APOA4 | ENSG00000110244 | NCBI 337

Details for: APOA4

Gene ID: 337

Symbol: APOA4

Ensembl ID: ENSG00000110244

Description: apolipoprotein A4

Associated with

Amyloid fiber formation
(R-HSA-977225)
Assembly of active lpl and lipc lipase complexes
(R-HSA-8963889)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Retinoid metabolism and transport
(R-HSA-975634)
Sensory perception
(R-HSA-9709957)
Transport of small molecules
(R-HSA-382551)
Visual phototransduction
(R-HSA-2187338)
Acylglycerol homeostasis
(GO:0055090)
Antioxidant activity
(GO:0016209)
Blood microparticle
(GO:0072562)
Cell surface
(GO:0009986)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transfer activity
(GO:0120020)
Chylomicron
(GO:0042627)
Chylomicron assembly
(GO:0034378)
Chylomicron remodeling
(GO:0034371)
Collagen-containing extracellular matrix
(GO:0062023)
Copper ion binding
(GO:0005507)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extracellular vesicle
(GO:1903561)
High-density lipoprotein particle
(GO:0034364)
High-density lipoprotein particle remodeling
(GO:0034375)
Hydrogen peroxide catabolic process
(GO:0042744)
Identical protein binding
(GO:0042802)
Innate immune response in mucosa
(GO:0002227)
Intermembrane lipid transfer
(GO:0120009)
Leukocyte cell-cell adhesion
(GO:0007159)
Lipid binding
(GO:0008289)
Lipid catabolic process
(GO:0016042)
Lipid homeostasis
(GO:0055088)
Lipid transport
(GO:0006869)
Lipid transporter activity
(GO:0005319)
Lipoprotein metabolic process
(GO:0042157)
Low-density lipoprotein particle
(GO:0034362)
Negative regulation of plasma lipoprotein oxidation
(GO:0034445)
Peripheral nervous system axon regeneration
(GO:0014012)
Phosphatidylcholine-sterol o-acyltransferase activator activity
(GO:0060228)
Phosphatidylcholine binding
(GO:0031210)
Phosphatidylcholine metabolic process
(GO:0046470)
Phospholipid binding
(GO:0005543)
Phospholipid efflux
(GO:0033700)
Positive regulation of coa-transferase activity
(GO:1905920)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of triglyceride catabolic process
(GO:0010898)
Protein-lipid complex assembly
(GO:0065005)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of cholesterol transport
(GO:0032374)
Removal of superoxide radicals
(GO:0019430)
Response to lipid hydroperoxide
(GO:0006982)
Response to stilbenoid
(GO:0035634)
Response to triglyceride
(GO:0034014)
Reverse cholesterol transport
(GO:0043691)
Synapse
(GO:0045202)
Very-low-density lipoprotein particle
(GO:0034361)
Very-low-density lipoprotein particle remodeling
(GO:0034372)

Other Information

Proteins

Apolipoprotein A-IV

Genular Protein ID: 673944583

Symbol: APOA4_HUMAN

Name: Apolipoprotein A-IV

UniProtKB Accession Codes:

P06727 A8MSL6 Q14CW8 Q6Q787

Database IDs:

Citations:

PubMed ID: 3755616

Title: Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV.

PubMed ID: 3755616

DOI: 10.1021/bi00361a034

PubMed ID: 3095836

Title: Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4).

PubMed ID: 3095836

DOI: 10.1073/pnas.83.22.8457

PubMed ID: 3036793

Title: Structure and expression of the human apolipoprotein A-IV gene.

PubMed ID: 3036793

DOI: 10.1016/s0021-9258(18)47513-8

PubMed ID: 2930771

Title: The primary structure of human apolipoprotein A-IV.

PubMed ID: 2930771

DOI: 10.1016/0005-2760(89)90292-0

PubMed ID: 15108119

Title: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.

PubMed ID: 15108119

DOI: 10.1007/s00439-004-1106-x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3080432

Title: The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.

PubMed ID: 3080432

DOI: 10.1016/s0021-9258(17)35888-x

PubMed ID: 6706947

Title: Biosynthesis of human preapolipoprotein A-IV.

PubMed ID: 6706947

DOI: 10.1016/s0021-9258(17)43684-2

PubMed ID: 2351649

Title: Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.

PubMed ID: 2351649

DOI: 10.1016/s0021-9258(19)38779-4

PubMed ID: 1973689

Title: Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.

PubMed ID: 1973689

DOI: 10.1016/s0021-9258(19)38406-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22579246

Title: The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.

PubMed ID: 22579246

DOI: 10.1016/j.str.2012.02.020

PubMed ID: 2065039

Title: The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.

PubMed ID: 2065039

DOI: 10.1161/01.atv.11.4.851

PubMed ID: 1677358

Title: Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys).

PubMed ID: 1677358

DOI: 10.1016/s0021-9258(18)92728-6

PubMed ID: 1349197

Title: Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.

PubMed ID: 1349197

PubMed ID: 1737067

Title: A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.

PubMed ID: 1737067

DOI: 10.1016/0925-4439(92)90147-f

PubMed ID: 1487136

Title: Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism.

PubMed ID: 1487136

DOI: 10.1002/gepi.1370090602

PubMed ID: 7728150

Title: Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants.

PubMed ID: 7728150

DOI: 10.1002/humu.1380050108

PubMed ID: 8956036

Title: Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity.

PubMed ID: 8956036

DOI: 10.1002/(sici)1098-1004(1996)8:4<319::aid-humu4>3.0.co;2-2

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

Length: 396
Mass: 45372
Checksum: 19307A196CAE0A4A
Sequence:

MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ KSELTQQLNA 
LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE EIGKELEELR ARLLPHANEV 
SQKIGDNLRE LQQRLEPYAD QLRTQVSTQA EQLRRQLTPY AQRMERVLRE NADSLQASLR 
PHADELKAKI DQNVEELKGR LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG 
LTFQMKKNAE ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV 
EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE 
KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOA4

Associated with

Other Information

Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV. PubMed ID: 3755616

Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). PubMed ID: 3095836

Structure and expression of the human apolipoprotein A-IV gene. PubMed ID: 3036793

The primary structure of human apolipoprotein A-IV. PubMed ID: 2930771

The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. PubMed ID: 15108119

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. PubMed ID: 3080432

Biosynthesis of human preapolipoprotein A-IV. PubMed ID: 6706947

Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. PubMed ID: 2351649

Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1. PubMed ID: 1973689

Initial characterization of the human central proteome. PubMed ID: 21269460

The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. PubMed ID: 22579246

The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360. PubMed ID: 2065039

Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347--&gt;Ser), apoA-IV-0(Lys-167--&gt;Glu,Gln-360--&gt;His), and apoA-IV-3(Glu-165--&gt;Lys). PubMed ID: 1677358

Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. PubMed ID: 1349197

A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. PubMed ID: 1737067

Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism. PubMed ID: 1487136

Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants. PubMed ID: 7728150

Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. PubMed ID: 8956036

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210