Details for: APBA2

Gene ID: 321

Symbol: APBA2

Ensembl ID: ENSG00000034053

Description: amyloid beta precursor protein binding family A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.4592
    Cell Significance Index: -38.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.6158
    Cell Significance Index: -38.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.9771
    Cell Significance Index: -30.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.9458
    Cell Significance Index: -30.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.0473
    Cell Significance Index: -38.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8276
    Cell Significance Index: -38.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.7463
    Cell Significance Index: 64.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7182
    Cell Significance Index: 545.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.8606
    Cell Significance Index: 24.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5939
    Cell Significance Index: 19.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5743
    Cell Significance Index: 564.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0772
    Cell Significance Index: 745.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9194
    Cell Significance Index: 51.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8156
    Cell Significance Index: 161.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7461
    Cell Significance Index: 33.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7331
    Cell Significance Index: 27.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5394
    Cell Significance Index: 17.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4714
    Cell Significance Index: 24.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3903
    Cell Significance Index: 74.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1846
    Cell Significance Index: 166.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1128
    Cell Significance Index: 51.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0494
    Cell Significance Index: 1.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0178
    Cell Significance Index: 1.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0150
    Cell Significance Index: 8.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0040
    Cell Significance Index: 0.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0102
    Cell Significance Index: -1.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0147
    Cell Significance Index: -0.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0154
    Cell Significance Index: -29.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0187
    Cell Significance Index: -34.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0203
    Cell Significance Index: -31.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0240
    Cell Significance Index: -0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0296
    Cell Significance Index: -40.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0467
    Cell Significance Index: -29.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0467
    Cell Significance Index: -34.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0486
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0530
    Cell Significance Index: -39.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0563
    Cell Significance Index: -42.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0594
    Cell Significance Index: -1.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0726
    Cell Significance Index: -40.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0747
    Cell Significance Index: -33.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0775
    Cell Significance Index: -10.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0877
    Cell Significance Index: -1.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0887
    Cell Significance Index: -4.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1117
    Cell Significance Index: -32.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1130
    Cell Significance Index: -14.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1192
    Cell Significance Index: -4.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1198
    Cell Significance Index: -3.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1306
    Cell Significance Index: -3.6500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1315
    Cell Significance Index: -1.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1338
    Cell Significance Index: -24.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1398
    Cell Significance Index: -15.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1413
    Cell Significance Index: -24.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1669
    Cell Significance Index: -2.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1820
    Cell Significance Index: -5.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1831
    Cell Significance Index: -8.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1867
    Cell Significance Index: -3.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1897
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2096
    Cell Significance Index: -44.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2141
    Cell Significance Index: -6.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2201
    Cell Significance Index: -27.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2364
    Cell Significance Index: -30.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2389
    Cell Significance Index: -34.7300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2947
    Cell Significance Index: -3.0700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2985
    Cell Significance Index: -2.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3007
    Cell Significance Index: -3.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3229
    Cell Significance Index: -22.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3304
    Cell Significance Index: -38.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3421
    Cell Significance Index: -34.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3510
    Cell Significance Index: -40.9000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3637
    Cell Significance Index: -7.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3721
    Cell Significance Index: -38.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3878
    Cell Significance Index: -23.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3909
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3939
    Cell Significance Index: -45.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4495
    Cell Significance Index: -15.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4607
    Cell Significance Index: -16.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4779
    Cell Significance Index: -36.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4990
    Cell Significance Index: -37.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5249
    Cell Significance Index: -11.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5297
    Cell Significance Index: -37.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5330
    Cell Significance Index: -25.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5598
    Cell Significance Index: -29.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5617
    Cell Significance Index: -36.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5703
    Cell Significance Index: -11.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5754
    Cell Significance Index: -29.8900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6184
    Cell Significance Index: -4.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6220
    Cell Significance Index: -10.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6270
    Cell Significance Index: -13.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6459
    Cell Significance Index: -8.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6593
    Cell Significance Index: -6.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6844
    Cell Significance Index: -13.4700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.7138
    Cell Significance Index: -5.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7427
    Cell Significance Index: -18.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7529
    Cell Significance Index: -22.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8383
    Cell Significance Index: -9.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8859
    Cell Significance Index: -55.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9279
    Cell Significance Index: -10.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9543
    Cell Significance Index: -35.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.9644
    Cell Significance Index: -10.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** APBA2 is predominantly expressed in neuronal cell types, including neurons, astrocytes, and interneurons, suggesting its involvement in the regulation of synaptic function and neuronal development. 2. **Function:** APBA2 interacts with APP, modulating its processing and clearance, and influencing the production of amyloid-beta peptides. 3. **Pathways:** APBA2 is involved in various signaling pathways, including amyloid-beta binding, chemical synaptic transmission, and regulation of gene expression, highlighting its role in the complex regulation of synaptic function. 4. **Protein Binding:** APBA2 interacts with multiple proteins, including APP, neurexins, and neuroligins, which are essential for the development and maintenance of the nervous system. **Pathways and Functions:** 1. **Amyloid-Beta Processing:** APBA2 modulates the processing and clearance of APP, influencing the production of amyloid-beta peptides, which are implicated in Alzheimer's disease. 2. **Synaptic Plasticity:** APBA2 is involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), which are essential for learning and memory. 3. **Neurotransmission:** APBA2 regulates neurotransmission by modulating the release and uptake of neurotransmitters, such as glutamate and GABA. 4. **Regulation of Gene Expression:** APBA2 influences the regulation of gene expression, including the modulation of genes involved in synaptic function and neuronal development. **Clinical Significance:** 1. **Alzheimer's Disease:** APBA2 dysfunction has been implicated in the pathogenesis of Alzheimer's disease, suggesting its potential as a therapeutic target. 2. **Neurodegenerative Disorders:** APBA2 may also play a role in other neurodegenerative disorders, such as frontotemporal dementia and Parkinson's disease. 3. **Synaptic Dysregulation:** APBA2 dysregulation can lead to synaptic dysregulation, which is a hallmark of various neurological disorders, including Alzheimer's disease and attention-deficit/hyperactivity disorder (ADHD). 4. **Potential Therapeutic Targets:** APBA2 may serve as a potential therapeutic target for the treatment of Alzheimer's disease and other neurodegenerative disorders. In conclusion, APBA2 is a critical gene that regulates APP processing, synaptic function, and neurotransmission. Its dysregulation has been implicated in various neurological disorders, highlighting its importance in the development and maintenance of the nervous system. Further research is needed to fully elucidate the role of APBA2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3676391037

Symbol: APBA2_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 10833507

Title: Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein.

PubMed ID: 10833507

DOI: 10.1074/jbc.c000302200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 749
  • Mass: 82512
  • Checksum: C15AE9CFAEF51D85
  • Sequence:
  • MAHRKLESVG SGMLDHRVRP GPVPHSQEPE SEDMELPLEG YVPEGLELAA LRPESPAPEE 
    QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGITYY IRYCPEDDSY LEGMDCNGEE 
    YLAHSAHPVD TDECQEAVEE WTDSAGPHPH GHEAEGSQDY PDGQLPIPED EPSVLEAHDQ 
    EEDGHYCASK EGYQDYYPEE ANGNTGASPY RLRRGDGDLE DQEEDIDQIV AEIKMSLSMT 
    SITSASEASP EHGPEPGPED SVEACPPIKA SCSPSRHEAR PKSLNLLPEA KHPGDPQRGF 
    KPKTRTPEER LKWPHEQVCN GLEQPRKQQR SDLNGPVDNN NIPETKKVAS FPSFVAVPGP 
    CEPEDLIDGI IFAANYLGST QLLSERNPSK NIRMMQAQEA VSRVKRMQKA AKIKKKANSE 
    GDAQTLTEVD LFISTQRIKV LNADTQETMM DHALRTISYI ADIGNIVVLM ARRRMPRSAS 
    QDCIETTPGA QEGKKQYKMI CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ 
    KEYSDIINTQ EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANM 
    MNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN IVSCPPVTTV 
    LIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI IEINGQSVVA TAHEKIVQAL 
    SNSVGEIHMK TMPAAMFRLL TGQETPLYI

Genular Protein ID: 841521375

Symbol: Q59G28_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 752
  • Mass: 82769
  • Checksum: 7309ABB550871C43
  • Sequence:
  • TTAMAHRKLE SVGSGMLDHR VRPGPVPHSQ EPESEDMELP LEGYVPEGLE LAALRPESPA 
    PEEQECHNHS PDGDSSSDYV NNTSEEEDYD EGLPEEEEGI TYYIRYCPED DSYLEGMDCN 
    GEEYLAHSAH PVDTDECQEA VEEWTDSAGP HPHGHEAEGS QDYPDGQLPI PEDEPSVLEA 
    HDQEEDGHYC ASKEGYQDYY PEEANGNTGA SPYRLRRGDG DLEDQEEDID QIVAEIKMSL 
    SMTSITSASE ASPEHGPEPG PEDSVEACPP IKASCSPSRH EARPKSLNLL PEAKHPGDPQ 
    RGFKPKTRTP EERPKWPHEQ VCNGLEQPRK QQRSDLNGPV DNNNIPETKK VASFPSFVAV 
    PGPCEPEDLI DGIIFAANYL GSTQLLSERN PSKNIRMMQA QEAVSRVKRM QKAAKIKKKA 
    NSEGDAQTLT EVDLFISTQR IKVLNADTQE TMMDHALRTI SYIADIGNIV VLMARRRMPR 
    SASQDCIETT PGAQEGKKQY KMICHVFESE DAQLIAQSIG QAFSVAYQEF LRANGINPED 
    LSQKEYSDII NTQEMYNDDL IHFSNSENCK ELQLEKHKGE ILGVVVVESG WGSILPTVIL 
    ANMMNGGPAA RSGKLSIGDQ IMSINGTSLV GLPLATCQGI IKGLKNQTQV KLNIVSCPPV 
    TTVLIKRPDL KYQLGFSVQN GIICSLMRGG IAERGGVRVG HRIIEINGQS VVATAHEKIV 
    QALSNSVGEI HMKTMPAAMF RLLTGQETPL YI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.