smo | FBgn0003444 | NCBI 33196

Details for: smo

Gene ID: 33196

Symbol: smo

Ensembl ID: FBgn0003444

Description: smoothened

Associated with

Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Anterior/posterior lineage restriction, imaginal disc
(GO:0048099)
Axon
(GO:0030424)
Blastoderm segmentation
(GO:0007350)
Bolwig's organ morphogenesis
(GO:0001746)
Cell surface receptor signaling pathway
(GO:0007166)
Central nervous system development
(GO:0007417)
Cilium
(GO:0005929)
Commissural neuron axon guidance
(GO:0071679)
Compound eye morphogenesis
(GO:0001745)
Dendrite
(GO:0030425)
Eye-antennal disc morphogenesis
(GO:0007455)
Follicle cell of egg chamber development
(GO:0030707)
Imaginal disc-derived wing morphogenesis
(GO:0007476)
Membrane
(GO:0016020)
Mucosal immune response
(GO:0002385)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Neuronal cell body
(GO:0043025)
Patched binding
(GO:0005113)
Pattern specification process
(GO:0007389)
Phosphatidylinositol-4-phosphate binding
(GO:0070273)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of stem cell differentiation
(GO:2000736)
Segment polarity determination
(GO:0007367)
Smoothened signaling pathway
(GO:0007224)
Somatic stem cell population maintenance
(GO:0035019)
Transmembrane signaling receptor activity
(GO:0004888)
Wing disc anterior/posterior pattern formation
(GO:0048100)

Other Information

Proteins

Protein smoothened

Genular Protein ID: 973430060

Symbol: SMO_DROME

Name: Protein smoothened

UniProtKB Accession Codes:

P91682 B7FNK1 Q9VPM8

Database IDs:

Citations:

PubMed ID: 8706127

Title: The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.

PubMed ID: 8706127

DOI: 10.1016/s0092-8674(00)80094-x

PubMed ID: 8700230

Title: smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.

PubMed ID: 8700230

DOI: 10.1038/382547a0

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 15616566

Title: Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

PubMed ID: 15616566

DOI: 10.1038/nature03179

PubMed ID: 15691767

Title: Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

PubMed ID: 15691767

DOI: 10.1016/j.devcel.2005.01.001

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 24768000

Title: Cilia-mediated hedgehog signaling in Drosophila.

PubMed ID: 24768000

DOI: 10.1016/j.celrep.2014.03.052

PubMed ID: 25639794

Title: Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.

PubMed ID: 25639794

DOI: 10.1016/j.chom.2014.12.012

PubMed ID: 24351982

Title: Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.

PubMed ID: 24351982

DOI: 10.1038/ncomms3965

Sequence Information:

Length: 1036
Mass: 116552
Checksum: 7797FC71A539A87A
Sequence:

MQYLNFPRMP NIMMFLEVAI LCLWVVADAS ASSAKFGSTT PASAQQSDVE LEPINGTLNY 
RLYAKKGRDD KPWFDGLDSR HIQCVRRARC YPTSNATNTC FGSKLPYELS SLDLTDFHTE 
KELNDKLNDY YALKHVPKCW AAIQPFLCAV FKPKCEKING EDMVYLPSYE MCRITMEPCR 
ILYNTTFFPK FLRCNETLFP TKCTNGARGM KFNGTGQCLS PLVPTDTSAS YYPGIEGCGV 
RCKDPLYTDD EHRQIHKLIG WAGSICLLSN LFVVSTFFID WKNANKYPAV IVFYINLCFL 
IACVGWLLQF TSGSREDIVC RKDGTLRHSE PTAGENLSCI VIFVLVYYFL TAGMVWFVFL 
TYAWHWRAMG HVQDRIDKKG SYFHLVAWSL PLVLTITTMA FSEVDGNSIV GICFVGYINH 
SMRAGLLLGP LCGVILIGGY FITRGMVMLF GLKHFANDIK STSASNKIHL IIMRMGVCAL 
LTLVFILVAI ACHVTEFRHA DEWAQSFRQF IICKISSVFE EKSSCRIENR PSVGVLQLHL 
LCLFSSGIVM STWCWTPSSI ETWKRYIRKK CGKEVVEEVK MPKHKVIAQT WAKRKDFEDK 
GRLSITLYNT HTDPVGLNFD VNDLNSSETN DISSTWAAYL PQCVKRRMAL TGAATGNSSS 
HGPRKNSLDS EISVSVRHVS VESRRNSVDS QVSVKIAEMK TKVASRSRGK HGGSSSNRRT 
QRRRDYIAAA TGKSSRRRES STSVESQVIA LKKTTYPNAS HKVGVFAHHS SKKQHNYTSS 
MKRRTANAGL DPSILNEFLQ KNGDFIFPFL QNQDMSSSSE EDNSRASQKI QDLNVVVKQQ 
EISEDDHDGI KIEELPNSKQ VALENFLKNI KKSNESNSNR HSRNSARSQS KKSQKRHLKN 
PAADLDFRKD CVKYRSNDSL SCSSEELDVA LDVGSLLNSS FSGISMGKPH SRNSKTSCDV 
GIQANPFELV PSYGEDELQQ AMRLLNAASR QRTEAANEDF GGTELQGLLG HSHRHQREPT 
FMSESDKLKM LLLPSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: smo

Associated with

Other Information

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. PubMed ID: 8706127

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. PubMed ID: 8700230

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. PubMed ID: 15616566

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. PubMed ID: 15691767

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Cilia-mediated hedgehog signaling in Drosophila. PubMed ID: 24768000

Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. PubMed ID: 25639794

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. PubMed ID: 24351982