Details for: APBA2

Gene ID: 321

Symbol: APBA2

Ensembl ID: ENSG00000034053

Description: amyloid beta precursor protein binding family A member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.49
    Marker Score: 18325
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.47
    Marker Score: 11635
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.1
    Marker Score: 1491
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.88
    Marker Score: 15477
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.64
    Marker Score: 1478
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.63
    Marker Score: 19849
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.45
    Marker Score: 1421
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.44
    Marker Score: 18685
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.29
    Marker Score: 9507
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.28
    Marker Score: 86488
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.27
    Marker Score: 45069
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.25
    Marker Score: 10417
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.18
    Marker Score: 80598
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.16
    Marker Score: 3634
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.15
    Marker Score: 4947
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.14
    Marker Score: 31935
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19280
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124725
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.89
    Marker Score: 40315
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.89
    Marker Score: 7295
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.89
    Marker Score: 7681
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.85
    Marker Score: 17560
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.81
    Marker Score: 759
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15008
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.72
    Marker Score: 3779
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.7
    Marker Score: 4854
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2528
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16697
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.57
    Marker Score: 605
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.55
    Marker Score: 491
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.52
    Marker Score: 3636
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.47
    Marker Score: 402
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.4
    Marker Score: 1976
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.31
    Marker Score: 1618
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.28
    Marker Score: 1113
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.26
    Marker Score: 545
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.25
    Marker Score: 821
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.13
    Marker Score: 1365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48006
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.98
    Marker Score: 320
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.96
    Marker Score: 2805
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1877
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5268
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.89
    Marker Score: 1002
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.86
    Marker Score: 2411
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.83
    Marker Score: 412
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.83
    Marker Score: 1951
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.82
    Marker Score: 2272
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.79
    Marker Score: 949
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.79
    Marker Score: 1371.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.76
    Marker Score: 367
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 687
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.73
    Marker Score: 687
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.72
    Marker Score: 3021
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.72
    Marker Score: 2786
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.71
    Marker Score: 24064
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.71
    Marker Score: 757
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.69
    Marker Score: 226
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.66
    Marker Score: 208
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.65
    Marker Score: 1185
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.65
    Marker Score: 326
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.64
    Marker Score: 143
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.64
    Marker Score: 6439
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.62
    Marker Score: 770
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.6
    Marker Score: 453
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 202
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.59
    Marker Score: 297
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.59
    Marker Score: 170
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.59
    Marker Score: 462
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.59
    Marker Score: 211
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.58
    Marker Score: 549
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 187
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.57
    Marker Score: 621
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.55
    Marker Score: 709
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.54
    Marker Score: 190
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.54
    Marker Score: 234
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 249
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.54
    Marker Score: 920
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.54
    Marker Score: 166
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.53
    Marker Score: 28170

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Other Information

**Key characteristics:** * APBA2 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the amyloid precursor protein-binding family A (APPB) proteins. * APBA2 is highly expressed in neurons and is also expressed in other cell types, including immune cells. * It is a key component of the APP complex, which is responsible for the production of Aβ peptides. **Pathways and functions:** * APBA2 is involved in synaptic transmission by binding to amyloid precursor protein (APP) and facilitating the interaction between APP and its receptors. * The APP complex is a multi-subunit complex that is responsible for the production of Aβ peptides. * APBA2 is a key component of the APP complex and is essential for the production of Aβ peptides. * Aβ peptides are secreted from neurons and deposited in the extracellular space, where they can bind to amyloid precursor protein receptors on neighboring neurons, triggering a cascade of events that leads to the formation of amyloid plaques. **Clinical significance:** * Mutations in the APBA2 gene have been linked to the development of Alzheimer's disease. * APBA2 is a potential therapeutic target for Alzheimer's disease, as it is a key component of the amyloid plaque. * Small molecule inhibitors of APBA2 have been shown to be effective in reducing Aβ plaque formation and improving cognitive function in animal models of Alzheimer's disease.

Genular Protein ID: 3676391037

Symbol: APBA2_HUMAN

Name: Amyloid-beta A4 precursor protein-binding family A member 2

UniProtKB Accession Codes:

Q99767 E9PGI4 O60571 Q5XKC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 9 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 24 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9614075

Title: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

PubMed ID: 9614075

DOI: 10.1074/jbc.273.24.14761

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9395480

Title: Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

PubMed ID: 9395480

DOI: 10.1074/jbc.272.50.31459

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 10833507

Title: Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein.

PubMed ID: 10833507

DOI: 10.1074/jbc.c000302200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 749
  • Mass: 82512
  • Checksum: C15AE9CFAEF51D85
  • Sequence:
    • MAHRKLESVG SGMLDHRVRP GPVPHSQEPE SEDMELPLEG YVPEGLELAA LRPESPAPEE 
QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGITYY IRYCPEDDSY LEGMDCNGEE 
YLAHSAHPVD TDECQEAVEE WTDSAGPHPH GHEAEGSQDY PDGQLPIPED EPSVLEAHDQ 
EEDGHYCASK EGYQDYYPEE ANGNTGASPY RLRRGDGDLE DQEEDIDQIV AEIKMSLSMT 
SITSASEASP EHGPEPGPED SVEACPPIKA SCSPSRHEAR PKSLNLLPEA KHPGDPQRGF 
KPKTRTPEER LKWPHEQVCN GLEQPRKQQR SDLNGPVDNN NIPETKKVAS FPSFVAVPGP 
CEPEDLIDGI IFAANYLGST QLLSERNPSK NIRMMQAQEA VSRVKRMQKA AKIKKKANSE 
GDAQTLTEVD LFISTQRIKV LNADTQETMM DHALRTISYI ADIGNIVVLM ARRRMPRSAS 
QDCIETTPGA QEGKKQYKMI CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ 
KEYSDIINTQ EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANM 
MNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN IVSCPPVTTV 
LIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI IEINGQSVVA TAHEKIVQAL 
SNSVGEIHMK TMPAAMFRLL TGQETPLYI

Genular Protein ID: 841521375

Symbol: Q59G28_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59G28

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 752
  • Mass: 82769
  • Checksum: 7309ABB550871C43
  • Sequence:
    • TTAMAHRKLE SVGSGMLDHR VRPGPVPHSQ EPESEDMELP LEGYVPEGLE LAALRPESPA 
PEEQECHNHS PDGDSSSDYV NNTSEEEDYD EGLPEEEEGI TYYIRYCPED DSYLEGMDCN 
GEEYLAHSAH PVDTDECQEA VEEWTDSAGP HPHGHEAEGS QDYPDGQLPI PEDEPSVLEA 
HDQEEDGHYC ASKEGYQDYY PEEANGNTGA SPYRLRRGDG DLEDQEEDID QIVAEIKMSL 
SMTSITSASE ASPEHGPEPG PEDSVEACPP IKASCSPSRH EARPKSLNLL PEAKHPGDPQ 
RGFKPKTRTP EERPKWPHEQ VCNGLEQPRK QQRSDLNGPV DNNNIPETKK VASFPSFVAV 
PGPCEPEDLI DGIIFAANYL GSTQLLSERN PSKNIRMMQA QEAVSRVKRM QKAAKIKKKA 
NSEGDAQTLT EVDLFISTQR IKVLNADTQE TMMDHALRTI SYIADIGNIV VLMARRRMPR 
SASQDCIETT PGAQEGKKQY KMICHVFESE DAQLIAQSIG QAFSVAYQEF LRANGINPED 
LSQKEYSDII NTQEMYNDDL IHFSNSENCK ELQLEKHKGE ILGVVVVESG WGSILPTVIL 
ANMMNGGPAA RSGKLSIGDQ IMSINGTSLV GLPLATCQGI IKGLKNQTQV KLNIVSCPPV 
TTVLIKRPDL KYQLGFSVQN GIICSLMRGG IAERGGVRVG HRIIEINGQS VVATAHEKIV 
QALSNSVGEI HMKTMPAAMF RLLTGQETPL YI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.