Details for: msl 2

Gene ID: 33565

Symbol: msl 2

Ensembl ID: FBgn0005616

Description: male-specific lethal 2

Associated with

Other Information

Genular Protein ID: 1131221228

Symbol: MSL2_DROME

Name: N/A

UniProtKB Accession Codes:

P50534 Q9VQR1

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 20 ComplexPortal 1 DNASU 1 EC 1 EMBL 5 EnsemblMetazoa 2 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 21 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 UniPathway 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7781064

Title: Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila.

PubMed ID: 7781064

DOI: 10.1016/0092-8674(95)90007-1

PubMed ID: 7796814

Title: Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster.

PubMed ID: 7796814

DOI: 10.1002/j.1460-2075.1995.tb07288.x

PubMed ID: 7588059

Title: The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal.

PubMed ID: 7588059

DOI: 10.1242/dev.121.10.3245

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 9182767

Title: The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control.

PubMed ID: 9182767

DOI: 10.1016/s0092-8674(00)80262-7

PubMed ID: 9144292

Title: Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism.

PubMed ID: 9144292

DOI: 10.1038/387195a0

PubMed ID: 10617208

Title: Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG.

PubMed ID: 10617208

DOI: 10.1038/45602

PubMed ID: 10679323

Title: Ordered assembly of roX RNAs into MSL complexes on the dosage-compensated X chromosome in Drosophila.

PubMed ID: 10679323

DOI: 10.1016/s0960-9822(00)00311-0

PubMed ID: 11014199

Title: Chromodomains are protein-RNA interaction modules.

PubMed ID: 11014199

DOI: 10.1038/35030169

PubMed ID: 16543150

Title: Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.

PubMed ID: 16543150

DOI: 10.1016/j.molcel.2006.02.007

PubMed ID: 18724933

Title: A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome.

PubMed ID: 18724933

DOI: 10.1016/j.cell.2008.06.033

PubMed ID: 18086881

Title: Incorporation of the noncoding roX RNAs alters the chromatin-binding specificity of the Drosophila MSL1/MSL2 complex.

PubMed ID: 18086881

DOI: 10.1128/mcb.00910-07

PubMed ID: 20139418

Title: The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome.

PubMed ID: 20139418

DOI: 10.1093/nar/gkq026

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 21551218

Title: msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster.

PubMed ID: 21551218

DOI: 10.1093/nar/gkr236

PubMed ID: 23084834

Title: MSL2 combines sensor and effector functions in homeostatic control of the Drosophila dosage compensation machinery.

PubMed ID: 23084834

DOI: 10.1016/j.molcel.2012.09.012

PubMed ID: 23084835

Title: Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila.

PubMed ID: 23084835

DOI: 10.1016/j.molcel.2012.09.014

PubMed ID: 23870142

Title: Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.

PubMed ID: 23870142

DOI: 10.1016/j.molcel.2013.07.001

PubMed ID: 27580037

Title: PionX sites mark the X chromosome for dosage compensation.

PubMed ID: 27580037

DOI: 10.1038/nature19338

PubMed ID: 28510597

Title: Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster.

PubMed ID: 28510597

DOI: 10.1371/journal.pone.0177408

PubMed ID: 31320325

Title: The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.

PubMed ID: 31320325

DOI: 10.1242/dev.179663

PubMed ID: 33208948

Title: RNA nucleation by MSL2 induces selective X chromosome compartmentalization.

PubMed ID: 33208948

DOI: 10.1038/s41586-020-2935-z

PubMed ID: 35648444

Title: Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.

PubMed ID: 35648444

DOI: 10.1093/nar/gkac455

PubMed ID: 37602401

Title: Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.

PubMed ID: 37602401

DOI: 10.1093/nar/gkad680

PubMed ID: 23029009

Title: Solution structure of MSL2 CXC domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases.

PubMed ID: 23029009

DOI: 10.1371/journal.pone.0045437

PubMed ID: 25452275

Title: Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.

PubMed ID: 25452275

DOI: 10.1101/gad.250936.114

Sequence Information:

  • Length: 773
  • Mass: 84856
  • Checksum: 31830142AD64F4D7
  • Sequence:
    • MAQTAYLKVT RIAMRSASNL SKRRVEELNS GLGELRQLLS CVVCCQLLVD PYSPKGKRCQ 
HNVCRLCLRG KKHLFPSCTQ CEGCSDFKTY EENRMMAAQL LCYKTLCVHL LHSALFGELA 
GMRPQVAREL VPRIKLPPKT TQEFIREGSN ISDTFDIFLP QPDLPFLKDM PTSLPAETPP 
TSAVTTPELP YDHHLNISDI EAEAAATAEQ GHFSPLPLLP TGSRMGMLSH AGQIVIATES 
SESGFMDQAW TDQVDLSGTV SVSKYTNSGN NFAVSYVMPT SATTKFDPQE LQIGQVVQMA 
DSTQLAVLAA VEETVETSTQ LTVLSTTVEE TVETSTQLEV LTSAEEPNEI SDQLANLQVE 
ESDEALVEET VEEAEGTSIP SEVVAEHMEE DQHLDVHTSQ SPTQTEMEEA VEEHVATKTQ 
LGHVQTELQD AESLQKDFED AKAAAEEAKE KEKDLHAISA ELQKEDSDEP TLKRKRTRTL 
KASQAAKIEP VPSEVKTKVQ SGKGALRRIR GKDKEEKVKP PKPKCRCGIS GSSNTLTTCR 
NSRCPCYKSY NSCAGCHCVC CKNPHKEDYV ESDEDDDLED FEMPKDVPEP MTQSEEPVVA 
EPRQEENSMA PPDSSAPISL VPLNNLQQSQ HPLVLVQNEK GEYQGFNIFQ GSKPLDPVTV 
GFTIRVQLQH TDGFGSLPQY AYIMPTIDPP NPPAPSLSPP PPPAPDREVI EPPAKKFRTS 
RTRRGRANFS ALDTVDELVS GGSRSNSAAG DRSSATDNAH SLFEEIMSGS DDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.