APOC1 | ENSG00000130208 | NCBI 341

Details for: APOC1

Gene ID: 341

Symbol: APOC1

Ensembl ID: ENSG00000130208

Description: apolipoprotein C1

Associated with

Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Vldl assembly
(R-HSA-8866423)
Vldl clearance
(R-HSA-8964046)
Cholesterol efflux
(GO:0033344)
Cholesterol metabolic process
(GO:0008203)
Chylomicron
(GO:0042627)
Chylomicron remnant clearance
(GO:0034382)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Fatty acid binding
(GO:0005504)
High-density lipoprotein particle
(GO:0034364)
High-density lipoprotein particle remodeling
(GO:0034375)
Lipase inhibitor activity
(GO:0055102)
Lipid metabolic process
(GO:0006629)
Lipoprotein metabolic process
(GO:0042157)
Negative regulation of cholesterol transport
(GO:0032375)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of lipid metabolic process
(GO:0045833)
Negative regulation of lipoprotein lipase activity
(GO:0051005)
Negative regulation of phosphatidylcholine catabolic process
(GO:0010900)
Negative regulation of receptor-mediated endocytosis
(GO:0048261)
Negative regulation of very-low-density lipoprotein particle clearance
(GO:0010916)
Phosphatidylcholine-sterol o-acyltransferase activator activity
(GO:0060228)
Phosphatidylcholine binding
(GO:0031210)
Phospholipase inhibitor activity
(GO:0004859)
Phospholipid efflux
(GO:0033700)
Plasma lipoprotein particle remodeling
(GO:0034369)
Protein binding
(GO:0005515)
Regulation of cholesterol transport
(GO:0032374)
Triglyceride metabolic process
(GO:0006641)
Very-low-density lipoprotein particle
(GO:0034361)
Very-low-density lipoprotein particle assembly
(GO:0034379)
Very-low-density lipoprotein particle clearance
(GO:0034447)

Other Information

Proteins

Apolipoprotein C-I

Genular Protein ID: 2135632176

Symbol: APOC1_HUMAN

Name: Apolipoprotein C-I

UniProtKB Accession Codes:

P02654 B2R526 Q6IB97

Database IDs:

Citations:

PubMed ID: 6328444

Title: Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

PubMed ID: 6328444

DOI: 10.1093/nar/12.9.3909

PubMed ID: 2835369

Title: Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

PubMed ID: 2835369

DOI: 10.1016/s0021-9258(18)68638-7

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985493

Title: Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

PubMed ID: 2985493

DOI: 10.1007/bf00291654

PubMed ID: 166984

Title: The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

PubMed ID: 166984

DOI: 10.1016/s0021-9258(19)41998-4

PubMed ID: 4369340

Title: The primary structure of apolipoprotein-serine.

PubMed ID: 4369340

DOI: 10.1016/s0021-9258(19)42365-x

PubMed ID: 2897845

Title: Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene.

PubMed ID: 2897845

DOI: 10.1016/s0006-291x(88)80424-8

PubMed ID: 17339654

Title: Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.

PubMed ID: 17339654

DOI: 10.1194/jlr.m700024-jlr200

PubMed ID: 28757862

Title: Proteogenomic Review of the Changes in Primate apoC-I during Evolution.

PubMed ID: 28757862

DOI: 10.1007/s11515-013-1278-7

PubMed ID: 25160599

Title: Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.

PubMed ID: 25160599

DOI: 10.1016/j.cbd.2014.08.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Title: MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a protein peak corresponding to ApoC1 and LuzP6.

DOI: 10.4236/ojmn.2018.83021

PubMed ID: 7779782

Title: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy.

PubMed ID: 7779782

DOI: 10.1021/bi00022a013

PubMed ID: 9300485

Title: Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy.

PubMed ID: 9300485

DOI: 10.1002/pro.5560060906

PubMed ID: 10545169

Title: Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy.

PubMed ID: 10545169

DOI: 10.1021/bi982966h

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 16981907

Title: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry.

PubMed ID: 16981907

DOI: 10.1111/j.1742-4658.2006.05473.x

Sequence Information:

Length: 83
Mass: 9332
Checksum: 4A3614626624AE6A
Sequence:

MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL 
SAKMREWFSE TFQKVKEKLK IDS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOC1

Associated with

Other Information

Characterisation of mRNAs encoding the precursor for human apolipoprotein CI. PubMed ID: 6328444

Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. PubMed ID: 2835369

Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. PubMed ID: 10520737

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. PubMed ID: 2985493

The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins. PubMed ID: 166984

The primary structure of apolipoprotein-serine. PubMed ID: 4369340

Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. PubMed ID: 2897845

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification. PubMed ID: 17339654

Proteogenomic Review of the Changes in Primate apoC-I during Evolution. PubMed ID: 28757862

Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes. PubMed ID: 25160599

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a protein peak corresponding to ApoC1 and LuzP6.

Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. PubMed ID: 7779782

Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. PubMed ID: 9300485

Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy. PubMed ID: 10545169

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210

A functional polymorphism of apolipoprotein C1 detected by mass spectrometry. PubMed ID: 16981907