Gene ACACB - ENSG00000076555 | NCBI Gene ID: 32

Details for: ACACB

Gene ID: 32

Symbol: ACACB

Ensembl ID: ENSG00000076555

Description: acetyl-CoA carboxylase beta

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Biotin transport and metabolism
(R-HSA-196780)
Carnitine metabolism
(R-HSA-200425)
Chrebp activates metabolic gene expression
(R-HSA-163765)
Fatty acid metabolism
(R-HSA-8978868)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Acetyl-coa carboxylase activity
(GO:0003989)
Acetyl-coa metabolic process
(GO:0006084)
Atp binding
(GO:0005524)
Biotin binding
(GO:0009374)
Cytosol
(GO:0005829)
Energy homeostasis
(GO:0097009)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid oxidation
(GO:0019395)
Glucose import
(GO:0046323)
Identical protein binding
(GO:0042802)
Intracellular aspartate homeostasis
(GO:0090459)
Intracellular glutamate homeostasis
(GO:0090461)
Lactic acid secretion
(GO:0046722)
Malonyl-coa biosynthetic process
(GO:2001295)
Metal ion binding
(GO:0046872)
Mitochondrial fatty acid beta-oxidation multienzyme complex
(GO:0016507)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Negative regulation of gene expression
(GO:0010629)
Nucleus
(GO:0005634)
Pentose-phosphate shunt
(GO:0006098)
Positive regulation of heart growth
(GO:0060421)
Positive regulation of lipid storage
(GO:0010884)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of cardiac muscle hypertrophy in response to stress
(GO:1903242)
Regulation of glucose metabolic process
(GO:0010906)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Tricarboxylic acid metabolic process
(GO:0072350)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 6.56
Marker Score: 16418
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 5.65
Marker Score: 2064
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 4.22
Marker Score: 94401
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.97
Marker Score: 63338
Cell Name: fat cell (CL0000136)
Fold Change: 2.93
Marker Score: 1635
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.81
Marker Score: 49965
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.78
Marker Score: 6101
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.72
Marker Score: 11377
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.5
Marker Score: 1927
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.47
Marker Score: 721
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.33
Marker Score: 8268.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.22
Marker Score: 1167
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.11
Marker Score: 11347
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.92
Marker Score: 2397
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.88
Marker Score: 1239
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.81
Marker Score: 11623
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.77
Marker Score: 1690
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.74
Marker Score: 7518
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.73
Marker Score: 1855
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.71
Marker Score: 3287
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.7
Marker Score: 2290
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.7
Marker Score: 991.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.62
Marker Score: 5743.5
Cell Name: astrocyte (CL0000127)
Fold Change: 1.62
Marker Score: 1400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.51
Marker Score: 478
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.42
Marker Score: 373
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.39
Marker Score: 771
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.38
Marker Score: 1669
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.37
Marker Score: 3222
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.32
Marker Score: 20699
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.22
Marker Score: 381
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.16
Marker Score: 485
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.13
Marker Score: 674
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.12
Marker Score: 3008
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.09
Marker Score: 1252
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.08
Marker Score: 344
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.07
Marker Score: 2177
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.04
Marker Score: 3411
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.03
Marker Score: 284
Cell Name: keratocyte (CL0002363)
Fold Change: 1.01
Marker Score: 232
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71784
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48008
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.97
Marker Score: 1500
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.96
Marker Score: 2719
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.93
Marker Score: 339
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.93
Marker Score: 3868
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.92
Marker Score: 252
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2727
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.9
Marker Score: 612
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.89
Marker Score: 963
Cell Name: contractile cell (CL0000183)
Fold Change: 0.89
Marker Score: 483
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5047.5
Cell Name: podocyte (CL0000653)
Fold Change: 0.88
Marker Score: 326.5
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.88
Marker Score: 1283
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.88
Marker Score: 514
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.86
Marker Score: 184
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.86
Marker Score: 952
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.85
Marker Score: 288
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.83
Marker Score: 206
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.83
Marker Score: 5012
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.83
Marker Score: 200
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.82
Marker Score: 393
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.82
Marker Score: 213
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.82
Marker Score: 396
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 608
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.79
Marker Score: 297
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.79
Marker Score: 202
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.78
Marker Score: 247
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.78
Marker Score: 822
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 305
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 385
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3104
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 643
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.7
Marker Score: 170
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.69
Marker Score: 979
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.69
Marker Score: 593
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.69
Marker Score: 221
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.66
Marker Score: 399
Cell Name: acinar cell (CL0000622)
Fold Change: 0.64
Marker Score: 453
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.63
Marker Score: 675
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.63
Marker Score: 1591
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.62
Marker Score: 233
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.61
Marker Score: 606.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.61
Marker Score: 545
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.6
Marker Score: 5166
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.59
Marker Score: 8846
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.59
Marker Score: 119
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.58
Marker Score: 1167
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.58
Marker Score: 190
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.57
Marker Score: 173
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.57
Marker Score: 34923.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.57
Marker Score: 700

Hover over a box to see details here...

**Key characteristics:** * Protein type: Enzyme * Ensembl ID: ENSG00000076555 * Pathway/Ontology: Acetyl-CoA carboxylase activity, Acetyl-CoA metabolic process * Subcellular location: Cytoplasm **Pathways and functions:** * Acetyl-CoA carboxylase activity: The ACACB enzyme catalyzes the carboxylation of acetyl-CoA to produce acetate, which is then used in various metabolic pathways. * Acetyl-CoA metabolic process: The product of ACACB activity, acetate, enters the citric acid cycle and is used to generate energy in the form of ATP. **Clinical significance:** * Dysfunction of the ACACB gene has been linked to several human diseases, including hyperlipidemia and obesity. * Overexpression of ACACB has been observed in some cancers, where it may contribute to the development of tumors. * Inhibition of ACACB has been shown to improve insulin sensitivity and reduce blood sugar levels in diabetic mice. **Additional information:** * The ACACB gene is highly expressed in skeletal muscle fiber, subcutaneous fat cell, and regular ventricular cardiac myocyte. * It is also expressed in astrocytes of the cerebral cortex, fat cells, cortical cell of the adrenal gland, ciliary muscle cell, and pigmented epithelial cell.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ACC-beta

Genular Protein ID: 3803571407

Symbol: ACACB_HUMAN

Name: ACC-beta

UniProtKB Accession Codes:

O00763 A6NK36 Q16852 Q1HEC1 Q6KE87 Q6KE89 Q6TY48

Database IDs:

Citations:

PubMed ID: 9099716

Title: Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

PubMed ID: 9099716

DOI: 10.1074/jbc.272.16.10669

PubMed ID: 16854592

Title: Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.

PubMed ID: 16854592

DOI: 10.1016/j.pep.2006.06.005

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 8670171

Title: Identification of a second human acetyl-CoA carboxylase gene.

PubMed ID: 8670171

DOI: 10.1042/bj3160915

PubMed ID: 10677481

Title: The subcellular localization of acetyl-CoA carboxylase 2.

PubMed ID: 10677481

DOI: 10.1073/pnas.97.4.1444

PubMed ID: 12488245

Title: Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle.

PubMed ID: 12488245

DOI: 10.1152/ajpendo.00436.2002

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19236960

Title: Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics.

PubMed ID: 19236960

DOI: 10.1016/j.bbapap.2009.02.004

PubMed ID: 19190759

Title: ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus.

PubMed ID: 19190759

DOI: 10.1371/journal.pone.0004369

PubMed ID: 20457939

Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

PubMed ID: 20457939

DOI: 10.1073/pnas.1001292107

PubMed ID: 20952656

Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.

PubMed ID: 20952656

DOI: 10.1073/pnas.1012736107

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17876819

Title: Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.

PubMed ID: 17876819

DOI: 10.1002/prot.21611

PubMed ID: 18247344

Title: Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism.

PubMed ID: 18247344

DOI: 10.1002/prot.21952

PubMed ID: 19390150

Title: The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.

PubMed ID: 19390150

DOI: 10.1107/s0907444909008014

PubMed ID: 19900410

Title: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.

PubMed ID: 19900410

DOI: 10.1016/j.bbrc.2009.11.029

PubMed ID: 26976583

Title: Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

PubMed ID: 26976583

DOI: 10.1073/pnas.1520686113

PubMed ID: 18772397

Title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

PubMed ID: 18772397

DOI: 10.1126/science.1164368

Sequence Information:

Length: 2458
Mass: 276541
Checksum: ED12674A1A8A0706
Sequence:

MVLLLCLSCL IFSCLTFSWL KIWGKMTDSK PITKSKSEAN LIPSQEPFPA SDNSGETPQR 
NGEGHTLPKT PSQAEPASHK GPKDAGRRRN SLPPSHQKPP RNPLSSSDAA PSPELQANGT 
GTQGLEATDT NGLSSSARPQ GQQAGSPSKE DKKQANIKRQ LMTNFILGSF DDYSSDEDSV 
AGSSRESTRK GSRASLGALS LEAYLTTGEA ETRVPTMRPS MSGLHLVKRG REHKKLDLHR 
DFTVASPAEF VTRFGGDRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT 
PEDLKANAEY IKMADHYVPV PGGPNNNNYA NVELIVDIAK RIPVQAVWAG WGHASENPKL 
PELLCKNGVA FLGPPSEAMW ALGDKIASTV VAQTLQVPTL PWSGSGLTVE WTEDDLQQGK 
RISVPEDVYD KGCVKDVDEG LEAAERIGFP LMIKASEGGG GKGIRKAESA EDFPILFRQV 
QSEIPGSPIF LMKLAQHARH LEVQILADQY GNAVSLFGRD CSIQRRHQKI VEEAPATIAP 
LAIFEFMEQC AIRLAKTVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL 
PAAQLQIAMG VPLHRLKDIR LLYGESPWGV TPISFETPSN PPLARGHVIA ARITSENPDE 
GFKPSSGTVQ ELNFRSSKNV WGYFSVAATG GLHEFADSQF GHCFSWGENR EEAISNMVVA 
LKELSIRGDF RTTVEYLINL LETESFQNND IDTGWLDYLI AEKVQAEKPD IMLGVVCGAL 
NVADAMFRTC MTDFLHSLER GQVLPADSLL NLVDVELIYG GVKYILKVAR QSLTMFVLIM 
NGCHIEIDAH RLNDGGLLLS YNGNSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP 
SAGKLTQYTV EDGGHVEAGS SYAEMEVMKM IMTLNVQERG RVKYIKRPGA VLEAGCVVAR 
LELDDPSKVH PAEPFTGELP AQQTLPILGE KLHQVFHSVL ENLTNVMSGF CLPEPVFSIK 
LKEWVQKLMM TLRHPSLPLL ELQEIMTSVA GRIPAPVEKS VRRVMAQYAS NITSVLCQFP 
SQQIATILDC HAATLQRKAD REVFFINTQS IVQLVQRYRS GIRGYMKTVV LDLLRRYLRV 
EHHFQQAHYD KCVINLREQF KPDMSQVLDC IFSHAQVAKK NQLVIMLIDE LCGPDPSLSD 
ELISILNELT QLSKSEHCKV ALRARQILIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP 
ENLKKLILSE TTIFDVLPTF FYHANKVVCM ASLEVYVRRG YIAYELNSLQ HRQLPDGTCV 
VEFQFMLPSS HPNRMTVPIS ITNPDLLRHS TELFMDSGFS PLCQRMGAMV AFRRFEDFTR 
NFDEVISCFA NVPKDTPLFS EARTSLYSED DCKSLREEPI HILNVSIQCA DHLEDEALVP 
ILRTFVQSKK NILVDYGLRR ITFLIAQEKE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL 
ELNRMRNFDL TAVPCANHKM HLYLGAAKVK EGVEVTDHRF FIRAIIRHSD LITKEASFEY 
LQNEGERLLL EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPFKIEES VRYMVMRYGS 
RLWKLRVLQA EVKINIRQTT TGSAVPIRLF ITNESGYYLD ISLYKEVTDS RSGNIMFHSF 
GNKQGPQHGM LINTPYVTKD LLQAKRFQAQ TLGTTYIYDF PEMFRQALFK LWGSPDKYPK 
DILTYTELVL DSQGQLVEMN RLPGGNEVGM VAFKMRFKTQ EYPEGRDVIV IGNDITFRIG 
SFGPGEDLLY LRASEMARAE GIPKIYVAAN SGARIGMAEE IKHMFHVAWV DPEDPHKGFK 
YLYLTPQDYT RISSLNSVHC KHIEEGGESR YMITDIIGKD DGLGVENLRG SGMIAGESSL 
AYEEIVTISL VTCRAIGIGA YLVRLGQRVI QVENSHIILT GASALNKVLG REVYTSNNQL 
GGVQIMHYNG VSHITVPDDF EGVYTILEWL SYMPKDNHSP VPIITPTDPI DREIEFLPSR 
APYDPRWMLA GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE 
TRTVEVAVPA DPANLDSEAK IIQQAGQVWF PDSAYKTAQA VKDFNREKLP LMIFANWRGF 
SGGMKDMYDQ VLKFGAYIVD GLRQYKQPIL IYIPPYAELR GGSWVVIDAT INPLCIEMYA 
DKESRGGVLE PEGTVEIKFR KKDLIKSMRR IDPAYKKLME QLGEPDLSDK DRKDLEGRLK 
AREDLLLPIY HQVAVQFADF HDTPGRMLEK GVISDILEWK TARTFLYWRL RRLLLEDQVK 
QEILQASGEL SHVHIQSMLR RWFVETEGAV KAYLWDNNQV VVQWLEQHWQ AGDGPRSTIR 
ENITYLKHDS VLKTIRGLVE ENPEVAVDCV IYLSQHISPA ERAQVVHLLS TMDSPAST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ACACB

Associated with

Cells (max top 100)

Other Information

Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. PubMed ID: 9099716

Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes. PubMed ID: 16854592

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

Identification of a second human acetyl-CoA carboxylase gene. PubMed ID: 8670171

The subcellular localization of acetyl-CoA carboxylase 2. PubMed ID: 10677481

Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. PubMed ID: 12488245

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. PubMed ID: 19236960

ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus. PubMed ID: 19190759

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. PubMed ID: 20457939

Crystal structure of Spot 14, a modulator of fatty acid synthesis. PubMed ID: 20952656

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2. PubMed ID: 17876819

Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism. PubMed ID: 18247344

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. PubMed ID: 19390150

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. PubMed ID: 19900410

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. PubMed ID: 26976583

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. PubMed ID: 18772397