Details for: APC

Gene ID: 324

Symbol: APC

Ensembl ID: ENSG00000134982

Description: APC regulator of WNT signaling pathway

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 447.2011
    Cell Significance Index: -69.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 279.0532
    Cell Significance Index: -70.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.1260
    Cell Significance Index: -71.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.3946
    Cell Significance Index: -53.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 122.4374
    Cell Significance Index: -62.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.4368
    Cell Significance Index: -72.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.0779
    Cell Significance Index: -53.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9546
    Cell Significance Index: -66.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.2110
    Cell Significance Index: -68.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.4007
    Cell Significance Index: -72.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.0736
    Cell Significance Index: -32.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.3192
    Cell Significance Index: 65.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.1103
    Cell Significance Index: 122.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.6257
    Cell Significance Index: 284.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.5120
    Cell Significance Index: 27.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.9505
    Cell Significance Index: 1058.2800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.8255
    Cell Significance Index: 39.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4353
    Cell Significance Index: 488.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1956
    Cell Significance Index: 1982.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0416
    Cell Significance Index: 1412.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6074
    Cell Significance Index: 71.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5100
    Cell Significance Index: 57.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4230
    Cell Significance Index: 79.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2898
    Cell Significance Index: 209.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2416
    Cell Significance Index: 95.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1696
    Cell Significance Index: 127.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0474
    Cell Significance Index: 70.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9047
    Cell Significance Index: 19.8100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.8448
    Cell Significance Index: 8.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8159
    Cell Significance Index: 161.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7435
    Cell Significance Index: 38.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5726
    Cell Significance Index: 39.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5660
    Cell Significance Index: 102.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4521
    Cell Significance Index: 13.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3703
    Cell Significance Index: 45.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2702
    Cell Significance Index: 5.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2555
    Cell Significance Index: 112.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2516
    Cell Significance Index: 11.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2233
    Cell Significance Index: 42.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2182
    Cell Significance Index: 3.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1850
    Cell Significance Index: 348.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1817
    Cell Significance Index: 99.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1020
    Cell Significance Index: 188.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0799
    Cell Significance Index: 123.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0669
    Cell Significance Index: 3.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0602
    Cell Significance Index: 2.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0591
    Cell Significance Index: 8.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0452
    Cell Significance Index: 61.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0415
    Cell Significance Index: 26.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0413
    Cell Significance Index: 18.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0042
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0340
    Cell Significance Index: -24.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0346
    Cell Significance Index: -5.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0480
    Cell Significance Index: -29.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0513
    Cell Significance Index: -7.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0707
    Cell Significance Index: -39.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0937
    Cell Significance Index: -70.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1244
    Cell Significance Index: -7.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1388
    Cell Significance Index: -3.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1586
    Cell Significance Index: -3.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1669
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1777
    Cell Significance Index: -37.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1839
    Cell Significance Index: -21.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2062
    Cell Significance Index: -5.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2074
    Cell Significance Index: -59.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2136
    Cell Significance Index: -5.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2736
    Cell Significance Index: -35.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2836
    Cell Significance Index: -3.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3238
    Cell Significance Index: -33.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3350
    Cell Significance Index: -21.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3813
    Cell Significance Index: -43.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3841
    Cell Significance Index: -44.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4091
    Cell Significance Index: -52.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4635
    Cell Significance Index: -5.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4935
    Cell Significance Index: -23.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5232
    Cell Significance Index: -37.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5788
    Cell Significance Index: -60.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5845
    Cell Significance Index: -66.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5929
    Cell Significance Index: -12.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6058
    Cell Significance Index: -31.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7190
    Cell Significance Index: -9.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7284
    Cell Significance Index: -57.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7671
    Cell Significance Index: -57.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7798
    Cell Significance Index: -15.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8161
    Cell Significance Index: -17.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9800
    Cell Significance Index: -20.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0168
    Cell Significance Index: -27.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0254
    Cell Significance Index: -25.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0381
    Cell Significance Index: -11.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0953
    Cell Significance Index: -67.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0965
    Cell Significance Index: -35.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1026
    Cell Significance Index: -29.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1056
    Cell Significance Index: -13.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1271
    Cell Significance Index: -36.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1955
    Cell Significance Index: -25.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.2660
    Cell Significance Index: -21.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2829
    Cell Significance Index: -40.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3125
    Cell Significance Index: -26.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.3147
    Cell Significance Index: -19.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The APC gene is a large gene (approximately 15 kb) located on chromosome 5q21-q22. It is a member of the E3 ubiquitin ligase family and contains 15 exons. The APC protein is a 3,000-amino acid protein that is composed of three main domains: the N-terminal domain, the central domain, and the C-terminal domain. The APC protein interacts with multiple signaling molecules, including beta-catenin, axin, and GSK-3beta, to regulate the WNT signaling pathway. Mutations in the APC gene can lead to the formation of truncated or aberrant APC proteins, which can disrupt normal APC function and lead to the activation of the WNT signaling pathway. **Pathways and Functions** The APC gene plays a critical role in regulating the WNT signaling pathway, which is involved in various cellular processes, including: 1. **Cell Growth and Differentiation**: The APC protein regulates the WNT signaling pathway to control cell growth and differentiation. Mutations in the APC gene can lead to the activation of the WNT signaling pathway, resulting in uncontrolled cell growth and tumor formation. 2. **Apoptosis**: The APC protein also regulates apoptosis, or programmed cell death, by interacting with pro-apoptotic and anti-apoptotic proteins. 3. **Cell Migration**: The APC protein regulates cell migration by interacting with cytoskeletal proteins and signaling molecules. 4. **Cancer**: Mutations in the APC gene have been implicated in several cancers, including colorectal cancer, breast cancer, and brain cancer. **Clinical Significance** Dysregulation of the APC gene has been implicated in various diseases, including: 1. **Colorectal Cancer**: Mutations in the APC gene are a common cause of colorectal cancer. 2. **Neurodegenerative Disorders**: Mutations in the APC gene have been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Developmental Abnormalities**: Mutations in the APC gene can lead to developmental abnormalities, including heart valve defects and craniofacial abnormalities. 4. **Cancer Therapy**: The APC gene is a target for cancer therapy, with several APC-targeting therapies being developed to treat cancers associated with APC mutations. In conclusion, the APC gene is a critical regulator of the WNT signaling pathway, playing a significant role in various cellular processes, including cell growth, differentiation, and survival. Mutations in the APC gene have been implicated in several diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Further research is needed to understand the role of the APC gene in human disease and to develop effective therapeutic strategies to treat cancers associated with APC mutations.

Genular Protein ID: 497018514

Symbol: APC_HUMAN

Name: Adenomatous polyposis coli protein

UniProtKB Accession Codes:

P25054 B7Z2B6 D3DT03 Q15162 Q15163 Q93042

Database IDs:

AGR 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 13 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 15 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 15 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1678319

Title: Identification of deletion mutations and three new genes at the familial polyposis locus.

PubMed ID: 1678319

DOI: 10.1016/0092-8674(81)90022-2

PubMed ID: 1651562

Title: Identification of FAP locus genes from chromosome 5q21.

PubMed ID: 1651562

DOI: 10.1126/science.1651562

PubMed ID: 10947987

Title: Asef, a link between the tumor suppressor APC and G-protein signaling.

PubMed ID: 10947987

DOI: 10.1126/science.289.5482.1194

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1310068

Title: Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

PubMed ID: 1310068

PubMed ID: 8259519

Title: Association of the APC tumor suppressor protein with catenins.

PubMed ID: 8259519

DOI: 10.1126/science.8259519

PubMed ID: 8638125

Title: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

PubMed ID: 8638125

DOI: 10.1126/science.272.5264.1020

PubMed ID: 9188857

Title: Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.

PubMed ID: 9188857

DOI: 10.1038/sj.onc.1201087

PubMed ID: 11691822

Title: Human APC2 localization and allelic imbalance.

PubMed ID: 11691822

PubMed ID: 14514668

Title: Characterization of functional domains of human EB1 family proteins.

PubMed ID: 14514668

DOI: 10.1074/jbc.m306194200

PubMed ID: 15355978

Title: Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.

PubMed ID: 15355978

DOI: 10.1074/jbc.m404655200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16611247

Title: Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.

PubMed ID: 16611247

DOI: 10.1111/j.1365-2443.2006.00954.x

PubMed ID: 17293347

Title: Regulated binding of adenomatous polyposis coli protein to actin.

PubMed ID: 17293347

DOI: 10.1074/jbc.m610615200

PubMed ID: 17599059

Title: Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.

PubMed ID: 17599059

DOI: 10.1038/sj.onc.1210574

PubMed ID: 18281465

Title: Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.

PubMed ID: 18281465

DOI: 10.1101/gad.463208

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19527921

Title: Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis.

PubMed ID: 19527921

DOI: 10.1016/j.canlet.2009.05.016

PubMed ID: 19632184

Title: An EB1-binding motif acts as a microtubule tip localization signal.

PubMed ID: 19632184

DOI: 10.1016/j.cell.2009.04.065

PubMed ID: 19893577

Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.

PubMed ID: 19893577

DOI: 10.1038/embor.2009.233

PubMed ID: 19151759

Title: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.

PubMed ID: 19151759

DOI: 10.1038/onc.2008.478

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21498506

Title: Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).

PubMed ID: 21498506

DOI: 10.1074/jbc.m111.224881

PubMed ID: 21643010

Title: Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis.

PubMed ID: 21643010

DOI: 10.1038/onc.2011.201

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22128170

Title: Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning.

PubMed ID: 22128170

DOI: 10.1074/jbc.m111.308650

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

PubMed ID: 27217144

Title: Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis.

PubMed ID: 27217144

DOI: 10.1038/srep26011

PubMed ID: 10926498

Title: Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor.

PubMed ID: 10926498

DOI: 10.1006/jmbi.2000.3895

PubMed ID: 11707392

Title: Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.

PubMed ID: 11707392

DOI: 10.1093/emboj/20.22.6203

PubMed ID: 10811618

Title: Structural basis of the axin-adenomatous polyposis coli interaction.

PubMed ID: 10811618

DOI: 10.1093/emboj/19.10.2270

PubMed ID: 8111410

Title: Mutations of the APC (adenomatous polyposis coli) gene.

PubMed ID: 8111410

DOI: 10.1002/humu.1380020602

PubMed ID: 20509626

Title: Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain.

PubMed ID: 20509626

DOI: 10.1021/bi100563z

PubMed ID: 21871439

Title: Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility.

PubMed ID: 21871439

DOI: 10.1016/j.bbrc.2011.08.044

PubMed ID: 22000517

Title: Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.

PubMed ID: 22000517

DOI: 10.1016/j.str.2011.07.013

PubMed ID: 1651563

Title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

PubMed ID: 1651563

DOI: 10.1126/science.1651563

PubMed ID: 1338904

Title: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

PubMed ID: 1338904

DOI: 10.1093/hmg/1.4.229

PubMed ID: 1338691

Title: Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.

PubMed ID: 1338691

DOI: 10.1093/hmg/1.8.559

PubMed ID: 1338764

Title: Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients.

PubMed ID: 1338764

DOI: 10.1002/humu.1380010603

PubMed ID: 1316610

Title: Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

PubMed ID: 1316610

DOI: 10.1073/pnas.89.10.4452

PubMed ID: 7833149

Title: Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene.

PubMed ID: 7833149

DOI: 10.1016/0959-8049(94)00294-f

PubMed ID: 7833931

Title: Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients.

PubMed ID: 7833931

DOI: 10.1093/hmg/3.9.1687

PubMed ID: 7661930

Title: The molecular basis of Turcot's syndrome.

PubMed ID: 7661930

DOI: 10.1056/nejm199503303321302

PubMed ID: 8940264

Title: Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.

PubMed ID: 8940264

PubMed ID: 8764128

Title: Somatic mutations of the APC gene in sporadic hepatoblastomas.

PubMed ID: 8764128

PubMed ID: 8990002

Title: Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis.

PubMed ID: 8990002

DOI: 10.1002/(sici)1098-1004(1997)9:1<7::aid-humu2>3.0.co;2-8

PubMed ID: 9419979

Title: Drastic genetic instability of tumors and normal tissues in Turcot syndrome.

PubMed ID: 9419979

DOI: 10.1038/sj.onc.1201668

PubMed ID: 9731522

Title: The APC I1307K allele and breast cancer risk.

PubMed ID: 9731522

DOI: 10.1038/1666

PubMed ID: 9724771

Title: The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.

PubMed ID: 9724771

DOI: 10.1073/pnas.95.18.10722

PubMed ID: 9731533

Title: The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews.

PubMed ID: 9731533

DOI: 10.1038/1722

PubMed ID: 9973276

Title: Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.

PubMed ID: 9973276

DOI: 10.1086/302262

PubMed ID: 9950360

Title: Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition.

PubMed ID: 9950360

PubMed ID: 10470088

Title: The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.

PubMed ID: 10470088

DOI: 10.1038/12511

PubMed ID: 10666372

Title: APC mutations in sporadic medulloblastomas.

PubMed ID: 10666372

DOI: 10.1016/s0002-9440(10)64747-5

PubMed ID: 10782927

Title: A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.

PubMed ID: 10782927

DOI: 10.1034/j.1399-0004.2000.570306.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27087319

Title: Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.

PubMed ID: 27087319

DOI: 10.1016/j.ajhg.2016.03.001

PubMed ID: 27343414

Title: The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature.

PubMed ID: 27343414

DOI: 10.1016/j.gie.2016.06.023

PubMed ID: 29753700

Title: Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

PubMed ID: 29753700

DOI: 10.1016/s1470-2045(18)30242-0

PubMed ID: 33242120

Title: Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy.

PubMed ID: 33242120

DOI: 10.1007/s12328-020-01290-6

Sequence Information:

  • Length: 2843
  • Mass: 311646
  • Checksum: 77E194AE4A91DC5A
  • Sequence:
    • MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM 
ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR 
RGFVNGSRES TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL 
QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT 
EAERSSQNKH ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA 
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL 
HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC 
WEWQEAHEPG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG GLQAIAELLQ 
VDCEMYGLTN DHYSITLRRY AGMALTNLTF GDVANKATLC SMKGCMRALV AQLKSESEDL 
QQVIASVLRN LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS ALWNLSAHCT 
ENKADICAVD GALAFLVGTL TYRSQTNTLA IIESGGGILR NVSSLIATNE DHRQILRENN 
CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD MGAVSMLKNL IHSKHKMIAM 
GSAAALRNLM ANRPAKYKDA NIMSPGSSLP SLHVRKQKAL EAELDAQHLS ETFDNIDNLS 
PKASHRSKQR HKQSLYGDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV LPSSSSSRGS 
LDSSRSEKDR SLERERGIGL GNYHPATENP GTSSKRGLQI STTAAQIAKV MEEVSAIHTS 
QEDRSSGSTT ELHCVTDERN ALRRSSAAHT HSNTYNFTKS ENSNRTCSMP YAKLEYKRSS 
NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY PADLAHKIHS ANHMDDNDGE 
LDTPINYSLK YSDEQLNSGR QSPSQNERWA RPKHIIEDEI KQSEQRQSRN QSTTYPVYTE 
STDDKHLKFQ PHFGQQECVS PYRSRGANGS ETNRVGSNHG INQNVSQSLC QEDDYEDDKP 
TNYSERYSEE EQHEEEERPT NYSIKYNEEK RHVDQPIDYS LKYATDIPSS QKQSFSFSKS 
SSGQSSKTEH MSSSSENTST PSSNAKRQNQ LHPSSAQSRS GQPQKAATCK VSSINQETIQ 
TYCVEDTPIC FSRCSSLSSL SSAEDEIGCN QTTQEADSAN TLQIAEIKEK IGTRSAEDPV 
SEVPAVSQHP RTKSSRLQGS SLSSESARHK AVEFSSGAKS PSKSGAQTPK SPPEHYVQET 
PLMFSRCTSV SSLDSFESRS IASSVQSEPC SGMVSGIISP SDLPDSPGQT MPPSRSKTPP 
PPPQTAQTKR EVPKNKAPTA EKRESGPKQA AVNAAVQRVQ VLPDADTLLH FATESTPDGF 
SCSSSLSALS LDEPFIQKDV ELRIMPPVQE NDNGNETESE QPKESNENQE KEAEKTIDSE 
KDLLDDSDDD DIEILEECII SAMPTKSSRK AKKPAQTASK LPPPVARKPS QLPVYKLLPS 
QNRLQPQKHV SFTPGDDMPR VYCVEGTPIN FSTATSLSDL TIESPPNELA AGEGVRGGAQ 
SGEFEKRDTI PTEGRSTDEA QGGKTSSVTI PELDDNKAEE GDILAECINS AMPKGKSHKP 
FRVKKIMDQV QQASASSSAP NKNQLDGKKK KPTSPVKPIP QNTEYRTRVR KNADSKNNLN 
AERVFSDNKD SKKQNLKNNS KVFNDKLPNN EDRVRGSFAF DSPHHYTPIE GTPYCFSRND 
SLSSLDFDDD DVDLSREKAE LRKAKENKES EAKVTSHTEL TSNQQSANKT QAIAKQPINR 
GQPKPILQKQ STFPQSSKDI PDRGAATDEK LQNFAIENTP VCFSHNSSLS SLSDIDQENN 
NKENEPIKET EPPDSQGEPS KPQASGYAPK SFHVEDTPVC FSRNSSLSSL SIDSEDDLLQ 
ECISSAMPKK KKPSRLKGDN EKHSPRNMGG ILGEDLTLDL KDIQRPDSEH GLSPDSENFD 
WKAIQEGANS IVSSLHQAAA AACLSRQASS DSDSILSLKS GISLGSPFHL TPDQEEKPFT 
SNKGPRILKP GEKSTLETKK IESESKGIKG GKKVYKSLIT GKVRSNSEIS GQMKQPLQAN 
MPSISRGRTM IHIPGVRNSS SSTSPVSKKG PPLKTPASKS PSEGQTATTS PRGAKPSVKS 
ELSPVARQTS QIGGSSKAPS RSGSRDSTPS RPAQQPLSRP IQSPGRNSIS PGRNGISPPN 
KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQMSQQNLTK QTGLSKNASS IPRSESASKG 
LNQMNNGNGA NKKVELSRMS STKSSGSESD RSERPVLVRQ STFIKEAPSP TLRRKLEESA 
SFESLSPSSR PASPTRSQAQ TPVLSPSLPD MSLSTHSSVQ AGGWRKLPPN LSPTIEYNDG 
RPAKRHDIAR SHSESPSRLP INRSGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES 
SEKAKSEDEK HVNSISGTKQ SKENQVSAKG TWRKIKENEF SPTNSTSQTV SSGATNGAES 
KTLIYQMAPA VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKA NPNIKDSKDN 
QAKQNVGNGS VPMRTVGLEN RLNSFIQVDA PDQKGTEIKP GQNNPVPVSE TNESSIVERT 
PFSSSSSSKH SSPSGTVAAR VTPFNYNPSP RKSSADSTSA RPSQIPTPVN NNTKKRDSKT 
DSTESSGTQS PKRHSGSYLV TSV

Genular Protein ID: 403287635

Symbol: Q4LE70_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE70

Database IDs:

ARBA 4 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 18 PharmGKB 1 RefSeq 3 SAM 2 SMART 1 SUPFAM 3

Sequence Information:

  • Length: 2845
  • Mass: 311899
  • Checksum: B83A16839FB61181
  • Sequence:
    • PRMAAASYDQ LLKQVEALKM ENSNLRQELE DNSNHLTKLE TEASNMKEVL KQLQGSIEDE 
AMASSGQIDL LERLKELNLD SSNFPGVKLR SKMSLRSYGS REGSVSSRSG ECSPVPMGSF 
PRRGFVNGSR ESTGYLEELE KERSLLLADL DKEEKEKDWY YAQLQNLTKR IDSLPLTENF 
SLQTDMTRRQ LEYEARQIRV AMEEQLGTCQ DMEKRAQRRI ARIQQIEKDI LRIRQLLQSQ 
ATEAERSSQN KHETGSHDAE RQNEGQGVGE INMATSGNGQ GSTTRMDHET ASVLSSSSTH 
SAPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCISMR QSGCLPLLIQ 
LLHGNDKDSV LLGNSRGSKE ARARASAALH NIIHSQPDDK RGRREIRVLH LLEQIRAYCE 
TCWEWQEAHE PGMDQDKNPM PAPVEHQICP AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL 
LQVDCEMYGL TNDHYSITLR RYAGMALTNL TFGDVANKAT LCSMKGCMRA LVAQLKSESE 
DLQQVIASVL RNLSWRADVN SKKTLREVGS VKALMECALE VKKESTLKSV LSALWNLSAH 
CTENKADICA VDGALAFLVG TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEDHRQILRE 
NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNPKDQEAL WDMGAVSMLK NLIHSKHKMI 
AMGSAAALRN LMANRPAKYK DANIMSPGSS LPSLHVRKQK ALEAELDAQH LSETFDNIDN 
LSPKASHRSK QRHKQSLYGD YVFDTNRHDD NRSDNFNTGN MTVLSPYLNT TVLPSSSSSR 
GSLDSSRSEK DRSLERERGI GLGNYHPATE NPGTSSKRGL QISTTAAQIA KVMEEVSAIH 
TSQEDRSSGS TTELHCVTDE RNALRRSSAA HTHSNTYNFT KSENSNRTCS MPYAKLEYKR 
SSNDSLNSVS SSDGYGKRGQ MKPSIESYSE DDESKFCSYG QYPADLAHKI HSANHMDDND 
GELDTPINYS LKYSDEQLNS GRQSPSQNER WARPKHIIED EIKQSEQRQS RNQSTTYPVY 
TESTDDKHLK FQPHFGQQEC VSPYRSRGAN GSETNRVGSN HGINQNVSQS LCQEDDYEDD 
KPTNYSERYS EEEQHEEEER PTNYSIKYNE EKRHVDQPID YSLKYATDIP SSQKQSFSFS 
KSSSGQSSKT EHMSSSSENT STPSSNAKRQ NQLHPSSAQS RSGQPQKAAT CKVSSINQET 
IQTYCVEDTP ICFSRCSSLS SLSSAEDEIG CNQTTQEADS ANTLQIAEIK EKIGTRSAED 
PVSEVPAVSQ HPRTKSSRLQ GSSLSSESAR HKAVEFSSGA KSPSKSGAQT PKSPPEHYVQ 
ETPLMFSRCT SVSSLDSFES RSIASSVQSE PCSGMVSGII SPSDLPDSPG QTMPPSRSKT 
PPPPPQTAQT KREVPKNKAP TAEKRESGPK QAAVNAAVQR VQVLPDADTL LHFATESTPD 
GFSCSSSLSA LSLDEPFIQK DVELRIMPPV QENDNGNETE SEQPKESNEN QEKEAEKTID 
SEKDLLDDSD DDDIEILEEC IISAMPTKSS RKAKKPAQTA SKLPPPVARK PSQLPVYKLL 
PSQNRLQPQK HVSFTPGDDM PRVYCVEGTP INFSTATSLS DLTIESPPNE LAAGEGVRGG 
AQSGEFEKRD TIPTEGRSTD EAQGGKTSSV TIPELDDNKA EEGDILAECI NSAMPKGKSH 
KPFRVKKIMD QVQQASASSS APNKNQLDGK KKKPTSPVKP IPQNTEYRTR VRKNADSKNN 
LNAERVFSDN KDSKKQNLKN NSKVFNDKLP NNEDRVRGSF AFDSPHHYTP IEGTPYCFSR 
NDSLSSLDFD DDDVDLSREK AELRKAKENK ESEAKVTSHT ELTSNQQSAN KTQAIAKQPI 
NRGQPKPILQ KQSTFPQSSK DIPDRGAATD EKLQNFAIEN TPVCFSHNSS LSSLSDIDQE 
NNNKENEPIK ETEPPDSQGE PSKPQASGYA PKSFHVEDTP VCFSRNSSLS SLSIDSEDDL 
LQECISSAMP KKKKPSRLKG DNEKHSPRNM GGILGEDLTL DLKDIQRPDS EHGLSPDSEN 
FDWKAIQEGA NSIVSSLHQA AAAACLSRQA SSDSDSILSL KSGISLGSPF HLTPDQEEKP 
FTSNKGPRIL KPGEKSTLET KKIESESKGI KGGKKVYKSL ITGKVRSNSE ISGQMKQPLQ 
ANMPSISRGR TMIHIPGVRN SSSSTSPVSK KGPPLKTPAS KSPSEGQTAT TSPRGAKPSV 
KSELSPVARQ TSQIGGSSKA PSRSGSRDST PSRPAQQPLS RPIQSPGRNS ISPGRNGISP 
PNKLSQLPRT SSPSTASTKS SGSGKMSYTS PGRQMSQQNL TKQTGLSKNA SSIPRSESAS 
KGLNQMNNGN GANKKVELSR MSSTKSSGSE SDRSERPVLV RQSTFIKEAP SPTLRRKLEE 
SASFESLSPS SRPASPTRSQ AQTPVLSPSL PDMSLSTHSS VQAGGWRKLP PNLSPTIEYN 
DGRPAKRHDI ARSHSESPSR LPINRSGTWK REHSKHSSSL PRVSTWRRTG SSSSILSASS 
ESSEKAKSED EKHVNSISGT KQSKENQVSA KGTWRKIKEN EFSPTNSTSQ TVSSGATNGA 
ESKTLIYQMA PAVSKTEDVW VRIEDCPINN PRSGRSPTGN TPPVIDSVSE KANPNIKDSK 
DNQAKQNVGN GSVPMRTVGL ENRLNSFIQV DAPDQKGTEI KPGQNNPVPV SETNESSIVE 
RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST SARPSQIPTP VNNNTKKRDS 
KTDSTESSGT QSPKRHSGSY LVTSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.