Details for: ACADL

Gene ID: 33

Symbol: ACADL

Ensembl ID: ENSG00000115361

Description: acyl-CoA dehydrogenase long chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.48
    Marker Score: 30382
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.11
    Marker Score: 6018
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.99
    Marker Score: 3777
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.9
    Marker Score: 922
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.82
    Marker Score: 15375
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.6
    Marker Score: 1534.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168676
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.42
    Marker Score: 1420
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2744
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.33
    Marker Score: 700.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.28
    Marker Score: 1274
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2812
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.19
    Marker Score: 43765
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17583
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 651
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.11
    Marker Score: 549
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.05
    Marker Score: 16939
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.05
    Marker Score: 588
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.02
    Marker Score: 6585
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.98
    Marker Score: 590
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.97
    Marker Score: 640
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1106
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.94
    Marker Score: 3464
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.93
    Marker Score: 215
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.92
    Marker Score: 5994
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3941
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13398
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.88
    Marker Score: 953
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.81
    Marker Score: 4381
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.81
    Marker Score: 4854
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.78
    Marker Score: 350
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 340
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.69
    Marker Score: 315
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.68
    Marker Score: 2412
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.67
    Marker Score: 252.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.66
    Marker Score: 798
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.66
    Marker Score: 383
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1379
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.64
    Marker Score: 1626
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.64
    Marker Score: 2665
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.64
    Marker Score: 1058
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.64
    Marker Score: 680
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.63
    Marker Score: 2430
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6
    Marker Score: 1377
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 397
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 212.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.57
    Marker Score: 911
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.55
    Marker Score: 305
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.55
    Marker Score: 4227
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.55
    Marker Score: 200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.54
    Marker Score: 837
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 230
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.51
    Marker Score: 715
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.5
    Marker Score: 123
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.49
    Marker Score: 781
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.46
    Marker Score: 135
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.46
    Marker Score: 140
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.42
    Marker Score: 365
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.39
    Marker Score: 320
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.37
    Marker Score: 389
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 378
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 168
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.35
    Marker Score: 1477
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.34
    Marker Score: 445
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.34
    Marker Score: 419
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.34
    Marker Score: 738
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.34
    Marker Score: 359
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.32
    Marker Score: 617.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 287
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.31
    Marker Score: 115
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3
    Marker Score: 321
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.3
    Marker Score: 867

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Other Information

**Key characteristics:** - The ACADL gene is a single gene with a single product. - It is located on chromosome 19p13.2. - It is a member of the acyl-CoA dehydrogenase family of enzymes. - It is expressed in a variety of cell types, including retinal rod cells, cardiac endothelial cells, and colonic epithelial cells. **Pathways and functions:** - The ACADL enzyme catalyzes the beta oxidation of fatty acids to produce CoA and a longer-chain fatty acid. - This reaction is essential for the metabolism of long-chain fatty acids, which are not efficiently metabolized by the citric acid cycle. - The ACADL enzyme is also involved in the carnitine catabolic process and the fatty-acid beta-oxidation of saturated and unsaturated fatty acids. **Clinical significance:** - Mutations in the ACADL gene have been linked to a number of human diseases, including retinitis pigmentosa, macular dystrophy, and obesity. - These diseases are characterized by a deficiency of long-chain fatty acid oxidation, which leads to the accumulation of long-chain fatty acids in the eyes and tissues. - Targeting the ACADL gene has been investigated as a treatment for these diseases.

Genular Protein ID: 2572049284

Symbol: ACADL_HUMAN

Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P28330 B2R8T3 Q8IUN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 77 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 56 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1774065

Title: Molecular cloning and nucleotide sequence of cDNAs encoding human long-chain acyl-CoA dehydrogenase and assignment of the location of its gene (ACADL) to chromosome 2.

PubMed ID: 1774065

DOI: 10.1016/0888-7543(91)90068-p

PubMed ID: 1559716

Title:

PubMed ID: 1559716

DOI: 10.1016/0888-7543(92)90462-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8155643

Title: Identification of the catalytic base in long chain acyl-CoA dehydrogenase.

PubMed ID: 8155643

DOI: 10.1021/bi00180a021

PubMed ID: 8823175

Title: Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase.

PubMed ID: 8823175

DOI: 10.1021/bi960785e

PubMed ID: 21237683

Title: Identification and characterization of new long chain acyl-CoA dehydrogenases.

PubMed ID: 21237683

DOI: 10.1016/j.ymgme.2010.12.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 430
  • Mass: 47656
  • Checksum: 72F9803685406DF9
  • Sequence:
    • MAARLLRGSL RVLGGHRAPR QLPAARCSHS GGEERLETPS AKKLTDIGIR RIFSPEHDIF 
RKSVRKFFQE EVIPHHSEWE KAGEVSREVW EKAGKQGLLG VNIAEHLGGI GGDLYSAAIV 
WEEQAYSNCS GPGFSIHSGI VMSYITNHGS EEQIKHFIPQ MTAGKCIGAI AMTEPGAGSD 
LQGIKTNAKK DGSDWILNGS KVFISNGSLS DVVIVVAVTN HEAPSPAHGI SLFLVENGMK 
GFIKGRKLHK MGLKAQDTAE LFFEDIRLPA SALLGEENKG FYYIMKELPQ ERLLIADVAI 
SASEFMFEET RNYVKQRKAF GKTVAHLQTV QHKLAELKTH ICVTRAFVDN CLQLHEAKRL 
DSATACMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE 
LIAREIVFDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.