PGRP SA | FBgn0030310 | NCBI 32099

Details for: PGRP SA

Gene ID: 32099

Symbol: PGRP SA

Ensembl ID: FBgn0030310

Description: Peptidoglycan recognition protein SA

Associated with

Antimicrobial peptides
(R-DME-6803157)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Neutrophil degranulation
(R-DME-6798695)
Defense response to bacterium
(GO:0042742)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Muramoyltetrapeptide carboxypeptidase activity
(GO:0106415)
Muramyl dipeptide binding
(GO:0032500)
N-acetylmuramoyl-l-alanine amidase activity
(GO:0008745)
Pattern recognition receptor activity
(GO:0038187)
Peptidoglycan binding
(GO:0042834)
Peptidoglycan catabolic process
(GO:0009253)
Peptidoglycan immune receptor activity
(GO:0016019)
Positive regulation of biosynthetic process of antibacterial peptides active against gram-positive bacteria
(GO:0006965)
Protein binding
(GO:0005515)
Response to peptidoglycan
(GO:0032494)
Toll receptor ligand protein activation cascade
(GO:0160032)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Peptidoglycan-recognition protein SA

Genular Protein ID: 2003576561

Symbol: PGPSA_DROME

Name: Peptidoglycan-recognition protein SA

UniProtKB Accession Codes:

Q9VYX7

Database IDs:

Citations:

PubMed ID: 11106397

Title: A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster.

PubMed ID: 11106397

DOI: 10.1073/pnas.97.25.13772

PubMed ID: 14738318

Title: The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins.

PubMed ID: 14738318

DOI: 10.1007/s00239-003-2506-6

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11742401

Title: Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.

PubMed ID: 11742401

DOI: 10.1038/414756a

PubMed ID: 12032070

Title: The Toll and Imd pathways are the major regulators of the immune response in Drosophila.

PubMed ID: 12032070

DOI: 10.1093/emboj/21.11.2568

PubMed ID: 14684822

Title: Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

PubMed ID: 14684822

DOI: 10.1126/science.1085432

PubMed ID: 14722090

Title: In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults.

PubMed ID: 14722090

DOI: 10.1074/jbc.m313324200

PubMed ID: 15448690

Title: Function of the Drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

PubMed ID: 15448690

DOI: 10.1038/ni1123

PubMed ID: 16399077

Title: A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity.

PubMed ID: 16399077

DOI: 10.1016/j.devcel.2005.11.013

PubMed ID: 15223330

Title: Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution.

PubMed ID: 15223330

DOI: 10.1016/j.jmb.2004.04.077

PubMed ID: 15361936

Title: A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity.

PubMed ID: 15361936

DOI: 10.1371/journal.pbio.0020277

Sequence Information:

Length: 203
Mass: 22260
Checksum: D200A6EA79C66731
Sequence:

MQPVRFGSPW IMAIGLVLLL LAFVSAGKSR QRSPANCPTI KLKRQWGGKP SLGLHYQVRP 
IRYVVIHHTV TGECSGLLKC AEILQNMQAY HQNELDFNDI SYNFLIGNDG IVYEGTGWGL 
RGAHTYGYNA IGTGIAFIGN FVDKLPSDAA LQAAKDLLAC GVQQGELSED YALIAGSQVI 
STQSPGLTLY NEIQEWPHWL SNP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PGRP SA

Associated with

Other Information

A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. PubMed ID: 11106397

The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins. PubMed ID: 14738318

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. PubMed ID: 11742401

The Toll and Imd pathways are the major regulators of the immune response in Drosophila. PubMed ID: 12032070

Dual activation of the Drosophila toll pathway by two pattern recognition receptors. PubMed ID: 14684822

In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. PubMed ID: 14722090

Function of the Drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. PubMed ID: 15448690

A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. PubMed ID: 16399077

Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution. PubMed ID: 15223330

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. PubMed ID: 15361936