Details for: APEH

Gene ID: 327

Symbol: APEH

Ensembl ID: ENSG00000164062

Description: acylaminoacyl-peptide hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.3403
    Cell Significance Index: -10.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.2745
    Cell Significance Index: -14.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.4330
    Cell Significance Index: -19.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.4694
    Cell Significance Index: -21.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.4670
    Cell Significance Index: -21.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.3328
    Cell Significance Index: -21.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.3406
    Cell Significance Index: -19.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8667
    Cell Significance Index: -18.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5845
    Cell Significance Index: -14.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4958
    Cell Significance Index: -16.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0354
    Cell Significance Index: -19.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6345
    Cell Significance Index: 182.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2249
    Cell Significance Index: 259.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4388
    Cell Significance Index: 156.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3666
    Cell Significance Index: 12.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1275
    Cell Significance Index: 58.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9747
    Cell Significance Index: 28.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7922
    Cell Significance Index: 6.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7289
    Cell Significance Index: 398.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7059
    Cell Significance Index: 18.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6100
    Cell Significance Index: 109.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6095
    Cell Significance Index: 74.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5958
    Cell Significance Index: 38.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5458
    Cell Significance Index: 24.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5142
    Cell Significance Index: 11.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4667
    Cell Significance Index: 21.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4617
    Cell Significance Index: 12.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4380
    Cell Significance Index: 12.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4191
    Cell Significance Index: 49.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3883
    Cell Significance Index: 10.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3187
    Cell Significance Index: 43.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2891
    Cell Significance Index: 7.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2820
    Cell Significance Index: 9.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2809
    Cell Significance Index: 5.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2788
    Cell Significance Index: 19.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2381
    Cell Significance Index: 105.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2220
    Cell Significance Index: 7.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2163
    Cell Significance Index: 41.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1913
    Cell Significance Index: 37.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1770
    Cell Significance Index: 13.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1750
    Cell Significance Index: 22.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1706
    Cell Significance Index: 34.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1662
    Cell Significance Index: 4.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1567
    Cell Significance Index: 25.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1488
    Cell Significance Index: 19.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1122
    Cell Significance Index: 1.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1094
    Cell Significance Index: 2.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0898
    Cell Significance Index: 8.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0748
    Cell Significance Index: 26.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0630
    Cell Significance Index: 43.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0357
    Cell Significance Index: 32.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0342
    Cell Significance Index: 0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0336
    Cell Significance Index: 0.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0115
    Cell Significance Index: 8.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0070
    Cell Significance Index: 0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0065
    Cell Significance Index: 4.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0045
    Cell Significance Index: 0.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0130
    Cell Significance Index: -1.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0164
    Cell Significance Index: -22.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0211
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0231
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0251
    Cell Significance Index: -18.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0321
    Cell Significance Index: -18.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0357
    Cell Significance Index: -16.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0397
    Cell Significance Index: -0.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0548
    Cell Significance Index: -15.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0751
    Cell Significance Index: -10.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0820
    Cell Significance Index: -9.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0924
    Cell Significance Index: -1.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0992
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1074
    Cell Significance Index: -22.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1075
    Cell Significance Index: -1.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1687
    Cell Significance Index: -13.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1707
    Cell Significance Index: -8.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1806
    Cell Significance Index: -13.8600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1819
    Cell Significance Index: -0.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1869
    Cell Significance Index: -19.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2131
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2152
    Cell Significance Index: -11.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2372
    Cell Significance Index: -2.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2440
    Cell Significance Index: -15.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2466
    Cell Significance Index: -16.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2490
    Cell Significance Index: -7.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2855
    Cell Significance Index: -16.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3031
    Cell Significance Index: -18.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3167
    Cell Significance Index: -4.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3319
    Cell Significance Index: -4.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3744
    Cell Significance Index: -16.5600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3999
    Cell Significance Index: -5.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4107
    Cell Significance Index: -8.5200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4132
    Cell Significance Index: -4.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4517
    Cell Significance Index: -16.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4517
    Cell Significance Index: -17.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** APEH possesses hydrolase activity, specifically hydrolyzing peptides, which allows it to regulate the activity of various proteins involved in immune responses. 2. **Widespread Expression:** APEH is expressed in multiple cell types, including immune cells, erythroid progenitor cells, and placental villous trophoblasts, indicating its critical role in maintaining cellular homeostasis. 3. **Multiple Signaling Pathways:** APEH is involved in various signaling pathways, including amyloid-beta metabolic process, eukaryotic translation termination, and proteolysis, highlighting its importance in regulating immune responses and cellular homeostasis. 4. **Proteolytic Activity:** APEH exhibits serine-type endopeptidase activity, which allows it to hydrolyze peptides and regulate protein activity. **Pathways and Functions:** 1. **Amyloid-beta Metabolic Process:** APEH is involved in the degradation of amyloid-beta peptides, which are associated with Alzheimer's disease. 2. **Eukaryotic Translation Termination:** APEH plays a role in regulating the termination of eukaryotic translation, which is essential for protein synthesis and cellular homeostasis. 3. **Proteolysis:** APEH exhibits proteolytic activity, which allows it to hydrolyze peptides and regulate protein activity. 4. **Immune System:** APEH is involved in regulating immune responses, including neutrophil degranulation and immune system development. 5. **Translation:** APEH is involved in regulating translation, which is essential for protein synthesis and cellular homeostasis. **Clinical Significance:** Dysregulation of APEH has been implicated in various diseases, including: 1. **Alzheimer's Disease:** APEH's role in amyloid-beta degradation suggests its potential involvement in Alzheimer's disease pathogenesis. 2. **Autoimmune Disorders:** APEH's involvement in immune system regulation suggests its potential role in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** APEH's proteolytic activity and involvement in translation regulation suggest its potential role in cancer development and progression. 4. **Neurological Disorders:** APEH's involvement in eukaryotic translation termination and amyloid-beta degradation suggests its potential role in neurological disorders, such as Parkinson's disease and Huntington's disease. In conclusion, the APEH gene plays a critical role in regulating immune responses and cellular homeostasis. Its involvement in multiple signaling pathways and proteolytic activity underscores its importance in maintaining cellular homeostasis and immune function. Further research is necessary to elucidate the clinical significance of APEH dysregulation and its potential role in various diseases.

Genular Protein ID: 1703787310

Symbol: ACPH_HUMAN

Name: Acylamino-acid-releasing enzyme

UniProtKB Accession Codes:

P13798 Q9BQ33 Q9P0Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724851

Title: The nucleotide sequence of human acylamino acid-releasing enzyme.

PubMed ID: 8724851

DOI: 10.1093/dnares/3.1.31

PubMed ID: 10719179

Title: Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase.

PubMed ID: 10719179

DOI: 10.1016/s0167-4838(00)00004-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565880

Title: The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer.

PubMed ID: 2565880

DOI: 10.1016/0888-7543(89)90342-x

PubMed ID: 10395453

Title: Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures.

PubMed ID: 10395453

DOI: 10.1023/a:1021047730831

PubMed ID: 1861871

Title: The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.

PubMed ID: 1861871

PubMed ID: 2006156

Title: Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.

PubMed ID: 2006156

DOI: 10.1073/pnas.88.6.2194

PubMed ID: 1740429

Title: Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.

PubMed ID: 1740429

DOI: 10.1016/s0021-9258(19)50598-1

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8411161

Title: Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase.

PubMed ID: 8411161

DOI: 10.1006/jmbi.1993.1531

Sequence Information:

  • Length: 732
  • Mass: 81225
  • Checksum: A2C370516324D851
  • Sequence:
    • MERQVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GQYRTVHTEW TQRDLERMEN 
IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG TMKAVLRKAG GTGPGEEKQF 
LEVWEKNRKL KSFNLSALEK HGPVYEDDCF GCLSWSHSET HLLYVAEKKR PKAESFFQTK 
ALDVSASDDE IARLKKPDQA IKGDQFVFYE DWGENMVSKS IPVLCVLDVE SGNISVLEGV 
PENVSPGQAF WAPGDAGVVF VGWWHEPFRL GIRFCTNRRS ALYYVDLIGG KCELLSDDSL 
AVSSPRLSPD QCRIVYLQYP SLIPHHQCSQ LCLYDWYTKV TSVVVDVVPR QLGENFSGIY 
CSLLPLGCWS ADSQRVVFDS AQRSRQDLFA VDTQVGTVTS LTAGGSGGSW KLLTIDQDLM 
VAQFSTPSLP PTLKVGFLPS AGKEQSVLWV SLEEAEPIPD IHWGIRVLQP PPEQENVQYA 
GLDFEAILLQ PGSPPDKTQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS 
TGFGQDSILS LPGNVGHQDV KDVQFAVEQV LQEEHFDASH VALMGGSHGG FISCHLIGQY 
PETYRACVAR NPVINIASML GSTDIPDWCV VEAGFPFSSD CLPDLSVWAE MLDKSPIRYI 
PQVKTPLLLM LGQEDRRVPF KQGMEYYRAL KTRNVPVRLL LYPKSTHALS EVEVESDSFM 
NAVLWLRTHL GS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.