Details for: NUDT2

Gene ID: 318

Symbol: NUDT2

Ensembl ID: ENSG00000164978

Description: nudix hydrolase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.8091
    Cell Significance Index: -21.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.3744
    Cell Significance Index: -17.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.9735
    Cell Significance Index: -25.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.4741
    Cell Significance Index: -24.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.4950
    Cell Significance Index: -25.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.0761
    Cell Significance Index: -23.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8168
    Cell Significance Index: -20.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1606
    Cell Significance Index: -24.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8674
    Cell Significance Index: -14.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7604
    Cell Significance Index: -8.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2777
    Cell Significance Index: 157.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5203
    Cell Significance Index: 12.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1728
    Cell Significance Index: 127.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0351
    Cell Significance Index: 53.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8700
    Cell Significance Index: 141.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6032
    Cell Significance Index: 5.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5712
    Cell Significance Index: 78.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5710
    Cell Significance Index: 16.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5548
    Cell Significance Index: 245.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5540
    Cell Significance Index: 25.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5347
    Cell Significance Index: 292.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5008
    Cell Significance Index: 35.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4640
    Cell Significance Index: 57.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4250
    Cell Significance Index: 76.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3744
    Cell Significance Index: 48.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3709
    Cell Significance Index: 73.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3574
    Cell Significance Index: 7.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3301
    Cell Significance Index: 56.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3291
    Cell Significance Index: 20.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3250
    Cell Significance Index: 4.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3209
    Cell Significance Index: 41.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3072
    Cell Significance Index: 8.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2998
    Cell Significance Index: 22.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2833
    Cell Significance Index: 3.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2759
    Cell Significance Index: 55.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2746
    Cell Significance Index: 14.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2674
    Cell Significance Index: 7.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2568
    Cell Significance Index: 11.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1857
    Cell Significance Index: 4.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1836
    Cell Significance Index: 8.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1812
    Cell Significance Index: 34.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1583
    Cell Significance Index: 5.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1163
    Cell Significance Index: 2.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1129
    Cell Significance Index: 3.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1051
    Cell Significance Index: 37.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0916
    Cell Significance Index: 5.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0772
    Cell Significance Index: 9.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0612
    Cell Significance Index: 6.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0275
    Cell Significance Index: 0.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0172
    Cell Significance Index: 0.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0154
    Cell Significance Index: 0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0004
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0045
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0090
    Cell Significance Index: -2.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0228
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0245
    Cell Significance Index: -15.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0251
    Cell Significance Index: -18.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0266
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0308
    Cell Significance Index: -2.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0323
    Cell Significance Index: -1.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0357
    Cell Significance Index: -16.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0437
    Cell Significance Index: -9.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0475
    Cell Significance Index: -2.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0526
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0583
    Cell Significance Index: -6.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0729
    Cell Significance Index: -8.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1256
    Cell Significance Index: -18.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1461
    Cell Significance Index: -1.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1484
    Cell Significance Index: -3.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1773
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1979
    Cell Significance Index: -22.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2021
    Cell Significance Index: -5.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2139
    Cell Significance Index: -14.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2234
    Cell Significance Index: -9.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2295
    Cell Significance Index: -23.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2301
    Cell Significance Index: -18.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2324
    Cell Significance Index: -14.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2424
    Cell Significance Index: -6.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2791
    Cell Significance Index: -10.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3494
    Cell Significance Index: -4.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3532
    Cell Significance Index: -2.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3734
    Cell Significance Index: -3.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3816
    Cell Significance Index: -9.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4357
    Cell Significance Index: -5.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4444
    Cell Significance Index: -7.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4510
    Cell Significance Index: -8.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4594
    Cell Significance Index: -16.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4821
    Cell Significance Index: -13.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4951
    Cell Significance Index: -10.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5013
    Cell Significance Index: -17.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDT2 is a small, cytosolic enzyme that belongs to the nudix hydrolase family. It is characterized by its ability to hydrolyze various nucleoside triphosphates, including ATP, GTP, and CTP. NUDT2 is also known to interact with various proteins, including those involved in energy metabolism, stress response, and detoxification of reactive oxygen species. **Pathways and Functions:** NUDT2 is involved in several key pathways, including: 1. **Energy Metabolism:** NUDT2 is involved in the regulation of energy metabolism by hydrolyzing ATP and GTP, which are essential energy-rich molecules. 2. **Stress Response:** NUDT2 plays a crucial role in the cellular response to stress, including oxidative stress, by hydrolyzing reactive oxygen species (ROS) and detoxifying damaged nucleosides. 3. **Detoxification of Reactive Oxygen Species:** NUDT2 is involved in the detoxification of ROS by hydrolyzing nucleoside triphosphates, which are reactive molecules that can cause cellular damage. 4. **Amp Biosynthetic Process:** NUDT2 is also involved in the biosynthesis of AMP, a crucial energy-rich molecule. **Clinical Significance:** NUDT2 has been implicated in various diseases, including: 1. **Osteoporosis:** NUDT2 has been shown to play a crucial role in the regulation of osteoclast activity, which is essential for bone resorption. 2. **Neurodegenerative Diseases:** NUDT2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it plays a crucial role in the regulation of energy metabolism and stress response. 3. **Cancer:** NUDT2 has been shown to play a role in the regulation of cancer cell growth and survival by hydrolyzing nucleoside triphosphates and detoxifying ROS. In conclusion, NUDT2 is a multifunctional enzyme that plays a crucial role in maintaining cellular homeostasis. Its expression is widespread across different cell types, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions and significance of NUDT2 in human health and disease. **Recommendations:** 1. **Future Research Directions:** Further research is needed to fully understand the functions and significance of NUDT2 in human health and disease. 2. **Therapeutic Targeting:** NUDT2 may serve as a therapeutic target for the treatment of various diseases, including osteoporosis, neurodegenerative diseases, and cancer. 3. **Diagnostic Biomarkers:** NUDT2 may serve as a diagnostic biomarker for various diseases, including osteoporosis and neurodegenerative diseases.

Genular Protein ID: 1245584722

Symbol: AP4A_HUMAN

Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

UniProtKB Accession Codes:

P50583 D3DRM0 Q5T589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 4 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 9 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7487923

Title: Human diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases.

PubMed ID: 7487923

DOI: 10.1042/bj3110717

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 15596429

Title: Structure and substrate-binding mechanism of human Ap4A hydrolase.

PubMed ID: 15596429

DOI: 10.1074/jbc.m412318200

PubMed ID: 27431290

Title: Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield.

PubMed ID: 27431290

DOI: 10.1038/mp.2016.113

PubMed ID: 30059600

Title: A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children.

PubMed ID: 30059600

DOI: 10.1111/cge.13386

PubMed ID: 33058507

Title: Novel NUDT2 variant causes intellectual disability and polyneuropathy.

PubMed ID: 33058507

DOI: 10.1002/acn3.51209

Sequence Information:

  • Length: 147
  • Mass: 16829
  • Checksum: 3599B12719F94AB8
  • Sequence:
    • MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED DLETALRETQ 
EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD YDVEIRLSHE HQAYRWLGLE 
EACQLAQFKE MKAALQEGHQ FLCSIEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.