APCS | ENSG00000132703 | NCBI 325

Details for: APCS

Gene ID: 325

Symbol: APCS

Ensembl ID: ENSG00000132703

Description: amyloid P component, serum

Associated with

Amyloid fiber formation
(R-HSA-977225)
Metabolism of proteins
(R-HSA-392499)
Acute-phase response
(GO:0006953)
Blood microparticle
(GO:0072562)
Calcium ion binding
(GO:0005509)
Carbohydrate binding
(GO:0030246)
Chaperone-mediated protein complex assembly
(GO:0051131)
Collagen-containing extracellular matrix
(GO:0062023)
Complement component c1q complex binding
(GO:0001849)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Negative regulation by host of viral exo-alpha-sialidase activity
(GO:0044869)
Negative regulation by host of viral glycoprotein metabolic process
(GO:0044871)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of exo-alpha-sialidase activity
(GO:1903016)
Negative regulation of glycoprotein metabolic process
(GO:1903019)
Negative regulation of monocyte differentiation
(GO:0045656)
Negative regulation of viral entry into host cell
(GO:0046597)
Negative regulation of viral process
(GO:0048525)
Negative regulation of wound healing
(GO:0061045)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Unfolded protein binding
(GO:0051082)
Virion binding
(GO:0046790)

Other Information

Proteins

Serum amyloid P-component

Genular Protein ID: 2157106348

Symbol: SAMP_HUMAN

Name: Serum amyloid P-component

UniProtKB Accession Codes:

P02743

Database IDs:

Citations:

PubMed ID: 2987268

Title: Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

PubMed ID: 2987268

DOI: 10.1016/s0021-9258(17)39671-0

PubMed ID: 3029048

Title: Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component.

PubMed ID: 3029048

DOI: 10.1093/oxfordjournals.jbchem.a121797

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4055725

Title: The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

PubMed ID: 4055725

DOI: 10.1016/s0021-9258(17)38809-9

PubMed ID: 81686

Title: Human plasma P component: isolation and characterization.

PubMed ID: 81686

DOI: 10.1021/bi00613a030

PubMed ID: 8202534

Title: Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.

PubMed ID: 8202534

DOI: 10.1073/pnas.91.12.5602

PubMed ID: 15174148

Title: Proteomic characterization of novel serum amyloid P component variants from human plasma and urine.

PubMed ID: 15174148

DOI: 10.1002/pmic.200300690

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8114934

Title: Structure of pentameric human serum amyloid P component.

PubMed ID: 8114934

DOI: 10.1038/367338a0

PubMed ID: 9217261

Title: Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.

PubMed ID: 9217261

DOI: 10.1006/jmbi.1997.1075

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 223
Mass: 25387
Checksum: 6C88A515FE88B393
Sequence:

MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS 
DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 
SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 
SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APCS

Associated with

Other Information

Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1. PubMed ID: 2987268

Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component. PubMed ID: 3029048

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis. PubMed ID: 4055725

Human plasma P component: isolation and characterization. PubMed ID: 81686

Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. PubMed ID: 8202534

Proteomic characterization of novel serum amyloid P component variants from human plasma and urine. PubMed ID: 15174148

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of pentameric human serum amyloid P component. PubMed ID: 8114934

Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. PubMed ID: 9217261

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974