Details for: APOA1

Gene ID: 335

Symbol: APOA1

Ensembl ID: ENSG00000118137

Description: apolipoprotein A1

Associated with

Other Information

Genular Protein ID: 3505038240

Symbol: APOA1_HUMAN

Name: Apolipoprotein A1

UniProtKB Accession Codes:

P02647 A8K866 Q6LDN9 Q6Q785 Q9UCS8 Q9UCT8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 EMBL 20 EMDB 3 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 26 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 17 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6406984

Title: Gene structure of human apolipoprotein A1.

PubMed ID: 6406984

DOI: 10.1093/nar/11.9.2827

PubMed ID: 6304641

Title: Nucleotide sequence of cloned cDNA of human apolipoprotein A-I.

PubMed ID: 6304641

DOI: 10.1093/nar/11.11.3703

PubMed ID: 6413973

Title: Isolation and characterization of the human apolipoprotein A-I gene.

PubMed ID: 6413973

DOI: 10.1073/pnas.80.20.6147

PubMed ID: 6207999

Title: Isolation and DNA sequence of full-length cDNA and of the entire gene for human apolipoprotein AI -- discovery of a new genetic polymorphism in the apo AI gene.

PubMed ID: 6207999

DOI: 10.1089/dna.1.1984.3.309

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 6198645

Title: Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA.

PubMed ID: 6198645

DOI: 10.1073/pnas.81.1.66

PubMed ID: 2995392

Title: Tangier disease. The complete mRNA sequence encoding for preproapo-A-I.

PubMed ID: 2995392

DOI: 10.1016/s0021-9258(17)38949-4

PubMed ID: 3129297

Title: Sequence and expression of Tangier apoA-I gene.

PubMed ID: 3129297

DOI: 10.1111/j.1432-1033.1988.tb14022.x

PubMed ID: 2673706

Title: Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization.

PubMed ID: 2673706

DOI: 10.1089/dna.1.1989.8.429

PubMed ID: 15108119

Title: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.

PubMed ID: 15108119

DOI: 10.1007/s00439-004-1106-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6409108

Title: Human plasma proapoA-I: isolation and amino-terminal sequence.

PubMed ID: 6409108

DOI: 10.1016/0006-291x(83)91772-2

PubMed ID: 164450

Title: The primary structure of human plasma high density apolipoprotein glutamine I (ApoA-I). II. The amino acid sequence and alignment of cyanogen bromide fragments IV, III, and I.

PubMed ID: 164450

DOI: 10.1016/s0021-9258(19)41662-1

PubMed ID: 204308

Title: The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins.

PubMed ID: 204308

DOI: 10.1016/0006-291x(78)91614-5

PubMed ID: 3047170

Title: Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I.

PubMed ID: 3047170

DOI: 10.1172/jci113682

PubMed ID: 1909888

Title: Identification of apolipoprotein A1 and immunoglobulin as components of a serum complex that mediates activation of human sperm motility.

PubMed ID: 1909888

DOI: 10.1021/bi00101a011

PubMed ID: 2506184

Title: Apolipoprotein A-I binds to a family of bovine seminal plasma proteins.

PubMed ID: 2506184

DOI: 10.1016/s0021-9258(19)84784-1

PubMed ID: 3120314

Title: Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein.

PubMed ID: 3120314

DOI: 10.1126/science.3120314

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1742316

Title: The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I.

PubMed ID: 1742316

DOI: 10.1016/0005-2760(91)90167-g

PubMed ID: 6800349

Title: Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease.

PubMed ID: 6800349

DOI: 10.1161/01.atv.2.1.16

PubMed ID: 6294659

Title: Isolation and characterization of cDNA clones for human apolipoprotein A-I.

PubMed ID: 6294659

DOI: 10.1073/pnas.79.22.6861

PubMed ID: 3005308

Title: Human apolipoprotein A-I. Post-translational modification by fatty acid acylation.

PubMed ID: 3005308

DOI: 10.1016/s0021-9258(17)35598-9

PubMed ID: 6405383

Title: Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.

PubMed ID: 6405383

DOI: 10.1073/pnas.80.9.2574

PubMed ID: 1898657

Title: A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities.

PubMed ID: 1898657

DOI: 10.1172/jci114997

PubMed ID: 8261628

Title: The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo.

PubMed ID: 8261628

DOI: 10.1016/0009-8981(93)90165-z

PubMed ID: 11991719

Title: Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.

PubMed ID: 11991719

DOI: 10.1006/geno.2002.6761

PubMed ID: 12847263

Title: Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.

PubMed ID: 12847263

DOI: 10.4049/jimmunol.171.2.924

PubMed ID: 12576517

Title: Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.

PubMed ID: 12576517

DOI: 10.1194/jlr.m200256-jlr200

PubMed ID: 12562854

Title: Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins.

PubMed ID: 12562854

DOI: 10.1194/jlr.d200034-jlr200

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23719382

Title: Control of angiogenesis by AIBP-mediated cholesterol efflux.

PubMed ID: 23719382

DOI: 10.1038/nature12166

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24755625

Title: Secondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility.

PubMed ID: 24755625

DOI: 10.1371/journal.pone.0096150

PubMed ID: 8664326

Title: Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions.

PubMed ID: 8664326

DOI: 10.1016/0005-2760(96)00037-9

PubMed ID: 9356442

Title: Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation.

PubMed ID: 9356442

DOI: 10.1073/pnas.94.23.12291

PubMed ID: 8240372

Title: Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene.

PubMed ID: 8240372

DOI: 10.1006/bbrc.1993.2341

PubMed ID: 8282791

Title: Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia.

PubMed ID: 8282791

DOI: 10.1172/jci116949

PubMed ID: 6401735

Title: Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.

PubMed ID: 6401735

DOI: 10.1016/s0021-9258(18)32955-7

PubMed ID: 6412234

Title: Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-I) with high density lipoproteins.

PubMed ID: 6412234

DOI: 10.1073/pnas.80.19.6081

PubMed ID: 6489332

Title: Apolipoprotein A-IGiessen (Pro143-->Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase.

PubMed ID: 6489332

DOI: 10.1111/j.1432-1033.1984.tb08467.x

PubMed ID: 6432779

Title: Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.

PubMed ID: 6432779

DOI: 10.1016/s0021-9258(18)90928-2

PubMed ID: 3142462

Title: Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.

PubMed ID: 3142462

DOI: 10.1016/s0006-291x(88)80909-4

PubMed ID: 2123470

Title: A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy.

PubMed ID: 2123470

DOI: 10.1016/0888-7543(90)90288-6

PubMed ID: 2107878

Title: Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu-->Lys). A novel apolipoprotein variant.

PubMed ID: 2107878

DOI: 10.1016/0005-2760(90)90292-6

PubMed ID: 1502149

Title: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis.

PubMed ID: 1502149

DOI: 10.1073/pnas.89.16.7389

PubMed ID: 2108924

Title: Apolipoprotein A1 Baltimore (Arg-10-->Leu), a new ApoA1 variant.

PubMed ID: 2108924

DOI: 10.1007/bf00195816

PubMed ID: 2512329

Title: Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I.

PubMed ID: 2512329

DOI: 10.1172/jci114355

PubMed ID: 2111322

Title: Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure.

PubMed ID: 2111322

DOI: 10.1016/s0021-9258(19)38931-8

PubMed ID: 1901417

Title: Apolipoprotein A-I deficiency due to a codon 84 nonsense mutation of the apolipoprotein A-I gene.

PubMed ID: 1901417

DOI: 10.1073/pnas.88.7.2793

PubMed ID: 7981179

Title: A nonsense mutation in the apolipoprotein A-I gene is associated with high-density lipoprotein deficiency and periorbital xanthelasmas.

PubMed ID: 7981179

DOI: 10.1161/01.atv.14.12.1915

PubMed ID: 7918609

Title: Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108-->Arg) and A-I Hita (Ala-95-->Asp).

PubMed ID: 7918609

PubMed ID: 8208902

Title: Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26.

PubMed ID: 8208902

PubMed ID: 10487826

Title: The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide.

PubMed ID: 10487826

DOI: 10.1016/s0002-9440(10)65167-x

PubMed ID: 9514407

Title: A novel homozygous missense mutation in the apo A-I gene with apo A-I deficiency.

PubMed ID: 9514407

DOI: 10.1161/01.atv.18.3.389

PubMed ID: 10198255

Title: A novel apolipoprotein A-1 variant, Arg173Pro, associated with cardiac and cutaneous amyloidosis.

PubMed ID: 10198255

DOI: 10.1006/bbrc.1999.0518

PubMed ID: 12050338

Title: Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis.

PubMed ID: 12050338

DOI: 10.1056/nejmoa013354

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 26073399

Title: Case report: A novel apolipoprotein A-I missense mutation apoA-I (Arg149Ser)Boston associated with decreased lecithin-cholesterol acyltransferase activation and cellular cholesterol efflux.

PubMed ID: 26073399

DOI: 10.1016/j.jacl.2015.02.005

Sequence Information:

  • Length: 267
  • Mass: 30778
  • Checksum: 1A28B8366E620310
  • Sequence:
    • MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS 
ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK 
VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV 
DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ 
GLLPVLESFK VSFLSALEEY TKKLNTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.