Details for: APBA1

Gene ID: 320

Symbol: APBA1

Ensembl ID: ENSG00000107282

Description: amyloid beta precursor protein binding family A member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.01
    Marker Score: 135,570
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.02
    Marker Score: 957
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.61
    Marker Score: 39,098
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.51
    Marker Score: 8,428
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.49
    Marker Score: 1,457
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.48
    Marker Score: 19,021
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.48
    Marker Score: 5,702
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.45
    Marker Score: 11,354
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.42
    Marker Score: 91,794
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.33
    Marker Score: 1,356
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46,228
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.27
    Marker Score: 3,188
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.26
    Marker Score: 12,155
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.23
    Marker Score: 16,832
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.23
    Marker Score: 6,356
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.2
    Marker Score: 81,063
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.16
    Marker Score: 8,952
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20,053
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.13
    Marker Score: 893
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.04
    Marker Score: 10,698
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.01
    Marker Score: 7,757
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.99
    Marker Score: 764
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.98
    Marker Score: 20,496
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.97
    Marker Score: 120,855
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17,482
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.83
    Marker Score: 3,074
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15,694
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.8
    Marker Score: 865
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.74
    Marker Score: 37,082
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.71
    Marker Score: 6,966
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.7
    Marker Score: 465
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.66
    Marker Score: 827
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,515
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.51
    Marker Score: 3,625
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.48
    Marker Score: 830
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,831
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.39
    Marker Score: 807
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.33
    Marker Score: 8,536
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.31
    Marker Score: 1,615
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.26
    Marker Score: 2,757
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.22
    Marker Score: 5,272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2,871
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 536
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.19
    Marker Score: 2,283
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.18
    Marker Score: 6,354
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.15
    Marker Score: 1,432
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,806
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.12
    Marker Score: 406
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.09
    Marker Score: 1,202
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.08
    Marker Score: 392
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4,456
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1,253
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,034
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.99
    Marker Score: 652
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1,127
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.95
    Marker Score: 1,185
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,270
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.92
    Marker Score: 340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 277
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.84
    Marker Score: 255
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.83
    Marker Score: 544
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.79
    Marker Score: 260
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.75
    Marker Score: 645
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.69
    Marker Score: 2,884
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 596
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2,345
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.65
    Marker Score: 784
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.63
    Marker Score: 178
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 424
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.62
    Marker Score: 196
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.59
    Marker Score: 446
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.59
    Marker Score: 168
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.58
    Marker Score: 315
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 255
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 605
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.56
    Marker Score: 188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.56
    Marker Score: 532
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location and Expression**: APBA1 is primarily expressed in the nervous system, particularly in specific neuronal populations such as Purkinje cells, GABAergic cortical interneurons, and brainstem motor neurons. 2. **Function**: APBA1 plays a crucial role in regulating neurotransmitter release, synaptic function, and the assembly of neurotransmitter receptors. 3. **Interactions**: APBA1 interacts with amyloid-beta precursor protein to modulate synaptic function and contribute to the development and maintenance of the nervous system. 4. **Cellular Localization**: APBA1 is localized to the plasma membrane, Golgi apparatus, and cytosol, indicating its involvement in various cellular processes. **Pathways and Functions** 1. **Activation of NMDA Receptors and Postsynaptic Events**: APBA1 is involved in the assembly and cell surface presentation of NMDA receptors, which are critical for synaptic plasticity and learning. 2. **Amyloid-beta Binding**: APBA1 interacts with amyloid-beta precursor protein to modulate synaptic function and contribute to the development of neurodegenerative diseases such as Alzheimer's disease. 3. **Axo-dendritic Transport**: APBA1 is involved in the transport of neurotransmitters and proteins across the synapse, regulating synaptic function and neurotransmitter release. 4. **Cell Adhesion**: APBA1 contributes to cell adhesion, which is essential for maintaining the structure and function of the nervous system. 5. **Regulation of Gene Expression**: APBA1 regulates gene expression by interacting with transcription factors and influencing the expression of other genes involved in synaptic function. **Clinical Significance** 1. **Alzheimer's Disease**: APBA1 has been implicated in the development of Alzheimer's disease, a neurodegenerative disorder characterized by amyloid-beta accumulation and synaptic dysfunction. 2. **Neurodevelopmental Disorders**: APBA1 has been linked to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, which are characterized by abnormalities in synaptic function and neurotransmitter regulation. 3. **Neuroprotection**: APBA1 may have neuroprotective functions, as its products interact with amyloid-beta precursor protein to modulate synaptic function and reduce the risk of neurodegenerative diseases. 4. **Therapeutic Targeting**: APBA1 may be a potential therapeutic target for the treatment of Alzheimer's disease and other neurodegenerative disorders, as its products can be modulated to regulate synaptic function and reduce the risk of disease progression. In conclusion, APBA1 plays a critical role in regulating neurotransmitter release, synaptic function, and the assembly of neurotransmitter receptors. Its products interact with amyloid-beta precursor protein to modulate synaptic function and contribute to the development and maintenance of the nervous system. Further research is necessary to fully understand the functions of APBA1 and its potential therapeutic applications in the treatment of neurodegenerative diseases.

Genular Protein ID: 2752850820

Symbol: APBA1_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 1

UniProtKB Accession Codes:

Q02410 O14914 O60570 Q5VYR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7678331

Title: Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.

PubMed ID: 7678331

DOI: 10.1073/pnas.90.1.109

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20531236

Title: An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

PubMed ID: 20531236

DOI: 10.1097/wnr.0b013e32833bfca0

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9321393

Title: Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

PubMed ID: 9321393

DOI: 10.1093/emboj/16.20.6141

Sequence Information:

  • Length: 837
  • Mass: 92865
  • Checksum: 29C3620BBC89534B
  • Sequence:
    • MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR HQRGRALEDL 
RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA RDGYDAERAQ DPEDESAYAV 
QYRPEAEEYT EQAEAEHAEA THRRALPNHL HFHSLEHEEA MNAAYSGYVY THRLFHRGED 
EPYSEPYADY GGLQEHVYEE IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE 
RSDGESDSPE KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI KDIKEAIEEV 
KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD SPSPGSSSPL GAESSSTSLH 
PSDPVEASTN KESRKSLASF PTYVEVPGPC DPEDLIDGII FAANYLGSTQ LLSDKTPSKN 
VRMMQAQEAV SRIKMAQKLA KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH 
PLRTISYIAD IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK SENCKDVFIE 
KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL NIGDQIMSIN GTSLVGLPLS 
TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI RRPDLRYQLG FSVQNGIICS LMRGGIAERG 
GVRVGHRIIE INGQSVVATP HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.