BIRC3 | ENSG00000023445 | NCBI 330

Details for: BIRC3

Gene ID: 330

Symbol: BIRC3

Ensembl ID: ENSG00000023445

Description: baculoviral IAP repeat containing 3

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signal transduction
(R-HSA-162582)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Apoptotic process
(GO:0006915)
Canonical nf-kappab signal transduction
(GO:0007249)
Cell surface receptor signaling pathway
(GO:0007166)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of necroptotic process
(GO:0060546)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of protein ubiquitination
(GO:0031398)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of cysteine-type endopeptidase activity
(GO:2000116)
Regulation of inflammatory response
(GO:0050727)
Regulation of innate immune response
(GO:0045088)
Regulation of necroptotic process
(GO:0060544)
Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0070424)
Regulation of rig-i signaling pathway
(GO:0039535)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Spermatogenesis
(GO:0007283)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Baculoviral IAP repeat-containing protein 3

Genular Protein ID: 1543263337

Symbol: BIRC3_HUMAN

Name: Baculoviral IAP repeat-containing protein 3

UniProtKB Accession Codes:

Q13489 Q16628 Q9HC27 Q9UP46

Database IDs:

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 10233894

Title: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.

PubMed ID: 10233894

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11066071

Title: Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.

PubMed ID: 11066071

DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1036>3.0.co;2-i

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

Sequence Information:

Length: 604
Mass: 68372
Checksum: 8581A00BA9AAB4A7
Sequence:

MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV 
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS 
THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP 
LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ 
DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR 
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS 
IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL 
LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD 
VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS 
DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR 
TFLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BIRC3

Associated with

Other Information

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. PubMed ID: 8548810

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. PubMed ID: 8552191

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. PubMed ID: 8643514

Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. PubMed ID: 10233894

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. PubMed ID: 11066071

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. PubMed ID: 15665297

IAPs: more than just inhibitors of apoptosis proteins. PubMed ID: 18414036

To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. PubMed ID: 20888210

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. PubMed ID: 20651737

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity. PubMed ID: 21447281

The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. PubMed ID: 21849505

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

IAPs: guardians of RIPK1. PubMed ID: 22095281

IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. PubMed ID: 23453969