Details for: APOBEC1

Gene ID: 339

Symbol: APOBEC1

Ensembl ID: ENSG00000111701

Description: apolipoprotein B mRNA editing enzyme catalytic subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6130
    Cell Significance Index: 75.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3858
    Cell Significance Index: 454.0400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.4981
    Cell Significance Index: 11.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3574
    Cell Significance Index: 81.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1341
    Cell Significance Index: 27.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0778
    Cell Significance Index: 23.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0614
    Cell Significance Index: 958.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9530
    Cell Significance Index: 103.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7521
    Cell Significance Index: 11.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6710
    Cell Significance Index: 14.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5736
    Cell Significance Index: 39.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5590
    Cell Significance Index: 90.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4898
    Cell Significance Index: 5.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3629
    Cell Significance Index: 5.2900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3492
    Cell Significance Index: 3.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2099
    Cell Significance Index: 20.7600
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1116
    Cell Significance Index: 0.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1115
    Cell Significance Index: 2.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1110
    Cell Significance Index: 1.1500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1100
    Cell Significance Index: 1.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1074
    Cell Significance Index: 1.8400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0809
    Cell Significance Index: 0.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0598
    Cell Significance Index: 0.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0535
    Cell Significance Index: 0.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0507
    Cell Significance Index: 2.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0412
    Cell Significance Index: 0.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0360
    Cell Significance Index: 0.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0339
    Cell Significance Index: 1.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0305
    Cell Significance Index: 3.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0272
    Cell Significance Index: 0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0266
    Cell Significance Index: 0.6800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0164
    Cell Significance Index: 0.2300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0079
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0012
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0024
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0027
    Cell Significance Index: -1.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0032
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0051
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0073
    Cell Significance Index: -1.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0074
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0078
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0086
    Cell Significance Index: -1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0101
    Cell Significance Index: -1.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0106
    Cell Significance Index: -0.3400
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0115
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0145
    Cell Significance Index: -1.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0147
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0165
    Cell Significance Index: -2.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0171
    Cell Significance Index: -0.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0173
    Cell Significance Index: -0.2600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0199
    Cell Significance Index: -1.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0199
    Cell Significance Index: -1.3400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0206
    Cell Significance Index: -0.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0215
    Cell Significance Index: -0.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0260
    Cell Significance Index: -2.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0273
    Cell Significance Index: -1.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0281
    Cell Significance Index: -0.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0304
    Cell Significance Index: -0.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0305
    Cell Significance Index: -1.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0308
    Cell Significance Index: -1.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0348
    Cell Significance Index: -1.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0352
    Cell Significance Index: -1.8300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0371
    Cell Significance Index: -0.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0386
    Cell Significance Index: -0.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0393
    Cell Significance Index: -1.0500
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0408
    Cell Significance Index: -0.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0411
    Cell Significance Index: -1.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0437
    Cell Significance Index: -1.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0463
    Cell Significance Index: -2.6000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0465
    Cell Significance Index: -0.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0466
    Cell Significance Index: -0.9100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0470
    Cell Significance Index: -0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0475
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0475
    Cell Significance Index: -1.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0487
    Cell Significance Index: -1.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0489
    Cell Significance Index: -1.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0506
    Cell Significance Index: -1.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0528
    Cell Significance Index: -0.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0537
    Cell Significance Index: -0.7700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0538
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0586
    Cell Significance Index: -0.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0588
    Cell Significance Index: -1.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0602
    Cell Significance Index: -1.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0604
    Cell Significance Index: -1.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** APOBEC1 exhibits several key characteristics that distinguish it from other cytidine deaminases: 1. **Specificity**: APOBEC1 is highly specific for cytidine, with a low specificity for other nucleotides. 2. **Catalytic activity**: APOBEC1 catalyzes the conversion of cytidine to uridine, a process that is essential for maintaining genomic stability. 3. **RNA editing**: APOBEC1 is involved in the editing of RNA, including apolipoprotein B mRNA, which is critical for lipid metabolism and lipoprotein formation. 4. **DNA demethylation**: APOBEC1 is also involved in the regulation of DNA methylation, a process that is essential for maintaining genomic stability and preventing mutations. **Pathways and Functions** APOBEC1 is involved in several critical pathways, including: 1. **Apolipoprotein B mRNA editing**: APOBEC1 is involved in the editing of apolipoprotein B mRNA, a critical step in lipid metabolism and lipoprotein formation. 2. **DNA demethylation**: APOBEC1 is involved in the regulation of DNA methylation, a process that is essential for maintaining genomic stability and preventing mutations. 3. **RNA editing**: APOBEC1 is involved in the editing of RNA, including apolipoprotein B mRNA, which is critical for lipid metabolism and lipoprotein formation. 4. **Lipid metabolism**: APOBEC1 is involved in the regulation of lipid metabolism, including the formation of lipoproteins. **Clinical Significance** APOBEC1 has significant clinical implications, including: 1. **Cancer**: APOBEC1 has been implicated in the development of several types of cancer, including colorectal, breast, and prostate cancer. 2. **Autoimmune disorders**: APOBEC1 has been implicated in the development of autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Infectious diseases**: APOBEC1 has been implicated in the regulation of immune responses to viral infections, including HIV and herpes simplex virus. 4. **Genetic disorders**: APOBEC1 has been implicated in the development of genetic disorders, including sickle cell anemia and thalassemia. In conclusion, APOBEC1 is a critical gene that plays a pivotal role in the regulation of DNA methylation, RNA editing, and lipid metabolism. Its dysregulation has significant clinical implications, including the development of cancer, autoimmune disorders, infectious diseases, and genetic disorders. Further research is necessary to fully understand the mechanisms and clinical significance of APOBEC1.

Genular Protein ID: 2915535221

Symbol: ABEC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P41238 Q9UE64 Q9UM71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8208612

Title: Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein.

PubMed ID: 8208612

DOI: 10.1093/nar/22.10.1874

PubMed ID: 8078915

Title: Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.

PubMed ID: 8078915

DOI: 10.1073/pnas.91.18.8522

PubMed ID: 9186903

Title: Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide.

PubMed ID: 9186903

PubMed ID: 9479499

Title: Human apolipoprotein B RNA editing deaminase gene (APOBEC1).

PubMed ID: 9479499

DOI: 10.1006/geno.1997.5110

PubMed ID: 8999813

Title: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing.

PubMed ID: 8999813

DOI: 10.1074/jbc.272.3.1452

PubMed ID: 11352648

Title: Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome.

PubMed ID: 11352648

DOI: 10.1006/bbrc.2001.4679

PubMed ID: 11727199

Title: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.

PubMed ID: 11727199

DOI: 10.1086/337952

PubMed ID: 22580899

Title: Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor.

PubMed ID: 22580899

DOI: 10.1161/atvbaha.112.250043

PubMed ID: 24916387

Title: C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.

PubMed ID: 24916387

DOI: 10.15252/embr.201438450

PubMed ID: 30844405

Title: Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.

PubMed ID: 30844405

DOI: 10.1016/j.jmb.2019.02.025

Sequence Information:

  • Length: 236
  • Mass: 28192
  • Checksum: 28466B43F7FD82F7
  • Sequence:
    • MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN 
HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI REFLSRHPGV TLVIYVARLF 
WHMDQQNRQG LRDLVNSGVT IQIMRASEYY HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL 
ELHCIILSLP PCLKISRRWQ NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.