Details for: APOA4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: paneth cell of colon (CL0009009)
Fold Change: 47.8642
Cell Significance Index: 717.2000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 34.9697
Cell Significance Index: -16.5100 - Cell Name: precursor cell (CL0011115)
Fold Change: 10.6587
Cell Significance Index: 80.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 4.8738
Cell Significance Index: 140.4300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 4.6677
Cell Significance Index: 48.3200 - Cell Name: thymocyte (CL0000893)
Fold Change: 1.2679
Cell Significance Index: 16.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1638
Cell Significance Index: 37.2800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0727
Cell Significance Index: 23.2400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0401
Cell Significance Index: 62.4400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7422
Cell Significance Index: 73.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7385
Cell Significance Index: 666.8000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6134
Cell Significance Index: 42.4200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5574
Cell Significance Index: 11.8700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5093
Cell Significance Index: 101.0700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5070
Cell Significance Index: 55.1500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4623
Cell Significance Index: 16.2500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4190
Cell Significance Index: 68.1500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3694
Cell Significance Index: 70.2900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.0823
Cell Significance Index: 0.8300 - Cell Name: club cell (CL0000158)
Fold Change: -0.0012
Cell Significance Index: -0.0100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0162
Cell Significance Index: -10.1100 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0177
Cell Significance Index: -0.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0215
Cell Significance Index: -15.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0270
Cell Significance Index: -15.2200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0340
Cell Significance Index: -0.8500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0371
Cell Significance Index: -6.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0408
Cell Significance Index: -8.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0517
Cell Significance Index: -10.3700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0904
Cell Significance Index: -11.1200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0941
Cell Significance Index: -12.9200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1122
Cell Significance Index: -6.8800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1311
Cell Significance Index: -15.0200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1377
Cell Significance Index: -6.2400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2561
Cell Significance Index: -3.8600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2589
Cell Significance Index: -8.4800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2600
Cell Significance Index: -8.2800 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.2721
Cell Significance Index: -2.8700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2721
Cell Significance Index: -12.7900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3101
Cell Significance Index: -8.8900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3119
Cell Significance Index: -8.9000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3183
Cell Significance Index: -7.9500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3293
Cell Significance Index: -6.8300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3331
Cell Significance Index: -8.3100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3401
Cell Significance Index: -17.8600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3402
Cell Significance Index: -8.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3510
Cell Significance Index: -5.8800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3809
Cell Significance Index: -8.2300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3906
Cell Significance Index: -8.2900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4055
Cell Significance Index: -8.1400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4162
Cell Significance Index: -8.2300 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.4202
Cell Significance Index: -8.2700 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.4903
Cell Significance Index: -3.0300 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.5150
Cell Significance Index: -8.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5666
Cell Significance Index: -15.1300 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.5907
Cell Significance Index: -8.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6188
Cell Significance Index: -16.5800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.6224
Cell Significance Index: -8.8600 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.6364
Cell Significance Index: -12.6900 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.6522
Cell Significance Index: -4.5900 - Cell Name: granulocyte (CL0000094)
Fold Change: -0.6831
Cell Significance Index: -8.2400 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.6908
Cell Significance Index: -17.6000 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.7046
Cell Significance Index: -8.2900 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.7094
Cell Significance Index: -10.3400 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.7213
Cell Significance Index: -7.8900 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.7291
Cell Significance Index: -10.3600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.7328
Cell Significance Index: -10.5400 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.7429
Cell Significance Index: -8.0100 - Cell Name: mural cell (CL0008034)
Fold Change: -0.7483
Cell Significance Index: -9.1100 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.7485
Cell Significance Index: -12.5900 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.7506
Cell Significance Index: -12.8300 - Cell Name: promonocyte (CL0000559)
Fold Change: -0.7715
Cell Significance Index: -8.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7740
Cell Significance Index: -10.5600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.7786
Cell Significance Index: -12.8300 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.7900
Cell Significance Index: -8.2200 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.8155
Cell Significance Index: -8.2800 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.8242
Cell Significance Index: -9.2200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.8255
Cell Significance Index: -11.5700 - Cell Name: promyelocyte (CL0000836)
Fold Change: -0.8397
Cell Significance Index: -8.3000 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.8524
Cell Significance Index: -16.6700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8697
Cell Significance Index: -12.8400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.8729
Cell Significance Index: -12.5000 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.8782
Cell Significance Index: -7.3400 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: -0.8832
Cell Significance Index: -8.6500 - Cell Name: stem cell (CL0000034)
Fold Change: -0.8847
Cell Significance Index: -6.4300 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.8847
Cell Significance Index: -10.1300 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.8885
Cell Significance Index: -14.3900 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.9124
Cell Significance Index: -11.7500 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.9204
Cell Significance Index: -7.9200 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.9468
Cell Significance Index: -15.1900 - Cell Name: goblet cell (CL0000160)
Fold Change: -0.9663
Cell Significance Index: -8.7400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.9765
Cell Significance Index: -8.3000 - Cell Name: urothelial cell (CL0000731)
Fold Change: -0.9813
Cell Significance Index: -6.8400 - Cell Name: basal cell (CL0000646)
Fold Change: -0.9824
Cell Significance Index: -11.6900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0041
Cell Significance Index: -14.8200 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.0055
Cell Significance Index: -8.6400 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -1.0063
Cell Significance Index: -12.2400 - Cell Name: proerythroblast (CL0000547)
Fold Change: -1.0098
Cell Significance Index: -14.4700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.0111
Cell Significance Index: -17.4300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.0134
Cell Significance Index: -17.0700 - Cell Name: progenitor cell (CL0011026)
Fold Change: -1.0355
Cell Significance Index: -11.0000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 673944583
Symbol: APOA4_HUMAN
Name: Apolipoprotein A-IV
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3755616
Title: Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV.
PubMed ID: 3755616
DOI: 10.1021/bi00361a034
PubMed ID: 3095836
Title: Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4).
PubMed ID: 3095836
PubMed ID: 3036793
Title: Structure and expression of the human apolipoprotein A-IV gene.
PubMed ID: 3036793
PubMed ID: 2930771
Title: The primary structure of human apolipoprotein A-IV.
PubMed ID: 2930771
PubMed ID: 15108119
Title: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.
PubMed ID: 15108119
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3080432
Title: The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.
PubMed ID: 3080432
PubMed ID: 6706947
Title: Biosynthesis of human preapolipoprotein A-IV.
PubMed ID: 6706947
PubMed ID: 2351649
Title: Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.
PubMed ID: 2351649
PubMed ID: 1973689
Title: Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.
PubMed ID: 1973689
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22579246
Title: The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.
PubMed ID: 22579246
PubMed ID: 2065039
Title: The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.
PubMed ID: 2065039
PubMed ID: 1677358
Title: Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys).
PubMed ID: 1677358
PubMed ID: 1349197
Title: Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.
PubMed ID: 1349197
PubMed ID: 1737067
Title: A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.
PubMed ID: 1737067
PubMed ID: 1487136
Title: Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism.
PubMed ID: 1487136
PubMed ID: 7728150
Title: Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants.
PubMed ID: 7728150
PubMed ID: 8956036
Title: Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity.
PubMed ID: 8956036
DOI: 10.1002/(sici)1098-1004(1996)8:4<319::aid-humu4>3.0.co;2-2
PubMed ID: 10391210
Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
PubMed ID: 10391210
DOI: 10.1038/10297
Sequence Information:
- Length: 396
- Mass: 45372
- Checksum: 19307A196CAE0A4A
- Sequence:
MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE EIGKELEELR ARLLPHANEV SQKIGDNLRE LQQRLEPYAD QLRTQVSTQA EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG LTFQMKKNAE ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.