Details for: APOC1

Gene ID: 341

Symbol: APOC1

Ensembl ID: ENSG00000130208

Description: apolipoprotein C1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.94
    Marker Score: 29,272
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.7
    Marker Score: 83,404
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.61
    Marker Score: 19,432
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.59
    Marker Score: 3,858
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.58
    Marker Score: 21,739
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.31
    Marker Score: 3,539
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.23
    Marker Score: 2,016
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.05
    Marker Score: 77,986
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.53
    Marker Score: 16,512
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.36
    Marker Score: 10,182
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.23
    Marker Score: 2,227
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.16
    Marker Score: 2,319
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.14
    Marker Score: 3,437
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.13
    Marker Score: 13,672
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.12
    Marker Score: 2,288
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2
    Marker Score: 834
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.98
    Marker Score: 1,346
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.89
    Marker Score: 3,133
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.82
    Marker Score: 7,850
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.73
    Marker Score: 3,296
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.71
    Marker Score: 2,143
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.68
    Marker Score: 838
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.66
    Marker Score: 2,391
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.66
    Marker Score: 8,740
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.65
    Marker Score: 1,129
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.63
    Marker Score: 2,263
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.58
    Marker Score: 346
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.58
    Marker Score: 594
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.51
    Marker Score: 384
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.44
    Marker Score: 16,233
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.38
    Marker Score: 46,897
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.37
    Marker Score: 1,572
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.34
    Marker Score: 486
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.31
    Marker Score: 623
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.27
    Marker Score: 3,313
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.26
    Marker Score: 346
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.26
    Marker Score: 1,804
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.25
    Marker Score: 3,249
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.24
    Marker Score: 660
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.19
    Marker Score: 1,435
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.16
    Marker Score: 829
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 865
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.13
    Marker Score: 972
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.13
    Marker Score: 18,109
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.11
    Marker Score: 2,831
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.1
    Marker Score: 14,783
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.09
    Marker Score: 1,538
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.08
    Marker Score: 323
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2,520
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.07
    Marker Score: 522
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.03
    Marker Score: 385
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.02
    Marker Score: 1,478
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.01
    Marker Score: 9,953
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,750
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1
    Marker Score: 549
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.97
    Marker Score: 284
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.96
    Marker Score: 1,394
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.93
    Marker Score: 681
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.92
    Marker Score: 456
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.92
    Marker Score: 1,021
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,192
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1,400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.9
    Marker Score: 387
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.88
    Marker Score: 922
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.88
    Marker Score: 1,090
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.85
    Marker Score: 352
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.83
    Marker Score: 1,143
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 634
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.82
    Marker Score: 1,501
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.82
    Marker Score: 254
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.81
    Marker Score: 403
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8
    Marker Score: 228
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1,285
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.79
    Marker Score: 4,676
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.78
    Marker Score: 175
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3,028
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.77
    Marker Score: 902
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,218
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1,254
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.76
    Marker Score: 1,178
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.76
    Marker Score: 523
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.75
    Marker Score: 239
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.74
    Marker Score: 524
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1,150
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.72
    Marker Score: 328
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.71
    Marker Score: 2,620
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7
    Marker Score: 7,036
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.7
    Marker Score: 1,930
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.7
    Marker Score: 183

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOC1 is a small, secreted protein that belongs to the apolipoprotein family. It is composed of 108 amino acids and is characterized by its ability to bind phospholipids, fatty acids, and cholesterol. APOC1's lipid-binding properties enable it to participate in various lipid metabolic processes, including cholesterol efflux, fatty acid biosynthesis, and lipoprotein assembly and clearance. The gene is highly conserved across species, suggesting its evolutionary importance in lipid metabolism. **Pathways and Functions:** APOC1 is involved in several key lipid metabolic pathways, including: 1. **Cholesterol Efflux:** APOC1 facilitates the transfer of cholesterol from peripheral tissues to the liver, promoting cholesterol efflux and reducing the risk of atherosclerosis. 2. **Fatty Acid Biosynthesis:** APOC1 inhibits fatty acid biosynthesis by regulating the activity of key enzymes, such as acetyl-CoA carboxylase and fatty acid synthase. 3. **Lipoprotein Assembly and Clearance:** APOC1 participates in the assembly and clearance of plasma lipoproteins, including high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL). 4. **Phospholipid Metabolism:** APOC1 regulates phospholipid metabolism by inhibiting phospholipase activity and promoting phosphatidylcholine synthesis. 5. **Signal Transduction:** APOC1 interacts with nuclear receptors, such as NR1H2 and NR1H3, to regulate gene expression linked to lipid transport and metabolism. **Clinical Significance:** Dysregulation of APOC1 has been implicated in various metabolic disorders, including: 1. **Atherosclerosis:** Reduced APOC1 expression has been linked to increased risk of atherosclerosis and cardiovascular disease. 2. **Hyperlipidemia:** APOC1's role in lipid metabolism makes it a potential therapeutic target for the treatment of hyperlipidemia and dyslipidemia. 3. **Type 2 Diabetes:** APOC1's involvement in fatty acid biosynthesis and lipoprotein metabolism suggests its potential role in the pathogenesis of type 2 diabetes. In conclusion, APOC1 is a crucial regulator of lipid metabolism, and its dysregulation can have significant consequences for human health. Further research is needed to fully elucidate the mechanisms by which APOC1 influences lipid metabolism and to explore its therapeutic potential in metabolic disorders.

Genular Protein ID: 2135632176

Symbol: APOC1_HUMAN

Name: Apolipoprotein C-I

UniProtKB Accession Codes:

P02654 B2R526 Q6IB97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6328444

Title: Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

PubMed ID: 6328444

DOI: 10.1093/nar/12.9.3909

PubMed ID: 2835369

Title: Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

PubMed ID: 2835369

DOI: 10.1016/s0021-9258(18)68638-7

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985493

Title: Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

PubMed ID: 2985493

DOI: 10.1007/bf00291654

PubMed ID: 166984

Title: The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

PubMed ID: 166984

DOI: 10.1016/s0021-9258(19)41998-4

PubMed ID: 4369340

Title: The primary structure of apolipoprotein-serine.

PubMed ID: 4369340

DOI: 10.1016/s0021-9258(19)42365-x

PubMed ID: 2897845

Title: Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene.

PubMed ID: 2897845

DOI: 10.1016/s0006-291x(88)80424-8

PubMed ID: 17339654

Title: Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.

PubMed ID: 17339654

DOI: 10.1194/jlr.m700024-jlr200

PubMed ID: 28757862

Title: Proteogenomic Review of the Changes in Primate apoC-I during Evolution.

PubMed ID: 28757862

DOI: 10.1007/s11515-013-1278-7

PubMed ID: 25160599

Title: Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.

PubMed ID: 25160599

DOI: 10.1016/j.cbd.2014.08.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Title: MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a protein peak corresponding to ApoC1 and LuzP6.

DOI: 10.4236/ojmn.2018.83021

PubMed ID: 7779782

Title: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy.

PubMed ID: 7779782

DOI: 10.1021/bi00022a013

PubMed ID: 9300485

Title: Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy.

PubMed ID: 9300485

DOI: 10.1002/pro.5560060906

PubMed ID: 10545169

Title: Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy.

PubMed ID: 10545169

DOI: 10.1021/bi982966h

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 16981907

Title: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry.

PubMed ID: 16981907

DOI: 10.1111/j.1742-4658.2006.05473.x

Sequence Information:

  • Length: 83
  • Mass: 9332
  • Checksum: 4A3614626624AE6A
  • Sequence:
    • MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL 
SAKMREWFSE TFQKVKEKLK IDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.