Details for: APOA2

Gene ID: 336

Symbol: APOA2

Ensembl ID: ENSG00000158874

Description: apolipoprotein A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 14.4
    Marker Score: 47174
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 5.53
    Marker Score: 3451
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.42
    Marker Score: 18361
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 3.38
    Marker Score: 5208.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.27
    Marker Score: 9799
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.22
    Marker Score: 688
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.07
    Marker Score: 2215
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1990
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.97
    Marker Score: 12692
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.85
    Marker Score: 1853
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.73
    Marker Score: 379
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.47
    Marker Score: 1004
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.3
    Marker Score: 356.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.18
    Marker Score: 446.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7681
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.13
    Marker Score: 1265
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.12
    Marker Score: 465
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.12
    Marker Score: 708
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.03
    Marker Score: 694
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 438
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1920.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1345
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1540
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.81
    Marker Score: 614
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.81
    Marker Score: 370.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 460.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11854
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.67
    Marker Score: 252
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 408.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.62
    Marker Score: 897
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.55
    Marker Score: 197
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.53
    Marker Score: 247
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.53
    Marker Score: 302
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 139
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.52
    Marker Score: 454.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.51
    Marker Score: 516.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.49
    Marker Score: 1011
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 228
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.48
    Marker Score: 232
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.47
    Marker Score: 231
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2776
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.45
    Marker Score: 425.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 203
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.37
    Marker Score: 326.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.35
    Marker Score: 366
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 545
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 333
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 339
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.32
    Marker Score: 137
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.32
    Marker Score: 383
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.31
    Marker Score: 174
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.31
    Marker Score: 294
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.31
    Marker Score: 378
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 249.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.28
    Marker Score: 1788
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 265
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 460
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 302
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.25
    Marker Score: 593.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.25
    Marker Score: 54
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.23
    Marker Score: 190
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.22
    Marker Score: 150
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.22
    Marker Score: 192.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.21
    Marker Score: 199
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.19
    Marker Score: 147
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.18
    Marker Score: 3243
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 196
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.15
    Marker Score: 641

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Other Information

**Key characteristics:** * APOA2 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the liver, particularly in hepatocytes. * APOA2 is a key regulator of chylomicron assembly and remodeling. * It interacts with various proteins involved in the assembly and function of chylomicrons. * Mutations in APOA2 have been linked to several human diseases, including hyperalphalipoproteinemia and atherosclerosis. **Pathways and functions:** * APOA2 is involved in the assembly of chylomicrons from precursor proteins, including apolipoprotein A1 (APOA1) and apolipoprotein B (APOB). * It also plays a role in the remodeling and clearance of chylomicrons. * APOA2 is a key regulator of the transport of cholesterol and fat-soluble vitamins in the bloodstream. * It is involved in the metabolism of vitamin D, which is a key factor in the regulation of calcium and phosphate metabolism. * APOA2 is also involved in the regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs). **Clinical significance:** * Mutations in APOA2 have been linked to several human diseases, including hyperalphalipoproteinemia and atherosclerosis. * Hyperalphalipoproteinemia is a condition in which the blood contains too much cholesterol. * Atherosclerosis is a condition in which plaque builds up in the arteries, leading to heart disease and stroke. * APOA2 is a potential target for the treatment of these diseases. **Additional notes:** * APOA2 is a highly conserved protein, with similar sequences found in organisms from humans to mice. * It is a scaffolding protein, meaning that it helps to assemble other proteins into chylomicrons. * APOA2 is a very important protein in the metabolism of cholesterol and fat-soluble vitamins.

Genular Protein ID: 4018813222

Symbol: APOA2_HUMAN

Name: Apolipoprotein A-II

UniProtKB Accession Codes:

P02652 B2R524

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6428397

Title: Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII.

PubMed ID: 6428397

DOI: 10.1016/s0006-291x(84)80168-0

PubMed ID: 6089788

Title: Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1.

PubMed ID: 6089788

DOI: 10.1016/0006-291x(84)90371-1

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 2989800

Title: The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.

PubMed ID: 2989800

DOI: 10.1093/nar/13.12.4597

PubMed ID: 2995928

Title: The human apolipoprotein AII gene: structural organization and sites of expression.

PubMed ID: 2995928

DOI: 10.1093/nar/13.17.6387

PubMed ID: 3088392

Title: Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.

PubMed ID: 3088392

DOI: 10.1016/0076-6879(86)28103-3

PubMed ID: 12136239

Title: Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample.

PubMed ID: 12136239

DOI: 10.1007/s00439-002-0763-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4344225

Title: Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.

PubMed ID: 4344225

DOI: 10.1016/s0021-9258(19)44556-0

PubMed ID: 24116940

Title: Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris.

PubMed ID: 24116940

DOI: 10.1089/adt.2013.511

PubMed ID: 6407957

Title: Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products.

PubMed ID: 6407957

DOI: 10.1515/bchm2.1983.364.1.227

PubMed ID: 2107739

Title: A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.

PubMed ID: 2107739

PubMed ID: 7918467

Title: Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.

PubMed ID: 7918467

DOI: 10.1021/bi00207a011

PubMed ID: 10498661

Title: Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates.

PubMed ID: 10498661

DOI: 10.1002/hep.510300429

PubMed ID: 12269810

Title: Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions.

PubMed ID: 12269810

DOI: 10.1021/bi026069w

PubMed ID: 30278611

Title:

PubMed ID: 30278611

DOI: 10.1021/acs.biochem.8b00956

PubMed ID: 11991719

Title: Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.

PubMed ID: 11991719

DOI: 10.1006/geno.2002.6761

PubMed ID: 12576517

Title: Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.

PubMed ID: 12576517

DOI: 10.1194/jlr.m200256-jlr200

PubMed ID: 12562854

Title: Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins.

PubMed ID: 12562854

DOI: 10.1194/jlr.d200034-jlr200

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 19824718

Title: An initial characterization of the serum phosphoproteome.

PubMed ID: 19824718

DOI: 10.1021/pr900603n

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 100
  • Mass: 11175
  • Checksum: 1247868A25EC3AF2
  • Sequence:
    • MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME KVKSPELQAE 
AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.