Details for: msl 2
Associated with
Other Information
Genular Protein ID: 1131221228
Symbol: MSL2_DROME
Name: E3 ubiquitin-protein ligase msl-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7781064
Title: Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila.
PubMed ID: 7781064
PubMed ID: 7796814
Title: Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster.
PubMed ID: 7796814
PubMed ID: 7588059
Title: The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal.
PubMed ID: 7588059
PubMed ID: 10731132
Title: The genome sequence of Drosophila melanogaster.
PubMed ID: 10731132
PubMed ID: 12537572
Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
PubMed ID: 12537572
PubMed ID: 12537569
Title: A Drosophila full-length cDNA resource.
PubMed ID: 12537569
PubMed ID: 16543150
Title: Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.
PubMed ID: 16543150
PubMed ID: 21726816
Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.
PubMed ID: 21726816
PubMed ID: 27580037
Title: PionX sites mark the X chromosome for dosage compensation.
PubMed ID: 27580037
DOI: 10.1038/nature19338
PubMed ID: 31320325
Title: The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.
PubMed ID: 31320325
DOI: 10.1242/dev.179663
PubMed ID: 35648444
Title: Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
PubMed ID: 35648444
DOI: 10.1093/nar/gkac455
PubMed ID: 37602401
Title: Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
PubMed ID: 37602401
DOI: 10.1093/nar/gkad680
Sequence Information:
- Length: 773
- Mass: 84856
- Checksum: 31830142AD64F4D7
- Sequence:
MAQTAYLKVT RIAMRSASNL SKRRVEELNS GLGELRQLLS CVVCCQLLVD PYSPKGKRCQ HNVCRLCLRG KKHLFPSCTQ CEGCSDFKTY EENRMMAAQL LCYKTLCVHL LHSALFGELA GMRPQVAREL VPRIKLPPKT TQEFIREGSN ISDTFDIFLP QPDLPFLKDM PTSLPAETPP TSAVTTPELP YDHHLNISDI EAEAAATAEQ GHFSPLPLLP TGSRMGMLSH AGQIVIATES SESGFMDQAW TDQVDLSGTV SVSKYTNSGN NFAVSYVMPT SATTKFDPQE LQIGQVVQMA DSTQLAVLAA VEETVETSTQ LTVLSTTVEE TVETSTQLEV LTSAEEPNEI SDQLANLQVE ESDEALVEET VEEAEGTSIP SEVVAEHMEE DQHLDVHTSQ SPTQTEMEEA VEEHVATKTQ LGHVQTELQD AESLQKDFED AKAAAEEAKE KEKDLHAISA ELQKEDSDEP TLKRKRTRTL KASQAAKIEP VPSEVKTKVQ SGKGALRRIR GKDKEEKVKP PKPKCRCGIS GSSNTLTTCR NSRCPCYKSY NSCAGCHCVC CKNPHKEDYV ESDEDDDLED FEMPKDVPEP MTQSEEPVVA EPRQEENSMA PPDSSAPISL VPLNNLQQSQ HPLVLVQNEK GEYQGFNIFQ GSKPLDPVTV GFTIRVQLQH TDGFGSLPQY AYIMPTIDPP NPPAPSLSPP PPPAPDREVI EPPAKKFRTS RTRRGRANFS ALDTVDELVS GGSRSNSAAG DRSSATDNAH SLFEEIMSGS DDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.