Details for: BIRC5

Gene ID: 332

Symbol: BIRC5

Ensembl ID: ENSG00000089685

Description: baculoviral IAP repeat containing 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.42
    Marker Score: 2159
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.12
    Marker Score: 1994
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.64
    Marker Score: 4468
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.47
    Marker Score: 1574
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.43
    Marker Score: 1897.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.36
    Marker Score: 449
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.35
    Marker Score: 4007
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.16
    Marker Score: 871
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.12
    Marker Score: 813
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.08
    Marker Score: 679
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.03
    Marker Score: 1479
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.03
    Marker Score: 3969
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.01
    Marker Score: 1712
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.94
    Marker Score: 469
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.92
    Marker Score: 1922
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.88
    Marker Score: 11838
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1062
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.84
    Marker Score: 447
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.83
    Marker Score: 833
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.78
    Marker Score: 386
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.75
    Marker Score: 1774
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.74
    Marker Score: 2922
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 654
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.71
    Marker Score: 1691
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.66
    Marker Score: 2717
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.66
    Marker Score: 318
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2743
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1289
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.6
    Marker Score: 7849
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 549
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.58
    Marker Score: 1578
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.58
    Marker Score: 164
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 692
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.53
    Marker Score: 157
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.51
    Marker Score: 534.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 963
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.51
    Marker Score: 249
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5
    Marker Score: 273
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.48
    Marker Score: 1772
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.47
    Marker Score: 16202
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.46
    Marker Score: 263
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.45
    Marker Score: 166
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 259
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4
    Marker Score: 186
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.4
    Marker Score: 416
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.4
    Marker Score: 111
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.39
    Marker Score: 99
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.37
    Marker Score: 151
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.37
    Marker Score: 128
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.37
    Marker Score: 91
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.36
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 338
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 139
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5196
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.33
    Marker Score: 177
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 95
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.33
    Marker Score: 904
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.32
    Marker Score: 2060
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.32
    Marker Score: 227
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.32
    Marker Score: 197
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.31
    Marker Score: 147
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.31
    Marker Score: 1953
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.3
    Marker Score: 174
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3
    Marker Score: 475
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.3
    Marker Score: 585
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.29
    Marker Score: 1746
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 590.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.29
    Marker Score: 224
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 270
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.28
    Marker Score: 78
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.28
    Marker Score: 144

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Other Information

**Key characteristics:** - BIRC5 is a protein of the IAP family. - It is expressed in a variety of cell types. - It is involved in cell growth, differentiation, and apoptosis. **Pathways and functions:** - BIRC5 is involved in the regulation of cell cycle checkpoints, including the G1/S and G2/M checkpoints. - It is also involved in the regulation of apoptosis. - It is involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the BIRC5 gene have been linked to a number of human diseases, including cancer. - Studies of BIRC5 have shown that mutations in the gene can lead to the development of cancer cells. - Targeting BIRC5 has been explored as a therapeutic strategy for cancer. **Additional notes:** - BIRC5 is a highly conserved protein. - It is a key regulator of cell growth and differentiation. - It is a target for cancer therapy.

Genular Protein ID: 2413752124

Symbol: BIRC5_HUMAN

Name: Baculoviral IAP repeat-containing protein 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9256286

Title: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.

PubMed ID: 9256286

DOI: 10.1038/nm0897-917

PubMed ID: 10626797

Title: Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.

PubMed ID: 10626797

PubMed ID: 11084331

Title: Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.

PubMed ID: 11084331

DOI: 10.1016/s0960-9822(00)00769-7

PubMed ID: 14741722

Title: Identification of a novel splice variant of the human anti-apoptosis gene survivin.

PubMed ID: 14741722

DOI: 10.1016/j.bbrc.2003.12.178

PubMed ID: 16329164

Title: Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.

PubMed ID: 16329164

DOI: 10.1080/10425170500226490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9859993

Title: Control of apoptosis and mitotic spindle checkpoint by survivin.

PubMed ID: 9859993

DOI: 10.1038/25141

PubMed ID: 11069302

Title: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.

PubMed ID: 11069302

DOI: 10.1073/pnas.240390697

PubMed ID: 12773388

Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.

PubMed ID: 12773388

DOI: 10.1093/emboj/cdg263

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 16344111

Title: Survivin: a protein with dual roles in mitosis and apoptosis.

PubMed ID: 16344111

DOI: 10.1016/s0074-7696(05)47002-3

PubMed ID: 16322459

Title: Chromosome alignment and segregation regulated by ubiquitination of survivin.

PubMed ID: 16322459

DOI: 10.1126/science.1120160

PubMed ID: 16762323

Title: Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.

PubMed ID: 16762323

DOI: 10.1016/j.bbrc.2006.05.131

PubMed ID: 16239925

Title: Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.

PubMed ID: 16239925

DOI: 10.1038/sj.embor.7400562

PubMed ID: 16427043

Title: Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer.

PubMed ID: 16427043

DOI: 10.1016/j.yexcr.2005.12.015

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 16291752

Title: Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.

PubMed ID: 16291752

DOI: 10.1074/jbc.m508773200

PubMed ID: 16436504

Title: Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

PubMed ID: 16436504

DOI: 10.1091/mbc.e05-08-0727

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 17993464

Title: Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.

PubMed ID: 17993464

DOI: 10.1074/jbc.m704035200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 21364656

Title: An otoprotective role for the apoptosis inhibitor protein survivin.

PubMed ID: 21364656

DOI: 10.1038/cddis.2010.25

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20627126

Title: Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.

PubMed ID: 20627126

DOI: 10.1016/j.mcn.2010.07.003

PubMed ID: 20929775

Title: Two histone marks establish the inner centromere and chromosome bi-orientation.

PubMed ID: 20929775

DOI: 10.1126/science.1194498

PubMed ID: 21252625

Title: Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.

PubMed ID: 21252625

DOI: 10.4161/cc.10.3.14758

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 21536684

Title: Survivin monomer plays an essential role in apoptosis regulation.

PubMed ID: 21536684

DOI: 10.1074/jbc.m111.237586

PubMed ID: 24866247

Title: ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.

PubMed ID: 24866247

DOI: 10.1016/j.bbrc.2014.05.070

PubMed ID: 24793696

Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.

PubMed ID: 24793696

DOI: 10.1016/j.molcel.2014.03.046

PubMed ID: 25778398

Title: The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

PubMed ID: 25778398

DOI: 10.1074/jbc.m114.629931

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 28218735

Title: Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

PubMed ID: 28218735

DOI: 10.1038/oncsis.2016.80

PubMed ID: 28077791

Title: Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.

PubMed ID: 28077791

DOI: 10.18632/oncotarget.14540

PubMed ID: 34438346

Title: Regulation of survivin protein stability by USP35 is evolutionarily conserved.

PubMed ID: 34438346

DOI: 10.1016/j.bbrc.2021.08.050

PubMed ID: 10949039

Title: Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.

PubMed ID: 10949039

DOI: 10.1016/s1097-2765(05)00020-1

PubMed ID: 10876248

Title: Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.

PubMed ID: 10876248

DOI: 10.1038/76838

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 19530738

Title: Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

PubMed ID: 19530738

DOI: 10.1021/bi900530v

Sequence Information:

  • Length: 142
  • Mass: 16389
  • Checksum: 9E7CADCDF2822286
  • Sequence:
  • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
    FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
    KKEFEETAKK VRRAIEQLAA MD

Genular Protein ID: 3065195198

Symbol: H3BLT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 165
  • Mass: 18637
  • Checksum: D1E961E51AD0661E
  • Sequence:
  • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
    FKELEGWEPD DDPIGPGTVA YACNTSTLGG RGGRITREEH KKHSSGCAFL SVKKQFEELT 
    LGEFLKLDRE RAKNKIAKET NNKKKEFEET AEKVRRAIEQ LAAMD

Genular Protein ID: 1145453245

Symbol: A0A0B4J1S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 142
  • Mass: 16390
  • Checksum: 9E7CADCDF28F9486
  • Sequence:
  • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
    FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
    KKEFEETAEK VRRAIEQLAA MD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.