Details for: APLP1

Gene ID: 333

Symbol: APLP1

Ensembl ID: ENSG00000105290

Description: amyloid beta precursor like protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 262.1746
    Cell Significance Index: -40.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.8270
    Cell Significance Index: -41.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4788
    Cell Significance Index: -41.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4055
    Cell Significance Index: -31.9600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.5286
    Cell Significance Index: 19.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0352
    Cell Significance Index: 128.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9732
    Cell Significance Index: 103.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4702
    Cell Significance Index: 294.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3821
    Cell Significance Index: 39.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3047
    Cell Significance Index: 28.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2038
    Cell Significance Index: 26.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1321
    Cell Significance Index: 36.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0987
    Cell Significance Index: 73.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6522
    Cell Significance Index: 40.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6073
    Cell Significance Index: 217.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3958
    Cell Significance Index: 357.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3249
    Cell Significance Index: 61.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3028
    Cell Significance Index: 29.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1949
    Cell Significance Index: 134.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1506
    Cell Significance Index: 2.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1502
    Cell Significance Index: 24.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1379
    Cell Significance Index: 16.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1377
    Cell Significance Index: 23.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0776
    Cell Significance Index: 42.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0226
    Cell Significance Index: 2.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0039
    Cell Significance Index: 2.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0128
    Cell Significance Index: -0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0156
    Cell Significance Index: -2.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0200
    Cell Significance Index: -37.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0217
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -14.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0245
    Cell Significance Index: -37.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0247
    Cell Significance Index: -45.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0301
    Cell Significance Index: -40.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0314
    Cell Significance Index: -6.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0445
    Cell Significance Index: -2.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0476
    Cell Significance Index: -21.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0526
    Cell Significance Index: -38.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0567
    Cell Significance Index: -36.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0570
    Cell Significance Index: -43.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0899
    Cell Significance Index: -40.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0940
    Cell Significance Index: -10.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1094
    Cell Significance Index: -31.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1590
    Cell Significance Index: -1.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1746
    Cell Significance Index: -31.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1749
    Cell Significance Index: -12.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1963
    Cell Significance Index: -38.9500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2126
    Cell Significance Index: -2.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2255
    Cell Significance Index: -13.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2296
    Cell Significance Index: -31.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2349
    Cell Significance Index: -10.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2477
    Cell Significance Index: -13.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2559
    Cell Significance Index: -31.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2599
    Cell Significance Index: -26.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2613
    Cell Significance Index: -37.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2943
    Cell Significance Index: -38.0200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3120
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3334
    Cell Significance Index: -38.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3491
    Cell Significance Index: -13.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3574
    Cell Significance Index: -42.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3578
    Cell Significance Index: -10.0000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3688
    Cell Significance Index: -4.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3935
    Cell Significance Index: -27.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3939
    Cell Significance Index: -10.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4050
    Cell Significance Index: -42.1700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4452
    Cell Significance Index: -5.0300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4811
    Cell Significance Index: -3.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5083
    Cell Significance Index: -37.8800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5587
    Cell Significance Index: -5.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5660
    Cell Significance Index: -43.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5672
    Cell Significance Index: -6.1800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.5778
    Cell Significance Index: -5.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5894
    Cell Significance Index: -30.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5929
    Cell Significance Index: -19.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6273
    Cell Significance Index: -19.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6458
    Cell Significance Index: -8.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6543
    Cell Significance Index: -42.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6795
    Cell Significance Index: -10.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7217
    Cell Significance Index: -37.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7241
    Cell Significance Index: -15.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7469
    Cell Significance Index: -15.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7639
    Cell Significance Index: -26.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7879
    Cell Significance Index: -15.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8021
    Cell Significance Index: -37.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8657
    Cell Significance Index: -18.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8676
    Cell Significance Index: -18.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8687
    Cell Significance Index: -18.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8834
    Cell Significance Index: -41.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8878
    Cell Significance Index: -30.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8967
    Cell Significance Index: -8.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9355
    Cell Significance Index: -15.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9961
    Cell Significance Index: -21.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0124
    Cell Significance Index: -25.2600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0521
    Cell Significance Index: -10.0100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0532
    Cell Significance Index: -14.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.0558
    Cell Significance Index: -15.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1245
    Cell Significance Index: -18.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APLP1 is a type II transmembrane protein that shares structural similarities with amyloid precursor protein (APP), which is a key player in the pathogenesis of Alzheimer's disease. APLP1 is primarily expressed in the central nervous system, including the forebrain, hippocampus, and cerebellum, where it is highly abundant in oligodendrocytes, endocrine cells, and neurons. The protein's extracellular domain is rich in laminin-binding sites, which enables it to interact with the extracellular matrix and regulate cell adhesion. **Pathways and Functions:** APLP1 is involved in a wide range of cellular processes, including: 1. **Neurodevelopment:** APLP1 plays a crucial role in the development of the central nervous system, particularly during axonogenesis and synaptic plasticity. 2. **Cellular adhesion:** APLP1 interacts with the extracellular matrix and regulates cell adhesion, which is essential for maintaining the integrity of the blood-brain barrier. 3. **Apoptotic regulation:** APLP1 modulates the apoptotic process, which is crucial for eliminating damaged or dysfunctional cells in the nervous system. 4. **Neurotransmitter regulation:** APLP1 interacts with neurotransmitters, such as norepinephrine, and regulates their release and uptake. **Clinical Significance:** Dysregulation of APLP1 has been implicated in various neurodegenerative diseases, including: 1. **Alzheimer's disease:** APLP1 has been shown to play a role in the pathogenesis of Alzheimer's disease, particularly in the formation of amyloid plaques. 2. **Amyotrophic lateral sclerosis (ALS):** APLP1 has been found to be downregulated in ALS patients, which may contribute to the disease's progression. 3. **Parkinson's disease:** APLP1 has been implicated in the regulation of dopamine release and may play a role in the development of Parkinson's disease. In conclusion, APLP1 is a multifunctional protein that plays a critical role in neurodevelopment, cellular adhesion, and apoptotic regulation. Its dysregulation has been implicated in various neurodegenerative diseases, highlighting the importance of APLP1 in maintaining the integrity of the nervous system. Further research is necessary to fully understand the mechanisms of APLP1 and its role in neurodegenerative diseases.

Genular Protein ID: 969522823

Symbol: APLP1_HUMAN

Name: C30

UniProtKB Accession Codes:

P51693 O00113 Q96A92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9428684

Title: Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.

PubMed ID: 9428684

DOI: 10.1111/j.1432-1033.1997.0354a.x

PubMed ID: 9521588

Title: Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.

PubMed ID: 9521588

DOI: 10.1007/s004390050676

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7494461

Title: Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.

PubMed ID: 7494461

DOI: 10.1016/0169-328x(95)00328-p

PubMed ID: 7929392

Title: The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.

PubMed ID: 7929392

DOI: 10.1016/s0021-9258(18)47062-7

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 12135352

Title: Evidence for a copper-binding superfamily of the amyloid precursor protein.

PubMed ID: 12135352

DOI: 10.1021/bi0258647

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 21574595

Title: The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.

PubMed ID: 21574595

DOI: 10.1021/bi101846x

Sequence Information:

  • Length: 650
  • Mass: 72176
  • Checksum: B95F0F4D1C5CBAC7
  • Sequence:
    • MGPASPAARG LSRRPGQPPL PLLLPLLLLL LRAQPAIGSL AGGSPGAAEA PGSAQVAGLC 
GRLTLHRDLR TGRWEPDPQR SRRCLRDPQR VLEYCRQMYP ELQIARVEQA TQAIPMERWC 
GGSRSGSCAH PHHQVVPFRC LPGEFVSEAL LVPEGCRFLH QERMDQCESS TRRHQEAQEA 
CSSQGLILHG SGMLLPCGSD RFRGVEYVCC PPPGTPDPSG TAVGDPSTRS WPPGSRVEGA 
EDEEEEESFP QPVDDYFVEP PQAEEEEETV PPPSSHTLAV VGKVTPTPRP TDGVDIYFGM 
PGEISEHEGF LRAKMDLEER RMRQINEVMR EWAMADNQSK NLPKADRQAL NEHFQSILQT 
LEEQVSGERQ RLVETHATRV IALINDQRRA ALEGFLAALQ ADPPQAERVL LALRRYLRAE 
QKEQRHTLRH YQHVAAVDPE KAQQMRFQVH THLQVIEERV NQSLGLLDQN PHLAQELRPQ 
IQELLHSEHL GPSELEAPAP GGSSEDKGGL QPPDSKDDTP MTLPKGSTEQ DAASPEKEKM 
NPLEQYERKV NASVPRGFPF HSSEIQRDEL APAGTGVSRE AVSGLLIMGA GGGSLIVLSM 
LLLRRKKPYG AISHGVVEVD PMLTLEEQQL RELQRHGYEN PTYRFLEERP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.