Details for: BIRC5

Gene ID: 332

Symbol: BIRC5

Ensembl ID: ENSG00000089685

Description: baculoviral IAP repeat containing 5

Associated with

Other Information

Genular Protein ID: 2413752124

Symbol: BIRC5_HUMAN

Name: Baculoviral IAP repeat-containing protein 5

UniProtKB Accession Codes:

O15392 A2SUH6 B2R4R1 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 21 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 54 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 29 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256286

Title: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.

PubMed ID: 9256286

DOI: 10.1038/nm0897-917

PubMed ID: 10626797

Title: Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.

PubMed ID: 10626797

PubMed ID: 11084331

Title: Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.

PubMed ID: 11084331

DOI: 10.1016/s0960-9822(00)00769-7

PubMed ID: 14741722

Title: Identification of a novel splice variant of the human anti-apoptosis gene survivin.

PubMed ID: 14741722

DOI: 10.1016/j.bbrc.2003.12.178

PubMed ID: 16329164

Title: Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.

PubMed ID: 16329164

DOI: 10.1080/10425170500226490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9859993

Title: Control of apoptosis and mitotic spindle checkpoint by survivin.

PubMed ID: 9859993

DOI: 10.1038/25141

PubMed ID: 11069302

Title: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.

PubMed ID: 11069302

DOI: 10.1073/pnas.240390697

PubMed ID: 12773388

Title: HBXIP functions as a cofactor of survivin in apoptosis suppression.

PubMed ID: 12773388

DOI: 10.1093/emboj/cdg263

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 15665297

Title: cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

PubMed ID: 15665297

DOI: 10.1158/0008-5472.210.65.1

PubMed ID: 16344111

Title: Survivin: a protein with dual roles in mitosis and apoptosis.

PubMed ID: 16344111

DOI: 10.1016/s0074-7696(05)47002-3

PubMed ID: 16322459

Title: Chromosome alignment and segregation regulated by ubiquitination of survivin.

PubMed ID: 16322459

DOI: 10.1126/science.1120160

PubMed ID: 16762323

Title: Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.

PubMed ID: 16762323

DOI: 10.1016/j.bbrc.2006.05.131

PubMed ID: 16239925

Title: Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.

PubMed ID: 16239925

DOI: 10.1038/sj.embor.7400562

PubMed ID: 16427043

Title: Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer.

PubMed ID: 16427043

DOI: 10.1016/j.yexcr.2005.12.015

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 16291752

Title: Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.

PubMed ID: 16291752

DOI: 10.1074/jbc.m508773200

PubMed ID: 16436504

Title: Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

PubMed ID: 16436504

DOI: 10.1091/mbc.e05-08-0727

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 17993464

Title: Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.

PubMed ID: 17993464

DOI: 10.1074/jbc.m704035200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 21364656

Title: An otoprotective role for the apoptosis inhibitor protein survivin.

PubMed ID: 21364656

DOI: 10.1038/cddis.2010.25

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20627126

Title: Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.

PubMed ID: 20627126

DOI: 10.1016/j.mcn.2010.07.003

PubMed ID: 20929775

Title: Two histone marks establish the inner centromere and chromosome bi-orientation.

PubMed ID: 20929775

DOI: 10.1126/science.1194498

PubMed ID: 21252625

Title: Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.

PubMed ID: 21252625

DOI: 10.4161/cc.10.3.14758

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 21536684

Title: Survivin monomer plays an essential role in apoptosis regulation.

PubMed ID: 21536684

DOI: 10.1074/jbc.m111.237586

PubMed ID: 24866247

Title: ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.

PubMed ID: 24866247

DOI: 10.1016/j.bbrc.2014.05.070

PubMed ID: 24793696

Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.

PubMed ID: 24793696

DOI: 10.1016/j.molcel.2014.03.046

PubMed ID: 25778398

Title: The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

PubMed ID: 25778398

DOI: 10.1074/jbc.m114.629931

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 28218735

Title: Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

PubMed ID: 28218735

DOI: 10.1038/oncsis.2016.80

PubMed ID: 28077791

Title: Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.

PubMed ID: 28077791

DOI: 10.18632/oncotarget.14540

PubMed ID: 34438346

Title: Regulation of survivin protein stability by USP35 is evolutionarily conserved.

PubMed ID: 34438346

DOI: 10.1016/j.bbrc.2021.08.050

PubMed ID: 10949039

Title: Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.

PubMed ID: 10949039

DOI: 10.1016/s1097-2765(05)00020-1

PubMed ID: 10876248

Title: Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.

PubMed ID: 10876248

DOI: 10.1038/76838

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 19530738

Title: Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

PubMed ID: 19530738

DOI: 10.1021/bi900530v

Sequence Information:

  • Length: 142
  • Mass: 16389
  • Checksum: 9E7CADCDF2822286
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
KKEFEETAKK VRRAIEQLAA MD

Genular Protein ID: 3065195198

Symbol: H3BLT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BLT4

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MEROPS 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 165
  • Mass: 18637
  • Checksum: D1E961E51AD0661E
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIGPGTVA YACNTSTLGG RGGRITREEH KKHSSGCAFL SVKKQFEELT 
LGEFLKLDRE RAKNKIAKET NNKKKEFEET AEKVRRAIEQ LAAMD

Genular Protein ID: 1145453245

Symbol: A0A0B4J1S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S3

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 KEGG 1 MANE-Select 1 MEROPS 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 142
  • Mass: 16390
  • Checksum: 9E7CADCDF28F9486
  • Sequence:
    • MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 
KKEFEETAEK VRRAIEQLAA MD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.