Details for: APCS

Gene ID: 325

Symbol: APCS

Ensembl ID: ENSG00000132703

Description: amyloid P component, serum

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.35
    Marker Score: 12,651
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.82
    Marker Score: 7,833
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7
    Marker Score: 10,955
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.05
    Marker Score: 1,121
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1,945
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.93
    Marker Score: 5,646
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1,616
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.78
    Marker Score: 242
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 452
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.49
    Marker Score: 135
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.48
    Marker Score: 485
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 105
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 270
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5,973
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.36
    Marker Score: 361
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 213
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.34
    Marker Score: 2,064
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 343
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 74
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.18
    Marker Score: 179
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 189
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 213
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 82
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 414
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.05
    Marker Score: 131
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.05
    Marker Score: 321
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 132
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.03
    Marker Score: 63
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.01
    Marker Score: 45
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** APC is a serine protease inhibitor that belongs to the serpin family of proteins. It is a pentameric protein composed of five identical subunits, each consisting of two immunoglobulin-like domains and a serpin domain. APC is secreted into the bloodstream and can bind to various ligands, including amyloid fibrils, collagen, and complement component C1q. Its binding properties and ability to regulate protein metabolism make it an essential component in the regulation of inflammatory responses and tissue repair. **Pathways and Functions** APC is involved in several key pathways, including: 1. **Acute-phase response**: APC is secreted in response to inflammation and infection, where it helps regulate the production of acute-phase proteins. 2. **Amyloid fiber formation**: APC binds to amyloid fibrils, preventing their aggregation and deposition in tissues. 3. **Innate immune response**: APC recognizes pathogen-associated molecular patterns (PAMPs) and triggers the activation of immune cells, such as macrophages and dendritic cells. 4. **Protein metabolism**: APC regulates the degradation of proteins, including those involved in inflammation and tissue repair. 5. **Negative regulation of viral processes**: APC inhibits the entry of viruses into host cells and regulates viral glycoprotein metabolism. **Clinical Significance** Dysregulation of APC has been implicated in various diseases, including: 1. **Amyloidosis**: APC's inability to bind amyloid fibrils can lead to their deposition in tissues, causing amyloidosis. 2. **Inflammatory diseases**: APC's dysregulation can contribute to excessive inflammation and tissue damage in conditions such as rheumatoid arthritis and atherosclerosis. 3. **Cancer**: APC's expression in neoplastic cells and its role in regulating protein metabolism make it a potential target for cancer therapy. 4. **Viral infections**: APC's ability to inhibit viral entry and regulate glycoprotein metabolism makes it a potential target for antiviral therapy. In conclusion, APC is a multifunctional protein that plays a critical role in regulating various physiological and pathological processes. Its dysregulation can contribute to the development of various diseases, making it an important target for therapeutic intervention.

Genular Protein ID: 2157106348

Symbol: SAMP_HUMAN

Name: Serum amyloid P-component

UniProtKB Accession Codes:

P02743

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 6 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2987268

Title: Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

PubMed ID: 2987268

DOI: 10.1016/s0021-9258(17)39671-0

PubMed ID: 3029048

Title: Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component.

PubMed ID: 3029048

DOI: 10.1093/oxfordjournals.jbchem.a121797

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4055725

Title: The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.

PubMed ID: 4055725

DOI: 10.1016/s0021-9258(17)38809-9

PubMed ID: 81686

Title: Human plasma P component: isolation and characterization.

PubMed ID: 81686

DOI: 10.1021/bi00613a030

PubMed ID: 8202534

Title: Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.

PubMed ID: 8202534

DOI: 10.1073/pnas.91.12.5602

PubMed ID: 15174148

Title: Proteomic characterization of novel serum amyloid P component variants from human plasma and urine.

PubMed ID: 15174148

DOI: 10.1002/pmic.200300690

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8114934

Title: Structure of pentameric human serum amyloid P component.

PubMed ID: 8114934

DOI: 10.1038/367338a0

PubMed ID: 9217261

Title: Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.

PubMed ID: 9217261

DOI: 10.1006/jmbi.1997.1075

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 223
  • Mass: 25387
  • Checksum: 6C88A515FE88B393
  • Sequence:
    • MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS 
DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 
SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 
SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.