Details for: ft

Gene ID: 33627

Symbol: ft

Ensembl ID: FBgn0001075

Description: fat

Associated with

  • Apicolateral plasma membrane
    (GO:0016327)
  • Cadherin binding
    (GO:0045296)
  • Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
    (GO:0016339)
  • Calcium ion binding
    (GO:0005509)
  • Cell-cell adhesion
    (GO:0098609)
  • Cell-cell adhesion mediated by cadherin
    (GO:0044331)
  • Equator specification
    (GO:0045317)
  • Establishment of body hair planar orientation
    (GO:0048105)
  • Establishment of imaginal disc-derived wing hair orientation
    (GO:0001737)
  • Establishment of ommatidial planar polarity
    (GO:0042067)
  • Establishment of planar polarity
    (GO:0001736)
  • Establishment of tissue polarity
    (GO:0007164)
  • Establishment or maintenance of polarity of larval imaginal disc epithelium
    (GO:0016336)
  • Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
    (GO:0007157)
  • Homophilic cell adhesion via plasma membrane adhesion molecules
    (GO:0007156)
  • Imaginal disc-derived wing morphogenesis
    (GO:0007476)
  • Imaginal disc growth
    (GO:0007446)
  • Imaginal disc pattern formation
    (GO:0007447)
  • Microtubule cytoskeleton organization involved in establishment of planar polarity
    (GO:0090176)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of growth
    (GO:0045926)
  • Negative regulation of imaginal disc growth
    (GO:0045571)
  • Negative regulation of organ growth
    (GO:0046621)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of hippo signaling
    (GO:0035332)
  • Protein binding
    (GO:0005515)
  • Protein localization involved in establishment of planar polarity
    (GO:0090251)
  • Pupal development
    (GO:0035209)
  • Regulation of establishment of planar polarity
    (GO:0090175)
  • Regulation of growth
    (GO:0040008)
  • Regulation of imaginal disc growth
    (GO:0045570)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of tube length, open tracheal system
    (GO:0035159)
  • Tissue development
    (GO:0009888)
  • Wing disc development
    (GO:0035220)

Other Information

Genular Protein ID: 3155023089

Symbol: FAT_DROME

Name: Cadherin-related tumor suppressor

UniProtKB Accession Codes:

P33450 Q9VQX5

Database IDs:

AGR 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 3 CTD 1 DIP 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 1 GO 38 Gene3D 3 GenomeRNAi 1 GlyCosmos 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PaxDb 1 Pfam 4 PhylomeDB 1 Proteomes 1 Reactome 3 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1959133

Title: The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily.

PubMed ID: 1959133

DOI: 10.1016/0092-8674(91)90359-7

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 11893338

Title: Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

PubMed ID: 11893338

DOI: 10.1016/s0092-8674(02)00658-x

PubMed ID: 12540853

Title: Fidelity in planar cell polarity signalling.

PubMed ID: 12540853

DOI: 10.1038/nature01366

PubMed ID: 15240556

Title: Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing.

PubMed ID: 15240556

DOI: 10.1242/dev.01254

PubMed ID: 15548581

Title: Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression.

PubMed ID: 15548581

DOI: 10.1242/dev.01550

PubMed ID: 16687445

Title: Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins.

PubMed ID: 16687445

DOI: 10.1242/dev.02401

PubMed ID: 16996265

Title: The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

PubMed ID: 16996265

DOI: 10.1016/j.cub.2006.09.005

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 18635802

Title: Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.

PubMed ID: 18635802

DOI: 10.1126/science.1158159

PubMed ID: 19574458

Title: Processing and phosphorylation of the Fat receptor.

PubMed ID: 19574458

DOI: 10.1073/pnas.0811540106

PubMed ID: 20434335

Title: Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed.

PubMed ID: 20434335

DOI: 10.1016/j.cub.2010.04.016

PubMed ID: 23667559

Title: The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.

PubMed ID: 23667559

DOI: 10.1371/journal.pone.0062998

PubMed ID: 25215488

Title: The atypical cadherin fat directly regulates mitochondrial function and metabolic state.

PubMed ID: 25215488

DOI: 10.1016/j.cell.2014.07.036

PubMed ID: 25107277

Title: The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.

PubMed ID: 25107277

DOI: 10.7554/elife.03383

Sequence Information:

  • Length: 5147
  • Mass: 564791
  • Checksum: 6A5A4743FC7E07D0
  • Sequence:
    • MERLLLLFFL LLAGRESLCQ TGDTKLELLA PRGRSYATTY EQYAAFPRRR SSSSSPSGEM 
QSRAVDTSAD FEVLEGQPRG TTVGFIPTKP KFSYRFNEPP REFTLDPVTG EVKTNVVLDR 
EGMRDHYDLV VLSSQPTYPI EVRIKVLDVN DNSPEFPEPS IAISFSESAT SGTRLLLDAA 
TDADVGENGV TDQYEIVAGN VDNKFRLVTT ANPSGDTSYL HLETTGNLDR ESRGSYQLNI 
SARDGGSPPR FGYLQVNVTI LDVNDNPPIF DHSDYNVSLN ETALPGTPVV TVMASDNDLG 
DNSKITYYLA ETEHQFTVNP ETGVISTTER VNCPQQTNVK SSASQKSCVF TVFARDHGSP 
RQDGRTYVTV NLLDTNDHDP IISFRFFPDG GKVATVDENA VNGTVVAAVA VKDSDSGLNG 
RTSVRIVSGN ELGHFRLEEA ADLHIVRVNG VLDREEIGKY NLTVVAMDQG TPARTTTAHL 
IIDVNDVNDH EPVFEKSEYS AVLSELAPTG SFVASITATD EDTGVNAQVH YDILSGNELK 
WFSMDPLTGL IVTTGPLDRE IRDTVELSIS ARDGGPNPKF AYTQLKVIIL DENDEAPQFS 
QREQNVTLGE DAPPQTIVAL MTATDHDQGT NGSVTFALAP SVERLYPLQF ALDALTGQLT 
TRRPLDREKM SQYEISVIAR DQGAPTPQSA TATVWLNVAD VNDNDPQFYP RHYIYSLADD 
DDDIKLKKEV EKERILLHVT ASDKDDGDNA LIEYRLESGG EGLFQLDARS GAISLRGDAP 
ASMHWKPHYK LLVSARDAGQ RRSQQDAIVE IVLKSKLEML ECGQAQAGGY EFQMVEDHEQ 
QRNSQPNREV GIVQVKSTNG KANSHIEYDI IQGDRAQNFR IDTRSGRITT ARPLDREEQA 
NYRLTILASS SSSSSAAASS VSYGQCIVNI AIIDLNDNAP VFALDRESEP TISLPENAAV 
GQEIYLSRVR DRDAGVNSRI SYSLTNNPNQ QFRIGPVTGV LYLQRPIRAE PGSLIHVELM 
ATDAGSPPLS SKLSLSVLIA DVNDHTPVFD HTSYETSLPE TTKVNTRFFA LAATDIDLGD 
NGRISYEIIE GNTERMFGVF PDGYLFVRAP LDREERDYYA LTVSCRDAGQ PSRSSVVPVV 
IHVIDENDNA PQFTNSTFTF SIPENAPADT FVGKLTAVDR DIGRNAELSF TLSSQTQDFT 
IDTRNGFIKT LRPFDREALV KVSRNAEASG EDGSLRGSMA GNYMLLEATV SDNGIPRLQD 
KVKVKVIVTD VNDNAPEFLR APYHVTISEG ASEGTHITHV FTQDADEGLN GDVYYSLAKG 
NEAGQFNLDS ATGQLSLGRR LDRESQEIHH LIVVAKDAAL KHPLSSNASI TIVVLDENDN 
APEFTQSSSE VSVLETSPTG TELMRFRASD ADQGVNSQVV FSISAGNRRD TFHIDSITGS 
LYLHKPLDYE DITSYTLNIT ASDCGTPSLS TTVLYNVLVV DDNDNPPIFP STAIVRQIKE 
GIPLKTPIVT VTADDPDSGL NGKVSYAISK QEPQLPQGRH FGINTETGVI HTLREIDRES 
IDTFRLTVVA TDRAQPSERQ LSTEKLVTVI VEDINDNAPV FVSMNAAILP PKFSTSKGSS 
TAVMQVHAKD ADSSSNGLVT YEIVSGPQEL FKLQRNTGII TFTPGPQFKQ EVRYQLTLKS 
TDEAVQSERR SSEVYITIIT PGSGGSESSV PQFEQRSKLS GSVYENEPIG TSILTVTAHL 
ASAEIEYFVT NVTATGSRGQ VDRLFDIDAK LGILSTAAEL DREAGPEEYE VEVYAIALGG 
QPRTSRTKVR VTVLDKNDSP PQFLDTPFVY NVSEDLQIGH TISTLRAHDP DTLGSVTFLL 
MDGHDGKFLL EPSTGKLILN DTLDRETKSK YELRIRVSDG VQYTEAYATI QVSDTNDNPP 
LFEDTVYSFD IPENAQRGYQ VGQIVARDAD LGQNAQLSYG VVSDWANDVF SLNPQTGMLT 
LTARLDYEEV QHYILIVQAQ DNGQPSLSTT ITVYCNVLDL NDNAPIFDPM SYSSEVFENV 
PIATEVVTVS AKDIDSGNNG LIEYSITAGD VDSEFGIDSN GTIRTRRNLD REHRSTYTLT 
VTARDCADEF ASFSELEETQ LKLKYRSPRK YQQTRQEFLA HQKQQRLSST VKVTILIKDV 
NDEVPVFISA NETAIMENVA INTVVIAVKA VDNDEGRNGY IDYLMKEARD EDMGQSDPLP 
FSLNPTDGQL RVVDALDREL RSSYLLNITA RDRGEPPQST ESQLLIRILD ENDNSPVFDP 
KQYSASVAEN ASIGAMVLQV SATDVDEGAN GRIRYSIVLG DQNHDFSISE DTGVVRVAKN 
LNYERLSRYS LTVRAEDCAL ENPAGDTAEL TINILDINDN RPTFLDSPYL ARVMENTVPP 
NGGYVLTVNA YDADTPPLNS QVRYFLKEGD SDLFRINASS GDIALLKPLD REQQSEYTLT 
LVAMDTGSPP LTGTGIVRVE VQDINDNDPV FELQSYHATV RENLPSGTHV LTPRATDKDE 
GLNAKLRFNL LGEHMHRFHI DSETGEISTA TTLDREETSV YHLTLMAQDS SITEPRASSV 
NLTISVSDVN DNIPKFDSTT YNVAVPERIS KGEFVFGARA LDLDDGENAV VHYTISGRDQ 
HYFDINTKTG VVSTKLELKT KTKSHDDLTY TIVISAMDQG EQSLSSKAEL TVILRPPELF 
PTFAYMANSH FAMSEDVRPG KMITKVSATS PKKGLVGKIR YAIAGGIMGD SLRVDPNSGL 
LSVGQDGLDY ELTHLYEIWI EAADGDTPSL RSVTLITLNV TDANDNAPVM EQLIYNAEVL 
EEESPPQLIA VVKASDRDSG DNGNVIYRLQ NDFDGTFEIT ESGEIYTRMR LDREEIGDYA 
FVVEAVDQGV PHMTGTASVL LHLLDKNDNP PKFTRLFSLN VTENAEIGSF VIRVTSSDLD 
LGANANASYS FSENPGEKFR IEPQSGNITV AGHLDREQQD EYILKVVASD GAWRAETPIT 
ITIQDQNDNA PEFEHSFYSF SFPELQQSIA LVGQIIATDR DKQGPNSVIS YSLQQPSPMF 
SIDPATGEVF SKKAVRFKHS QYVRSPENMY ALTVLATDNG KPPLYSECLV NINIVDAHNN 
PPKFEQAEYL APLPQDAVRG QRIVRVHAND KQDLGTNEMD YSLMTFNLSS IFSVGRHDGW 
ITLVKPIQVP PNTRYELVVR ATDRGVPPQS DETRVVIVVT GENMDTPRFS VNSYQVIVPE 
NEPVGSTILT VGATDDDTGP NGMLRYSISG GNERQDFSVD ERTGGIVIQQ QLDYDLIQEY 
HLNITVQDLG YHPLSSVAML TIILTDVNDN PPVFNHKEYH CYIPENKPVG TFVFQAHAAD 
KDSPKNAIIH YAFLPSGPDR HFFIMNQSNG TISSAVSFDY EERRIYTLQI KAKNPDSSME 
SYANLYVHVL GVNEFYPQFL QPVFHFDVSE TSAVGTRVGA VQATDKDSGE DGRVYYLLVG 
SSNDKGFRID TNTGLIYVAR HLDRETQNRV VLTVMAKNYG SIRGNDTDEA QVIISIQDGN 
DPPEFIKHYY TSTISEAAPV GTKVTTVKAI DKDVRTQNNQ FSYSIINGNL KQSFKIDVQT 
GEISTASRLD REETSTYNLV IGAIDTGLPP QTGSATVHIE LEDVNDNGPT FTPEGLNGYI 
SENEPAGTSI MTLIASDPDL PRNGGPFTYQ LIGGKHKSWL SVDRNSGVVR STTSFDREMT 
PILEAIIEVE DSGKPKQKSQ HLLTITVLDQ NDNPSTTRSL HIAVSLFNGD LPSNVKLADV 
RPNDIDIVGD YRCRLQKNPA QSQLQLAIPR ACDLITTSHT TPIASVFSYT GNDGKHGDVS 
SKVSVAFQSF NNETLANSVS IMVRNMTAYH FLANHYRPIL EMIKSRMSNE DEVILYSLLE 
GGSGNSTNLQ LLMAVRLAKT SYQQPKYLIE RLREKRSAFS ELLQKEVIVG YEPCSEPDVC 
ENGGVCSATM RLLDAHSFVI QDSPALVLSG PRVVHDYSCQ CTSGFSGEQC SRRQDPCLPN 
PCHSQVQCRR LGSDFQCMCP ANRDGKHCEK ERSDVCYSKP CRNGGSCQRS PDGSSYFCLC 
RPGFRGNQCE SVSDSCRPNP CLHGGLCVSL KPGYKCNCTP GRYGRHCERF SYGFQPLSYM 
TFPALDVTTN DISIVFATTK PNSLLLYNYG MQSGGRSDFL AIELVHGRAY FSSGGARTAI 
STVIAGRNLA DGGWHKVTAT RNGRVMSLSV AKCADSGDVC TECLPGDSSC YADEVGPVGT 
LNFNKQPLMI GGLSSADPIL ERPGQVHSDD LVGCLHSVHI GGRALNLSLP LQQKGILAGC 
NRQACQPALA AERCGGFAGQ CIDRWSSSLC QCGGHLQSPD CSDSLEPITL GEGAFVEFRI 
SEIYRRMQLL DNLYNSKSAW LDNQQMRERR AVSNFSTASQ IYEAPKMLSM LFRTYKDQGQ 
ILYAATNQMF TSLSLREGRL VYYSKQHLTI NMTVQETSTL NDGKWHNVSL FSESRSLRLI 
VDGRQVGDEL DIAGVHDFLD PYLTILNVGG EAFVGCLANV TVNNELQPLN GSGSIFPEVR 
YHGKIESGCR GDIGQDAAQV ADPLSIGFTL VIVFFVILVV AILGSYVIYR FRGKQEKIGS 
LSCGVPGFKI KHPGGPVTQS QVDHVLVRNL HPSEAPSPPV GAGDHMRPPV GSHHLVGPEL 
LTKKFKEPTA EMPQPQQQQQ RPQRPDIIER ESPLIREDHH LPIPPLHPLP LEHASSVDMG 
SEYPEHYDLE NASSIAPSDI DIVYHYKGYR EAAGLRKYKA SVPPVSAYTH HKHQNSGSQQ 
QQQQHRHTAP FVTRNQGGQP PPPPTSASRT HQSTPLARLS PSSELSSQQP RILTLHDISG 
KPLQSALLAT TSSSGGVGKD VHSNSERSLN SPVMSQLSGQ SSSASRQKPG VPQQQAQQTS 
MGLTAEEIER LNGRPRTCSL ISTLDAVSSS SEAPRVSSSA LHMSLGGDVD AHSSTSTDES 
GNDSFTCSEI EYDNNSLSGD GKYSTSKSLL DGRSPVSRAL SGGETSRNPP TTVVKTPPIP 
PHAYDGFESS FRGSLSTLVA SDDDIANHLS GIYRKANGAA SPSATTLGWE YLLNWGPSYE 
NLMGVFKDIA ELPDTNGPSQ QQQQQTQVVS TLRMPSSNGP AAPEEYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.