Details for: APCS

Gene ID: 325

Symbol: APCS

Ensembl ID: ENSG00000132703

Description: amyloid P component, serum

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmablast (CL0000980)
    Fold Change: 14.9957
    Cell Significance Index: 139.1700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.8898
    Cell Significance Index: 14.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.5898
    Cell Significance Index: 43.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.8929
    Cell Significance Index: 31.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2231
    Cell Significance Index: 29.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.9061
    Cell Significance Index: 15.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7852
    Cell Significance Index: 11.5900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7536
    Cell Significance Index: 4.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4751
    Cell Significance Index: 94.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4559
    Cell Significance Index: 52.2300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1755
    Cell Significance Index: 2.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0798
    Cell Significance Index: 49.8600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0494
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0308
    Cell Significance Index: 5.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0001
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0132
    Cell Significance Index: -0.8400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0165
    Cell Significance Index: -1.8900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0195
    Cell Significance Index: -0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0293
    Cell Significance Index: -5.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1028
    Cell Significance Index: -5.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1098
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1194
    Cell Significance Index: -1.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1238
    Cell Significance Index: -6.5000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1924
    Cell Significance Index: -1.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2191
    Cell Significance Index: -4.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2461
    Cell Significance Index: -3.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2483
    Cell Significance Index: -6.6300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2537
    Cell Significance Index: -2.7200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2637
    Cell Significance Index: -3.1000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2776
    Cell Significance Index: -3.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2814
    Cell Significance Index: -3.7400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3222
    Cell Significance Index: -3.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3233
    Cell Significance Index: -4.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3315
    Cell Significance Index: -33.8700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3517
    Cell Significance Index: -4.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3545
    Cell Significance Index: -9.5000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3790
    Cell Significance Index: -4.7600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3912
    Cell Significance Index: -3.9100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.4151
    Cell Significance Index: -1.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4194
    Cell Significance Index: -4.8000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4268
    Cell Significance Index: -4.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4376
    Cell Significance Index: -5.6400
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.4476
    Cell Significance Index: -5.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4482
    Cell Significance Index: -11.4200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4551
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.4571
    Cell Significance Index: -4.2400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4632
    Cell Significance Index: -5.6400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4635
    Cell Significance Index: -5.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4649
    Cell Significance Index: -5.6400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4694
    Cell Significance Index: -5.8900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4696
    Cell Significance Index: -4.8600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4726
    Cell Significance Index: -5.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4907
    Cell Significance Index: -5.8500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4934
    Cell Significance Index: -5.7300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5009
    Cell Significance Index: -5.8200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5057
    Cell Significance Index: -5.8200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.5066
    Cell Significance Index: -5.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5079
    Cell Significance Index: -6.3000
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.5253
    Cell Significance Index: -5.5300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.5283
    Cell Significance Index: -5.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5310
    Cell Significance Index: -5.4300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5345
    Cell Significance Index: -6.2000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5384
    Cell Significance Index: -6.7800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5515
    Cell Significance Index: -6.2300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5548
    Cell Significance Index: -5.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5558
    Cell Significance Index: -9.5000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5564
    Cell Significance Index: -5.9000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5664
    Cell Significance Index: -5.9000
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.5676
    Cell Significance Index: -5.3200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.5783
    Cell Significance Index: -6.6300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5801
    Cell Significance Index: -6.6800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.5820
    Cell Significance Index: -5.8800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.5834
    Cell Significance Index: -4.9700
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.6046
    Cell Significance Index: -6.5000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6077
    Cell Significance Index: -5.6900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6129
    Cell Significance Index: -6.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6181
    Cell Significance Index: -6.5200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.6196
    Cell Significance Index: -4.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6337
    Cell Significance Index: -6.4300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.6410
    Cell Significance Index: -6.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.6586
    Cell Significance Index: -6.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6693
    Cell Significance Index: -10.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6729
    Cell Significance Index: -9.7700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6730
    Cell Significance Index: -5.5600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6773
    Cell Significance Index: -6.0300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6876
    Cell Significance Index: -5.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6886
    Cell Significance Index: -5.6200
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.6944
    Cell Significance Index: -6.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.6957
    Cell Significance Index: -5.8800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.7266
    Cell Significance Index: -6.8600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7526
    Cell Significance Index: -5.8600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.7589
    Cell Significance Index: -9.8200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.7602
    Cell Significance Index: -6.5600
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.7817
    Cell Significance Index: -6.5900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.7938
    Cell Significance Index: -5.5100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.8133
    Cell Significance Index: -6.5000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.8262
    Cell Significance Index: -10.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** APC is a serine protease inhibitor that belongs to the serpin family of proteins. It is a pentameric protein composed of five identical subunits, each consisting of two immunoglobulin-like domains and a serpin domain. APC is secreted into the bloodstream and can bind to various ligands, including amyloid fibrils, collagen, and complement component C1q. Its binding properties and ability to regulate protein metabolism make it an essential component in the regulation of inflammatory responses and tissue repair. **Pathways and Functions** APC is involved in several key pathways, including: 1. **Acute-phase response**: APC is secreted in response to inflammation and infection, where it helps regulate the production of acute-phase proteins. 2. **Amyloid fiber formation**: APC binds to amyloid fibrils, preventing their aggregation and deposition in tissues. 3. **Innate immune response**: APC recognizes pathogen-associated molecular patterns (PAMPs) and triggers the activation of immune cells, such as macrophages and dendritic cells. 4. **Protein metabolism**: APC regulates the degradation of proteins, including those involved in inflammation and tissue repair. 5. **Negative regulation of viral processes**: APC inhibits the entry of viruses into host cells and regulates viral glycoprotein metabolism. **Clinical Significance** Dysregulation of APC has been implicated in various diseases, including: 1. **Amyloidosis**: APC's inability to bind amyloid fibrils can lead to their deposition in tissues, causing amyloidosis. 2. **Inflammatory diseases**: APC's dysregulation can contribute to excessive inflammation and tissue damage in conditions such as rheumatoid arthritis and atherosclerosis. 3. **Cancer**: APC's expression in neoplastic cells and its role in regulating protein metabolism make it a potential target for cancer therapy. 4. **Viral infections**: APC's ability to inhibit viral entry and regulate glycoprotein metabolism makes it a potential target for antiviral therapy. In conclusion, APC is a multifunctional protein that plays a critical role in regulating various physiological and pathological processes. Its dysregulation can contribute to the development of various diseases, making it an important target for therapeutic intervention.

Genular Protein ID: 2157106348

Symbol: SAMP_HUMAN

Name: Serum amyloid P-component

UniProtKB Accession Codes:

P02743

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2987268

Title: Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

PubMed ID: 2987268

DOI: 10.1016/s0021-9258(17)39671-0

PubMed ID: 3029048

Title: Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component.

PubMed ID: 3029048

DOI: 10.1093/oxfordjournals.jbchem.a121797

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4055725

Title: The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

PubMed ID: 4055725

DOI: 10.1016/s0021-9258(17)38809-9

PubMed ID: 81686

Title: Human plasma P component: isolation and characterization.

PubMed ID: 81686

DOI: 10.1021/bi00613a030

PubMed ID: 8202534

Title: Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.

PubMed ID: 8202534

DOI: 10.1073/pnas.91.12.5602

PubMed ID: 15174148

Title: Proteomic characterization of novel serum amyloid P component variants from human plasma and urine.

PubMed ID: 15174148

DOI: 10.1002/pmic.200300690

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8114934

Title: Structure of pentameric human serum amyloid P component.

PubMed ID: 8114934

DOI: 10.1038/367338a0

PubMed ID: 9217261

Title: Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.

PubMed ID: 9217261

DOI: 10.1006/jmbi.1997.1075

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 223
  • Mass: 25387
  • Checksum: 6C88A515FE88B393
  • Sequence:
    • MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS 
DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 
SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 
SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.