Details for: APEX1

Gene ID: 328

Symbol: APEX1

Ensembl ID: ENSG00000100823

Description: apurinic/apyrimidinic endodeoxyribonuclease 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.02
    Marker Score: 3155
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.98
    Marker Score: 39272
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.88
    Marker Score: 2172
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.84
    Marker Score: 18476
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.65
    Marker Score: 1664
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.63
    Marker Score: 10758
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.59
    Marker Score: 5410
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.48
    Marker Score: 2651
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.47
    Marker Score: 4300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.39
    Marker Score: 6515
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.36
    Marker Score: 2503
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.33
    Marker Score: 2189
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.32
    Marker Score: 3948
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3
    Marker Score: 25856
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.26
    Marker Score: 835
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.22
    Marker Score: 2237
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.22
    Marker Score: 22507
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.21
    Marker Score: 76527.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.2
    Marker Score: 1590
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.19
    Marker Score: 9453
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.19
    Marker Score: 1461
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.18
    Marker Score: 21909
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.16
    Marker Score: 3064
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.15
    Marker Score: 2277
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2.14
    Marker Score: 1050
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.12
    Marker Score: 3477
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.11
    Marker Score: 2373.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.09
    Marker Score: 4916
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.08
    Marker Score: 7696
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.06
    Marker Score: 1084
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.04
    Marker Score: 2183
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.99
    Marker Score: 2142
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.98
    Marker Score: 7783
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.97
    Marker Score: 1083
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.96
    Marker Score: 629
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.96
    Marker Score: 7581
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.95
    Marker Score: 3451
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.95
    Marker Score: 3475
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.94
    Marker Score: 679
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.93
    Marker Score: 4594
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.93
    Marker Score: 912.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.93
    Marker Score: 7438
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2812
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.91
    Marker Score: 1131.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.91
    Marker Score: 22153
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.89
    Marker Score: 914
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.89
    Marker Score: 14075
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.89
    Marker Score: 4897
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.84
    Marker Score: 2833
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.83
    Marker Score: 912
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.81
    Marker Score: 46433
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.8
    Marker Score: 1225
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.77
    Marker Score: 3332
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.76
    Marker Score: 591
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.73
    Marker Score: 890.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.71
    Marker Score: 1296
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.71
    Marker Score: 911
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.71
    Marker Score: 1526
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7
    Marker Score: 1217
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.69
    Marker Score: 542
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.69
    Marker Score: 599
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.68
    Marker Score: 394
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.67
    Marker Score: 534
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.67
    Marker Score: 1969
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.67
    Marker Score: 88237
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.66
    Marker Score: 1168
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.65
    Marker Score: 2649
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.64
    Marker Score: 1540
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.63
    Marker Score: 390
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.63
    Marker Score: 982
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.62
    Marker Score: 1903
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.62
    Marker Score: 803
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.62
    Marker Score: 1703
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.61
    Marker Score: 3157
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.61
    Marker Score: 1263
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.61
    Marker Score: 464
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.6
    Marker Score: 1063
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.6
    Marker Score: 2003
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6
    Marker Score: 910
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.59
    Marker Score: 549
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.59
    Marker Score: 1192
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.59
    Marker Score: 791
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.58
    Marker Score: 725
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.58
    Marker Score: 4292
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.58
    Marker Score: 1522
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.58
    Marker Score: 4676
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.57
    Marker Score: 1792.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.56
    Marker Score: 9977
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.55
    Marker Score: 2003
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.55
    Marker Score: 1454
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.55
    Marker Score: 356
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.54
    Marker Score: 1022
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.54
    Marker Score: 971
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.53
    Marker Score: 1112
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.53
    Marker Score: 840
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.52
    Marker Score: 501
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.52
    Marker Score: 307
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.52
    Marker Score: 538
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.52
    Marker Score: 2021
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.52
    Marker Score: 332

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary APEX1 is an endonuclease that plays a crucial role in maintaining genomic integrity by removing abasic (apurinic or apyrimidinic) sites in DNA. It is significantly expressed in various cell types, including hematopoietic stem cells, neural crest cells, and epithelial cells. ## Key characteristics * APEX1 is a single-nucleotide endonuclease that specifically recognizes and cleaves DNA sequences containing abasic lesions. * It is involved in repairing DNA damage caused by various agents, including oxidative stress, DNA-damaging agents, and oncogenes. * APEX1 is a key regulator of genomic stability and has been implicated in maintaining genome integrity and preventing the accumulation of mutations. ## Pathways and functions APEX1 is involved in several important cellular processes, including: * **Abasic sugar-phosphate removal:** APEX1 is responsible for repairing DNA damage caused by abasic lesions, which are formed when the sugar component of DNA is lost or damaged. * **Base excision repair:** APEX1 can also remove damaged bases from DNA, contributing to base excision repair pathways. * **DNA damage detection:** APEX1 can bind to DNA sequences containing abasic lesions and initiate the repair mechanism. * **DNA repair:** Once APEX1 is activated, it can remove the damaged nucleotide and re-ligate the DNA strand. ## Clinical significance Mutations in the APEX1 gene have been linked to several human diseases, including xeroderma pigmentosum, a genetic disorder characterized by abnormal skin and eye development due to impaired repair of DNA damage. APEX1 is a promising target for cancer therapy, as it is frequently overexpressed in cancer cells and can be used to inhibit their growth and survival. However, the development of effective APEX1 inhibitors is challenging due to the enzyme's critical role in maintaining genomic integrity.

Genular Protein ID: 1350274706

Symbol: APEX1_HUMAN

Name: DNA-(apurinic or apyrimidinic site) endonuclease

UniProtKB Accession Codes:

P27695 Q969L5 Q99775

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 17 EMDB 1 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 77 PDBsum 62 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1719477

Title: Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.

PubMed ID: 1719477

DOI: 10.1093/nar/19.20.5519

PubMed ID: 1722334

Title: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

PubMed ID: 1722334

DOI: 10.1073/pnas.88.24.11450

PubMed ID: 1627644

Title: cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.

PubMed ID: 1627644

DOI: 10.1016/0167-4781(92)90027-w

PubMed ID: 1380454

Title: Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

PubMed ID: 1380454

DOI: 10.1002/j.1460-2075.1992.tb05411.x

PubMed ID: 1371347

Title: Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells.

PubMed ID: 1371347

DOI: 10.1093/nar/20.2.370

PubMed ID: 1380694

Title: The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.

PubMed ID: 1380694

DOI: 10.1093/nar/20.15.4097

PubMed ID: 1383925

Title: Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12.

PubMed ID: 1383925

DOI: 10.1093/nar/20.17.4417

PubMed ID: 8086453

Title: Structure, promoter analysis and chromosomal assignment of the human APEX gene.

PubMed ID: 8086453

DOI: 10.1016/0167-4781(94)90241-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12524539

Title: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

PubMed ID: 12524539

DOI: 10.1038/ni885

PubMed ID: 1284593

Title: Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12).

PubMed ID: 1284593

DOI: 10.1093/hmg/1.9.677

PubMed ID: 8355688

Title: Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

PubMed ID: 8355688

DOI: 10.1128/mcb.13.9.5370-5376.1993

PubMed ID: 8621488

Title: The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

PubMed ID: 8621488

DOI: 10.1074/jbc.271.15.8593

PubMed ID: 8932375

Title: Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.

PubMed ID: 8932375

DOI: 10.1093/nar/24.21.4217

PubMed ID: 9108029

Title: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

PubMed ID: 9108029

DOI: 10.1073/pnas.94.8.3633

PubMed ID: 9207062

Title: Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

PubMed ID: 9207062

DOI: 10.1073/pnas.94.14.7166

PubMed ID: 9804799

Title: Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium.

PubMed ID: 9804799

DOI: 10.1074/jbc.273.46.30360

PubMed ID: 9560228

Title: Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.

PubMed ID: 9560228

DOI: 10.1073/pnas.95.9.5061

PubMed ID: 10023679

Title: Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.

PubMed ID: 10023679

DOI: 10.1038/sj.onc.1202394

PubMed ID: 11118054

Title: Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

PubMed ID: 11118054

PubMed ID: 11452037

Title: Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation.

PubMed ID: 11452037

DOI: 10.1093/nar/29.14.3116

PubMed ID: 11909973

Title: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

PubMed ID: 11909973

DOI: 10.1128/mcb.22.8.2810-2820.2002

PubMed ID: 11832948

Title: An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.

PubMed ID: 11832948

DOI: 10.1038/415655a

PubMed ID: 11809897

Title: Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.

PubMed ID: 11809897

DOI: 10.1093/nar/30.3.823

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 15380100

Title: Novel role of tyrosine in catalysis by human AP endonuclease 1.

PubMed ID: 15380100

DOI: 10.1016/j.dnarep.2004.06.009

PubMed ID: 15942031

Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

PubMed ID: 15942031

DOI: 10.1093/nar/gki641

PubMed ID: 16617147

Title: Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.

PubMed ID: 16617147

DOI: 10.1093/nar/gkl177

PubMed ID: 17148573

Title: UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.

PubMed ID: 17148573

DOI: 10.1242/jcs.03312

PubMed ID: 17403694

Title: Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310.

PubMed ID: 17403694

DOI: 10.1093/nar/gkl1163

PubMed ID: 18439621

Title: Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.

PubMed ID: 18439621

DOI: 10.1016/j.jmb.2008.03.053

PubMed ID: 18809583

Title: Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

PubMed ID: 18809583

DOI: 10.1128/mcb.00244-08

PubMed ID: 18179823

Title: Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity.

PubMed ID: 18179823

DOI: 10.1016/j.molimm.2007.11.020

PubMed ID: 18579163

Title: Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease.

PubMed ID: 18579163

DOI: 10.1016/j.mrfmmm.2008.04.008

PubMed ID: 19123919

Title: Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.

PubMed ID: 19123919

DOI: 10.1021/bi8016137

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 26760506

Title: R152C DNA Pol beta mutation impairs base excision repair and induces cellular transformation.

PubMed ID: 26760506

DOI: 10.18632/oncotarget.6849

PubMed ID: 19401441

Title: Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.

PubMed ID: 19401441

DOI: 10.1093/nar/gkp275

PubMed ID: 19219073

Title: Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.

PubMed ID: 19219073

DOI: 10.1038/onc.2009.5

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20231292

Title: Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.

PubMed ID: 20231292

DOI: 10.1074/jbc.m109.069591

PubMed ID: 19934257

Title: SIRT1 deacetylates APE1 and regulates cellular base excision repair.

PubMed ID: 19934257

DOI: 10.1093/nar/gkp1039

PubMed ID: 20699270

Title: Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.

PubMed ID: 20699270

DOI: 10.1093/nar/gkq691

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 21762700

Title: Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.

PubMed ID: 21762700

DOI: 10.1016/j.jmb.2011.06.050

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9351835

Title: The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

PubMed ID: 9351835

DOI: 10.1093/emboj/16.21.6548

PubMed ID: 10667800

Title: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination.

PubMed ID: 10667800

DOI: 10.1038/35000249

PubMed ID: 11286553

Title: Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.

PubMed ID: 11286553

DOI: 10.1006/jmbi.2001.4529

Sequence Information:

  • Length: 318
  • Mass: 35555
  • Checksum: B88579C01BAF80C6
  • Sequence:
    • MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA 
TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS ENKLPAELQE LPGLSHQYWS 
APSDKEGYSG VGLLSRQCPL KVSYGIGDEE HDQEGRVIVA EFDSFVLVTA YVPNAGRGLV 
RLEYRQRWDE AFRKFLKGLA SRKPLVLCGD LNVAHEEIDL RNPKGNKKNA GFTPQERQGF 
GELLQAVPLA DSFRHLYPNT PYAYTFWTYM MNARSKNVGW RLDYFLLSHS LLPALCDSKI 
RSKALGSDHC PITLYLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.