APOBEC1 | ENSG00000111701 | NCBI 339

Details for: APOBEC1

Gene ID: 339

Symbol: APOBEC1

Ensembl ID: ENSG00000111701

Description: apolipoprotein B mRNA editing enzyme catalytic subunit 1

Associated with

Formation of the editosome
(R-HSA-75094)
Metabolism of rna
(R-HSA-8953854)
Mrna editing
(R-HSA-75072)
Mrna editing: c to u conversion
(R-HSA-72200)
Apolipoprotein b mrna editing enzyme complex
(GO:0030895)
Cytidine deaminase activity
(GO:0004126)
Cytidine deamination
(GO:0009972)
Cytidine to uridine editing
(GO:0016554)
Cytoplasm
(GO:0005737)
Dna demethylation
(GO:0080111)
Establishment of localization in cell
(GO:0051649)
Lipid metabolic process
(GO:0006629)
Lipoprotein biosynthetic process
(GO:0042158)
Lipoprotein transport
(GO:0042953)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna editing complex
(GO:0045293)
Mrna modification
(GO:0016556)
Mrna processing
(GO:0006397)
Mrna stabilization
(GO:0048255)
Negative regulation of dna methylation-dependent heterochromatin formation
(GO:0090310)
Negative regulation of nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:2000623)
Negative regulation of triglyceride metabolic process
(GO:0090209)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna demethylation
(GO:1901537)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Response to gamma radiation
(GO:0010332)
Rna binding
(GO:0003723)
Triglyceride metabolic process
(GO:0006641)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

ABEC1_HUMAN

Genular Protein ID: 2915535221

Symbol: ABEC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P41238 Q9UE64 Q9UM71

Database IDs:

Citations:

PubMed ID: 8208612

Title: Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein.

PubMed ID: 8208612

DOI: 10.1093/nar/22.10.1874

PubMed ID: 8078915

Title: Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.

PubMed ID: 8078915

DOI: 10.1073/pnas.91.18.8522

PubMed ID: 9186903

Title: Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide.

PubMed ID: 9186903

PubMed ID: 9479499

Title: Human apolipoprotein B RNA editing deaminase gene (APOBEC1).

PubMed ID: 9479499

DOI: 10.1006/geno.1997.5110

PubMed ID: 8999813

Title: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing.

PubMed ID: 8999813

DOI: 10.1074/jbc.272.3.1452

PubMed ID: 11352648

Title: Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome.

PubMed ID: 11352648

DOI: 10.1006/bbrc.2001.4679

PubMed ID: 11727199

Title: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.

PubMed ID: 11727199

DOI: 10.1086/337952

PubMed ID: 22580899

Title: Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor.

PubMed ID: 22580899

DOI: 10.1161/atvbaha.112.250043

PubMed ID: 24916387

Title: C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.

PubMed ID: 24916387

DOI: 10.15252/embr.201438450

PubMed ID: 30844405

Title: Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.

PubMed ID: 30844405

DOI: 10.1016/j.jmb.2019.02.025

Sequence Information:

Length: 236
Mass: 28192
Checksum: 28466B43F7FD82F7
Sequence:

MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN 
HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI REFLSRHPGV TLVIYVARLF 
WHMDQQNRQG LRDLVNSGVT IQIMRASEYY HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL 
ELHCIILSLP PCLKISRRWQ NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOBEC1

Associated with

Other Information

Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. PubMed ID: 8208612

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. PubMed ID: 8078915

Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. PubMed ID: 9186903

Human apolipoprotein B RNA editing deaminase gene (APOBEC1). PubMed ID: 9479499

Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. PubMed ID: 8999813

Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. PubMed ID: 11352648

C--&gt;U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. PubMed ID: 11727199

Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. PubMed ID: 22580899

C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. PubMed ID: 24916387

Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells. PubMed ID: 30844405