Details for: APEX1
Associated with
Other Information
Genular Protein ID: 1350274706
Symbol: APEX1_HUMAN
Name: DNA-(apurinic or apyrimidinic site) endonuclease
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1719477
Title: Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.
PubMed ID: 1719477
PubMed ID: 1722334
Title: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.
PubMed ID: 1722334
PubMed ID: 1627644
Title: cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.
PubMed ID: 1627644
PubMed ID: 1380454
Title: Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.
PubMed ID: 1380454
PubMed ID: 1371347
Title: Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells.
PubMed ID: 1371347
DOI: 10.1093/nar/20.2.370
PubMed ID: 1380694
Title: The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.
PubMed ID: 1380694
PubMed ID: 1383925
Title: Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12.
PubMed ID: 1383925
PubMed ID: 8086453
Title: Structure, promoter analysis and chromosomal assignment of the human APEX gene.
PubMed ID: 8086453
PubMed ID: 9110174
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12524539
Title: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
PubMed ID: 12524539
DOI: 10.1038/ni885
PubMed ID: 1284593
Title: Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12).
PubMed ID: 1284593
DOI: 10.1093/hmg/1.9.677
PubMed ID: 8355688
Title: Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.
PubMed ID: 8355688
PubMed ID: 8621488
Title: The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.
PubMed ID: 8621488
PubMed ID: 8932375
Title: Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.
PubMed ID: 8932375
PubMed ID: 9108029
Title: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.
PubMed ID: 9108029
PubMed ID: 9207062
Title: Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
PubMed ID: 9207062
PubMed ID: 9804799
Title: Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium.
PubMed ID: 9804799
PubMed ID: 9560228
Title: Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
PubMed ID: 9560228
PubMed ID: 10023679
Title: Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.
PubMed ID: 10023679
PubMed ID: 11118054
Title: Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.
PubMed ID: 11118054
PubMed ID: 11452037
Title: Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation.
PubMed ID: 11452037
PubMed ID: 11909973
Title: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.
PubMed ID: 11909973
PubMed ID: 11832948
Title: An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.
PubMed ID: 11832948
DOI: 10.1038/415655a
PubMed ID: 11809897
Title: Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.
PubMed ID: 11809897
DOI: 10.1093/nar/30.3.823
PubMed ID: 14633989
Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
PubMed ID: 14633989
DOI: 10.1093/emboj/cdg595
PubMed ID: 15380100
Title: Novel role of tyrosine in catalysis by human AP endonuclease 1.
PubMed ID: 15380100
PubMed ID: 15942031
Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).
PubMed ID: 15942031
DOI: 10.1093/nar/gki641
PubMed ID: 16617147
Title: Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.
PubMed ID: 16617147
DOI: 10.1093/nar/gkl177
PubMed ID: 17148573
Title: UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.
PubMed ID: 17148573
DOI: 10.1242/jcs.03312
PubMed ID: 17403694
Title: Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310.
PubMed ID: 17403694
DOI: 10.1093/nar/gkl1163
PubMed ID: 18439621
Title: Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.
PubMed ID: 18439621
PubMed ID: 18809583
Title: Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
PubMed ID: 18809583
DOI: 10.1128/mcb.00244-08
PubMed ID: 18179823
Title: Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity.
PubMed ID: 18179823
PubMed ID: 18579163
Title: Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease.
PubMed ID: 18579163
PubMed ID: 19123919
Title: Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.
PubMed ID: 19123919
DOI: 10.1021/bi8016137
PubMed ID: 19188445
Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
PubMed ID: 19188445
DOI: 10.1128/mcb.01337-08
PubMed ID: 26760506
Title: R152C DNA Pol beta mutation impairs base excision repair and induces cellular transformation.
PubMed ID: 26760506
PubMed ID: 19401441
Title: Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.
PubMed ID: 19401441
DOI: 10.1093/nar/gkp275
PubMed ID: 19219073
Title: Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
PubMed ID: 19219073
DOI: 10.1038/onc.2009.5
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20231292
Title: Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.
PubMed ID: 20231292
PubMed ID: 19934257
Title: SIRT1 deacetylates APE1 and regulates cellular base excision repair.
PubMed ID: 19934257
DOI: 10.1093/nar/gkp1039
PubMed ID: 20699270
Title: Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
PubMed ID: 20699270
DOI: 10.1093/nar/gkq691
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21496894
Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.
PubMed ID: 21496894
PubMed ID: 21762700
Title: Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.
PubMed ID: 21762700
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9351835
Title: The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
PubMed ID: 9351835
PubMed ID: 10667800
Title: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination.
PubMed ID: 10667800
DOI: 10.1038/35000249
PubMed ID: 11286553
Title: Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.
PubMed ID: 11286553
Sequence Information:
- Length: 318
- Mass: 35555
- Checksum: B88579C01BAF80C6
- Sequence:
MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS ENKLPAELQE LPGLSHQYWS APSDKEGYSG VGLLSRQCPL KVSYGIGDEE HDQEGRVIVA EFDSFVLVTA YVPNAGRGLV RLEYRQRWDE AFRKFLKGLA SRKPLVLCGD LNVAHEEIDL RNPKGNKKNA GFTPQERQGF GELLQAVPLA DSFRHLYPNT PYAYTFWTYM MNARSKNVGW RLDYFLLSHS LLPALCDSKI RSKALGSDHC PITLYLAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.