APAF1 | ENSG00000120868 | NCBI 317

Details for: APAF1

Gene ID: 317

Symbol: APAF1

Ensembl ID: ENSG00000120868

Description: apoptotic peptidase activating factor 1

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-HSA-111459)
Apoptosis
(R-HSA-109581)
Apoptotic factor-mediated response
(R-HSA-111471)
Cytochrome c-mediated apoptotic response
(R-HSA-111461)
Formation of apoptosome
(R-HSA-111458)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Neutrophil degranulation
(R-HSA-6798695)
Programmed cell death
(R-HSA-5357801)
Regulation of the apoptosome activity
(R-HSA-9627069)
Rna polymerase ii transcription
(R-HSA-73857)
Smac(diablo)-mediated dissociation of iap:caspase complexes
(R-HSA-111464)
Smac (diablo) binds to iaps
(R-HSA-111463)
Smac, xiap-regulated apoptotic response
(R-HSA-111469)
Tp53 regulates transcription of caspase activators and caspases
(R-HSA-6803207)
Tp53 regulates transcription of cell death genes
(R-HSA-5633008)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
(GO:0008635)
Adp binding
(GO:0043531)
Apoptosome
(GO:0043293)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cardiac muscle cell apoptotic process
(GO:0010659)
Cell differentiation
(GO:0030154)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Forebrain development
(GO:0030900)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Kidney development
(GO:0001822)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Neuron apoptotic process
(GO:0051402)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of apoptotic dna fragmentation
(GO:1902510)
Regulation of apoptotic process
(GO:0042981)
Response to g1 dna damage checkpoint signaling
(GO:0072432)
Response to hypoxia
(GO:0001666)
Response to nutrient
(GO:0007584)
Secretory granule lumen
(GO:0034774)

Other Information

Proteins

APAF_HUMAN

Genular Protein ID: 3751522192

Symbol: APAF_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14727 B2RMX8 O43297 Q7Z438 Q9BXZ6 Q9UBZ5 Q9UGN8 Q9UGN9 Q9UGP0 Q9UJ58 Q9UJ59 Q9UJ60 Q9UJ61 Q9UJ62 Q9UJ63 Q9UJ64 Q9UJ65 Q9UJ66 Q9UJ67 Q9UNC9

Database IDs:

Citations:

PubMed ID: 9267021

Title: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

PubMed ID: 9267021

DOI: 10.1016/s0092-8674(00)80501-2

PubMed ID: 10441496

Title: Three new types of Apaf-1 in mammalian cells.

PubMed ID: 10441496

DOI: 10.1006/bbrc.1999.1124

PubMed ID: 10364241

Title: Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.

PubMed ID: 10364241

DOI: 10.1074/jbc.274.25.17941

PubMed ID: 10393175

Title: Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.

PubMed ID: 10393175

DOI: 10.1093/emboj/18.13.3586

PubMed ID: 12804598

Title: APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.

PubMed ID: 12804598

DOI: 10.1016/s0006-291x(03)00995-1

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9651578

Title: Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

PubMed ID: 9651578

DOI: 10.1016/s1097-2765(00)80095-7

PubMed ID: 11389439

Title: Apaf-1 is a transcriptional target for E2F and p53.

PubMed ID: 11389439

DOI: 10.1038/35078527

PubMed ID: 15262985

Title: Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.

PubMed ID: 15262985

DOI: 10.1074/jbc.m405747200

PubMed ID: 17244527

Title: Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

PubMed ID: 17244527

DOI: 10.1016/j.molcel.2006.12.013

PubMed ID: 21371431

Title: Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.

PubMed ID: 21371431

DOI: 10.1016/j.bbrc.2011.02.130

PubMed ID: 25716227

Title: FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.

PubMed ID: 25716227

DOI: 10.1002/ijc.29498

PubMed ID: 31498791

Title: EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.

PubMed ID: 31498791

DOI: 10.1371/journal.pone.0221048

PubMed ID: 10543941

Title: Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.

PubMed ID: 10543941

DOI: 10.1006/jmbi.1999.3177

PubMed ID: 10578182

Title: Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.

PubMed ID: 10578182

DOI: 10.1038/sj.cdd.4400584

Sequence Information:

Length: 1248
Mass: 141840
Checksum: 0750D05817AC9B3B
Sequence:

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 
QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEAVRD HSLLEGCFPG 
GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL 
ILDDVWDSWV LKAFDSQCQI LLTTRDKSVT DSVMGPKYVV PVESSLGKEK GLEILSLFVN 
MKKADLPEQA HSIIKECKGS PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD 
YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN 
KSLLFCDRNG KSFRYYLHDL QVDFLTEKNC SQLQDLHKKI ITQFQRYHQP HTLSPDQEDC 
MYWYNFLAYH MASAKMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV 
SENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDN GMLYLEWINK 
KNITNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV 
LCCAFSTDDR FIATCSVDKK VKIWNSMTGE LVHTYDEHSE QVNCCHFTNS SHHLLLATGS 
SDCFLKLWDL NQKECRNTMF GHTNSVNHCR FSPDDKLLAS CSADGTLKLW DATSANERKS 
INVKQFFLNL EDPQEDMEVI VKCCSWSADG ARIMVAAKNK IFLFDIHTSG LLGEIHTGHH 
STIQYCDFSP QNHLAVVALS QYCVELWNTD SRSKVADCRG HLSWVHGVMF SPDGSSFLTS 
SDDQTIRLWE TKKVCKNSAV MLKQEVDVVF QENEVMVLAV DHIRRLQLIN GRTGQIDYLT 
EAQVSCCCLS PHLQYIAFGD ENGAIEILEL VNNRIFQSRF QHKKTVWHIQ FTADEKTLIS 
SSDDAEIQVW NWQLDKCIFL RGHQETVKDF RLLKNSRLLS WSFDGTVKVW NIITGNKEKD 
FVCHQGTVLS CDISHDATKF SSTSADKTAK IWSFDLLLPL HELRGHNGCV RCSAFSVDST 
LLATGDDNGE IRIWNVSNGE LLHLCAPLSE EGAATHGGWV TDLCFSPDGK MLISAGGYIK 
WWNVVTGESS QTFYTNGTNL KKIHVSPDFK TYVTVDNLGI LYILQTLE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APAF1

Associated with

Other Information

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. PubMed ID: 9267021

Three new types of Apaf-1 in mammalian cells. PubMed ID: 10441496

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. PubMed ID: 10364241

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. PubMed ID: 10393175

APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. PubMed ID: 12804598

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9455477

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. PubMed ID: 9651578

Apaf-1 is a transcriptional target for E2F and p53. PubMed ID: 11389439

Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. PubMed ID: 15262985

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. PubMed ID: 17244527

Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP. PubMed ID: 21371431

FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. PubMed ID: 25716227

EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation. PubMed ID: 31498791

Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling. PubMed ID: 10543941

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1. PubMed ID: 10578182