BIRC2 | ENSG00000110330 | NCBI 329

Details for: BIRC2

Gene ID: 329

Symbol: BIRC2

Ensembl ID: ENSG00000110330

Description: baculoviral IAP repeat containing 2

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signal transduction
(R-HSA-162582)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Apoptotic process
(GO:0006915)
Canonical nf-kappab signal transduction
(GO:0007249)
Cd40 receptor complex
(GO:0035631)
Cell surface receptor signaling pathway
(GO:0007166)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Fbxo family protein binding
(GO:0098770)
Identical protein binding
(GO:0042802)
Necroptotic process
(GO:0070266)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of ripoptosome assembly involved in necroptotic process
(GO:1902443)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein k48-linked ubiquitination
(GO:1902524)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Positive regulation of protein monoubiquitination
(GO:1902527)
Positive regulation of protein ubiquitination
(GO:0031398)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cysteine-type endopeptidase activity
(GO:2000116)
Regulation of inflammatory response
(GO:0050727)
Regulation of innate immune response
(GO:0045088)
Regulation of necroptotic process
(GO:0060544)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0070424)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of rig-i signaling pathway
(GO:0039535)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Response to camp
(GO:0051591)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Xy body
(GO:0001741)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Baculoviral IAP repeat-containing protein 2

Genular Protein ID: 4140955930

Symbol: BIRC2_HUMAN

Name: Baculoviral IAP repeat-containing protein 2

UniProtKB Accession Codes:

Q13490 B4E026 Q16516 Q4TTG0

Database IDs:

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18082613

Title: c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

PubMed ID: 18082613

DOI: 10.1016/j.molcel.2007.10.027

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 21145488

Title: Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

PubMed ID: 21145488

DOI: 10.1016/j.molcel.2010.11.011

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21653699

Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

PubMed ID: 21653699

DOI: 10.1074/jbc.m110.191239

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 25486457

Title: Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.

PubMed ID: 25486457

DOI: 10.1016/j.bbamcr.2014.11.026

PubMed ID: 25681446

Title: Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling.

PubMed ID: 25681446

DOI: 10.1074/jbc.m114.631689

PubMed ID: 10404221

Title: Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.

PubMed ID: 10404221

DOI: 10.1038/10701

PubMed ID: 19153467

Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.

PubMed ID: 19153467

DOI: 10.1107/s0907444908039243

PubMed ID: 21549626

Title: CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

PubMed ID: 21549626

DOI: 10.1016/j.molcel.2011.04.008

Sequence Information:

Length: 618
Mass: 69900
Checksum: C1778D328063586D
Sequence:

MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA 
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH 
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR 
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL 
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT 
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD 
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF 
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR 
KCPICRGIIK GTVRTFLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BIRC2

Associated with

Other Information

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. PubMed ID: 8548810

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. PubMed ID: 8552191

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. PubMed ID: 8643514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. PubMed ID: 15665297

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. PubMed ID: 18082613

IAPs: more than just inhibitors of apoptosis proteins. PubMed ID: 18414036

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. PubMed ID: 20888210

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. PubMed ID: 21145488

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. PubMed ID: 20651737

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. PubMed ID: 21447281

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. PubMed ID: 21653699

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. PubMed ID: 21849505

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

IAPs: guardians of RIPK1. PubMed ID: 22095281

IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. PubMed ID: 23453969

Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast. PubMed ID: 25486457

Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling. PubMed ID: 25681446

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. PubMed ID: 10404221

The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. PubMed ID: 19153467

CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. PubMed ID: 21549626