Details for: APCS

Gene ID: 325

Symbol: APCS

Ensembl ID: ENSG00000132703

Description: amyloid P component, serum

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.35
    Marker Score: 12651
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.82
    Marker Score: 7833
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7
    Marker Score: 10955
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.05
    Marker Score: 1121
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1945
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.93
    Marker Score: 5646
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1616
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.78
    Marker Score: 242
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 452
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.49
    Marker Score: 134.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.48
    Marker Score: 485
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 105
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 270
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5973
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.36
    Marker Score: 361
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 213
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.34
    Marker Score: 2064
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 343
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 74
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 179
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 189
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 213
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 19.5
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 82
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 414
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.05
    Marker Score: 131
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.05
    Marker Score: 321
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 132
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.03
    Marker Score: 63
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 12.5
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.01
    Marker Score: 45
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16

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Other Information

**Key characteristics:** * APCS is a glycoprotein with a molecular weight of approximately 130 kDa. * It is expressed in high levels in the liver, particularly in the periportal, midzonal, and centrilobular regions of hepatocytes. * It is also expressed in endothelial cells of the pericentral hepatic sinusoid, cardiac endothelial cells, and neoplastic cells. * APCS is a negative regulator of viral entry into host cells. * It is involved in the regulation of the acute inflammatory response to viral infection. **Pathways and functions:** * APCS binds to amyloid proteins, which are components of viral glycoproteins. * This binding prevents the entry of viral glycoproteins into host cells. * APCS also binds to calcium ions, which are important for the activation of inflammatory mediators. * It also binds to complement proteins, which are involved in the complement cascade. * APCS is involved in the regulation of the innate immune response to viral infection. **Clinical significance:** * Mutations in the APCS gene have been linked to the development of liver diseases, including amyloidosis. * APCS is a potential therapeutic target for the treatment of amyloidosis. **Additional notes:** * APCS is a member of the amyloid precursor protein family of proteins. * It is expressed in high levels in healthy adults, but its expression is increased in patients with liver disease. * APCS is a promising target for the treatment of liver diseases, as it is expressed in a variety of cell types that are involved in the innate immune response to viral infection.

Genular Protein ID: 2157106348

Symbol: SAMP_HUMAN

Name: Serum amyloid P-component

UniProtKB Accession Codes:

P02743

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 6 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2987268

Title: Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

PubMed ID: 2987268

DOI: 10.1016/s0021-9258(17)39671-0

PubMed ID: 3029048

Title: Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component.

PubMed ID: 3029048

DOI: 10.1093/oxfordjournals.jbchem.a121797

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4055725

Title: The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

PubMed ID: 4055725

DOI: 10.1016/s0021-9258(17)38809-9

PubMed ID: 81686

Title: Human plasma P component: isolation and characterization.

PubMed ID: 81686

DOI: 10.1021/bi00613a030

PubMed ID: 8202534

Title: Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.

PubMed ID: 8202534

DOI: 10.1073/pnas.91.12.5602

PubMed ID: 15174148

Title: Proteomic characterization of novel serum amyloid P component variants from human plasma and urine.

PubMed ID: 15174148

DOI: 10.1002/pmic.200300690

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8114934

Title: Structure of pentameric human serum amyloid P component.

PubMed ID: 8114934

DOI: 10.1038/367338a0

PubMed ID: 9217261

Title: Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.

PubMed ID: 9217261

DOI: 10.1006/jmbi.1997.1075

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 223
  • Mass: 25387
  • Checksum: 6C88A515FE88B393
  • Sequence:
    • MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS 
DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 
SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 
SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.