Details for: APBA1

Gene ID: 320

Symbol: APBA1

Ensembl ID: ENSG00000107282

Description: amyloid beta precursor protein binding family A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.6082
    Cell Significance Index: -43.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.8360
    Cell Significance Index: -43.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.3352
    Cell Significance Index: -37.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8459
    Cell Significance Index: -19.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.7240
    Cell Significance Index: 62.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.7193
    Cell Significance Index: 81.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.5735
    Cell Significance Index: 52.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8325
    Cell Significance Index: 125.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7285
    Cell Significance Index: 103.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5200
    Cell Significance Index: 505.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.2127
    Cell Significance Index: 37.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9402
    Cell Significance Index: 695.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6666
    Cell Significance Index: 93.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5288
    Cell Significance Index: 1057.3500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.4477
    Cell Significance Index: 15.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2714
    Cell Significance Index: 15.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5404
    Cell Significance Index: 13.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4456
    Cell Significance Index: 605.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4331
    Cell Significance Index: 391.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2488
    Cell Significance Index: 12.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1743
    Cell Significance Index: 34.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1460
    Cell Significance Index: 5.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1170
    Cell Significance Index: 19.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0803
    Cell Significance Index: 151.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0729
    Cell Significance Index: 112.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0648
    Cell Significance Index: 29.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0563
    Cell Significance Index: 10.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0457
    Cell Significance Index: 4.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0286
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0194
    Cell Significance Index: 35.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0169
    Cell Significance Index: -10.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0347
    Cell Significance Index: -6.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0512
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0513
    Cell Significance Index: -37.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0566
    Cell Significance Index: -8.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0573
    Cell Significance Index: -42.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0623
    Cell Significance Index: -47.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0646
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0709
    Cell Significance Index: -44.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0735
    Cell Significance Index: -40.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0737
    Cell Significance Index: -41.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0768
    Cell Significance Index: -1.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0806
    Cell Significance Index: -2.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0808
    Cell Significance Index: -35.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0824
    Cell Significance Index: -1.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0826
    Cell Significance Index: -8.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0869
    Cell Significance Index: -1.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1000
    Cell Significance Index: -2.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1282
    Cell Significance Index: -36.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1949
    Cell Significance Index: -23.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2149
    Cell Significance Index: -45.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2250
    Cell Significance Index: -2.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2327
    Cell Significance Index: -7.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2347
    Cell Significance Index: -14.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2461
    Cell Significance Index: -42.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2483
    Cell Significance Index: -34.1000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2519
    Cell Significance Index: -3.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2962
    Cell Significance Index: -22.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3132
    Cell Significance Index: -16.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3257
    Cell Significance Index: -22.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3320
    Cell Significance Index: -42.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3414
    Cell Significance Index: -43.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3509
    Cell Significance Index: -7.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3587
    Cell Significance Index: -7.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3664
    Cell Significance Index: -19.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3729
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3777
    Cell Significance Index: -39.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3829
    Cell Significance Index: -43.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3957
    Cell Significance Index: -46.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4212
    Cell Significance Index: -13.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4220
    Cell Significance Index: -43.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4367
    Cell Significance Index: -3.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4654
    Cell Significance Index: -5.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5022
    Cell Significance Index: -10.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5047
    Cell Significance Index: -12.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5104
    Cell Significance Index: -30.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5356
    Cell Significance Index: -42.4200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5384
    Cell Significance Index: -6.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5388
    Cell Significance Index: -25.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5799
    Cell Significance Index: -20.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5909
    Cell Significance Index: -44.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5951
    Cell Significance Index: -8.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6037
    Cell Significance Index: -28.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6144
    Cell Significance Index: -17.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6145
    Cell Significance Index: -43.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6492
    Cell Significance Index: -11.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6496
    Cell Significance Index: -41.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6694
    Cell Significance Index: -13.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7180
    Cell Significance Index: -37.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8103
    Cell Significance Index: -7.7100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.9073
    Cell Significance Index: -10.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9220
    Cell Significance Index: -8.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9720
    Cell Significance Index: -42.2700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9981
    Cell Significance Index: -15.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0611
    Cell Significance Index: -43.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0680
    Cell Significance Index: -33.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1031
    Cell Significance Index: -13.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.1112
    Cell Significance Index: -21.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1180
    Cell Significance Index: -41.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location and Expression**: APBA1 is primarily expressed in the nervous system, particularly in specific neuronal populations such as Purkinje cells, GABAergic cortical interneurons, and brainstem motor neurons. 2. **Function**: APBA1 plays a crucial role in regulating neurotransmitter release, synaptic function, and the assembly of neurotransmitter receptors. 3. **Interactions**: APBA1 interacts with amyloid-beta precursor protein to modulate synaptic function and contribute to the development and maintenance of the nervous system. 4. **Cellular Localization**: APBA1 is localized to the plasma membrane, Golgi apparatus, and cytosol, indicating its involvement in various cellular processes. **Pathways and Functions** 1. **Activation of NMDA Receptors and Postsynaptic Events**: APBA1 is involved in the assembly and cell surface presentation of NMDA receptors, which are critical for synaptic plasticity and learning. 2. **Amyloid-beta Binding**: APBA1 interacts with amyloid-beta precursor protein to modulate synaptic function and contribute to the development of neurodegenerative diseases such as Alzheimer's disease. 3. **Axo-dendritic Transport**: APBA1 is involved in the transport of neurotransmitters and proteins across the synapse, regulating synaptic function and neurotransmitter release. 4. **Cell Adhesion**: APBA1 contributes to cell adhesion, which is essential for maintaining the structure and function of the nervous system. 5. **Regulation of Gene Expression**: APBA1 regulates gene expression by interacting with transcription factors and influencing the expression of other genes involved in synaptic function. **Clinical Significance** 1. **Alzheimer's Disease**: APBA1 has been implicated in the development of Alzheimer's disease, a neurodegenerative disorder characterized by amyloid-beta accumulation and synaptic dysfunction. 2. **Neurodevelopmental Disorders**: APBA1 has been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, which are characterized by abnormalities in synaptic function and neurotransmitter regulation. 3. **Neuroprotection**: APBA1 may have neuroprotective functions, as its products interact with amyloid-beta precursor protein to modulate synaptic function and reduce the risk of neurodegenerative diseases. 4. **Therapeutic Targeting**: APBA1 may be a potential therapeutic target for the treatment of Alzheimer's disease and other neurodegenerative disorders, as its products can be modulated to regulate synaptic function and reduce the risk of disease progression. In conclusion, APBA1 plays a critical role in regulating neurotransmitter release, synaptic function, and the assembly of neurotransmitter receptors. Its products interact with amyloid-beta precursor protein to modulate synaptic function and contribute to the development and maintenance of the nervous system. Further research is necessary to fully understand the functions of APBA1 and its potential therapeutic applications in the treatment of neurodegenerative diseases.

Genular Protein ID: 2752850820

Symbol: APBA1_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 1

UniProtKB Accession Codes:

Q02410 O14914 O60570 Q5VYR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7678331

Title: Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.

PubMed ID: 7678331

DOI: 10.1073/pnas.90.1.109

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20531236

Title: An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

PubMed ID: 20531236

DOI: 10.1097/wnr.0b013e32833bfca0

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9321393

Title: Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

PubMed ID: 9321393

DOI: 10.1093/emboj/16.20.6141

Sequence Information:

  • Length: 837
  • Mass: 92865
  • Checksum: 29C3620BBC89534B
  • Sequence:
    • MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR HQRGRALEDL 
RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA RDGYDAERAQ DPEDESAYAV 
QYRPEAEEYT EQAEAEHAEA THRRALPNHL HFHSLEHEEA MNAAYSGYVY THRLFHRGED 
EPYSEPYADY GGLQEHVYEE IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE 
RSDGESDSPE KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI KDIKEAIEEV 
KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD SPSPGSSSPL GAESSSTSLH 
PSDPVEASTN KESRKSLASF PTYVEVPGPC DPEDLIDGII FAANYLGSTQ LLSDKTPSKN 
VRMMQAQEAV SRIKMAQKLA KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH 
PLRTISYIAD IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK SENCKDVFIE 
KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL NIGDQIMSIN GTSLVGLPLS 
TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI RRPDLRYQLG FSVQNGIICS LMRGGIAERG 
GVRVGHRIIE INGQSVVATP HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.