Details for: APOA2

Gene ID: 336

Symbol: APOA2

Ensembl ID: ENSG00000158874

Description: apolipoprotein A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 41.6182
    Cell Significance Index: 699.9900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 14.2292
    Cell Significance Index: 10.8600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 11.8394
    Cell Significance Index: 92.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.4598
    Cell Significance Index: 142.5100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.1149
    Cell Significance Index: 19.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 7.0745
    Cell Significance Index: 1403.9500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 3.1777
    Cell Significance Index: 11.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.8591
    Cell Significance Index: 42.2000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.8105
    Cell Significance Index: 16.1900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.4985
    Cell Significance Index: 19.7300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.9490
    Cell Significance Index: 27.9300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.4763
    Cell Significance Index: 14.5700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.2813
    Cell Significance Index: 3.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8898
    Cell Significance Index: 28.5000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.7595
    Cell Significance Index: 7.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5847
    Cell Significance Index: 14.5800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3292
    Cell Significance Index: 1.2400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.3254
    Cell Significance Index: 3.0200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2882
    Cell Significance Index: 3.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2749
    Cell Significance Index: 7.3700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2625
    Cell Significance Index: 2.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1852
    Cell Significance Index: 11.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1819
    Cell Significance Index: 29.5800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.1260
    Cell Significance Index: 1.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1196
    Cell Significance Index: 22.7700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1084
    Cell Significance Index: 1.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0887
    Cell Significance Index: 1.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0492
    Cell Significance Index: 0.7900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0485
    Cell Significance Index: 0.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0447
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0306
    Cell Significance Index: 3.5700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0278
    Cell Significance Index: 0.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0022
    Cell Significance Index: 0.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.0005
    Cell Significance Index: 0.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0045
    Cell Significance Index: -1.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0055
    Cell Significance Index: -1.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0056
    Cell Significance Index: -3.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0063
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0111
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0120
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0123
    Cell Significance Index: -2.1100
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0130
    Cell Significance Index: -0.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0163
    Cell Significance Index: -1.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0172
    Cell Significance Index: -1.7100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0213
    Cell Significance Index: -1.4300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0217
    Cell Significance Index: -0.3100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0371
    Cell Significance Index: -0.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0375
    Cell Significance Index: -0.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0379
    Cell Significance Index: -2.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0418
    Cell Significance Index: -0.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0424
    Cell Significance Index: -2.6700
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0430
    Cell Significance Index: -0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0449
    Cell Significance Index: -8.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0464
    Cell Significance Index: -1.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0515
    Cell Significance Index: -0.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0573
    Cell Significance Index: -3.5200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0573
    Cell Significance Index: -0.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0597
    Cell Significance Index: -1.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0607
    Cell Significance Index: -1.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0615
    Cell Significance Index: -1.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0618
    Cell Significance Index: -2.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0627
    Cell Significance Index: -9.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0652
    Cell Significance Index: -1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0656
    Cell Significance Index: -3.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0662
    Cell Significance Index: -8.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0674
    Cell Significance Index: -1.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0687
    Cell Significance Index: -1.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0717
    Cell Significance Index: -3.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0738
    Cell Significance Index: -2.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0746
    Cell Significance Index: -3.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0757
    Cell Significance Index: -4.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0761
    Cell Significance Index: -1.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0764
    Cell Significance Index: -2.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0823
    Cell Significance Index: -2.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0832
    Cell Significance Index: -3.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0916
    Cell Significance Index: -3.2200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0929
    Cell Significance Index: -1.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0937
    Cell Significance Index: -4.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0945
    Cell Significance Index: -1.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0954
    Cell Significance Index: -2.3800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0979
    Cell Significance Index: -1.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0990
    Cell Significance Index: -10.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0992
    Cell Significance Index: -2.0700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.1130
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1168
    Cell Significance Index: -3.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1213
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1232
    Cell Significance Index: -1.3000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1235
    Cell Significance Index: -2.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1260
    Cell Significance Index: -3.1500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1282
    Cell Significance Index: -1.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** APOA2 is a small, hydrophobic protein that is structurally similar to apolipoprotein A1 (APOA1), another major component of HDL particles. It is characterized by its ability to bind phospholipids, cholesterol, and triglycerides, facilitating the transport of lipids within the bloodstream. APOA2 also exhibits a high degree of conservation across species, suggesting its importance in lipid metabolism and cardiovascular health. The protein has a relatively short half-life, which allows for rapid regulation of lipid metabolism in response to changes in cholesterol levels. **Pathways and Functions** APOA2 is involved in various cellular processes, including: 1. **Cholesterol efflux**: APOA2 facilitates the transfer of cholesterol from peripheral tissues to HDL particles, promoting the removal of excess cholesterol from the bloodstream. 2. **Reverse cholesterol transport**: APOA2 plays a critical role in the transport of cholesterol from peripheral tissues to the liver for excretion. 3. **Lipid metabolism**: APOA2 is involved in the regulation of lipid metabolism, including the breakdown and synthesis of triglycerides and phospholipids. 4. **Anti-inflammatory responses**: APOA2 inhibits the production of pro-inflammatory cytokines and promotes the clearance of apoptotic cells, reducing inflammation and oxidative stress. 5. **Cellular signaling**: APOA2 interacts with various signaling molecules, including PPARα, to regulate lipid metabolism and cardiovascular health. **Clinical Significance** Dysregulation of APOA2 has been implicated in various cardiovascular diseases, including atherosclerosis, coronary artery disease, and hypertriglyceridemia. Abnormal levels of APOA2 have been observed in individuals with familial hypercholesterolemia, a genetic disorder characterized by elevated LDL cholesterol levels. Additionally, APOA2 has been shown to have anti-inflammatory properties, making it a potential therapeutic target for the treatment of inflammatory disorders, such as atherosclerosis and cardiovascular disease. In conclusion, APOA2 is a critical protein involved in lipid metabolism, cholesterol homeostasis, and anti-inflammatory responses. Its dysregulation has significant implications for cardiovascular health, highlighting the importance of further research into the mechanisms underlying APOA2 function and its role in disease pathogenesis.

Genular Protein ID: 4018813222

Symbol: APOA2_HUMAN

Name: Apolipoprotein A-II

UniProtKB Accession Codes:

P02652 B2R524

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 66 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6428397

Title: Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII.

PubMed ID: 6428397

DOI: 10.1016/s0006-291x(84)80168-0

PubMed ID: 6089788

Title: Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1.

PubMed ID: 6089788

DOI: 10.1016/0006-291x(84)90371-1

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 2989800

Title: The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.

PubMed ID: 2989800

DOI: 10.1093/nar/13.12.4597

PubMed ID: 2995928

Title: The human apolipoprotein AII gene: structural organization and sites of expression.

PubMed ID: 2995928

DOI: 10.1093/nar/13.17.6387

PubMed ID: 3088392

Title: Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.

PubMed ID: 3088392

DOI: 10.1016/0076-6879(86)28103-3

PubMed ID: 12136239

Title: Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample.

PubMed ID: 12136239

DOI: 10.1007/s00439-002-0763-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4344225

Title: Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.

PubMed ID: 4344225

DOI: 10.1016/s0021-9258(19)44556-0

PubMed ID: 24116940

Title: Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris.

PubMed ID: 24116940

DOI: 10.1089/adt.2013.511

PubMed ID: 6407957

Title: Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products.

PubMed ID: 6407957

DOI: 10.1515/bchm2.1983.364.1.227

PubMed ID: 2107739

Title: A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.

PubMed ID: 2107739

PubMed ID: 7918467

Title: Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.

PubMed ID: 7918467

DOI: 10.1021/bi00207a011

PubMed ID: 10498661

Title: Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates.

PubMed ID: 10498661

DOI: 10.1002/hep.510300429

PubMed ID: 12269810

Title: Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions.

PubMed ID: 12269810

DOI: 10.1021/bi026069w

PubMed ID: 30278611

Title:

PubMed ID: 30278611

DOI: 10.1021/acs.biochem.8b00956

PubMed ID: 11991719

Title: Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.

PubMed ID: 11991719

DOI: 10.1006/geno.2002.6761

PubMed ID: 12576517

Title: Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.

PubMed ID: 12576517

DOI: 10.1194/jlr.m200256-jlr200

PubMed ID: 12562854

Title: Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins.

PubMed ID: 12562854

DOI: 10.1194/jlr.d200034-jlr200

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 19824718

Title: An initial characterization of the serum phosphoproteome.

PubMed ID: 19824718

DOI: 10.1021/pr900603n

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 100
  • Mass: 11175
  • Checksum: 1247868A25EC3AF2
  • Sequence:
    • MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME KVKSPELQAE 
AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.