APBA1 | ENSG00000107282 | NCBI 320

Details for: APBA1

Gene ID: 320

Symbol: APBA1

Ensembl ID: ENSG00000107282

Description: amyloid beta precursor protein binding family A member 1

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Dopamine neurotransmitter release cycle
(R-HSA-212676)
Neurexins and neuroligins
(R-HSA-6794361)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neurotransmitter release cycle
(R-HSA-112310)
Protein-protein interactions at synapses
(R-HSA-6794362)
Transmission across chemical synapses
(R-HSA-112315)
Amyloid-beta binding
(GO:0001540)
Axo-dendritic transport
(GO:0008088)
Cell adhesion
(GO:0007155)
Chemical synaptic transmission
(GO:0007268)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Gamma-aminobutyric acid secretion
(GO:0014051)
Glutamatergic synapse
(GO:0098978)
Glutamate secretion
(GO:0014047)
Golgi apparatus
(GO:0005794)
Intracellular protein transport
(GO:0006886)
In utero embryonic development
(GO:0001701)
Locomotory behavior
(GO:0007626)
Multicellular organism growth
(GO:0035264)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Schaffer collateral - ca1 synapse
(GO:0098685)
Synaptic vesicle
(GO:0008021)

Other Information

Proteins

Amyloid-beta A4 precursor protein-binding family A member 1

Genular Protein ID: 2752850820

Symbol: APBA1_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 1

UniProtKB Accession Codes:

Q02410 O14914 O60570 Q5VYR8

Database IDs:

Citations:

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7678331

Title: Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.

PubMed ID: 7678331

DOI: 10.1073/pnas.90.1.109

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20531236

Title: An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

PubMed ID: 20531236

DOI: 10.1097/wnr.0b013e32833bfca0

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9321393

Title: Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

PubMed ID: 9321393

DOI: 10.1093/emboj/16.20.6141

Sequence Information:

Length: 837
Mass: 92865
Checksum: 29C3620BBC89534B
Sequence:

MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR HQRGRALEDL 
RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA RDGYDAERAQ DPEDESAYAV 
QYRPEAEEYT EQAEAEHAEA THRRALPNHL HFHSLEHEEA MNAAYSGYVY THRLFHRGED 
EPYSEPYADY GGLQEHVYEE IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE 
RSDGESDSPE KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI KDIKEAIEEV 
KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD SPSPGSSSPL GAESSSTSLH 
PSDPVEASTN KESRKSLASF PTYVEVPGPC DPEDLIDGII FAANYLGSTQ LLSDKTPSKN 
VRMMQAQEAV SRIKMAQKLA KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH 
PLRTISYIAD IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK SENCKDVFIE 
KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL NIGDQIMSIN GTSLVGLPLS 
TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI RRPDLRYQLG FSVQNGIICS LMRGGIAERG 
GVRVGHRIIE INGQSVVATP HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APBA1

Associated with

Other Information

Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. PubMed ID: 9395480

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. PubMed ID: 9614075

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system. PubMed ID: 7678331

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. PubMed ID: 8887653

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. PubMed ID: 20531236

A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PubMed ID: 23737971

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. PubMed ID: 9321393