APLP1 | ENSG00000105290 | NCBI 333

Details for: APLP1

Gene ID: 333

Symbol: APLP1

Ensembl ID: ENSG00000105290

Description: amyloid beta precursor like protein 1

Associated with

Alpha-2a adrenergic receptor binding
(GO:0031694)
Alpha-2b adrenergic receptor binding
(GO:0031695)
Alpha-2c adrenergic receptor binding
(GO:0031696)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process
(GO:0006915)
Axonogenesis
(GO:0007409)
Basement membrane
(GO:0005604)
Cell adhesion
(GO:0007155)
Cellular response to norepinephrine stimulus
(GO:0071874)
Central nervous system development
(GO:0007417)
Cytoplasmic polyadenylation
(GO:0180011)
Endocytosis
(GO:0006897)
Extracellular matrix organization
(GO:0030198)
Forebrain development
(GO:0030900)
Golgi apparatus
(GO:0005794)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106072)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of translation
(GO:0006417)
Transition metal ion binding
(GO:0046914)

Other Information

Proteins

Genular Protein ID: 969522823

Symbol: APLP1_HUMAN

Name: C30

UniProtKB Accession Codes:

P51693 O00113 Q96A92

Database IDs:

Citations:

PubMed ID: 9428684

Title: Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.

PubMed ID: 9428684

DOI: 10.1111/j.1432-1033.1997.0354a.x

PubMed ID: 9521588

Title: Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.

PubMed ID: 9521588

DOI: 10.1007/s004390050676

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7494461

Title: Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.

PubMed ID: 7494461

DOI: 10.1016/0169-328x(95)00328-p

PubMed ID: 7929392

Title: The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.

PubMed ID: 7929392

DOI: 10.1016/s0021-9258(18)47062-7

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 12135352

Title: Evidence for a copper-binding superfamily of the amyloid precursor protein.

PubMed ID: 12135352

DOI: 10.1021/bi0258647

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 21574595

Title: The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.

PubMed ID: 21574595

DOI: 10.1021/bi101846x

Sequence Information:

Length: 650
Mass: 72176
Checksum: B95F0F4D1C5CBAC7
Sequence:

MGPASPAARG LSRRPGQPPL PLLLPLLLLL LRAQPAIGSL AGGSPGAAEA PGSAQVAGLC 
GRLTLHRDLR TGRWEPDPQR SRRCLRDPQR VLEYCRQMYP ELQIARVEQA TQAIPMERWC 
GGSRSGSCAH PHHQVVPFRC LPGEFVSEAL LVPEGCRFLH QERMDQCESS TRRHQEAQEA 
CSSQGLILHG SGMLLPCGSD RFRGVEYVCC PPPGTPDPSG TAVGDPSTRS WPPGSRVEGA 
EDEEEEESFP QPVDDYFVEP PQAEEEEETV PPPSSHTLAV VGKVTPTPRP TDGVDIYFGM 
PGEISEHEGF LRAKMDLEER RMRQINEVMR EWAMADNQSK NLPKADRQAL NEHFQSILQT 
LEEQVSGERQ RLVETHATRV IALINDQRRA ALEGFLAALQ ADPPQAERVL LALRRYLRAE 
QKEQRHTLRH YQHVAAVDPE KAQQMRFQVH THLQVIEERV NQSLGLLDQN PHLAQELRPQ 
IQELLHSEHL GPSELEAPAP GGSSEDKGGL QPPDSKDDTP MTLPKGSTEQ DAASPEKEKM 
NPLEQYERKV NASVPRGFPF HSSEIQRDEL APAGTGVSRE AVSGLLIMGA GGGSLIVLSM 
LLLRRKKPYG AISHGVVEVD PMLTLEEQQL RELQRHGYEN PTYRFLEERP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APLP1

Associated with

Other Information

Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. PubMed ID: 9428684

Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. PubMed ID: 9521588

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. PubMed ID: 7494461

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. PubMed ID: 7929392

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. PubMed ID: 9890987

Evidence for a copper-binding superfamily of the amyloid precursor protein. PubMed ID: 12135352

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. PubMed ID: 21574595