Details for: APEX1

Gene ID: 328

Symbol: APEX1

Ensembl ID: ENSG00000100823

Description: apurinic/apyrimidinic endodeoxyribonuclease 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 313.8637
    Cell Significance Index: -48.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 145.4190
    Cell Significance Index: -59.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.0586
    Cell Significance Index: -62.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.6624
    Cell Significance Index: -52.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 119.5602
    Cell Significance Index: -61.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.9181
    Cell Significance Index: -27.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 94.0207
    Cell Significance Index: -63.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.7428
    Cell Significance Index: -53.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.0042
    Cell Significance Index: -60.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5041
    Cell Significance Index: -49.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.1073
    Cell Significance Index: -63.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5727
    Cell Significance Index: -35.5500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.8134
    Cell Significance Index: 54.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5704
    Cell Significance Index: -14.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3554
    Cell Significance Index: 58.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.8358
    Cell Significance Index: 61.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.5238
    Cell Significance Index: 157.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3949
    Cell Significance Index: 71.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8567
    Cell Significance Index: 392.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8150
    Cell Significance Index: 74.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6810
    Cell Significance Index: 172.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.6143
    Cell Significance Index: 21.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4211
    Cell Significance Index: 171.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0662
    Cell Significance Index: 254.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0347
    Cell Significance Index: 1111.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9433
    Cell Significance Index: 17.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9272
    Cell Significance Index: 248.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8451
    Cell Significance Index: 815.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7572
    Cell Significance Index: 316.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7413
    Cell Significance Index: 81.8400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.6361
    Cell Significance Index: 9.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4280
    Cell Significance Index: 106.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2400
    Cell Significance Index: 64.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1675
    Cell Significance Index: 137.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0994
    Cell Significance Index: 12.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9767
    Cell Significance Index: 21.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9478
    Cell Significance Index: 855.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.8540
    Cell Significance Index: 12.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7792
    Cell Significance Index: 49.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7343
    Cell Significance Index: 34.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7274
    Cell Significance Index: 19.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6795
    Cell Significance Index: 19.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6676
    Cell Significance Index: 132.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5783
    Cell Significance Index: 74.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5651
    Cell Significance Index: 96.4900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5243
    Cell Significance Index: 3.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5051
    Cell Significance Index: 96.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4991
    Cell Significance Index: 11.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4602
    Cell Significance Index: 31.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3990
    Cell Significance Index: 11.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3612
    Cell Significance Index: 16.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3211
    Cell Significance Index: 64.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2805
    Cell Significance Index: 8.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2276
    Cell Significance Index: 11.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1438
    Cell Significance Index: 7.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1159
    Cell Significance Index: 5.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0904
    Cell Significance Index: 32.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0875
    Cell Significance Index: 1.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0682
    Cell Significance Index: 51.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0433
    Cell Significance Index: 1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0421
    Cell Significance Index: 2.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0397
    Cell Significance Index: 74.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0243
    Cell Significance Index: 2.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0163
    Cell Significance Index: -30.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0246
    Cell Significance Index: -37.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0337
    Cell Significance Index: -21.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0351
    Cell Significance Index: -22.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0419
    Cell Significance Index: -57.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0694
    Cell Significance Index: -39.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1061
    Cell Significance Index: -3.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1114
    Cell Significance Index: -50.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1248
    Cell Significance Index: -26.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1280
    Cell Significance Index: -14.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1515
    Cell Significance Index: -3.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1763
    Cell Significance Index: -20.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1774
    Cell Significance Index: -51.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1899
    Cell Significance Index: -1.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2324
    Cell Significance Index: -2.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2408
    Cell Significance Index: -35.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2564
    Cell Significance Index: -10.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2771
    Cell Significance Index: -45.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2844
    Cell Significance Index: -21.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4688
    Cell Significance Index: -53.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4977
    Cell Significance Index: -6.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5105
    Cell Significance Index: -40.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5913
    Cell Significance Index: -61.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6533
    Cell Significance Index: -11.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7983
    Cell Significance Index: -13.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8270
    Cell Significance Index: -11.6000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.8342
    Cell Significance Index: -5.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8965
    Cell Significance Index: -22.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9247
    Cell Significance Index: -17.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9266
    Cell Significance Index: -13.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9785
    Cell Significance Index: -26.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9944
    Cell Significance Index: -14.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APEX1 is a 3'-5' exonuclease, a type of DNA endonuclease that removes damaged DNA bases, and a phosphodiesterase that acts on 3'-phosphoglycolate-terminated DNA strands. It exhibits a broad range of enzymatic activities, including abasic sugar-phosphate removal via the single-nucleotide replacement pathway, base-excision repair, and gap-filling. These activities enable APEX1 to efficiently repair DNA damage caused by oxidative stress, alkylation, and other mutagenic agents. **Pathways and Functions:** APEX1's diverse enzymatic activities are intricately linked to various cellular pathways, including: 1. **Base Excision Repair (BER):** APEX1 plays a critical role in the BER pathway, which involves the removal of damaged bases and the subsequent repair of the resulting abasic sites. 2. **Telomere Maintenance:** APEX1 is involved in the maintenance of telomeres, the protective caps on the ends of chromosomes, by repairing damage to the telomeric region. 3. **Transcription Regulation:** APEX1 can act as a transcription coactivator or corepressor, modulating the activity of RNA polymerase II and other transcription factors. 4. **Apoptosis Regulation:** APEX1 can influence the apoptotic process by regulating the stability of mRNA and the activity of transcription factors involved in apoptosis. **Clinical Significance:** Dysregulation of APEX1 has been implicated in various diseases, including: 1. **Cancer:** Altered APEX1 expression has been observed in several types of cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases:** APEX1 has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where oxidative stress and DNA damage contribute to disease pathology. 3. **Aging and Telomere Shortening:** APEX1's role in telomere maintenance is critical for maintaining genome stability and preventing premature aging. In conclusion, APEX1 is a multifunctional enzyme that plays a crucial role in maintaining DNA integrity and regulating various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the importance of APEX1 in maintaining genome stability and overall health. Further research is needed to fully elucidate the mechanisms by which APEX1 contributes to disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1350274706

Symbol: APEX1_HUMAN

Name: DNA repair nuclease/redox regulator APEX1

UniProtKB Accession Codes:

P27695 Q969L5 Q99775

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 17 EMDB 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 62 PDBsum 62 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1719477

Title: Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.

PubMed ID: 1719477

DOI: 10.1093/nar/19.20.5519

PubMed ID: 1722334

Title: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

PubMed ID: 1722334

DOI: 10.1073/pnas.88.24.11450

PubMed ID: 1627644

Title: cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.

PubMed ID: 1627644

DOI: 10.1016/0167-4781(92)90027-w

PubMed ID: 1380454

Title: Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

PubMed ID: 1380454

DOI: 10.1002/j.1460-2075.1992.tb05411.x

PubMed ID: 1371347

Title: Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells.

PubMed ID: 1371347

DOI: 10.1093/nar/20.2.370

PubMed ID: 1380694

Title: The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.

PubMed ID: 1380694

DOI: 10.1093/nar/20.15.4097

PubMed ID: 1383925

Title: Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12.

PubMed ID: 1383925

DOI: 10.1093/nar/20.17.4417

PubMed ID: 8086453

Title: Structure, promoter analysis and chromosomal assignment of the human APEX gene.

PubMed ID: 8086453

DOI: 10.1016/0167-4781(94)90241-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12524539

Title: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

PubMed ID: 12524539

DOI: 10.1038/ni885

PubMed ID: 1284593

Title: Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12).

PubMed ID: 1284593

DOI: 10.1093/hmg/1.9.677

PubMed ID: 8355688

Title: Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

PubMed ID: 8355688

DOI: 10.1128/mcb.13.9.5370-5376.1993

PubMed ID: 8621488

Title: The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

PubMed ID: 8621488

DOI: 10.1074/jbc.271.15.8593

PubMed ID: 8932375

Title: Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.

PubMed ID: 8932375

DOI: 10.1093/nar/24.21.4217

PubMed ID: 9108029

Title: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

PubMed ID: 9108029

DOI: 10.1073/pnas.94.8.3633

PubMed ID: 9207062

Title: Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

PubMed ID: 9207062

DOI: 10.1073/pnas.94.14.7166

PubMed ID: 9804799

Title: Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium.

PubMed ID: 9804799

DOI: 10.1074/jbc.273.46.30360

PubMed ID: 9560228

Title: Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.

PubMed ID: 9560228

DOI: 10.1073/pnas.95.9.5061

PubMed ID: 10023679

Title: Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.

PubMed ID: 10023679

DOI: 10.1038/sj.onc.1202394

PubMed ID: 11118054

Title: Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

PubMed ID: 11118054

PubMed ID: 11452037

Title: Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation.

PubMed ID: 11452037

DOI: 10.1093/nar/29.14.3116

PubMed ID: 11909973

Title: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

PubMed ID: 11909973

DOI: 10.1128/mcb.22.8.2810-2820.2002

PubMed ID: 11832948

Title: An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.

PubMed ID: 11832948

DOI: 10.1038/415655a

PubMed ID: 11809897

Title: Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.

PubMed ID: 11809897

DOI: 10.1093/nar/30.3.823

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 15380100

Title: Novel role of tyrosine in catalysis by human AP endonuclease 1.

PubMed ID: 15380100

DOI: 10.1016/j.dnarep.2004.06.009

PubMed ID: 15942031

Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

PubMed ID: 15942031

DOI: 10.1093/nar/gki641

PubMed ID: 16617147

Title: Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.

PubMed ID: 16617147

DOI: 10.1093/nar/gkl177

PubMed ID: 17148573

Title: UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.

PubMed ID: 17148573

DOI: 10.1242/jcs.03312

PubMed ID: 17403694

Title: Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310.

PubMed ID: 17403694

DOI: 10.1093/nar/gkl1163

PubMed ID: 18439621

Title: Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.

PubMed ID: 18439621

DOI: 10.1016/j.jmb.2008.03.053

PubMed ID: 18809583

Title: Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

PubMed ID: 18809583

DOI: 10.1128/mcb.00244-08

PubMed ID: 18179823

Title: Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity.

PubMed ID: 18179823

DOI: 10.1016/j.molimm.2007.11.020

PubMed ID: 18579163

Title: Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease.

PubMed ID: 18579163

DOI: 10.1016/j.mrfmmm.2008.04.008

PubMed ID: 19123919

Title: Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.

PubMed ID: 19123919

DOI: 10.1021/bi8016137

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 26760506

Title: R152C DNA Pol beta mutation impairs base excision repair and induces cellular transformation.

PubMed ID: 26760506

DOI: 10.18632/oncotarget.6849

PubMed ID: 19401441

Title: Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.

PubMed ID: 19401441

DOI: 10.1093/nar/gkp275

PubMed ID: 19219073

Title: Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.

PubMed ID: 19219073

DOI: 10.1038/onc.2009.5

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20231292

Title: Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.

PubMed ID: 20231292

DOI: 10.1074/jbc.m109.069591

PubMed ID: 19934257

Title: SIRT1 deacetylates APE1 and regulates cellular base excision repair.

PubMed ID: 19934257

DOI: 10.1093/nar/gkp1039

PubMed ID: 20699270

Title: Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.

PubMed ID: 20699270

DOI: 10.1093/nar/gkq691

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 21762700

Title: Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.

PubMed ID: 21762700

DOI: 10.1016/j.jmb.2011.06.050

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9351835

Title: The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

PubMed ID: 9351835

DOI: 10.1093/emboj/16.21.6548

PubMed ID: 10667800

Title: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination.

PubMed ID: 10667800

DOI: 10.1038/35000249

PubMed ID: 11286553

Title: Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.

PubMed ID: 11286553

DOI: 10.1006/jmbi.2001.4529

Sequence Information:

  • Length: 318
  • Mass: 35555
  • Checksum: B88579C01BAF80C6
  • Sequence:
    • MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA 
TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS ENKLPAELQE LPGLSHQYWS 
APSDKEGYSG VGLLSRQCPL KVSYGIGDEE HDQEGRVIVA EFDSFVLVTA YVPNAGRGLV 
RLEYRQRWDE AFRKFLKGLA SRKPLVLCGD LNVAHEEIDL RNPKGNKKNA GFTPQERQGF 
GELLQAVPLA DSFRHLYPNT PYAYTFWTYM MNARSKNVGW RLDYFLLSHS LLPALCDSKI 
RSKALGSDHC PITLYLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.