CkIalpha | FBgn0015024 | NCBI 32221

Details for: CkIalpha

Gene ID: 32221

Symbol: CkIalpha

Ensembl ID: FBgn0015024

Description: Casein kinase Ialpha

Associated with

Atp binding
(GO:0005524)
Beta-catenin destruction complex
(GO:0030877)
Cell morphogenesis
(GO:0000902)
Cytoplasm
(GO:0005737)
Dna repair
(GO:0006281)
Glucose homeostasis
(GO:0042593)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of proteasomal protein catabolic process
(GO:1901800)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Signal transduction
(GO:0007165)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Casein kinase I isoform alpha

Genular Protein ID: 3172106517

Symbol: KC1A_DROME

Name: Casein kinase I isoform alpha

UniProtKB Accession Codes:

P54367 A4V4D3 Q0KHT2 Q9VYK2

Database IDs:

Citations:

PubMed ID: 8832407

Title: The casein kinase 1 alpha gene of Drosophila melanogaster is developmentally regulated and the kinase activity of the protein induced by DNA damage.

PubMed ID: 8832407

DOI: 10.1242/jcs.109.7.1847

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11955436

Title: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

PubMed ID: 11955436

DOI: 10.1016/s0092-8674(02)00685-2

PubMed ID: 11927557

Title: Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.

PubMed ID: 11927557

DOI: 10.1093/emboj/21.7.1733

PubMed ID: 15616566

Title: Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

PubMed ID: 15616566

DOI: 10.1038/nature03179

PubMed ID: 15691767

Title: Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

PubMed ID: 15691767

DOI: 10.1016/j.devcel.2005.01.001

PubMed ID: 16326393

Title: Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.

PubMed ID: 16326393

DOI: 10.1016/j.devcel.2005.10.006

PubMed ID: 22095083

Title: A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1alpha as an essential negative regulator of wingless signaling.

PubMed ID: 22095083

DOI: 10.1534/genetics.111.133827

PubMed ID: 25723539

Title: Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.

PubMed ID: 25723539

DOI: 10.1371/journal.pgen.1005014

Sequence Information:

Length: 337
Mass: 39535
Checksum: 495144945093E69D
Sequence:

MDKMRILKES RPEIIVGGKY RVIRKIGSGS FGDIYLGMSI QSGEEVAIKM ESAHARHPQL 
LYEAKLYRIL SGGVGFPRIR HHGKEKNFNT LVMDLLGPSL EDLFNFCTRH FTIKTVLMLV 
DQMIGRLEYI HLKCFIHRDI KPDNFLMGIG RHCNKLFLID FGLAKKFRDP HTRHHIVYRE 
DKNLTGTARY ASINAHLGIE QSRRDDMESL GYVMMYFNRG VLPWQGMKAN TKQQKYEKIS 
EKKMSTPIEV LCKGSPAEFS MYLNYCRSLR FEEQPDYMYL RQLFRILFRT LNHQYDYIYD 
WTMLKQKTHQ GQPNPAILLE QLDKDKEKQN GKPLIAD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CkIalpha

Associated with

Other Information

The casein kinase 1 alpha gene of Drosophila melanogaster is developmentally regulated and the kinase activity of the protein induced by DNA damage. PubMed ID: 8832407

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. PubMed ID: 11955436

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. PubMed ID: 11927557

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. PubMed ID: 15616566

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. PubMed ID: 15691767

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. PubMed ID: 16326393

A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1alpha as an essential negative regulator of wingless signaling. PubMed ID: 22095083

Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels. PubMed ID: 25723539