APOA2 | ENSG00000158874 | NCBI 336

Details for: APOA2

Gene ID: 336

Symbol: APOA2

Ensembl ID: ENSG00000158874

Description: apolipoprotein A2

Associated with

Chylomicron assembly
(R-HSA-8963888)
Chylomicron remodeling
(R-HSA-8963901)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Retinoid metabolism and transport
(R-HSA-975634)
Sensory perception
(R-HSA-9709957)
Transport of small molecules
(R-HSA-382551)
Visual phototransduction
(R-HSA-2187338)
Animal organ regeneration
(GO:0031100)
Apolipoprotein receptor binding
(GO:0034190)
Blood microparticle
(GO:0072562)
Cholesterol binding
(GO:0015485)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol transfer activity
(GO:0120020)
Cholesterol transport
(GO:0030301)
Chylomicron
(GO:0042627)
Cytosol
(GO:0005829)
Diacylglycerol catabolic process
(GO:0046340)
Early endosome
(GO:0005769)
Endoplasmic reticulum lumen
(GO:0005788)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Heat shock protein binding
(GO:0031072)
High-density lipoprotein particle
(GO:0034364)
High-density lipoprotein particle assembly
(GO:0034380)
High-density lipoprotein particle binding
(GO:0008035)
High-density lipoprotein particle clearance
(GO:0034384)
High-density lipoprotein particle receptor binding
(GO:0070653)
High-density lipoprotein particle remodeling
(GO:0034375)
Intermembrane lipid transfer
(GO:0120009)
Lipase inhibitor activity
(GO:0055102)
Lipid binding
(GO:0008289)
Lipid transporter activity
(GO:0005319)
Low-density lipoprotein particle remodeling
(GO:0034374)
Negative regulation of cholesterol import
(GO:0060621)
Negative regulation of cholesterol transport
(GO:0032375)
Negative regulation of cholesterol transporter activity
(GO:0060695)
Negative regulation of cytokine production involved in immune response
(GO:0002719)
Negative regulation of lipase activity
(GO:0060192)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of very-low-density lipoprotein particle remodeling
(GO:0010903)
Peptidyl-methionine modification
(GO:0018206)
Phosphatidylcholine-sterol o-acyltransferase activator activity
(GO:0060228)
Phosphatidylcholine binding
(GO:0031210)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Phospholipid binding
(GO:0005543)
Phospholipid catabolic process
(GO:0009395)
Phospholipid efflux
(GO:0033700)
Positive regulation of coa-transferase activity
(GO:1905920)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of lipid catabolic process
(GO:0050996)
Positive regulation of phagocytosis
(GO:0050766)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein oxidation
(GO:0018158)
Protein stabilization
(GO:0050821)
Regulation of intestinal cholesterol absorption
(GO:0030300)
Regulation of protein stability
(GO:0031647)
Response to estrogen
(GO:0043627)
Response to glucocorticoid
(GO:0051384)
Response to glucose
(GO:0009749)
Response to xenobiotic stimulus
(GO:0009410)
Reverse cholesterol transport
(GO:0043691)
Signaling receptor binding
(GO:0005102)
Spherical high-density lipoprotein particle
(GO:0034366)
Triglyceride-rich lipoprotein particle remodeling
(GO:0034370)
Triglyceride metabolic process
(GO:0006641)
Very-low-density lipoprotein particle
(GO:0034361)

Other Information

Proteins

Apolipoprotein A-II

Genular Protein ID: 4018813222

Symbol: APOA2_HUMAN

Name: Apolipoprotein A-II

UniProtKB Accession Codes:

P02652 B2R524

Database IDs:

Citations:

PubMed ID: 6428397

Title: Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII.

PubMed ID: 6428397

DOI: 10.1016/s0006-291x(84)80168-0

PubMed ID: 6089788

Title: Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1.

PubMed ID: 6089788

DOI: 10.1016/0006-291x(84)90371-1

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 2989800

Title: The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.

PubMed ID: 2989800

DOI: 10.1093/nar/13.12.4597

PubMed ID: 2995928

Title: The human apolipoprotein AII gene: structural organization and sites of expression.

PubMed ID: 2995928

DOI: 10.1093/nar/13.17.6387

PubMed ID: 3088392

Title: Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.

PubMed ID: 3088392

DOI: 10.1016/0076-6879(86)28103-3

PubMed ID: 12136239

Title: Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample.

PubMed ID: 12136239

DOI: 10.1007/s00439-002-0763-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4344225

Title: Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.

PubMed ID: 4344225

DOI: 10.1016/s0021-9258(19)44556-0

PubMed ID: 24116940

Title: Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris.

PubMed ID: 24116940

DOI: 10.1089/adt.2013.511

PubMed ID: 6407957

Title: Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products.

PubMed ID: 6407957

DOI: 10.1515/bchm2.1983.364.1.227

PubMed ID: 2107739

Title: A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.

PubMed ID: 2107739

PubMed ID: 7918467

Title: Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.

PubMed ID: 7918467

DOI: 10.1021/bi00207a011

PubMed ID: 10498661

Title: Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates.

PubMed ID: 10498661

DOI: 10.1002/hep.510300429

PubMed ID: 12269810

Title: Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions.

PubMed ID: 12269810

DOI: 10.1021/bi026069w

PubMed ID: 30278611

Title:

PubMed ID: 30278611

DOI: 10.1021/acs.biochem.8b00956

PubMed ID: 11991719

Title: Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.

PubMed ID: 11991719

DOI: 10.1006/geno.2002.6761

PubMed ID: 12576517

Title: Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.

PubMed ID: 12576517

DOI: 10.1194/jlr.m200256-jlr200

PubMed ID: 12562854

Title: Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins.

PubMed ID: 12562854

DOI: 10.1194/jlr.d200034-jlr200

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 19824718

Title: An initial characterization of the serum phosphoproteome.

PubMed ID: 19824718

DOI: 10.1021/pr900603n

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

Length: 100
Mass: 11175
Checksum: 1247868A25EC3AF2
Sequence:

MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME KVKSPELQAE 
AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOA2

Associated with

Other Information

Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII. PubMed ID: 6428397

Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1. PubMed ID: 6089788

Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. PubMed ID: 6328445

The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization. PubMed ID: 2989800

The human apolipoprotein AII gene: structural organization and sites of expression. PubMed ID: 2995928

Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA. PubMed ID: 3088392

Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. PubMed ID: 12136239

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein. PubMed ID: 4344225

Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris. PubMed ID: 24116940

Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products. PubMed ID: 6407957

A splice-junction mutation responsible for familial apolipoprotein A-II deficiency. PubMed ID: 2107739

Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. PubMed ID: 7918467

Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates. PubMed ID: 10498661

Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions. PubMed ID: 12269810