ACACB | ENSG00000076555 | NCBI 32

Details for: ACACB

Gene ID: 32

Symbol: ACACB

Ensembl ID: ENSG00000076555

Description: acetyl-CoA carboxylase beta

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Biotin transport and metabolism
(R-HSA-196780)
Carnitine shuttle
(R-HSA-200425)
Chrebp activates metabolic gene expression
(R-HSA-163765)
Fatty acid metabolism
(R-HSA-8978868)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Acetyl-coa carboxylase activity
(GO:0003989)
Acetyl-coa metabolic process
(GO:0006084)
Atp binding
(GO:0005524)
Biotin binding
(GO:0009374)
Cytosol
(GO:0005829)
D-glucose import
(GO:0046323)
Energy homeostasis
(GO:0097009)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid oxidation
(GO:0019395)
Identical protein binding
(GO:0042802)
Intracellular aspartate homeostasis
(GO:0090459)
Intracellular glutamate homeostasis
(GO:0090461)
Lactic acid secretion
(GO:0046722)
Malonyl-coa biosynthetic process
(GO:2001295)
Metal ion binding
(GO:0046872)
Mitochondrial fatty acid beta-oxidation multienzyme complex
(GO:0016507)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Nucleus
(GO:0005634)
Pentose-phosphate shunt
(GO:0006098)
Positive regulation of heart growth
(GO:0060421)
Positive regulation of lipid storage
(GO:0010884)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of cardiac muscle hypertrophy in response to stress
(GO:1903242)
Regulation of glucose metabolic process
(GO:0010906)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Tricarboxylic acid metabolic process
(GO:0072350)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 1
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: type I muscle cell (CL0002211)
Fold Change: 1
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 1
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1
Cell Significance Index: 1
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1
Cell Significance Index: 1
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: contractile cell (CL0000183)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** ACACB exhibits several distinct characteristics that make it an essential enzyme in the cell. These include: 1. **Acetyl-CoA carboxylase activity**: ACACB catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a reaction that is reversible and requires the presence of biotin as a cofactor. 2. **High expression levels**: ACACB is highly expressed in various tissues, including skeletal muscle, subcutaneous fat, cardiac myocytes, and astrocytes, indicating its importance in energy homeostasis and lipid metabolism. 3. **Regulatory mechanisms**: ACACB is subject to various regulatory mechanisms, including the activation of gene expression by SREBP (sterol regulatory element-binding protein) and the negative regulation of fatty acid beta-oxidation. 4. **Cofactor requirements**: ACACB requires biotin as a cofactor for its enzymatic activity, highlighting the importance of biotin in fatty acid synthesis and metabolism. **Pathways and Functions** ACACB is involved in several key pathways that regulate energy homeostasis and lipid metabolism, including: 1. **Fatty acid biosynthesis**: ACACB plays a crucial role in the biosynthesis of fatty acids by catalyzing the conversion of acetyl-CoA to malonyl-CoA. 2. **Fatty acid metabolism**: ACACB is also involved in the regulation of fatty acid metabolism, including the negative regulation of fatty acid beta-oxidation. 3. **Energy homeostasis**: ACACB helps maintain energy homeostasis by regulating the synthesis and oxidation of fatty acids. 4. **Regulation of cardiac muscle hypertrophy**: ACACB is involved in the regulation of cardiac muscle hypertrophy in response to stress, highlighting its importance in cardiac function and disease. **Clinical Significance** Dysregulation of ACACB has been implicated in various diseases, including: 1. **Metabolic disorders**: ACACB dysregulation has been linked to metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia. 2. **Cardiac disease**: ACACB dysregulation has been implicated in cardiac disease, including cardiac hypertrophy and heart failure. 3. **Cancer**: ACACB dysregulation has been linked to cancer, including the promotion of tumor growth and metastasis. 4. **Neurological disorders**: ACACB dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ACACB is a critical enzyme that regulates fatty acid synthesis and metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which ACACB regulates energy homeostasis and lipid metabolism, and to develop therapeutic strategies to target ACACB in the treatment of related diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.