Details for: ACACB

Gene ID: 32

Symbol: ACACB

Ensembl ID: ENSG00000076555

Description: acetyl-CoA carboxylase beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.2831
    Cell Significance Index: -27.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.5275
    Cell Significance Index: -27.0200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 58.9477
    Cell Significance Index: 256.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.9555
    Cell Significance Index: -26.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.6035
    Cell Significance Index: -23.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3285
    Cell Significance Index: -27.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 16.9176
    Cell Significance Index: 213.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2937
    Cell Significance Index: -20.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0121
    Cell Significance Index: -27.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.0587
    Cell Significance Index: 162.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.8645
    Cell Significance Index: 143.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.1876
    Cell Significance Index: 398.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.4684
    Cell Significance Index: 87.2100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.8586
    Cell Significance Index: 62.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6649
    Cell Significance Index: 44.8900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.4897
    Cell Significance Index: 34.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6622
    Cell Significance Index: 329.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5787
    Cell Significance Index: 40.5800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.3516
    Cell Significance Index: 19.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1407
    Cell Significance Index: 1029.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9074
    Cell Significance Index: 576.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8440
    Cell Significance Index: 12.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6966
    Cell Significance Index: 113.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6769
    Cell Significance Index: 73.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6147
    Cell Significance Index: 1157.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5319
    Cell Significance Index: 31.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4803
    Cell Significance Index: 47.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4767
    Cell Significance Index: 13.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4351
    Cell Significance Index: 197.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4192
    Cell Significance Index: 19.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3499
    Cell Significance Index: 24.2000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3282
    Cell Significance Index: 5.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3103
    Cell Significance Index: 3.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3080
    Cell Significance Index: 55.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2492
    Cell Significance Index: 47.4300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2298
    Cell Significance Index: 2.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2146
    Cell Significance Index: 43.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2099
    Cell Significance Index: 11.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1766
    Cell Significance Index: 122.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1549
    Cell Significance Index: 55.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1271
    Cell Significance Index: 234.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1206
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1033
    Cell Significance Index: 3.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1011
    Cell Significance Index: 155.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0494
    Cell Significance Index: 0.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0421
    Cell Significance Index: 1.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0198
    Cell Significance Index: 26.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0190
    Cell Significance Index: 13.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0063
    Cell Significance Index: -3.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0197
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0230
    Cell Significance Index: -3.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0246
    Cell Significance Index: -10.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0307
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0444
    Cell Significance Index: -25.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0449
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0470
    Cell Significance Index: -29.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0592
    Cell Significance Index: -8.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0717
    Cell Significance Index: -10.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0789
    Cell Significance Index: -1.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0820
    Cell Significance Index: -23.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0838
    Cell Significance Index: -1.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1050
    Cell Significance Index: -10.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1160
    Cell Significance Index: -13.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1400
    Cell Significance Index: -29.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1431
    Cell Significance Index: -16.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1809
    Cell Significance Index: -11.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1831
    Cell Significance Index: -8.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1871
    Cell Significance Index: -22.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1938
    Cell Significance Index: -25.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2068
    Cell Significance Index: -4.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2184
    Cell Significance Index: -11.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2462
    Cell Significance Index: -6.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2545
    Cell Significance Index: -13.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2616
    Cell Significance Index: -8.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2793
    Cell Significance Index: -19.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2856
    Cell Significance Index: -22.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3029
    Cell Significance Index: -4.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3031
    Cell Significance Index: -20.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3087
    Cell Significance Index: -23.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3118
    Cell Significance Index: -20.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3163
    Cell Significance Index: -6.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3171
    Cell Significance Index: -6.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3342
    Cell Significance Index: -17.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3352
    Cell Significance Index: -20.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3862
    Cell Significance Index: -5.8200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3985
    Cell Significance Index: -5.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4009
    Cell Significance Index: -25.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4320
    Cell Significance Index: -10.8000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4474
    Cell Significance Index: -5.1200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4477
    Cell Significance Index: -4.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4493
    Cell Significance Index: -7.7000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4687
    Cell Significance Index: -7.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4901
    Cell Significance Index: -21.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5317
    Cell Significance Index: -6.6300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.5343
    Cell Significance Index: -5.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5434
    Cell Significance Index: -14.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5667
    Cell Significance Index: -8.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5808
    Cell Significance Index: -25.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5832
    Cell Significance Index: -20.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACACB exhibits several distinct characteristics that make it an essential enzyme in the cell. These include: 1. **Acetyl-CoA carboxylase activity**: ACACB catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a reaction that is reversible and requires the presence of biotin as a cofactor. 2. **High expression levels**: ACACB is highly expressed in various tissues, including skeletal muscle, subcutaneous fat, cardiac myocytes, and astrocytes, indicating its importance in energy homeostasis and lipid metabolism. 3. **Regulatory mechanisms**: ACACB is subject to various regulatory mechanisms, including the activation of gene expression by SREBP (sterol regulatory element-binding protein) and the negative regulation of fatty acid beta-oxidation. 4. **Cofactor requirements**: ACACB requires biotin as a cofactor for its enzymatic activity, highlighting the importance of biotin in fatty acid synthesis and metabolism. **Pathways and Functions** ACACB is involved in several key pathways that regulate energy homeostasis and lipid metabolism, including: 1. **Fatty acid biosynthesis**: ACACB plays a crucial role in the biosynthesis of fatty acids by catalyzing the conversion of acetyl-CoA to malonyl-CoA. 2. **Fatty acid metabolism**: ACACB is also involved in the regulation of fatty acid metabolism, including the negative regulation of fatty acid beta-oxidation. 3. **Energy homeostasis**: ACACB helps maintain energy homeostasis by regulating the synthesis and oxidation of fatty acids. 4. **Regulation of cardiac muscle hypertrophy**: ACACB is involved in the regulation of cardiac muscle hypertrophy in response to stress, highlighting its importance in cardiac function and disease. **Clinical Significance** Dysregulation of ACACB has been implicated in various diseases, including: 1. **Metabolic disorders**: ACACB dysregulation has been linked to metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia. 2. **Cardiac disease**: ACACB dysregulation has been implicated in cardiac disease, including cardiac hypertrophy and heart failure. 3. **Cancer**: ACACB dysregulation has been linked to cancer, including the promotion of tumor growth and metastasis. 4. **Neurological disorders**: ACACB dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ACACB is a critical enzyme that regulates fatty acid synthesis and metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which ACACB regulates energy homeostasis and lipid metabolism, and to develop therapeutic strategies to target ACACB in the treatment of related diseases.

Genular Protein ID: 3803571407

Symbol: ACACB_HUMAN

Name: ACC-beta

UniProtKB Accession Codes:

O00763 A6NK36 Q16852 Q1HEC1 Q6KE87 Q6KE89 Q6TY48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 4 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9099716

Title: Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

PubMed ID: 9099716

DOI: 10.1074/jbc.272.16.10669

PubMed ID: 16854592

Title: Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.

PubMed ID: 16854592

DOI: 10.1016/j.pep.2006.06.005

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 8670171

Title: Identification of a second human acetyl-CoA carboxylase gene.

PubMed ID: 8670171

DOI: 10.1042/bj3160915

PubMed ID: 10677481

Title: The subcellular localization of acetyl-CoA carboxylase 2.

PubMed ID: 10677481

DOI: 10.1073/pnas.97.4.1444

PubMed ID: 12488245

Title: Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle.

PubMed ID: 12488245

DOI: 10.1152/ajpendo.00436.2002

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19236960

Title: Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics.

PubMed ID: 19236960

DOI: 10.1016/j.bbapap.2009.02.004

PubMed ID: 19190759

Title: ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus.

PubMed ID: 19190759

DOI: 10.1371/journal.pone.0004369

PubMed ID: 20457939

Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

PubMed ID: 20457939

DOI: 10.1073/pnas.1001292107

PubMed ID: 20952656

Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.

PubMed ID: 20952656

DOI: 10.1073/pnas.1012736107

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17876819

Title: Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.

PubMed ID: 17876819

DOI: 10.1002/prot.21611

PubMed ID: 18247344

Title: Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism.

PubMed ID: 18247344

DOI: 10.1002/prot.21952

PubMed ID: 19390150

Title: The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.

PubMed ID: 19390150

DOI: 10.1107/s0907444909008014

PubMed ID: 19900410

Title: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.

PubMed ID: 19900410

DOI: 10.1016/j.bbrc.2009.11.029

PubMed ID: 26976583

Title: Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

PubMed ID: 26976583

DOI: 10.1073/pnas.1520686113

PubMed ID: 18772397

Title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

PubMed ID: 18772397

DOI: 10.1126/science.1164368

Sequence Information:

  • Length: 2458
  • Mass: 276541
  • Checksum: ED12674A1A8A0706
  • Sequence:
    • MVLLLCLSCL IFSCLTFSWL KIWGKMTDSK PITKSKSEAN LIPSQEPFPA SDNSGETPQR 
NGEGHTLPKT PSQAEPASHK GPKDAGRRRN SLPPSHQKPP RNPLSSSDAA PSPELQANGT 
GTQGLEATDT NGLSSSARPQ GQQAGSPSKE DKKQANIKRQ LMTNFILGSF DDYSSDEDSV 
AGSSRESTRK GSRASLGALS LEAYLTTGEA ETRVPTMRPS MSGLHLVKRG REHKKLDLHR 
DFTVASPAEF VTRFGGDRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT 
PEDLKANAEY IKMADHYVPV PGGPNNNNYA NVELIVDIAK RIPVQAVWAG WGHASENPKL 
PELLCKNGVA FLGPPSEAMW ALGDKIASTV VAQTLQVPTL PWSGSGLTVE WTEDDLQQGK 
RISVPEDVYD KGCVKDVDEG LEAAERIGFP LMIKASEGGG GKGIRKAESA EDFPILFRQV 
QSEIPGSPIF LMKLAQHARH LEVQILADQY GNAVSLFGRD CSIQRRHQKI VEEAPATIAP 
LAIFEFMEQC AIRLAKTVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL 
PAAQLQIAMG VPLHRLKDIR LLYGESPWGV TPISFETPSN PPLARGHVIA ARITSENPDE 
GFKPSSGTVQ ELNFRSSKNV WGYFSVAATG GLHEFADSQF GHCFSWGENR EEAISNMVVA 
LKELSIRGDF RTTVEYLINL LETESFQNND IDTGWLDYLI AEKVQAEKPD IMLGVVCGAL 
NVADAMFRTC MTDFLHSLER GQVLPADSLL NLVDVELIYG GVKYILKVAR QSLTMFVLIM 
NGCHIEIDAH RLNDGGLLLS YNGNSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP 
SAGKLTQYTV EDGGHVEAGS SYAEMEVMKM IMTLNVQERG RVKYIKRPGA VLEAGCVVAR 
LELDDPSKVH PAEPFTGELP AQQTLPILGE KLHQVFHSVL ENLTNVMSGF CLPEPVFSIK 
LKEWVQKLMM TLRHPSLPLL ELQEIMTSVA GRIPAPVEKS VRRVMAQYAS NITSVLCQFP 
SQQIATILDC HAATLQRKAD REVFFINTQS IVQLVQRYRS GIRGYMKTVV LDLLRRYLRV 
EHHFQQAHYD KCVINLREQF KPDMSQVLDC IFSHAQVAKK NQLVIMLIDE LCGPDPSLSD 
ELISILNELT QLSKSEHCKV ALRARQILIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP 
ENLKKLILSE TTIFDVLPTF FYHANKVVCM ASLEVYVRRG YIAYELNSLQ HRQLPDGTCV 
VEFQFMLPSS HPNRMTVPIS ITNPDLLRHS TELFMDSGFS PLCQRMGAMV AFRRFEDFTR 
NFDEVISCFA NVPKDTPLFS EARTSLYSED DCKSLREEPI HILNVSIQCA DHLEDEALVP 
ILRTFVQSKK NILVDYGLRR ITFLIAQEKE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL 
ELNRMRNFDL TAVPCANHKM HLYLGAAKVK EGVEVTDHRF FIRAIIRHSD LITKEASFEY 
LQNEGERLLL EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPFKIEES VRYMVMRYGS 
RLWKLRVLQA EVKINIRQTT TGSAVPIRLF ITNESGYYLD ISLYKEVTDS RSGNIMFHSF 
GNKQGPQHGM LINTPYVTKD LLQAKRFQAQ TLGTTYIYDF PEMFRQALFK LWGSPDKYPK 
DILTYTELVL DSQGQLVEMN RLPGGNEVGM VAFKMRFKTQ EYPEGRDVIV IGNDITFRIG 
SFGPGEDLLY LRASEMARAE GIPKIYVAAN SGARIGMAEE IKHMFHVAWV DPEDPHKGFK 
YLYLTPQDYT RISSLNSVHC KHIEEGGESR YMITDIIGKD DGLGVENLRG SGMIAGESSL 
AYEEIVTISL VTCRAIGIGA YLVRLGQRVI QVENSHIILT GASALNKVLG REVYTSNNQL 
GGVQIMHYNG VSHITVPDDF EGVYTILEWL SYMPKDNHSP VPIITPTDPI DREIEFLPSR 
APYDPRWMLA GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE 
TRTVEVAVPA DPANLDSEAK IIQQAGQVWF PDSAYKTAQA VKDFNREKLP LMIFANWRGF 
SGGMKDMYDQ VLKFGAYIVD GLRQYKQPIL IYIPPYAELR GGSWVVIDAT INPLCIEMYA 
DKESRGGVLE PEGTVEIKFR KKDLIKSMRR IDPAYKKLME QLGEPDLSDK DRKDLEGRLK 
AREDLLLPIY HQVAVQFADF HDTPGRMLEK GVISDILEWK TARTFLYWRL RRLLLEDQVK 
QEILQASGEL SHVHIQSMLR RWFVETEGAV KAYLWDNNQV VVQWLEQHWQ AGDGPRSTIR 
ENITYLKHDS VLKTIRGLVE ENPEVAVDCV IYLSQHISPA ERAQVVHLLS TMDSPAST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.