Details for: BIRC3

Gene ID: 330

Symbol: BIRC3

Ensembl ID: ENSG00000023445

Description: baculoviral IAP repeat containing 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.87
    Marker Score: 2829
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.46
    Marker Score: 1545
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.31
    Marker Score: 4025.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.24
    Marker Score: 1365
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.16
    Marker Score: 3331
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.09
    Marker Score: 995
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.03
    Marker Score: 4251
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.02
    Marker Score: 706
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.99
    Marker Score: 1198
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.99
    Marker Score: 891
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.94
    Marker Score: 4776
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.92
    Marker Score: 1796.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.91
    Marker Score: 952
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.89
    Marker Score: 669
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.82
    Marker Score: 565
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.81
    Marker Score: 1545
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.79
    Marker Score: 919
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.79
    Marker Score: 1150
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.77
    Marker Score: 1388
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.76
    Marker Score: 1032
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.76
    Marker Score: 2883
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.74
    Marker Score: 92184
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.71
    Marker Score: 520
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.64
    Marker Score: 391
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.64
    Marker Score: 705
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.63
    Marker Score: 1756
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.63
    Marker Score: 1369
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.63
    Marker Score: 3662
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.63
    Marker Score: 1761.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.62
    Marker Score: 2748
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.62
    Marker Score: 1446
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.59
    Marker Score: 3850
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.59
    Marker Score: 1417
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.58
    Marker Score: 911
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.57
    Marker Score: 4648
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.56
    Marker Score: 2253
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.54
    Marker Score: 3754.5
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.53
    Marker Score: 441
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.51
    Marker Score: 651.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.5
    Marker Score: 1654
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.48
    Marker Score: 1074
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.47
    Marker Score: 14522
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.46
    Marker Score: 337
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.46
    Marker Score: 1374
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.45
    Marker Score: 1065.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166544
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.45
    Marker Score: 2641
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.43
    Marker Score: 6128.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.43
    Marker Score: 3236
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.42
    Marker Score: 6990
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.41
    Marker Score: 2414.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.4
    Marker Score: 1060
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.39
    Marker Score: 683
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.37
    Marker Score: 349
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.34
    Marker Score: 668
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.32
    Marker Score: 667
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 761
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.3
    Marker Score: 856
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.3
    Marker Score: 542
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.3
    Marker Score: 1513
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.29
    Marker Score: 343.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.26
    Marker Score: 861
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.23
    Marker Score: 892
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.23
    Marker Score: 1171
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.22
    Marker Score: 1040
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2154
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.2
    Marker Score: 1740
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.19
    Marker Score: 789.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.19
    Marker Score: 40455
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.19
    Marker Score: 13787
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.18
    Marker Score: 687
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.18
    Marker Score: 5682
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.18
    Marker Score: 3707.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.18
    Marker Score: 3001
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.17
    Marker Score: 674
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.16
    Marker Score: 570
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.15
    Marker Score: 433
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.14
    Marker Score: 406
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.14
    Marker Score: 637
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.13
    Marker Score: 245
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.11
    Marker Score: 218.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.1
    Marker Score: 950
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1141.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.08
    Marker Score: 1590
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.08
    Marker Score: 1170
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.07
    Marker Score: 2966
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.06
    Marker Score: 36786
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.06
    Marker Score: 719
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.06
    Marker Score: 410
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.05
    Marker Score: 261
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.04
    Marker Score: 763
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.04
    Marker Score: 261
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.03
    Marker Score: 225
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.03
    Marker Score: 369
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.02
    Marker Score: 869
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.02
    Marker Score: 238
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.02
    Marker Score: 1999
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2275
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1
    Marker Score: 2797

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Other Information

**Key characteristics:** - BIRC3 is a protein of the immunoglobulin superfamily. - It is expressed in a variety of cell types, including immune cells, epithelial cells, and cancer cells. - It is a key regulator of innate immunity and cell death. - It is involved in the regulation of inflammation and cell death through multiple signaling pathways. **Pathways and functions:** - BIRC3 is involved in the regulation of the innate immune system. - It plays a role in the control of inflammation and cell death. - It is involved in the regulation of the adaptive immune response. - It is involved in the regulation of cell death. - It is involved in the regulation of apoptosis. **Clinical significance:** - BIRC3 is a potential target for the treatment of cancer. - It is a target for immunotherapy in cancer. - It is a potential therapeutic target for autoimmune diseases. **Additional notes:** - BIRC3 is a multi-functional protein that has been shown to have both pro-apoptotic and anti-apoptotic functions. - It is a key regulator of inflammation and cell death. - It is a potential target for the treatment of cancer, autoimmune diseases, and other diseases.

Genular Protein ID: 1543263337

Symbol: BIRC3_HUMAN

Name: Baculoviral IAP repeat-containing protein 3

UniProtKB Accession Codes:

Q13489 Q16628 Q9HC27 Q9UP46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 10233894

Title: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.

PubMed ID: 10233894

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11066071

Title: Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.

PubMed ID: 11066071

DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1036>3.0.co;2-i

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

Sequence Information:

  • Length: 604
  • Mass: 68372
  • Checksum: 8581A00BA9AAB4A7
  • Sequence:
    • MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV 
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS 
THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP 
LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ 
DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR 
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS 
IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL 
LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD 
VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS 
DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR 
TFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.