Cdc42 | FBgn0010341 | NCBI 32981

Details for: Cdc42

Gene ID: 32981

Symbol: Cdc42

Ensembl ID: FBgn0010341

Description: Cell division cycle 42

Associated with

Adaptive immune system
(R-DME-1280218)
Cd28 co-stimulation
(R-DME-389356)
Cd28 dependent vav1 pathway
(R-DME-389359)
Cdc42 gtpase cycle
(R-DME-9013148)
Costimulation by the cd28 family
(R-DME-388841)
Dcc mediated attractive signaling
(R-DME-418885)
Developmental biology
(R-DME-1266738)
Egfr downregulation
(R-DME-182971)
Eph-ephrin signaling
(R-DME-2682334)
Ephb-mediated forward signaling
(R-DME-3928662)
Factors involved in megakaryocyte development and platelet production
(R-DME-983231)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-DME-2029480)
G-protein beta:gamma signalling
(R-DME-397795)
G beta:gamma signalling through cdc42
(R-DME-8964616)
Gpcr downstream signalling
(R-DME-388396)
Gpvi-mediated activation cascade
(R-DME-114604)
Hemostasis
(R-DME-109582)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Mapk6/mapk4 signaling
(R-DME-5687128)
Mapk family signaling cascades
(R-DME-5683057)
Myogenesis
(R-DME-525793)
Nervous system development
(R-DME-9675108)
Netrin-1 signaling
(R-DME-373752)
Platelet activation, signaling and aggregation
(R-DME-76002)
Rac1 gtpase cycle
(R-DME-9013149)
Rac2 gtpase cycle
(R-DME-9013404)
Rac3 gtpase cycle
(R-DME-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-DME-2029482)
Rhog gtpase cycle
(R-DME-9013408)
Rho gtpase cycle
(R-DME-9012999)
Rho gtpase effectors
(R-DME-195258)
Rho gtpases activate formins
(R-DME-5663220)
Rho gtpases activate paks
(R-DME-5627123)
Rho gtpases activate wasps and waves
(R-DME-5663213)
Rhoj gtpase cycle
(R-DME-9013409)
Rhoq gtpase cycle
(R-DME-9013406)
Rhou gtpase cycle
(R-DME-9013420)
Rhov gtpase cycle
(R-DME-9013424)
Signaling by egfr
(R-DME-177929)
Signaling by gpcr
(R-DME-372790)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signaling by vegf
(R-DME-194138)
Signal transduction
(R-DME-162582)
Vegfa-vegfr2 pathway
(R-DME-4420097)
Actin cytoskeleton organization
(GO:0030036)
Actin filament organization
(GO:0007015)
Actin filament polymerization
(GO:0030041)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Branch fusion, open tracheal system
(GO:0035147)
Cdc42 protein signal transduction
(GO:0032488)
Cell projection assembly
(GO:0030031)
Cellularization
(GO:0007349)
Cortical actin cytoskeleton organization
(GO:0030866)
Dorsal appendage formation
(GO:0046843)
Dorsal closure
(GO:0007391)
Dorsal closure, amnioserosa morphology change
(GO:0046664)
Encapsulation of foreign target
(GO:0035010)
Endocytosis
(GO:0006897)
Establishment of neuroblast polarity
(GO:0045200)
Establishment or maintenance of cell polarity
(GO:0007163)
Gtpase activating protein binding
(GO:0032794)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hemocyte migration
(GO:0035099)
Imaginal disc-derived wing hair outgrowth
(GO:0035318)
Maintenance of cell polarity
(GO:0030011)
Maintenance of protein location
(GO:0045185)
Melanotic encapsulation of foreign target
(GO:0035011)
Motor neuron axon guidance
(GO:0008045)
Neuromuscular synaptic transmission
(GO:0007274)
Neuron projection development
(GO:0031175)
Ommatidial rotation
(GO:0016318)
Phagocytosis
(GO:0006909)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of protein kinase activity
(GO:0045860)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of actin filament polymerization
(GO:0030833)
Regulation of cell shape
(GO:0008360)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of synaptic assembly at neuromuscular junction
(GO:0008582)
Response to wounding
(GO:0009611)
Rho protein signal transduction
(GO:0007266)
Small gtpase-mediated signal transduction
(GO:0007264)
Spermatid development
(GO:0007286)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)
Vesicle-mediated transport
(GO:0016192)
Wound healing
(GO:0042060)

Other Information

Proteins

Cdc42 homolog

Genular Protein ID: 2940672475

Symbol: CDC42_DROME

Name: Cdc42 homolog

UniProtKB Accession Codes:

P40793 Q540W4 Q9U9S3 Q9U9S4 Q9U9S5 Q9U9S6 Q9V465

Database IDs:

Citations:

PubMed ID: 7958857

Title: Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

PubMed ID: 7958857

DOI: 10.1101/gad.8.15.1787

PubMed ID: 10772800

Title: Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.

PubMed ID: 10772800

DOI: 10.1006/dbio.2000.9671

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8628256

Title: A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures.

PubMed ID: 8628256

DOI: 10.1128/mcb.16.5.1896

PubMed ID: 9371783

Title: Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.

PubMed ID: 9371783

DOI: 10.1073/pnas.94.24.12963

PubMed ID: 12490550

Title: Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis.

PubMed ID: 12490550

DOI: 10.1242/dev.00248

PubMed ID: 26801180

Title: Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.

PubMed ID: 26801180

DOI: 10.1534/genetics.115.181438

Sequence Information:

Length: 191
Mass: 21403
Checksum: 0AB96574ADC8E0E3
Sequence:

MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCQKTPF LLVGTQIDLR 
DENSTLEKLA KNKQKPITME QGEKLAKELK AVKYVECSAL TQKGLKNVFD EAILAALEPP 
EPTKKRKCKF L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdc42

Associated with

Other Information

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. PubMed ID: 7958857

Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. PubMed ID: 10772800

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. PubMed ID: 8628256

Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. PubMed ID: 9371783

Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis. PubMed ID: 12490550

Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. PubMed ID: 26801180