Details for: APLP2

Gene ID: 334

Symbol: APLP2

Ensembl ID: ENSG00000084234

Description: amyloid beta precursor like protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.37
    Marker Score: 40499
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.2
    Marker Score: 27267
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.06
    Marker Score: 27186
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.76
    Marker Score: 10948
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.55
    Marker Score: 18963
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.96
    Marker Score: 4767
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.85
    Marker Score: 3011
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.77
    Marker Score: 10095.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.65
    Marker Score: 204252
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.61
    Marker Score: 18981
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.6
    Marker Score: 1883
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.45
    Marker Score: 8690
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.4
    Marker Score: 4109
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.34
    Marker Score: 4487
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.31
    Marker Score: 21549.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113772
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3
    Marker Score: 5481.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.96
    Marker Score: 2526
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.95
    Marker Score: 7358.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.95
    Marker Score: 3129.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.93
    Marker Score: 3352
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.91
    Marker Score: 5908
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.9
    Marker Score: 21564
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.84
    Marker Score: 4568.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.82
    Marker Score: 1887
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.82
    Marker Score: 3010
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.81
    Marker Score: 4667
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.75
    Marker Score: 9753.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.71
    Marker Score: 3836
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.7
    Marker Score: 8833.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.67
    Marker Score: 5209.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.67
    Marker Score: 2190
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.64
    Marker Score: 2681
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.64
    Marker Score: 67685
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.63
    Marker Score: 10980
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.61
    Marker Score: 2459.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.6
    Marker Score: 10817
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.59
    Marker Score: 3129
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.58
    Marker Score: 22653
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.56
    Marker Score: 6708
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.56
    Marker Score: 2987.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.55
    Marker Score: 9823
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.55
    Marker Score: 86674.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.53
    Marker Score: 40682
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.53
    Marker Score: 1431
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.5
    Marker Score: 11574
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.49
    Marker Score: 4091.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.48
    Marker Score: 1446
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.46
    Marker Score: 791
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.45
    Marker Score: 1670
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.42
    Marker Score: 3129
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.42
    Marker Score: 4553
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.42
    Marker Score: 1008
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.41
    Marker Score: 1080
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.4
    Marker Score: 7536
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.39
    Marker Score: 10310
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.38
    Marker Score: 2378
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.37
    Marker Score: 2048
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.36
    Marker Score: 3473
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.35
    Marker Score: 2474
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.35
    Marker Score: 1671
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.35
    Marker Score: 8077
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.35
    Marker Score: 1374
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.33
    Marker Score: 1433
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.33
    Marker Score: 11179
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.29
    Marker Score: 8993
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.29
    Marker Score: 2209
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.29
    Marker Score: 40575
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.28
    Marker Score: 3633.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.28
    Marker Score: 2170
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.27
    Marker Score: 654
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.26
    Marker Score: 1246
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.26
    Marker Score: 26296
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.26
    Marker Score: 4008
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.25
    Marker Score: 785
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.25
    Marker Score: 5421
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.24
    Marker Score: 8280
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.24
    Marker Score: 6377
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.21
    Marker Score: 13417
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.19
    Marker Score: 18991
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.18
    Marker Score: 502
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.16
    Marker Score: 2665
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24249
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.15
    Marker Score: 1518
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.14
    Marker Score: 1409
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2587
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.12
    Marker Score: 2199
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.11
    Marker Score: 1886
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.1
    Marker Score: 877
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.1
    Marker Score: 2461
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.1
    Marker Score: 2731
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.09
    Marker Score: 1195
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.09
    Marker Score: 1398
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.09
    Marker Score: 725
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.09
    Marker Score: 5107
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.09
    Marker Score: 989.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.08
    Marker Score: 1864
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.06
    Marker Score: 2226
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.06
    Marker Score: 615
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.06
    Marker Score: 4309

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Other Information

**Key characteristics:** * The protein is a transmembrane protein that is expressed in neurons and glial cells. * It is a glycoprotein that is composed of 140 amino acids. * It is a member of the amyloid precursor protein family. * It is involved in the regulation of insulin-like growth factor (IGF) transport and uptake by IGF binding proteins. **Pathways and functions:** * APLP2 is involved in the regulation of IGF signaling. * It is a key component of the axonal transport of IGFs. * It is also involved in the regulation of neuronal differentiation and growth. * It is expressed in neurons and glial cells, and its expression is upregulated in conditions such as Alzheimer's disease. **Clinical significance:** * Mutations in the APLP2 gene have been linked to the development of a number of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * APLP2 is a potential target for therapeutic intervention in these diseases. **Other relevant information:** * The gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar gene found in mice and rats. * It is expressed in high levels in the brain and spinal cord.

Genular Protein ID: 1267156402

Symbol: APLP2_HUMAN

Name: APPH

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8485127

Title: Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family.

PubMed ID: 8485127

DOI: 10.1021/bi00068a002

PubMed ID: 8220435

Title: Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.

PubMed ID: 8220435

DOI: 10.1038/ng0993-95

PubMed ID: 7702756

Title: A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein.

PubMed ID: 7702756

DOI: 10.1089/dna.1994.13.1137

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7651835

Title: USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene.

PubMed ID: 7651835

DOI: 10.1093/nar/23.14.2734

PubMed ID: 11101689

Title: Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the alzheimer betaA4-amyloid precursor protein.

PubMed ID: 11101689

DOI: 10.1093/molehr/6.12.1069

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8307156

Title: Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog.

PubMed ID: 8307156

DOI: 10.1016/0014-5793(94)80115-0

PubMed ID: 8855266

Title: Association of a novel human FE65-like protein with the cytoplasmic domain of the amyloid-beta precursor protein.

PubMed ID: 8855266

DOI: 10.1073/pnas.93.20.10832

PubMed ID: 10081969

Title: Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.

PubMed ID: 10081969

DOI: 10.1016/s0304-3940(98)00995-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

Sequence Information:

  • Length: 763
  • Mass: 86956
  • Checksum: CA3A7D6DDB8A28D0
  • Sequence:
  • MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN 
    MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK 
    KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT 
    LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF 
    PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 
    EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC 
    KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK 
    NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ 
    SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR 
    NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 
    PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD 
    VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ 
    YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI

Genular Protein ID: 3589581016

Symbol: A0A140VJE9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 751
  • Mass: 85487
  • Checksum: 788BCDC6E4487E18
  • Sequence:
  • MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN 
    MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK 
    KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT 
    LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF 
    PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 
    EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC 
    KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK 
    NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ 
    SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR 
    NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 
    PFHPFPALPE NEGSGVGEQD GGLIGAEEKV INSKNKVDEN MVIDETLDVK EMIFNAERVG 
    GLEEERESVG PLREDFSLSS SALIGLLVIA VAIATVIVIS LVMLRKRQYG TISHGIVEVD 
    PMLTPEERHL NKMQNHGYEN PTYKYLEQMQ I

Genular Protein ID: 2499763155

Symbol: B4E3I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 689
  • Mass: 78765
  • Checksum: CAE94A167A8506E0
  • Sequence:
  • MAAAATGRLL LLLLVGLTAP ALALAGYIEA LAANAGTGFA VAEPQIAMFC GKLNMHVNIQ 
    TGKWEPDPTG TKSCFETKEE VLQYCQEMYP ELQITNVMEA NQRVSIDNWC RRDKKQCKSR 
    FVTPFKCLVG EFVSDVLLVP EKCQFFHKER MEVCENHQHW HTVVKEACLT QGMTLYSYGM 
    LLPCGVDQFH GTEYVCCPQT KIIGSVSKEE EEEDEEEEEE EDEEEDYDVY KSEFPTEADL 
    EDFTEAAVDE DDEDEEEGEE VVEDRDYYYD TFKGDDYNEE NPTEPGSDGT MSDKEITHDV 
    KVPPTPLPTN DVDVYFETSA DDNEHARFQK AKEQLEIRHR NRMDRVKKEW EEAELQAKNL 
    PKAERQTLIQ HFQAMVKALE KEAASEKQQL VETHLARVEA MLNDRRRMAL ENYLAALQSD 
    PPRPHRILQA LRRYVRAENK DRLHTIRHYQ HVLAVDPEKA AQMKSQVMTH LHVIEERRNQ 
    SLSLLYKVPY VAQEIQEEID ELLQEQRADM DQFTASISET PVDVRVSSEE SEEIPPFHPF 
    HPFPALPENE GSGVGEQDGG LIGAEEKVIN SKNKVDENMV IDETLDVKEM IFNAERVGGL 
    EEERESVGPL REDFSLSSSA LIGLLVIAVA IATVIVISLV MLRKRQYGTI SHGIVEVDPM 
    LTPEERHLNK MQNHGYENPT YKYLEQMQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.