Gene BIRC2 - ENSG00000110330 | NCBI Gene ID: 329

Details for: BIRC2

Gene ID: 329

Symbol: BIRC2

Ensembl ID: ENSG00000110330

Description: baculoviral IAP repeat containing 2

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signal transduction
(R-HSA-162582)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Apoptotic process
(GO:0006915)
Canonical nf-kappab signal transduction
(GO:0007249)
Cd40 receptor complex
(GO:0035631)
Cell surface receptor signaling pathway
(GO:0007166)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Fbxo family protein binding
(GO:0098770)
Identical protein binding
(GO:0042802)
Necroptotic process
(GO:0070266)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of ripoptosome assembly involved in necroptotic process
(GO:1902443)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein k48-linked ubiquitination
(GO:1902524)
Positive regulation of protein k63-linked ubiquitination
(GO:1902523)
Positive regulation of protein monoubiquitination
(GO:1902527)
Positive regulation of protein ubiquitination
(GO:0031398)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cysteine-type endopeptidase activity
(GO:2000116)
Regulation of inflammatory response
(GO:0050727)
Regulation of innate immune response
(GO:0045088)
Regulation of necroptotic process
(GO:0060544)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0070424)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Regulation of rig-i signaling pathway
(GO:0039535)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Response to camp
(GO:0051591)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Xy body
(GO:0001741)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.91
Marker Score: 9389
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.88
Marker Score: 63809
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.6
Marker Score: 3923
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 1.53
Marker Score: 1498
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.52
Marker Score: 3724.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.47
Marker Score: 1254
Cell Name: male germ cell (CL0000015)
Fold Change: 1.46
Marker Score: 420
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.42
Marker Score: 5941
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.41
Marker Score: 5015
Cell Name: PP cell (CL0000696)
Fold Change: 1.41
Marker Score: 317
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.38
Marker Score: 1470
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.36
Marker Score: 3749
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.33
Marker Score: 4940
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.33
Marker Score: 5147
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.33
Marker Score: 1958
Cell Name: acinar cell (CL0000622)
Fold Change: 1.3
Marker Score: 919
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.3
Marker Score: 367
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.29
Marker Score: 2146
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.29
Marker Score: 1360
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.29
Marker Score: 815
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.28
Marker Score: 1549
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.26
Marker Score: 1310
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.26
Marker Score: 544
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.25
Marker Score: 730
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.25
Marker Score: 729
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.25
Marker Score: 1795
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.24
Marker Score: 842
Cell Name: stromal cell (CL0000499)
Fold Change: 1.24
Marker Score: 1447
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.23
Marker Score: 555
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.23
Marker Score: 294
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.18
Marker Score: 1673
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.18
Marker Score: 1247
Cell Name: osteoblast (CL0000062)
Fold Change: 1.18
Marker Score: 632.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.18
Marker Score: 2683
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.18
Marker Score: 10333
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.17
Marker Score: 10009
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.16
Marker Score: 2444
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 1.15
Marker Score: 346
Cell Name: kidney cell (CL1000497)
Fold Change: 1.14
Marker Score: 758
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.13
Marker Score: 10732
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.12
Marker Score: 6836
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.12
Marker Score: 276
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.12
Marker Score: 883
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.11
Marker Score: 1974
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.11
Marker Score: 388
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.11
Marker Score: 453
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.11
Marker Score: 1127
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.11
Marker Score: 758
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.11
Marker Score: 2795
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.11
Marker Score: 1015
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.1
Marker Score: 1170
Cell Name: basal cell (CL0000646)
Fold Change: 1.1
Marker Score: 1421
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.1
Marker Score: 752
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.09
Marker Score: 2928
Cell Name: keratocyte (CL0002363)
Fold Change: 1.09
Marker Score: 251
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.08
Marker Score: 1359
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.08
Marker Score: 407
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.08
Marker Score: 439
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.07
Marker Score: 37080.5
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.07
Marker Score: 232
Cell Name: melanocyte (CL0000148)
Fold Change: 1.07
Marker Score: 432
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.06
Marker Score: 462
Cell Name: decidual cell (CL2000002)
Fold Change: 1.06
Marker Score: 4578
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.05
Marker Score: 238
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.05
Marker Score: 438
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.05
Marker Score: 278
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.05
Marker Score: 64420
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.05
Marker Score: 1139
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.05
Marker Score: 700
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 1.05
Marker Score: 260
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.05
Marker Score: 275
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.04
Marker Score: 245
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.04
Marker Score: 1610
Cell Name: granulocyte (CL0000094)
Fold Change: 1.04
Marker Score: 466
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 1.03
Marker Score: 293
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.03
Marker Score: 54536
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.03
Marker Score: 366
Cell Name: Unknown (CL0002371)
Fold Change: 1.03
Marker Score: 1094
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.03
Marker Score: 357
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.02
Marker Score: 252
Cell Name: oocyte (CL0000023)
Fold Change: 1.02
Marker Score: 252
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.02
Marker Score: 913
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.02
Marker Score: 1021
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.02
Marker Score: 56851
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.02
Marker Score: 1476
Cell Name: S cone cell (CL0003050)
Fold Change: 1.01
Marker Score: 305
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.01
Marker Score: 348
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.01
Marker Score: 2013
Cell Name: osteoclast (CL0000092)
Fold Change: 1.01
Marker Score: 501
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1
Marker Score: 2097
Cell Name: enterocyte (CL0000584)
Fold Change: 1
Marker Score: 4808
Cell Name: podocyte (CL0000653)
Fold Change: 1
Marker Score: 370
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1
Marker Score: 403
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 1
Marker Score: 291
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1
Marker Score: 316
Cell Name: neural cell (CL0002319)
Fold Change: 1
Marker Score: 481
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1
Marker Score: 1779
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.99
Marker Score: 71547
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.99
Marker Score: 247
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47770

Hover over a box to see details here...

**Key characteristics** - BIRC2 is a protein of the IAP family. - It is expressed in a variety of cell types. - It is involved in apoptosis. - It is a key regulator of tumor growth and metastasis. **Pathways and functions** - BIRC2 is involved in the regulation of apoptosis through the activation of the ASK1/p38 MAPK pathway. - It also regulates the expression of other IAP proteins, such as BIRC1 and BIRC3. - It is involved in the regulation of cell proliferation, differentiation, and migration. - It is also involved in the regulation of inflammation and cancer. **Clinical significance** - BIRC2 mutations are associated with a number of human cancers, including breast cancer, lung cancer, and prostate cancer. - Targeting BIRC2 has been shown to be a promising strategy for the treatment of cancer. **Additional information** - The gene was first identified in a screen for genes that are involved in the regulation of apoptosis. - BIRC2 is a highly conserved protein, with a similar protein found in other mammals. - The full-length sequence of BIRC2 has been determined, and it is a relatively simple protein that is composed of a single extracellular domain and a cytoplasmic domain.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Baculoviral IAP repeat-containing protein 2

Genular Protein ID: 4140955930

Symbol: BIRC2_HUMAN

Name: Baculoviral IAP repeat-containing protein 2

UniProtKB Accession Codes:

Q13490 B4E026 Q16516 Q4TTG0

Database IDs:

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18082613

Title: c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

PubMed ID: 18082613

DOI: 10.1016/j.molcel.2007.10.027

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 21145488

Title: Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

PubMed ID: 21145488

DOI: 10.1016/j.molcel.2010.11.011

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21653699

Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

PubMed ID: 21653699

DOI: 10.1074/jbc.m110.191239

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 25486457

Title: Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.

PubMed ID: 25486457

DOI: 10.1016/j.bbamcr.2014.11.026

PubMed ID: 25681446

Title: Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling.

PubMed ID: 25681446

DOI: 10.1074/jbc.m114.631689

PubMed ID: 10404221

Title: Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.

PubMed ID: 10404221

DOI: 10.1038/10701

PubMed ID: 19153467

Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.

PubMed ID: 19153467

DOI: 10.1107/s0907444908039243

PubMed ID: 21549626

Title: CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

PubMed ID: 21549626

DOI: 10.1016/j.molcel.2011.04.008

Sequence Information:

Length: 618
Mass: 69900
Checksum: C1778D328063586D
Sequence:

MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA 
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH 
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR 
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL 
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT 
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD 
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF 
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR 
KCPICRGIIK GTVRTFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BIRC2

Associated with

Cells (max top 100)

Other Information

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. PubMed ID: 8548810

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. PubMed ID: 8552191

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. PubMed ID: 8643514

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. PubMed ID: 15665297

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. PubMed ID: 18082613

IAPs: more than just inhibitors of apoptosis proteins. PubMed ID: 18414036

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. PubMed ID: 20888210

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. PubMed ID: 21145488

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. PubMed ID: 20651737

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. PubMed ID: 21447281

Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. PubMed ID: 21653699

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. PubMed ID: 21849505

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

IAPs: guardians of RIPK1. PubMed ID: 22095281

IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. PubMed ID: 23453969

Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast. PubMed ID: 25486457

Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling. PubMed ID: 25681446

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. PubMed ID: 10404221

The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. PubMed ID: 19153467

CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. PubMed ID: 21549626