APC | ENSG00000134982 | NCBI 324

Details for: APC

Gene ID: 324

Symbol: APC

Ensembl ID: ENSG00000134982

Description: APC regulator of WNT signaling pathway

Associated with

Apc truncation mutants are not k63 polyubiquitinated
(R-HSA-5467333)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Deubiquitination
(R-HSA-5688426)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Metabolism of proteins
(R-HSA-392499)
Ovarian tumor domain proteases
(R-HSA-5689896)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Beta-catenin binding
(GO:0008013)
Bicellular tight junction assembly
(GO:0070830)
Cadherin binding
(GO:0045296)
Cell adhesion
(GO:0007155)
Cell fate specification
(GO:0001708)
Cell migration
(GO:0016477)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule
(GO:0005881)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Dynein complex binding
(GO:0070840)
Endocardial cushion morphogenesis
(GO:0003203)
Gamma-catenin binding
(GO:0045295)
Golgi apparatus
(GO:0005794)
Heart valve development
(GO:0003170)
Insulin receptor signaling pathway
(GO:0008286)
Kinetochore
(GO:0000776)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Microtubule plus-end binding
(GO:0051010)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell cycle g1/s phase transition
(GO:1902807)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of microtubule depolymerization
(GO:0007026)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pattern specification process
(GO:0007389)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein localization to centrosome
(GO:1904781)
Positive regulation of pseudopodium assembly
(GO:0031274)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase regulator activity
(GO:0019887)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of cell differentiation
(GO:0045595)
Regulation of microtubule-based movement
(GO:0060632)
Regulation of microtubule-based process
(GO:0032886)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 6.28