dock | FBgn0010583 | NCBI 33262

Details for: dock

Gene ID: 33262

Symbol: dock

Ensembl ID: FBgn0010583

Description: dreadlocks

Associated with

Adaptive immune system
(R-DME-1280218)
Antiviral mechanism by ifn-stimulated genes
(R-DME-1169410)
Cell-cell communication
(R-DME-1500931)
Cytokine signaling in immune system
(R-DME-1280215)
Dcc mediated attractive signaling
(R-DME-418885)
Developmental biology
(R-DME-1266738)
Downstream signal transduction
(R-DME-186763)
Eph-ephrin signaling
(R-DME-2682334)
Ephrin signaling
(R-DME-3928664)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-DME-2029480)
Generation of second messenger molecules
(R-DME-202433)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Interferon signaling
(R-DME-913531)
Nephrin family interactions
(R-DME-373753)
Nervous system development
(R-DME-9675108)
Netrin-1 signaling
(R-DME-373752)
Pkr-mediated signaling
(R-DME-9833482)
Regulation of actin dynamics for phagocytic cup formation
(R-DME-2029482)
Rho gtpase cycle
(R-DME-9012999)
Rho gtpase effectors
(R-DME-195258)
Rho gtpases activate wasps and waves
(R-DME-5663213)
Rhou gtpase cycle
(R-DME-9013420)
Rhov gtpase cycle
(R-DME-9013424)
Signaling by pdgf
(R-DME-186797)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signaling by vegf
(R-DME-194138)
Signal transduction
(R-DME-162582)
Tcr signaling
(R-DME-202403)
Vegfa-vegfr2 pathway
(R-DME-4420097)
Axon guidance
(GO:0007411)
Cell adhesion molecule binding
(GO:0050839)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Ephrin receptor signaling pathway
(GO:0048013)
Insulin receptor binding
(GO:0005158)
Myoblast fusion
(GO:0007520)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902237)
Positive regulation of translation in response to endoplasmic reticulum stress
(GO:0036493)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Receptor tyrosine kinase binding
(GO:0030971)
Signaling adaptor activity
(GO:0035591)

Other Information

Proteins

NCK_DROME

Genular Protein ID: 1174705011

Symbol: NCK_DROME

Name: N/A

UniProtKB Accession Codes:

Q8IPW2 Q24218 Q9VPU1

Database IDs:

Citations:

PubMed ID: 8646773

Title: Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

PubMed ID: 8646773

DOI: 10.1016/s0092-8674(00)81231-3

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8663600

Title: A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance.

PubMed ID: 8663600

DOI: 10.1074/jbc.271.29.17002

PubMed ID: 9482841

Title: Domain requirements for the Dock adapter protein in growth- cone signaling.

PubMed ID: 9482841

DOI: 10.1073/pnas.95.5.2077

PubMed ID: 10399914

Title: Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila.

PubMed ID: 10399914

DOI: 10.1016/s0092-8674(00)80798-9

PubMed ID: 10068645

Title: The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron.

PubMed ID: 10068645

DOI: 10.1242/dev.126.7.1527

PubMed ID: 10892653

Title: Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.

PubMed ID: 10892653

DOI: 10.1016/s0092-8674(00)80878-8

PubMed ID: 12014990

Title: Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases.

PubMed ID: 12014990

DOI: 10.1042/bj20020298

PubMed ID: 12702880

Title: Axons guided by insulin receptor in Drosophila visual system.

PubMed ID: 12702880

DOI: 10.1126/science.1081203

PubMed ID: 21707536

Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.

PubMed ID: 21707536

DOI: 10.1042/bj20110799

Sequence Information:

Length: 548
Mass: 60406
Checksum: BD927B5239D1C4EF
Sequence:

MLEHPQRFVR NIPDSSASSQ QYPQQQQHPP QLPQHQNLNL NQNQNLNQNQ IYQYRPQVPV 
PVPGSPAHHQ RHSSLSQQQQ LHHHRTLSTA SSCSAQHKSV TFGQPALDCG GNGSGSANGS 
GSGNSSSGSA AGNAGTQSMA GNMKHGKSQD DVCYVVAKYD YAAQGAQELD LRKNERYLLL 
DDSKHWWRVQ NSRNQSGYVP SNYVKKEKPS LFDSIKKKVK KGSGSKTLPN CSPSRQVESP 
TMSRRLPPDP AEAIGTAVVK YNYQAQQPDE LSLTKGTRIL ILEKSNDGWW RGQSGNSVGW 
FPSNYTTEDC DNDGEIHTYA MAENVLDIVV ALYSFTSNND QELSFEKGDR LEIVDRPASD 
PDWYKARNNQ GQVGLVPRNY LQELNDYLAT PYRNASASAG NGNGGGSNGG AGGGGGNDSM 
ERRNEGNKPA AQSSGQPIER PNLAGKSWYY GAITRSQCDT VLNGHGHDGD FLIRDSETNM 
GDYSVSLKAP GRNKHFRVHV EQNMYCIGQR KFHSLDQLVD HYQRAPIYTN KQGEKLYLVR 
SLPKANGT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: dock

Associated with

Other Information

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. PubMed ID: 8646773

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. PubMed ID: 8663600

Domain requirements for the Dock adapter protein in growth- cone signaling. PubMed ID: 9482841

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. PubMed ID: 10399914

The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron. PubMed ID: 10068645

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. PubMed ID: 10892653

Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. PubMed ID: 12014990

Axons guided by insulin receptor in Drosophila visual system. PubMed ID: 12702880

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. PubMed ID: 21707536