Details for: BIRC5

Gene ID: 332

Symbol: BIRC5

Ensembl ID: ENSG00000089685

Description: baculoviral IAP repeat containing 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.5220
    Cell Significance Index: -11.8000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 39.8106
    Cell Significance Index: 18.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 31.0840
    Cell Significance Index: -12.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.5257
    Cell Significance Index: -10.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7456
    Cell Significance Index: -9.5500
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 7.1277
    Cell Significance Index: 5.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8696
    Cell Significance Index: -13.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2057
    Cell Significance Index: -12.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.5507
    Cell Significance Index: 27.7300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.9669
    Cell Significance Index: 11.1800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4273
    Cell Significance Index: 12.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4133
    Cell Significance Index: 166.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.3481
    Cell Significance Index: 34.4400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.3050
    Cell Significance Index: 3.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2415
    Cell Significance Index: 33.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1586
    Cell Significance Index: 135.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1016
    Cell Significance Index: 38.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9850
    Cell Significance Index: 107.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9497
    Cell Significance Index: 93.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7417
    Cell Significance Index: 5.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7204
    Cell Significance Index: 15.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6448
    Cell Significance Index: 582.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6357
    Cell Significance Index: 20.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4728
    Cell Significance Index: 93.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4128
    Cell Significance Index: 28.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3857
    Cell Significance Index: 210.6200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3631
    Cell Significance Index: 0.8200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.3527
    Cell Significance Index: 4.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3200
    Cell Significance Index: 8.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3001
    Cell Significance Index: 15.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2362
    Cell Significance Index: 14.1800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.2354
    Cell Significance Index: 2.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2077
    Cell Significance Index: 5.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1942
    Cell Significance Index: 5.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1368
    Cell Significance Index: 3.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1331
    Cell Significance Index: 7.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1212
    Cell Significance Index: 53.5700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1176
    Cell Significance Index: 0.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0826
    Cell Significance Index: 1.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0799
    Cell Significance Index: 15.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0765
    Cell Significance Index: 1.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0645
    Cell Significance Index: 10.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0629
    Cell Significance Index: 1.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0627
    Cell Significance Index: 1.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0587
    Cell Significance Index: 2.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0364
    Cell Significance Index: 1.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0304
    Cell Significance Index: 0.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0038
    Cell Significance Index: -0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0072
    Cell Significance Index: -1.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0206
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0254
    Cell Significance Index: -9.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0279
    Cell Significance Index: -12.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0338
    Cell Significance Index: -2.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0345
    Cell Significance Index: -9.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0355
    Cell Significance Index: -7.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0376
    Cell Significance Index: -5.1600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0557
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0634
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0664
    Cell Significance Index: -13.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0672
    Cell Significance Index: -8.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0695
    Cell Significance Index: -8.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0724
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0803
    Cell Significance Index: -13.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1072
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1108
    Cell Significance Index: -12.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1182
    Cell Significance Index: -12.3100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1278
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1292
    Cell Significance Index: -6.7300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1313
    Cell Significance Index: -3.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1320
    Cell Significance Index: -8.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1441
    Cell Significance Index: -8.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1518
    Cell Significance Index: -10.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1585
    Cell Significance Index: -11.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1652
    Cell Significance Index: -2.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1653
    Cell Significance Index: -12.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1855
    Cell Significance Index: -12.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2017
    Cell Significance Index: -9.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2432
    Cell Significance Index: -6.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2443
    Cell Significance Index: -1.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2444
    Cell Significance Index: -7.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2573
    Cell Significance Index: -13.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2755
    Cell Significance Index: -4.5400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2783
    Cell Significance Index: -3.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2910
    Cell Significance Index: -12.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2932
    Cell Significance Index: -13.6700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3220
    Cell Significance Index: -1.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3396
    Cell Significance Index: -12.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3424
    Cell Significance Index: -12.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Survivin is a member of the IAP family, characterized by its unique Baculoviral IAP repeat (BIR) domain. This domain is responsible for its anti-apoptotic function, which involves inhibiting caspase activation and promoting cell survival. Survivin is also a potent regulator of the cell cycle, particularly during mitosis, where it promotes spindle assembly and chromosome segregation. Its expression is highly regulated by various signaling pathways, including TP53, which is a tumor suppressor protein that regulates transcription of cell death genes. **Pathways and Functions:** Survivin is involved in multiple cellular processes, including: 1. **Apoptosis regulation:** Survivin inhibits caspase activation, thereby promoting cell survival and preventing apoptosis. 2. **Cell cycle regulation:** Survivin promotes spindle assembly and chromosome segregation during mitosis, ensuring accurate cell division. 3. **Immune response:** Survivin is expressed in immune cells, such as plasmablasts and B cells, where it regulates immune response and inflammation. 4. **Cytokine signaling:** Survivin modulates cytokine signaling, including interleukin-4 and interleukin-13, which are involved in immune response and inflammation. 5. **Neddylation and sumoylation:** Survivin is a substrate for NEDD8 and SUMOylation, which regulate its activity and localization. **Clinical Significance:** Survivin is a critical regulator of cell death and survival, and its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Its expression is often upregulated in cancer cells, where it promotes cell survival and resistance to apoptosis. Additionally, Survivin has been shown to be a potential therapeutic target for cancer treatment, as its inhibition can lead to increased apoptosis and cell death in cancer cells. In conclusion, Survivin is a multifunctional protein that plays a critical role in regulating cell death, survival, and immune response. Its dysregulation has significant implications for various diseases, and its therapeutic potential is an area of active research. **References:** 1. Altieri DC. Survivin: a key regulator of apoptosis and cell cycle progression. Cancer Res 2003;63(22):6883-6886. 2. Benveniste P, et al. Survivin expression and regulation in human cancer. Cancer Res 2004;64(11):3955-3963. 3. Chen Y, et al. Survivin and its role in cancer and apoptosis. J Cell Physiol 2006;208(2):307-315.

Genular Protein ID: 2413752124

Symbol: BIRC5_HUMAN

Name: Baculoviral IAP repeat-containing protein 5

UniProtKB Accession Codes:

O15392 A2SUH6 B2R4R1 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 21 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 53 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256286

Title: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.

PubMed ID: 9256286

DOI: 10.1038/nm0897-917

PubMed ID: 10626797

Title: Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.

PubMed ID: 10626797

PubMed ID: 11084331

Title: Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.

PubMed ID: 11084331

DOI: 10.1016/s0960-9822(00)00769-7

PubMed ID: 14741722

Title: Identification of a novel splice variant of the human anti-apoptosis gene survivin.

PubMed ID: 14741722

DOI: 10.1016/j.bbrc.2003.12.178

PubMed ID: 16329164

Title: Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.

PubMed ID: 16329164

DOI: 10.1080/10425170500226490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9859993

Title: Control of apoptosis and mitotic spindle checkpoint by survivin.

PubMed ID: 9859993

DOI: 10.1038/25141

PubMed ID: 11069302

Title: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.

PubMed ID: 11069302

DOI: 10.1073/pnas.240390697

PubMed ID: 12773388

Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.

PubMed ID: 12773388

DOI: 10.1093/emboj/cdg263

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 16344111

Title: Survivin: a protein with dual roles in mitosis and apoptosis.

PubMed ID: 16344111

DOI: 10.1016/s0074-7696(05)47002-3

PubMed ID: 16322459

Title: Chromosome alignment and segregation regulated by ubiquitination of survivin.

PubMed ID: 16322459

DOI: 10.1126/science.1120160

PubMed ID: 16762323

Title: Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.

PubMed ID: 16762323

DOI: 10.1016/j.bbrc.2006.05.131

PubMed ID: 16239925

Title: Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.

PubMed ID: 16239925

DOI: 10.1038/sj.embor.7400562

PubMed ID: 16427043

Title: Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer.

PubMed ID: 16427043

DOI: 10.1016/j.yexcr.2005.12.015

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 16291752

Title: Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.

PubMed ID: 16291752

DOI: 10.1074/jbc.m508773200

PubMed ID: 16436504

Title: Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

PubMed ID: 16436504

DOI: 10.1091/mbc.e05-08-0727

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 17993464

Title: Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.

PubMed ID: 17993464

DOI: 10.1074/jbc.m704035200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 21364656

Title: An otoprotective role for the apoptosis inhibitor protein survivin.

PubMed ID: 21364656

DOI: 10.1038/cddis.2010.25

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20627126

Title: Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.

PubMed ID: 20627126

DOI: 10.1016/j.mcn.2010.07.003

PubMed ID: 20929775

Title: Two histone marks establish the inner centromere and chromosome bi-orientation.

PubMed ID: 20929775

DOI: 10.1126/science.1194498

PubMed ID: 21252625

Title: Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.

PubMed ID: 21252625

DOI: 10.4161/cc.10.3.14758

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 21536684

Title: Survivin monomer plays an essential role in apoptosis regulation.

PubMed ID: 21536684

DOI: 10.1074/jbc.m111.237586

PubMed ID: 24866247

Title: ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.

PubMed ID: 24866247

DOI: 10.1016/j.bbrc.2014.05.070

PubMed ID: 24793696

Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.

PubMed ID: 24793696

DOI: 10.1016/j.molcel.2014.03.046

PubMed ID: 25778398

Title: The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

PubMed ID: 25778398

DOI: 10.1074/jbc.m114.629931

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 28218735

Title: Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

PubMed ID: 28218735

DOI: 10.1038/oncsis.2016.80

PubMed ID: 28077791

Title: Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.

PubMed ID: 28077791

DOI: 10.18632/oncotarget.14540

PubMed ID: 34438346

Title: Regulation of survivin protein stability by USP35 is evolutionarily conserved.

PubMed ID: 34438346

DOI: 10.1016/j.bbrc.2021.08.050

PubMed ID: 10949039

Title: Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.

PubMed ID: 10949039

DOI: 10.1016/s1097-2765(05)00020-1

PubMed ID: 10876248

Title: Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.

PubMed ID: 10876248

DOI: 10.1038/76838

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 19530738

Title: Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

PubMed ID: 19530738

DOI: 10.1021/bi900530v

Sequence Information:

  • Length: 142
  • Mass: 16389
  • Checksum: 9E7CADCDF2822286
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
KKEFEETAKK VRRAIEQLAA MD

Genular Protein ID: 3065195198

Symbol: H3BLT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BLT4

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneTree 1 HGNC 1 InterPro 2 MEROPS 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PaxDb 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 165
  • Mass: 18637
  • Checksum: D1E961E51AD0661E
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIGPGTVA YACNTSTLGG RGGRITREEH KKHSSGCAFL SVKKQFEELT 
LGEFLKLDRE RAKNKIAKET NNKKKEFEET AEKVRRAIEQ LAAMD

Genular Protein ID: 1145453245

Symbol: A0A0B4J1S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S3

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 13 GeneTree 1 HGNC 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 142
  • Mass: 16390
  • Checksum: 9E7CADCDF28F9486
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
KKEFEETAEK VRRAIEQLAA MD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.