCC 
LDQGINGLPE FEEGSKTSPK LFAEEEFLPL DPTQELIFPP ELMIMAEKQS QRTRVFGSER 
MMWFSPVTLK ELLEFKFKYP QAPVIMGNTS VGPEVKFKGV FHPVIISPDR IEELSVVNHA 
YNGLTLGAGL SLAQVKDILA DVVQKLPEEK TQMYHALLKH LGTLAGSQIR NMASLGGHII 
SRHPDSDLNP ILAVGNCTLN LLSKEGKRQI PLNEQFLSKC PNADLKPQEI LVSVNIPYSR 
KWEFVSAFRQ AQRQENALAI VNSGMRVFFG EGDGIIRELC ISYGGVGPAT ICAKNSCQKL 
IGRHWNEQML DIACRLILNE VSLLGSAPGG KVEFKRTLII SFLFKFYLEV SQILKKMDPV 
HYPSLADKYE SALEDLHSKH HCSTLKYQNI GPKQHPEDPI GHPIMHLSGV KHATGEAIYC 
DDMPLVDQEL FLTFVTSSRA HAKIVSIDLS EALSMPGVVD IMTAEHLSDV NSFCFFTEAE 
KFLATDKVFC VGQLVCAVLA DSEVQAKRAA KRVKIVYQDL EPLILTIEES IQHNSSFKPE 
RKLEYGNVDE AFKVVDQILE GEIHMGGQEH FYMETQSMLV VPKGEDQEMD VYVSTQFPKY 
IQDIVASTLK LPANKVMCHV RRVGGAFGGK VLKTGIIAAV TAFAANKHGR AVRCVLERGE 
DMLITGGRHP YLGKYKAGFM NDGRILALDM EHYSNAGASL DESLFVIEMG LLKMDNAYKF 
PNLRCRGWAC RTNLPSNTAF RGFGFPQAAL ITESCITEVA AKCGLSPEKV RIINMYKEID 
QTPYKQEINA KNLIQCWREC MAMSSYSLRK VAVEKFNAEN YWKKKGLAMV PLKFPVGLGS 
RAAGQAAALV HIYLDGSVLV THGGIEMGQG VHTKMIQVVS RELRMPMSNV HLRGTSTETV 
PNANISGGSV VADLNGLAVK DACQTLLKRL EPIISKNPKG TWKDWAQTAF DESINLSAVG 
YFRGYESDMN WEKGEGQPFE YFVYGAACSE VEIDCLTGDH KNIRTDIVMD VGCSINPAID 
IGQIEGAFIQ GMGLYTIEEL NYSPQGILHT RGPDQYKIPA ICDMPTELHI ALLPPSQNSN 
TLYSSKGLGE SGVFLGCSVF FAIHDAVSAA RQERGLHGPL TLNSPLTPEK IRMACEDKFT 
KMIPRDEPGS YVPWNVPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.