Details for: BIRC3

Gene ID: 330

Symbol: BIRC3

Ensembl ID: ENSG00000023445

Description: baculoviral IAP repeat containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.3124
    Cell Significance Index: -28.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.5993
    Cell Significance Index: -25.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.7627
    Cell Significance Index: -33.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.9234
    Cell Significance Index: -33.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.6018
    Cell Significance Index: -29.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6687
    Cell Significance Index: -28.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4353
    Cell Significance Index: -29.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3678
    Cell Significance Index: -22.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8309
    Cell Significance Index: -14.9500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 4.9093
    Cell Significance Index: 84.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5754
    Cell Significance Index: 97.3200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.3067
    Cell Significance Index: 18.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1515
    Cell Significance Index: 250.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1140
    Cell Significance Index: 273.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9096
    Cell Significance Index: 33.7500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.5988
    Cell Significance Index: 7.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4994
    Cell Significance Index: 176.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4171
    Cell Significance Index: 66.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1541
    Cell Significance Index: 1042.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8633
    Cell Significance Index: 6.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8410
    Cell Significance Index: 19.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8279
    Cell Significance Index: 94.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8051
    Cell Significance Index: 23.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8004
    Cell Significance Index: 87.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7788
    Cell Significance Index: 12.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7765
    Cell Significance Index: 424.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6426
    Cell Significance Index: 47.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6231
    Cell Significance Index: 32.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5920
    Cell Significance Index: 8.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3709
    Cell Significance Index: 45.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2786
    Cell Significance Index: 12.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2657
    Cell Significance Index: 50.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1919
    Cell Significance Index: 2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1916
    Cell Significance Index: 21.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1637
    Cell Significance Index: 16.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1144
    Cell Significance Index: 3.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1021
    Cell Significance Index: 70.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0798
    Cell Significance Index: 35.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0731
    Cell Significance Index: 13.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0594
    Cell Significance Index: 2.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0516
    Cell Significance Index: 1.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0421
    Cell Significance Index: 1.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0132
    Cell Significance Index: 2.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0122
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0012
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0189
    Cell Significance Index: -34.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0228
    Cell Significance Index: -35.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0261
    Cell Significance Index: -35.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0321
    Cell Significance Index: -23.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0360
    Cell Significance Index: -22.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0393
    Cell Significance Index: -4.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0623
    Cell Significance Index: -7.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0664
    Cell Significance Index: -13.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0687
    Cell Significance Index: -31.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0694
    Cell Significance Index: -13.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0741
    Cell Significance Index: -14.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0811
    Cell Significance Index: -23.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0844
    Cell Significance Index: -12.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1033
    Cell Significance Index: -14.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1074
    Cell Significance Index: -5.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1395
    Cell Significance Index: -2.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1514
    Cell Significance Index: -11.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1857
    Cell Significance Index: -7.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2507
    Cell Significance Index: -17.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2708
    Cell Significance Index: -28.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2785
    Cell Significance Index: -3.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2824
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2937
    Cell Significance Index: -4.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3390
    Cell Significance Index: -2.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3504
    Cell Significance Index: -21.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3815
    Cell Significance Index: -24.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3847
    Cell Significance Index: -25.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4091
    Cell Significance Index: -32.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4101
    Cell Significance Index: -10.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4351
    Cell Significance Index: -12.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4448
    Cell Significance Index: -4.4600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.4620
    Cell Significance Index: -1.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5028
    Cell Significance Index: -10.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5124
    Cell Significance Index: -9.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5192
    Cell Significance Index: -16.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5214
    Cell Significance Index: -32.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5547
    Cell Significance Index: -24.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5730
    Cell Significance Index: -15.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5735
    Cell Significance Index: -32.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5782
    Cell Significance Index: -16.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5840
    Cell Significance Index: -30.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6242
    Cell Significance Index: -19.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6565
    Cell Significance Index: -24.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6911
    Cell Significance Index: -25.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7175
    Cell Significance Index: -23.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7586
    Cell Significance Index: -22.3500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7744
    Cell Significance Index: -16.1500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7793
    Cell Significance Index: -8.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7829
    Cell Significance Index: -4.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7903
    Cell Significance Index: -11.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BIRC3 is a member of the IAP family, which is characterized by the presence of baculoviral IAP repeats. These repeats are responsible for inhibiting caspases and other proteases involved in apoptosis. BIRC3 is highly expressed in cells that undergo apoptosis, such as germinal center B cells, enterocytes, and basophils. It also plays a role in regulating immune responses, particularly in the context of innate immunity, where it interacts with pattern recognition receptors (PRRs) like Toll-like receptors (TLRs) and NOD-like receptors (NLRs). **Pathways and Functions** BIRC3 is involved in multiple signaling pathways that regulate apoptosis, inflammation, and immune responses. Some of the key pathways include: 1. **Apoptotic Process**: BIRC3 inhibits caspases, preventing the execution of apoptosis. This is achieved through its ability to bind and inhibit the activity of caspases, thereby modulating the apoptotic machinery. 2. **Canonical NF-κB Signaling**: BIRC3 regulates the activity of NF-κB, a transcription factor involved in inflammation and immune responses. By inhibiting the ubiquitination of NF-κB, BIRC3 promotes its activity, leading to the transcription of genes involved in inflammation and immune responses. 3. **Cell Surface Receptor Signaling Pathway**: BIRC3 interacts with cell surface receptors, such as TLRs and NLRs, to modulate immune responses. It binds to these receptors and inhibits their signaling, thereby regulating the production of pro-inflammatory cytokines. 4. **Cytoskeleton and Cell Cycle Regulation**: BIRC3 also regulates the cytoskeleton and cell cycle, preventing the formation of apoptotic bodies and promoting cell survival. **Clinical Significance** BIRC3 has been implicated in various diseases, including: 1. **Inflammatory Disorders**: BIRC3 is overexpressed in inflammatory disorders, such as rheumatoid arthritis, where it contributes to the production of pro-inflammatory cytokines. 2. **Cancer**: BIRC3 is overexpressed in various types of cancer, including colorectal, breast, and lung cancer, where it promotes tumor growth and survival. 3. **Autoimmune Diseases**: BIRC3 is involved in autoimmune diseases, such as multiple sclerosis and lupus, where it regulates the immune response and contributes to tissue damage. In conclusion, BIRC3 is a multifunctional protein that regulates apoptosis, inflammation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in maintaining cellular homeostasis.

Genular Protein ID: 1543263337

Symbol: BIRC3_HUMAN

Name: Baculoviral IAP repeat-containing protein 3

UniProtKB Accession Codes:

Q13489 Q16628 Q9HC27 Q9UP46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8548810

Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

PubMed ID: 8548810

DOI: 10.1016/0092-8674(95)90149-3

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 10233894

Title: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.

PubMed ID: 10233894

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11066071

Title: Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.

PubMed ID: 11066071

DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1036>3.0.co;2-i

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 18414036

Title: IAPs: more than just inhibitors of apoptosis proteins.

PubMed ID: 18414036

DOI: 10.4161/cc.7.8.5783

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 20651737

Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

PubMed ID: 20651737

DOI: 10.1038/nrc2889

PubMed ID: 21447281

Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

PubMed ID: 21447281

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

Sequence Information:

  • Length: 604
  • Mass: 68372
  • Checksum: 8581A00BA9AAB4A7
  • Sequence:
    • MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV 
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS 
THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP 
LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ 
DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR 
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS 
IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL 
LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD 
VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS 
DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR 
TFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.