APBB1 | ENSG00000166313 | NCBI 322

Details for: APBB1

Gene ID: 322

Symbol: APBB1

Ensembl ID: ENSG00000166313

Description: amyloid beta precursor protein binding family B member 1

Associated with

Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna repair
(R-HSA-73894)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Amyloid-beta binding
(GO:0001540)
Apoptotic process
(GO:0006915)
Axonogenesis
(GO:0007409)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Endoplasmic reticulum
(GO:0005783)
Growth cone
(GO:0030426)
Histone binding
(GO:0042393)
Lamellipodium
(GO:0030027)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cell cycle g1/s phase transition
(GO:1902807)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Synapse
(GO:0045202)
Transcription coactivator activity
(GO:0003713)
Transcription factor binding
(GO:0008134)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

APBB1_HUMAN
B7Z4M9_HUMAN

Genular Protein ID: 4107833375

Symbol: APBB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O00213 A1E379 A6NH82 A6NL69 B7Z1J5 B7Z1J6 B7Z2Y0 D3DQT2 Q7Z324 Q96A93 V9GYK0 V9GYT4

Database IDs:

Citations:

PubMed ID: 8894693

Title: cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.

PubMed ID: 8894693

DOI: 10.1093/hmg/5.10.1589

PubMed ID: 9799084

Title: The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.

PubMed ID: 9799084

DOI: 10.1007/s004390050820

PubMed ID: 21824145

Title: Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.

PubMed ID: 21824145

DOI: 10.1111/j.1471-4159.2011.07420.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15031292

Title: The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

PubMed ID: 15031292

DOI: 10.1074/jbc.m311479200

PubMed ID: 17512906

Title: Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.

PubMed ID: 17512906

DOI: 10.1016/j.bbrc.2007.04.203

PubMed ID: 18468999

Title: Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.

PubMed ID: 18468999

DOI: 10.1074/jbc.m801827200

PubMed ID: 18922798

Title: Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.

PubMed ID: 18922798

DOI: 10.1074/jbc.m801874200

PubMed ID: 19234442

Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

PubMed ID: 19234442

DOI: 10.1038/nature07849

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 25342469

Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.

PubMed ID: 25342469

DOI: 10.1038/cdd.2014.163

PubMed ID: 33938178

Title: Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.

PubMed ID: 33938178

DOI: 10.1515/hsz-2020-0279

PubMed ID: 36250347

Title: Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling.

PubMed ID: 36250347

DOI: 10.1096/fj.202200757r

PubMed ID: 17686488

Title: Structural basis for polyproline recognition by the FE65 WW domain.

PubMed ID: 17686488

DOI: 10.1016/j.jmb.2007.06.064

PubMed ID: 18833287

Title: Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.

PubMed ID: 18833287

DOI: 10.1038/embor.2008.188

PubMed ID: 18550529

Title: Crystal structure of the human Fe65-PTB1 domain.

PubMed ID: 18550529

DOI: 10.1074/jbc.m800861200

Sequence Information:

Length: 710
Mass: 77244
Checksum: FD4A2EF7E8D8E884
Sequence:

MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL QATAVGPKDL RSAMGEGGGP 
EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEPEMAPLGP KGLIHLYSEL 
ELSAHNAANR GLRGPGLIIS TQEQGPDEGE EKAAGEAEEE EEDDDDEEEE EDLSSPPGLP 
EPLESVEAPP RPQALTDGPR EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT 
DSFWNPNAFE TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
TWTGFAHGEG FEDGEFWKDE PSDEAPMELG LKEPEEGTLT FPAQSLSPEP LPQEEEKLPP 
RNTNPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ LSYHKNNLHD PMSGGWGEGK 
DLLLQLEDET LKLVEPQSQA LLHAQPIISI RVWGVGRDSG RERDFAYVAR DKLTQMLKCH 
VFRCEAPAKN IATSLHEICS KIMAERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV 
QKFQVYYLGN VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV 
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV QAACMLRYQK 
CLDARSQAST SCLPAPPAES VARRVGWTVR RGVQSLWGSL KPKRLGAHTP

Genular Protein ID: 11926176

Symbol: B7Z4M9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4M9

Database IDs:

Sequence Information:

Length: 451
Mass: 49871
Checksum: 91DFE374F9A27FE8
Sequence:

MRVQDTSGTY YWHIPTGTTQ WEPPGRASPS QGSSPQEESQ LTWTGFAHGE GFEDGEFWKD 
EPSDEAPMEL GLKEPEEGTL TFPAQSLSPE PLPQEEEKLP PRNTNPGIKC FAVRSLGWVE 
MTEEELAPER SSVAVNNCIR QLSYHKNNLH DPMSGGWGEG KGLLLQLEDE TLKLVEPQSQ 
ALLHAQPIIS IRVWGVGRDS GRERDFAYVA RDKLTQMLKC HVFRCEAPAK NIATSLHEIC 
SKIMAERRNA RCLVNGLSLD HSKLVDVPFQ VEFPAPKNEL VQKFQVYYLG NVPVAKPVGV 
DVINGALESV LSSSSREQWT PSHVSVAPAT LTILHQQTEA VLGECRVRFL SFLAVGRDVH 
TFAFIMAAGP ASFCCHMFWC EPNAASLSEA VQAACMLRYQ KCLDARSQAS TSCLPAPPAE 
SVARRVGWTV RRGVQSLWGS LKPKRLGAHT P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APBB1

Associated with

Other Information

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. PubMed ID: 8894693

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. PubMed ID: 9799084

Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform. PubMed ID: 21824145

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling. PubMed ID: 15031292

Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. PubMed ID: 17512906

Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells. PubMed ID: 18468999

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. PubMed ID: 18922798

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. PubMed ID: 19234442

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PubMed ID: 19343227

Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. PubMed ID: 25342469

Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity. PubMed ID: 33938178

Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling. PubMed ID: 36250347

Structural basis for polyproline recognition by the FE65 WW domain. PubMed ID: 17686488

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. PubMed ID: 18833287

Crystal structure of the human Fe65-PTB1 domain. PubMed ID: 18550529