Details for: APOF

Gene ID: 319

Symbol: APOF

Ensembl ID: ENSG00000175336

Description: apolipoprotein F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 9.5149
    Cell Significance Index: -1.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.7561
    Cell Significance Index: -1.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.3806
    Cell Significance Index: 56.8600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.6270
    Cell Significance Index: 6.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1625
    Cell Significance Index: 28.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1000
    Cell Significance Index: 35.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4404
    Cell Significance Index: 6.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3232
    Cell Significance Index: 5.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2560
    Cell Significance Index: 15.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2310
    Cell Significance Index: 37.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1784
    Cell Significance Index: 2.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1450
    Cell Significance Index: 10.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1444
    Cell Significance Index: 3.0800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1062
    Cell Significance Index: 0.4000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0616
    Cell Significance Index: 0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0339
    Cell Significance Index: 0.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0241
    Cell Significance Index: 4.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0192
    Cell Significance Index: 0.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0146
    Cell Significance Index: 0.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0143
    Cell Significance Index: 2.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0141
    Cell Significance Index: 0.2000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0126
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0120
    Cell Significance Index: 0.2600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0039
    Cell Significance Index: 0.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0033
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0023
    Cell Significance Index: -1.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0066
    Cell Significance Index: -0.7200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0076
    Cell Significance Index: -1.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0094
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0096
    Cell Significance Index: -1.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0097
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0099
    Cell Significance Index: -1.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0100
    Cell Significance Index: -1.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0102
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0105
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0127
    Cell Significance Index: -1.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0147
    Cell Significance Index: -0.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0160
    Cell Significance Index: -1.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0169
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0173
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0177
    Cell Significance Index: -0.1400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0187
    Cell Significance Index: -2.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0188
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0222
    Cell Significance Index: -1.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0231
    Cell Significance Index: -0.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0233
    Cell Significance Index: -1.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0252
    Cell Significance Index: -0.3800
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0259
    Cell Significance Index: -0.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0272
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0285
    Cell Significance Index: -0.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0294
    Cell Significance Index: -1.5500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0294
    Cell Significance Index: -0.3800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0301
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0301
    Cell Significance Index: -0.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0314
    Cell Significance Index: -1.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0316
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0318
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0323
    Cell Significance Index: -0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0343
    Cell Significance Index: -0.9200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0365
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0368
    Cell Significance Index: -1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0371
    Cell Significance Index: -1.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0412
    Cell Significance Index: -1.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0415
    Cell Significance Index: -0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0419
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0424
    Cell Significance Index: -0.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0429
    Cell Significance Index: -1.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0433
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0454
    Cell Significance Index: -0.6900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0459
    Cell Significance Index: -0.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0473
    Cell Significance Index: -1.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0479
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0493
    Cell Significance Index: -0.6800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0495
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0496
    Cell Significance Index: -1.5700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0497
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0498
    Cell Significance Index: -0.9200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0502
    Cell Significance Index: -0.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOF is a member of the apolipoprotein family, which is known for its involvement in lipid metabolism and transport. The protein is characterized by its ability to bind to cholesterol and other lipids, facilitating their transport and remodeling in the body. APOF is specifically expressed in cells involved in the gastrointestinal tract, such as goblet cells, enterocytes, and intestinal crypt stem cells, suggesting its role in maintaining gut homeostasis. **Pathways and Functions:** APOF is involved in several key pathways, including: 1. **Cholesterol Binding and Transport:** APOF binds to cholesterol and other lipids, facilitating their transport and remodeling in the body. 2. **Lipid Metabolic Process:** APOF is involved in the regulation of lipid metabolism, including the breakdown and synthesis of lipids. 3. **Extracellular Space:** APOF plays a role in maintaining the integrity of the extracellular space, including the gut and the central nervous system. 4. **Signaling Receptor Binding:** APOF interacts with signaling receptors, influencing cellular signaling pathways. 5. **Lipid Transport and Remodeling:** APOF is involved in the transport and remodeling of lipids in the body, including the formation and clearance of lipoproteins. **Clinical Significance:** The dysregulation of APOF has been implicated in various diseases, including: 1. **Atherosclerosis:** APOF has been shown to play a role in the development of atherosclerosis, a condition characterized by the buildup of cholesterol-rich plaques in the arteries. 2. **Metabolic Syndrome:** APOF has been linked to metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. 3. **Neurodegenerative Diseases:** APOF has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where it may play a role in the clearance of amyloid-β and other lipids. 4. **Gastrointestinal Disorders:** APOF has been linked to gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome, where it may play a role in maintaining gut homeostasis. In conclusion, APOF is a multifunctional protein that plays a crucial role in lipid metabolism and transport. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of APOF and its potential therapeutic applications.

Genular Protein ID: 2529461697

Symbol: APOF_HUMAN

Name: Apolipoprotein F

UniProtKB Accession Codes:

Q13790 Q8TC13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8093033

Title: Purification and molecular cloning of human apolipoprotein F.

PubMed ID: 8093033

DOI: 10.1006/bbrc.1994.2302

PubMed ID: 9880564

Title: Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F.

PubMed ID: 9880564

DOI: 10.1074/jbc.274.3.1814

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 204339

Title: Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma.

PubMed ID: 204339

DOI: 10.1021/bi00599a014

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28935895

Title: Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example.

PubMed ID: 28935895

DOI: 10.1038/s41598-017-12229-2

Sequence Information:

  • Length: 326
  • Mass: 35399
  • Checksum: 046A1E775E7D4320
  • Sequence:
    • MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP LSLESQTPSS 
DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC QADVWALQLQ LYRQGGVNAT 
QVLIQHLRGL QKGRSTERNV SVEALASALQ LLAREQQSTG RVGRSLPTED CENEKEQAVH 
NVVQLLPGVG TFYNLGTALY YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA 
ISAALKPALR SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV 
VSSAPYWGWA IIKSYDLDPG AGSLEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.