Su dx | FBgn0003557 | NCBI 33379

Details for: Su dx

Gene ID: 33379

Symbol: Su dx

Ensembl ID: FBgn0003557

Description: Suppressor of deltex

Associated with

Activated notch1 transmits signal to the nucleus
(R-DME-2122948)
Adaptive immune system
(R-DME-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-DME-983168)
Class i mhc mediated antigen processing & presentation
(R-DME-983169)
Downregulation of erbb4 signaling
(R-DME-1253288)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Immune system
(R-DME-168256)
Intracellular signaling by second messengers
(R-DME-9006925)
Pip3 activates akt signaling
(R-DME-1257604)
Pten regulation
(R-DME-6807070)
Regulation of pten stability and activity
(R-DME-8948751)
Rho gtpase cycle
(R-DME-9012999)
Rhoq gtpase cycle
(R-DME-9013406)
Rhou gtpase cycle
(R-DME-9013420)
Rna polymerase ii transcription
(R-DME-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-DME-8939236)
Signaling by erbb4
(R-DME-1236394)
Signaling by notch
(R-DME-157118)
Signaling by notch1
(R-DME-1980143)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signal transduction
(R-DME-162582)
Transcriptional regulation by runx1
(R-DME-8878171)
Cell cortex
(GO:0005938)
Cytoplasm
(GO:0005737)
Imaginal disc-derived leg joint morphogenesis
(GO:0016348)
Imaginal disc-derived wing margin morphogenesis
(GO:0008587)
Imaginal disc-derived wing vein morphogenesis
(GO:0008586)
Lipid storage
(GO:0019915)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Notch binding
(GO:0005112)
Positive regulation of endocytosis
(GO:0045807)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein targeting to lysosome
(GO:0006622)
Protein ubiquitination
(GO:0016567)
Pupal development
(GO:0035209)
R8 cell development
(GO:0045463)
Receptor internalization
(GO:0031623)
Regulation of protein localization
(GO:0032880)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Wing disc dorsal/ventral pattern formation
(GO:0048190)

Other Information

Proteins

E3 ubiquitin-protein ligase Su(dx)

Genular Protein ID: 1155173624

Symbol: SUDX_DROME

Name: E3 ubiquitin-protein ligase Su(dx)

UniProtKB Accession Codes:

Q9Y0H4 A4UZZ3 Q0E8U5 Q8T0C8

Database IDs:

Citations:

PubMed ID: 10353900

Title: The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.

PubMed ID: 10353900

DOI: 10.1093/genetics/152.2.567

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12648496

Title: Down-regulation of Notch target gene expression by Suppressor of deltex.

PubMed ID: 12648496

DOI: 10.1016/s0012-1606(02)00086-6

PubMed ID: 15620650

Title: Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.

PubMed ID: 15620650

DOI: 10.1016/j.cub.2004.11.030

PubMed ID: 15173166

Title: The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex.

PubMed ID: 15173166

DOI: 10.1074/jbc.m404987200

Sequence Information:

Length: 949
Mass: 107966
Checksum: 74B17A8B05AC6E6B
Sequence:

MADGNGLPAG AASGGMEAGQ TVNGAGSASP TPTSSSGAGA SGSANQGYHQ LSVTIEEASL 
RNNGFLKPNP YVELLIDSKS KRKTDLVKNS YLPKWNEEFT VLITPNSTLH FKVLDHSSFR 
KDAMLGERII NLAHILQHYN GRCEFLELTI DLFVTSKSDN RQTKSGELVA ILNGLKLDMS 
KLQIQPVAGQ QNGNPPVQAV NPSVVSDAAA GRSCMIYGGV RARMRLRSSS GNSNGGETRS 
PLPNGGGDHR RSTQAPPVWE QQQQQSQNQQ QPLRMVNGSG AAVPQTAPYP QQPPAPALAR 
PLTQVYGALP ENTQPAAVYL PAGGGAAVGP PGVAGPPIEQ PGVGLPVSQS TDPQLQTQPA 
DDEPLPAGWE IRLDQYGRRY YVDHNTRSTY WEKPTPLPPG WEIRKDGRGR VYYVDHNTRK 
TTWQRPNSER LMHFQHWQGQ RAHVVSQGNQ RYLYSQQQQQ PTAVTAQVTQ DDEDALGPLP 
DGWEKKIQSD NRVYFVNHKN RTTQWEDPRT QGQEVSLINE GPLPPGWEIR YTAAGERFFV 
DHNTRRTTFE DPRPGAPKGA KGVYGVPRAY ERSFRWKLSQ FRYLCQSNAL PSHIKITVTR 
QTLFEDSYHQ IMRLPAYELR RRLYIIFRGE EGLDYGGVSR EWFFLLSHEV LNPMYCLFEY 
ANKNNYSLQI NPASYVNPDH LQYFKFIGRF IAMALYHGRF IYSGFTMPFY KRMLNKKLTI 
KDIETIDPEF YNSLIWVKDN NIDECGLELW FSVDFEVLGQ IIHHELKENG EKERVTEENK 
EEYITLMTEW RMTRGIEQQT KTFLEGFNEV VPLEWLKYFD ERELELILCG MQDVDVEDWQ 
RNTIYRHYNR NSKQVVWFWQ FVRETDNEKR ARLLQFVTGT CRVPVGGFAE LMGSNGPQRF 
CIEKVGKETW LPRSHTCFNR LDLPPYKSYD QLVEKLTFAI EETEGFCQE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Su dx

Associated with

Other Information

The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. PubMed ID: 10353900

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Down-regulation of Notch target gene expression by Suppressor of deltex. PubMed ID: 12648496

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. PubMed ID: 15620650

The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex. PubMed ID: 15173166