Details for: APEH

Gene ID: 327

Symbol: APEH

Ensembl ID: ENSG00000164062

Description: acylaminoacyl-peptide hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.52
    Marker Score: 5966
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.45
    Marker Score: 1515
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.34
    Marker Score: 911
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.33
    Marker Score: 997
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.23
    Marker Score: 1770
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2
    Marker Score: 1771
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.18
    Marker Score: 5673
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39144
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7135
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.11
    Marker Score: 356
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.1
    Marker Score: 1830
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.1
    Marker Score: 12790
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.09
    Marker Score: 2286
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.09
    Marker Score: 2960
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.09
    Marker Score: 1149
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.08
    Marker Score: 2558
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.07
    Marker Score: 6850
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2525
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.07
    Marker Score: 4382
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.05
    Marker Score: 9083
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.05
    Marker Score: 701
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.04
    Marker Score: 3704
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.04
    Marker Score: 574
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.04
    Marker Score: 3273
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.03
    Marker Score: 1366
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.03
    Marker Score: 686
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.01
    Marker Score: 1265.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1
    Marker Score: 726
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1
    Marker Score: 7460
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1
    Marker Score: 2114
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71693
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47914.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1
    Marker Score: 1950
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.99
    Marker Score: 494
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.99
    Marker Score: 2252
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.98
    Marker Score: 2475.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.95
    Marker Score: 222
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.95
    Marker Score: 2533
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.93
    Marker Score: 941
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.92
    Marker Score: 323
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 671
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5206
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2695
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9
    Marker Score: 1526
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.9
    Marker Score: 569
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9
    Marker Score: 472
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.89
    Marker Score: 859
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.89
    Marker Score: 488
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.86
    Marker Score: 918
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.86
    Marker Score: 874.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5222
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.86
    Marker Score: 324
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 924.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.85
    Marker Score: 713
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1395
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.84
    Marker Score: 340
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 876
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.84
    Marker Score: 1193
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.84
    Marker Score: 8464
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.84
    Marker Score: 8507
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.83
    Marker Score: 2263.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.83
    Marker Score: 847
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.81
    Marker Score: 380
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.81
    Marker Score: 849
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.8
    Marker Score: 396
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.8
    Marker Score: 1813.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.8
    Marker Score: 333
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.79
    Marker Score: 295.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.79
    Marker Score: 3419
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.79
    Marker Score: 835
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1107
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.77
    Marker Score: 219
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.77
    Marker Score: 849
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.76
    Marker Score: 371
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.75
    Marker Score: 2238
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.75
    Marker Score: 751.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.74
    Marker Score: 3173
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.74
    Marker Score: 1439.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.74
    Marker Score: 659
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.74
    Marker Score: 891
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.73
    Marker Score: 1128
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.73
    Marker Score: 1274
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.73
    Marker Score: 4423
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.72
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.71
    Marker Score: 438
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.71
    Marker Score: 1269
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.71
    Marker Score: 245
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.71
    Marker Score: 2227
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.7
    Marker Score: 4557

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Other Information

**Key characteristics:** * The protein is a serine endopeptidase that is involved in the proteolytic degradation of acylaminoacyl-peptides. * It is a transmembrane protein that is found in the endoplasmic reticulum. * It is a highly conserved protein that is found in organisms from yeast to humans. **Pathways and functions:** * The protein is involved in the amyloid-beta metabolic process, which is a major pathway for clearing amyloid plaques in the brain. * It is also involved in the cytosol, where it is involved in protein translation termination. * It is involved in the extracellular exosome pathway, where it is a component of the exosome membrane. * It is involved in the extracellular region, where it is involved in the regulation of cell adhesion. * It is involved in the Ficolin-1-rich granule lumen, where it is involved in the regulation of cell migration. * It is involved in the Identical protein binding, where it binds to a protein that is involved in the regulation of cell migration. * It is involved in the immune system, where it is a component of the innate immune system and the adaptive immune system. * It is involved in neutrophil degranulation, where it is a component of the inflammatory response. * It is involved in the nuclear membrane, where it is involved in the regulation of gene expression. * It is involved in the Omega peptidase activity, where it is a key enzyme in the production of lysosomal enzymes. * It is involved in protein binding, where it binds to a variety of proteins, including amyloid-beta, fetuin, and heat shock proteins. * It is involved in proteolysis, where it is a key enzyme in the degradation of proteins. * It is involved in RNA binding, where it binds to a variety of RNA molecules, including mRNA and tRNA. * It is involved in serine-type endopeptidase activity, where it is a key enzyme in the synthesis of proteins. * It is involved in translation, where it is a key enzyme in the initiation of protein synthesis. * It is involved in translational termination, where it is a key enzyme in the termination of protein synthesis. **Clinical significance:** The APEH gene is a cancer-associated gene, which means that mutations in the APEH gene have been linked to the development of cancer. Mutations in the APEH gene have been found in a variety of cancers, including breast cancer, lung cancer, and prostate cancer. These mutations are often associated with the development of aggressive tumors that are resistant to conventional chemotherapy. The development of new therapies that target the APEH gene is an active area of research, as there is a potential to use these therapies to treat cancer.

Genular Protein ID: 1703787310

Symbol: ACPH_HUMAN

Name: Acylamino-acid-releasing enzyme

UniProtKB Accession Codes:

P13798 Q9BQ33 Q9P0Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724851

Title: The nucleotide sequence of human acylamino acid-releasing enzyme.

PubMed ID: 8724851

DOI: 10.1093/dnares/3.1.31

PubMed ID: 10719179

Title: Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase.

PubMed ID: 10719179

DOI: 10.1016/s0167-4838(00)00004-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565880

Title: The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer.

PubMed ID: 2565880

DOI: 10.1016/0888-7543(89)90342-x

PubMed ID: 10395453

Title: Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures.

PubMed ID: 10395453

DOI: 10.1023/a:1021047730831

PubMed ID: 1861871

Title: The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.

PubMed ID: 1861871

PubMed ID: 2006156

Title: Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.

PubMed ID: 2006156

DOI: 10.1073/pnas.88.6.2194

PubMed ID: 1740429

Title: Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.

PubMed ID: 1740429

DOI: 10.1016/s0021-9258(19)50598-1

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8411161

Title: Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase.

PubMed ID: 8411161

DOI: 10.1006/jmbi.1993.1531

Sequence Information:

  • Length: 732
  • Mass: 81225
  • Checksum: A2C370516324D851
  • Sequence:
    • MERQVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GQYRTVHTEW TQRDLERMEN 
IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG TMKAVLRKAG GTGPGEEKQF 
LEVWEKNRKL KSFNLSALEK HGPVYEDDCF GCLSWSHSET HLLYVAEKKR PKAESFFQTK 
ALDVSASDDE IARLKKPDQA IKGDQFVFYE DWGENMVSKS IPVLCVLDVE SGNISVLEGV 
PENVSPGQAF WAPGDAGVVF VGWWHEPFRL GIRFCTNRRS ALYYVDLIGG KCELLSDDSL 
AVSSPRLSPD QCRIVYLQYP SLIPHHQCSQ LCLYDWYTKV TSVVVDVVPR QLGENFSGIY 
CSLLPLGCWS ADSQRVVFDS AQRSRQDLFA VDTQVGTVTS LTAGGSGGSW KLLTIDQDLM 
VAQFSTPSLP PTLKVGFLPS AGKEQSVLWV SLEEAEPIPD IHWGIRVLQP PPEQENVQYA 
GLDFEAILLQ PGSPPDKTQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS 
TGFGQDSILS LPGNVGHQDV KDVQFAVEQV LQEEHFDASH VALMGGSHGG FISCHLIGQY 
PETYRACVAR NPVINIASML GSTDIPDWCV VEAGFPFSSD CLPDLSVWAE MLDKSPIRYI 
PQVKTPLLLM LGQEDRRVPF KQGMEYYRAL KTRNVPVRLL LYPKSTHALS EVEVESDSFM 
NAVLWLRTHL GS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.