Details for: APBA1

Gene ID: 320

Symbol: APBA1

Ensembl ID: ENSG00000107282

Description: amyloid beta precursor protein binding family A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.01
    Marker Score: 135569.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.02
    Marker Score: 957
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.61
    Marker Score: 39098
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.51
    Marker Score: 8428
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.49
    Marker Score: 1457
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.48
    Marker Score: 19021
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.48
    Marker Score: 5702
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.45
    Marker Score: 11354
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.42
    Marker Score: 91794
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.33
    Marker Score: 1356
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46228
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.27
    Marker Score: 3188
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.26
    Marker Score: 12155
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.23
    Marker Score: 16832
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.23
    Marker Score: 6356
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.2
    Marker Score: 81063
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.16
    Marker Score: 8952
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20053
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.13
    Marker Score: 893
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.04
    Marker Score: 10698
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.01
    Marker Score: 7757
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.99
    Marker Score: 764
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.98
    Marker Score: 20496
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.97
    Marker Score: 120855
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17482
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.83
    Marker Score: 3074
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15694
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.8
    Marker Score: 865
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.74
    Marker Score: 37082
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.71
    Marker Score: 6966
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.7
    Marker Score: 465
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.66
    Marker Score: 827
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2515
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.51
    Marker Score: 3625
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.48
    Marker Score: 830
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168831
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.39
    Marker Score: 807
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.33
    Marker Score: 8536
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.31
    Marker Score: 1615
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.26
    Marker Score: 2757
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.22
    Marker Score: 5272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2871
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 536
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.19
    Marker Score: 2282.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.18
    Marker Score: 6354
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.15
    Marker Score: 1432
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.12
    Marker Score: 406
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.09
    Marker Score: 1202
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.08
    Marker Score: 392
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4456
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1253
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.99
    Marker Score: 652
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1127
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.95
    Marker Score: 1185
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5270
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.92
    Marker Score: 339.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 277
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.84
    Marker Score: 255
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.83
    Marker Score: 544
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.79
    Marker Score: 260
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.75
    Marker Score: 645
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.69
    Marker Score: 2884
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 596
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2345
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.65
    Marker Score: 783.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.63
    Marker Score: 178
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 424
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.62
    Marker Score: 196
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.59
    Marker Score: 446
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.59
    Marker Score: 168
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.58
    Marker Score: 315
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 255
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 605
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.56
    Marker Score: 188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.56
    Marker Score: 532
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147

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Other Information

**Key characteristics:** * APBA1 is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including neurons, astrocytes, and oligodendrocytes. * It forms a complex with APP, which is a protein that is produced by the amyloid precursor protein-degrading enzyme (APP-degrading enzyme). * APBA1 is a key regulator of APP production and degradation. * It is involved in the assembly and stability of the APP complex. * It is also involved in the transport of APP from the endoplasmic reticulum to the cell surface. **Pathways and functions:** * APBA1 is involved in the activation of NMDA receptors, which are a class of ionotropic glutamate receptors that are expressed in the brain. * Activation of NMDA receptors by Aβ is thought to be a major contributor to the pathogenesis of Alzheimer's disease. * APBA1 is also involved in the assembly and stability of NMDA receptors. * It is also involved in the axo-dendritic transport of NMDA receptors from the endoplasmic reticulum to the cell surface. * APBA1 is also involved in cell adhesion, as it is expressed in cells that interact with neurons. * It is involved in the chemical synaptic transmission of neurotransmitters, such as glutamate. * It is also involved in the release of glutamate from presynaptic terminals. * APBA1 is also involved in the intracellular protein transport of APP and other proteins. **Clinical significance:** APBA1 is a promising target for the treatment of Alzheimer's disease. Mutations in the APBA1 gene have been linked to an increased risk of developing Alzheimer's disease. Drugs that block APBA1 have been shown to be effective in preventing or reversing the symptoms of Alzheimer's disease in animal models. **Additional notes:** * APBA1 is a highly conserved protein, with homologs found in other species. * It is a ubiquitin-dependent protein, which means that it is degraded by the proteasome when it is no longer needed. * It is a very important protein in the brain, and its dysfunction is thought to contribute to the pathogenesis of Alzheimer's disease.

Genular Protein ID: 2752850820

Symbol: APBA1_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 1

UniProtKB Accession Codes:

Q02410 O14914 O60570 Q5VYR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7678331

Title: Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.

PubMed ID: 7678331

DOI: 10.1073/pnas.90.1.109

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20531236

Title: An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

PubMed ID: 20531236

DOI: 10.1097/wnr.0b013e32833bfca0

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9321393

Title: Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

PubMed ID: 9321393

DOI: 10.1093/emboj/16.20.6141

Sequence Information:

  • Length: 837
  • Mass: 92865
  • Checksum: 29C3620BBC89534B
  • Sequence:
    • MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR HQRGRALEDL 
RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA RDGYDAERAQ DPEDESAYAV 
QYRPEAEEYT EQAEAEHAEA THRRALPNHL HFHSLEHEEA MNAAYSGYVY THRLFHRGED 
EPYSEPYADY GGLQEHVYEE IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE 
RSDGESDSPE KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI KDIKEAIEEV 
KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD SPSPGSSSPL GAESSSTSLH 
PSDPVEASTN KESRKSLASF PTYVEVPGPC DPEDLIDGII FAANYLGSTQ LLSDKTPSKN 
VRMMQAQEAV SRIKMAQKLA KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH 
PLRTISYIAD IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK SENCKDVFIE 
KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL NIGDQIMSIN GTSLVGLPLS 
TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI RRPDLRYQLG FSVQNGIICS LMRGGIAERG 
GVRVGHRIIE INGQSVVATP HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.