BIRC2 | ENSG00000110330 | NCBI 329

Details for: BIRC2

Gene ID: 329

Symbol: BIRC2

Ensembl ID: ENSG00000110330

Description: baculoviral IAP repeat containing 2

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signal transduction
(R-HSA-162582)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Apoptotic process
(GO:0006915)
Canonical nf-kappab signal transduction
(GO:0007249)
Cd40 receptor complex
(GO:0035631)
Cell surface receptor signaling pathway
(GO:0007166)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Fbxo family protein binding
(GO:0098770)
Identical protein binding
(GO:0042802)
Necroptotic process
(GO:0070266)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of ripoptosome assembly involved in necroptotic process
(GO:1902443)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein k48-linked ubiquitination
(GO:1902524)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Positive regulation of protein monoubiquitination
(GO:1902527)
Positive regulation of protein ubiquitination
(GO:0031398)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cysteine-type endopeptidase activity
(GO:2000116)
Regulation of inflammatory response
(GO:0050727)
Regulation of innate immune response
(GO:0045088)
Regulation of necroptotic process
(GO:0060544)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0070424)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of rig-i signaling pathway
(GO:0039535)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Response to camp
(GO:0051591)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Xy body
(GO:0001741)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 275.4826
Cell Significance Index: -42.8500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 177.0005
Cell Significance Index: -44.9000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 108.0477
Cell Significance Index: -44.5100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 103.4265
Cell Significance Index: -48.8300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 97.1552
Cell Significance Index: -39.4700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 90.1853
Cell Significance Index: -46.3900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 72.8292
Cell Significance Index: -48.8700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.8699
Cell Significance Index: -39.9800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.9485
Cell Significance Index: -43.0900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.0408
Cell Significance Index: -45.6500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.1995
Cell Significance Index: -48.1400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.2427
Cell Significance Index: -31.4600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.9131
Cell Significance Index: -15.1300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.5167
Cell Significance Index: 248.9600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4821
Cell Significance Index: 67.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2007
Cell Significance Index: 34.4200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9692
Cell Significance Index: 875.1300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9215
Cell Significance Index: 48.0000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8570
Cell Significance Index: 40.2800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8203
Cell Significance Index: 100.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8188
Cell Significance Index: 162.5000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8093
Cell Significance Index: 145.9000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7950
Cell Significance Index: 159.4700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7437
Cell Significance Index: 102.1300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6046
Cell Significance Index: 77.5000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5967
Cell Significance Index: 325.8700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5697
Cell Significance Index: 39.4000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5076
Cell Significance Index: 23.0100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4952
Cell Significance Index: 23.0900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4559
Cell Significance Index: 163.5300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4222
Cell Significance Index: 12.1700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4214
Cell Significance Index: 21.8900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4185
Cell Significance Index: 25.7200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3900
Cell Significance Index: 66.6000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3846
Cell Significance Index: 170.0200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3621
Cell Significance Index: 46.7900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3092
Cell Significance Index: 36.4700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3085
Cell Significance Index: 58.7000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2997
Cell Significance Index: 187.1500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2846
Cell Significance Index: 21.2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1848
Cell Significance Index: 14.1800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1700
Cell Significance Index: 117.6100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1599
Cell Significance Index: 4.2700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1278
Cell Significance Index: 3.3600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1079
Cell Significance Index: 17.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0839
Cell Significance Index: 5.2900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0828
Cell Significance Index: 2.9100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0327
Cell Significance Index: 61.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0107
Cell Significance Index: 6.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0061
Cell Significance Index: 0.1300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0092
Cell Significance Index: -17.0400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0135
Cell Significance Index: -20.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0189
Cell Significance Index: -13.8700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0219
Cell Significance Index: -29.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0226
Cell Significance Index: -10.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0366
Cell Significance Index: -27.6900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0379
Cell Significance Index: -2.4500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0548
Cell Significance Index: -30.9100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0554
Cell Significance Index: -8.0600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0756
Cell Significance Index: -1.2700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0802
Cell Significance Index: -8.2000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0977
Cell Significance Index: -5.4800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0998
Cell Significance Index: -2.7900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1035
Cell Significance Index: -7.3200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1059
Cell Significance Index: -22.3000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1104
Cell Significance Index: -12.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1204
Cell Significance Index: -34.6500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2058
Cell Significance Index: -5.5200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2229
Cell Significance Index: -5.7300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2276
Cell Significance Index: -7.9100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2288
Cell Significance Index: -26.6600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2456
Cell Significance Index: -2.0000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2737
Cell Significance Index: -14.3700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3005
Cell Significance Index: -6.5100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3015
Cell Significance Index: -6.3100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3310
Cell Significance Index: -6.4600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3313
Cell Significance Index: -4.5200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3379
Cell Significance Index: -38.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3414
Cell Significance Index: -6.3100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3974
Cell Significance Index: -26.7200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4008
Cell Significance Index: -20.2600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4245
Cell Significance Index: -44.2100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4670
Cell Significance Index: -36.9900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4877
Cell Significance Index: -12.1900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5346
Cell Significance Index: -8.0100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5695
Cell Significance Index: -25.1900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5853
Cell Significance Index: -10.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5876
Cell Significance Index: -36.0300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5952
Cell Significance Index: -9.0400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5975
Cell Significance Index: -14.3300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6152
Cell Significance Index: -19.7100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6397
Cell Significance Index: -10.7800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6703
Cell Significance Index: -25.3800
Cell Name: epidermal cell (CL0000362)
Fold Change: -0.6742
Cell Significance Index: -1.5200
Cell Name: peg cell (CL4033014)
Fold Change: -0.7350
Cell Significance Index: -16.9800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7945
Cell Significance Index: -4.8000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9248
Cell Significance Index: -27.2400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.9407
Cell Significance Index: -13.8900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9499
Cell Significance Index: -34.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** BIRC2 exhibits a range of characteristics that are essential for its function. These include: 1. **Anti-apoptotic activity**: BIRC2 inhibits apoptosis by binding to and inhibiting caspases, a family of proteases that play a central role in the apoptotic process. 2. **Necroptosis regulation**: BIRC2 also regulates necroptosis, a form of programmed cell death that is distinct from apoptosis. 3. **Immune system regulation**: BIRC2 is involved in the regulation of immune responses, including the activation of NF-κB, a transcription factor that plays a key role in immune cell function. 4. **Cell cycle regulation**: BIRC2 has been shown to regulate the cell cycle, preventing excessive cell proliferation and promoting cell differentiation. 5. **Deubiquitination activity**: BIRC2 possesses deubiquitination activity, which allows it to remove ubiquitin from proteins, thereby regulating protein degradation and stability. **Pathways and Functions:** BIRC2 is involved in a wide range of cellular pathways, including: 1. **Apoptosis**: BIRC2 inhibits apoptosis by binding to and inhibiting caspases, thereby preventing the execution of the apoptotic program. 2. **Necroptosis**: BIRC2 regulates necroptosis by modulating the activity of RIPK1, a protein that plays a central role in the necroptotic pathway. 3. **Immune system regulation**: BIRC2 is involved in the regulation of immune responses, including the activation of NF-κB and the activation of immune cells. 4. **Cell cycle regulation**: BIRC2 regulates the cell cycle by preventing excessive cell proliferation and promoting cell differentiation. 5. **Deubiquitination**: BIRC2 possesses deubiquitination activity, which allows it to remove ubiquitin from proteins, thereby regulating protein degradation and stability. **Clinical Significance:** BIRC2 has been implicated in a range of diseases, including: 1. **Cancer**: BIRC2 has been shown to be overexpressed in various types of cancer, including breast, prostate, and pancreatic cancer. 2. **Neurodegenerative diseases**: BIRC2 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Inflammatory disorders**: BIRC2 has been shown to play a role in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory disorders. 4. **Immunological disorders**: BIRC2 has been implicated in immunological disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, BIRC2 is a multifunctional protein that plays a critical role in regulating apoptosis, necroptosis, and immune responses. Its dysregulation has been implicated in a range of diseases, making it a potential target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms by which BIRC2 regulates cellular processes and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Baculoviral IAP repeat-containing protein 2

Genular Protein ID: 4140955930

Symbol: BIRC2_HUMAN

Name: Baculoviral IAP repeat-containing protein 2

UniProtKB Accession Codes:

Q13490 B4E026 Q16516 Q4TTG0

Database IDs:

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18082613

Title: c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

PubMed ID: 18082613

DOI: 10.1016/j.molcel.2007.10.027

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 21145488

Title: Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

PubMed ID: 21145488

DOI: 10.1016/j.molcel.2010.11.011

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21653699

Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

PubMed ID: 21653699

DOI: 10.1074/jbc.m110.191239

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 25486457

Title: Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.

PubMed ID: 25486457

DOI: 10.1016/j.bbamcr.2014.11.026

PubMed ID: 25681446

Title: Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling.

PubMed ID: 25681446

DOI: 10.1074/jbc.m114.631689

PubMed ID: 10404221

Title: Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.

PubMed ID: 10404221

DOI: 10.1038/10701

PubMed ID: 19153467

Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.

PubMed ID: 19153467

DOI: 10.1107/s0907444908039243

PubMed ID: 21549626

Title: CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

PubMed ID: 21549626

DOI: 10.1016/j.molcel.2011.04.008

Sequence Information:

Length: 618
Mass: 69900
Checksum: C1778D328063586D
Sequence:

MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA 
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH 
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR 
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL 
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT 
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD 
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF 
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR 
KCPICRGIIK GTVRTFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BIRC2

Associated with

Cells (max top 100)

Other Information

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. PubMed ID: 8548810

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. PubMed ID: 8552191

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. PubMed ID: 8643514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. PubMed ID: 15665297

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. PubMed ID: 18082613

IAPs: more than just inhibitors of apoptosis proteins. PubMed ID: 18414036

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. PubMed ID: 20888210

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. PubMed ID: 21145488

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. PubMed ID: 20651737

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. PubMed ID: 21447281

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. PubMed ID: 21653699

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. PubMed ID: 21849505

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

IAPs: guardians of RIPK1. PubMed ID: 22095281

IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. PubMed ID: 23453969

Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast. PubMed ID: 25486457

Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling. PubMed ID: 25681446

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. PubMed ID: 10404221

The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. PubMed ID: 19153467

CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. PubMed ID: 21549626