Details for: APAF1

Gene ID: 317

Symbol: APAF1

Ensembl ID: ENSG00000120868

Description: apoptotic peptidase activating factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.2159
    Cell Significance Index: -20.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.4566
    Cell Significance Index: -19.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.8823
    Cell Significance Index: -18.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.8355
    Cell Significance Index: -21.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.2337
    Cell Significance Index: -21.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7226
    Cell Significance Index: -18.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7484
    Cell Significance Index: -20.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7981
    Cell Significance Index: -20.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2863
    Cell Significance Index: -20.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2581
    Cell Significance Index: -16.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2989
    Cell Significance Index: -7.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5228
    Cell Significance Index: 247.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2994
    Cell Significance Index: 1173.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1884
    Cell Significance Index: 61.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9265
    Cell Significance Index: 100.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8237
    Cell Significance Index: 49.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6555
    Cell Significance Index: 36.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6450
    Cell Significance Index: 129.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5471
    Cell Significance Index: 108.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5121
    Cell Significance Index: 50.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5107
    Cell Significance Index: 14.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4837
    Cell Significance Index: 29.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4774
    Cell Significance Index: 33.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4752
    Cell Significance Index: 21.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4288
    Cell Significance Index: 9.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3497
    Cell Significance Index: 125.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3446
    Cell Significance Index: 238.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2848
    Cell Significance Index: 7.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2449
    Cell Significance Index: 4.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2325
    Cell Significance Index: 41.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2239
    Cell Significance Index: 14.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2089
    Cell Significance Index: 5.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1858
    Cell Significance Index: 21.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1719
    Cell Significance Index: 2.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1502
    Cell Significance Index: 2.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1419
    Cell Significance Index: 7.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1300
    Cell Significance Index: 15.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1241
    Cell Significance Index: 67.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0991
    Cell Significance Index: 2.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0979
    Cell Significance Index: 1.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0951
    Cell Significance Index: 3.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0675
    Cell Significance Index: 12.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0633
    Cell Significance Index: 8.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0560
    Cell Significance Index: 0.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0458
    Cell Significance Index: 20.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0385
    Cell Significance Index: 0.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0362
    Cell Significance Index: 55.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0274
    Cell Significance Index: 51.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0179
    Cell Significance Index: 33.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0169
    Cell Significance Index: 10.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0059
    Cell Significance Index: 2.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0130
    Cell Significance Index: -1.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0345
    Cell Significance Index: -19.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0355
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0382
    Cell Significance Index: -23.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0483
    Cell Significance Index: -13.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0562
    Cell Significance Index: -2.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0581
    Cell Significance Index: -4.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0633
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0669
    Cell Significance Index: -11.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0690
    Cell Significance Index: -8.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0833
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1121
    Cell Significance Index: -23.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1200
    Cell Significance Index: -13.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1234
    Cell Significance Index: -2.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1268
    Cell Significance Index: -5.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1291
    Cell Significance Index: -0.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1406
    Cell Significance Index: -6.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1422
    Cell Significance Index: -18.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1548
    Cell Significance Index: -7.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1580
    Cell Significance Index: -3.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1619
    Cell Significance Index: -2.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1671
    Cell Significance Index: -10.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1690
    Cell Significance Index: -17.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1693
    Cell Significance Index: -4.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1757
    Cell Significance Index: -4.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1801
    Cell Significance Index: -6.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1829
    Cell Significance Index: -4.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1845
    Cell Significance Index: -13.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1889
    Cell Significance Index: -6.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2187
    Cell Significance Index: -3.1400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2223
    Cell Significance Index: -3.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2241
    Cell Significance Index: -11.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2298
    Cell Significance Index: -17.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2452
    Cell Significance Index: -19.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2877
    Cell Significance Index: -4.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2994
    Cell Significance Index: -6.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2998
    Cell Significance Index: -8.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3024
    Cell Significance Index: -4.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3201
    Cell Significance Index: -3.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3460
    Cell Significance Index: -21.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3613
    Cell Significance Index: -11.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3699
    Cell Significance Index: -11.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3735
    Cell Significance Index: -10.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3739
    Cell Significance Index: -9.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3902
    Cell Significance Index: -13.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Apoptosis regulation**: APAF1 is a critical regulator of apoptosis, a process of programmed cell death that is essential for development, tissue homeostasis, and the elimination of damaged or dysfunctional cells. 2. **Caspase activation**: APAF1 activates caspases, a family of cysteine proteases that are essential for the execution of apoptosis. 3. **Apoptosome formation**: APAF1 is a key component of the apoptosome, a protein complex that assembles in response to cytochrome c release from the mitochondria. 4. **Cell type specificity**: APAF1 is expressed in various cell types, including mural cells, monocytes, endothelial cells, and neurons, suggesting a role in different cellular processes. **Pathways and Functions** 1. **Intrinsic apoptotic signaling pathway**: APAF1 is involved in the intrinsic apoptotic signaling pathway, which is triggered by endoplasmic reticulum stress, DNA damage, and other cellular insults. 2. **Apoptosome formation and activation**: APAF1 assembles with cytochrome c and other proteins to form the apoptosome, which activates caspases and executes apoptosis. 3. **Caspase activation and cleavage**: APAF1 activates caspases through a mechanism involving the cleavage of caspase-9, leading to the activation of downstream caspases. 4. **Regulation of cell death**: APAF1 regulates cell death by modulating the activity of caspases and the formation of the apoptosome. **Clinical Significance** 1. **Cancer therapy**: APAF1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting a potential role in cancer progression and therapy resistance. 2. **Neurodegenerative diseases**: APAF1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where apoptosis plays a key role in disease progression. 3. **Cardiac disease**: APAF1 has been linked to cardiac disease, including myocardial infarction and heart failure, where apoptosis contributes to tissue damage and dysfunction. 4. **Immunological disorders**: APAF1 has been implicated in immunological disorders, such as autoimmune diseases and inflammatory conditions, where apoptosis and immune cell regulation are critical. In conclusion, APAF1 is a critical regulator of apoptosis, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, cardiac disease, and immunological disorders. Further research is needed to fully understand the role of APAF1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3751522192

Symbol: APAF_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14727 B2RMX8 O43297 Q7Z438 Q9BXZ6 Q9UBZ5 Q9UGN8 Q9UGN9 Q9UGP0 Q9UJ58 Q9UJ59 Q9UJ60 Q9UJ61 Q9UJ62 Q9UJ63 Q9UJ64 Q9UJ65 Q9UJ66 Q9UJ67 Q9UNC9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 23 EMDB 5 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 8 RefSeq 5 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9267021

Title: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

PubMed ID: 9267021

DOI: 10.1016/s0092-8674(00)80501-2

PubMed ID: 10441496

Title: Three new types of Apaf-1 in mammalian cells.

PubMed ID: 10441496

DOI: 10.1006/bbrc.1999.1124

PubMed ID: 10364241

Title: Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.

PubMed ID: 10364241

DOI: 10.1074/jbc.274.25.17941

PubMed ID: 10393175

Title: Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.

PubMed ID: 10393175

DOI: 10.1093/emboj/18.13.3586

PubMed ID: 12804598

Title: APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.

PubMed ID: 12804598

DOI: 10.1016/s0006-291x(03)00995-1

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9651578

Title: Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

PubMed ID: 9651578

DOI: 10.1016/s1097-2765(00)80095-7

PubMed ID: 11389439

Title: Apaf-1 is a transcriptional target for E2F and p53.

PubMed ID: 11389439

DOI: 10.1038/35078527

PubMed ID: 15262985

Title: Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.

PubMed ID: 15262985

DOI: 10.1074/jbc.m405747200

PubMed ID: 17244527

Title: Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

PubMed ID: 17244527

DOI: 10.1016/j.molcel.2006.12.013

PubMed ID: 21371431

Title: Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.

PubMed ID: 21371431

DOI: 10.1016/j.bbrc.2011.02.130

PubMed ID: 25716227

Title: FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.

PubMed ID: 25716227

DOI: 10.1002/ijc.29498

PubMed ID: 31498791

Title: EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.

PubMed ID: 31498791

DOI: 10.1371/journal.pone.0221048

PubMed ID: 10543941

Title: Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.

PubMed ID: 10543941

DOI: 10.1006/jmbi.1999.3177

PubMed ID: 10578182

Title: Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.

PubMed ID: 10578182

DOI: 10.1038/sj.cdd.4400584

Sequence Information:

  • Length: 1248
  • Mass: 141840
  • Checksum: 0750D05817AC9B3B
  • Sequence:
    • MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 
QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEAVRD HSLLEGCFPG 
GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL 
ILDDVWDSWV LKAFDSQCQI LLTTRDKSVT DSVMGPKYVV PVESSLGKEK GLEILSLFVN 
MKKADLPEQA HSIIKECKGS PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD 
YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN 
KSLLFCDRNG KSFRYYLHDL QVDFLTEKNC SQLQDLHKKI ITQFQRYHQP HTLSPDQEDC 
MYWYNFLAYH MASAKMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV 
SENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDN GMLYLEWINK 
KNITNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV 
LCCAFSTDDR FIATCSVDKK VKIWNSMTGE LVHTYDEHSE QVNCCHFTNS SHHLLLATGS 
SDCFLKLWDL NQKECRNTMF GHTNSVNHCR FSPDDKLLAS CSADGTLKLW DATSANERKS 
INVKQFFLNL EDPQEDMEVI VKCCSWSADG ARIMVAAKNK IFLFDIHTSG LLGEIHTGHH 
STIQYCDFSP QNHLAVVALS QYCVELWNTD SRSKVADCRG HLSWVHGVMF SPDGSSFLTS 
SDDQTIRLWE TKKVCKNSAV MLKQEVDVVF QENEVMVLAV DHIRRLQLIN GRTGQIDYLT 
EAQVSCCCLS PHLQYIAFGD ENGAIEILEL VNNRIFQSRF QHKKTVWHIQ FTADEKTLIS 
SSDDAEIQVW NWQLDKCIFL RGHQETVKDF RLLKNSRLLS WSFDGTVKVW NIITGNKEKD 
FVCHQGTVLS CDISHDATKF SSTSADKTAK IWSFDLLLPL HELRGHNGCV RCSAFSVDST 
LLATGDDNGE IRIWNVSNGE LLHLCAPLSE EGAATHGGWV TDLCFSPDGK MLISAGGYIK 
WWNVVTGESS QTFYTNGTNL KKIHVSPDFK TYVTVDNLGI LYILQTLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.