Details for: APOC1

Gene ID: 341

Symbol: APOC1

Ensembl ID: ENSG00000130208

Description: apolipoprotein C1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.5315
    Cell Significance Index: -23.4700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.2631
    Cell Significance Index: -14.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.5180
    Cell Significance Index: -26.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.7650
    Cell Significance Index: -25.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.8721
    Cell Significance Index: -24.4900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 36.3522
    Cell Significance Index: 16.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1644
    Cell Significance Index: -25.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.0241
    Cell Significance Index: -20.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.1746
    Cell Significance Index: 245.8400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 8.0600
    Cell Significance Index: 40.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9807
    Cell Significance Index: -23.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.9439
    Cell Significance Index: 83.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.4094
    Cell Significance Index: 68.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.7568
    Cell Significance Index: 745.5500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.7533
    Cell Significance Index: 28.3400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.0740
    Cell Significance Index: 18.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.0594
    Cell Significance Index: 31.9400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.8756
    Cell Significance Index: 16.5600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.6466
    Cell Significance Index: 7.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.1138
    Cell Significance Index: 31.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9131
    Cell Significance Index: 54.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4241
    Cell Significance Index: 100.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1775
    Cell Significance Index: 161.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0530
    Cell Significance Index: 200.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7829
    Cell Significance Index: 77.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7480
    Cell Significance Index: 330.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5028
    Cell Significance Index: 4.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4712
    Cell Significance Index: 425.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4426
    Cell Significance Index: 71.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4200
    Cell Significance Index: 8.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3820
    Cell Significance Index: 41.5600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3734
    Cell Significance Index: 2.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3485
    Cell Significance Index: 45.0300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3148
    Cell Significance Index: 1.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3033
    Cell Significance Index: 54.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2837
    Cell Significance Index: 7.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2566
    Cell Significance Index: 15.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1966
    Cell Significance Index: 9.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1737
    Cell Significance Index: 131.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1380
    Cell Significance Index: 16.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0635
    Cell Significance Index: 2.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0473
    Cell Significance Index: 25.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0464
    Cell Significance Index: 4.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0124
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0194
    Cell Significance Index: -35.7000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0229
    Cell Significance Index: -0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0235
    Cell Significance Index: -36.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0269
    Cell Significance Index: -36.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0300
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0341
    Cell Significance Index: -25.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0357
    Cell Significance Index: -26.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0363
    Cell Significance Index: -20.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0401
    Cell Significance Index: -25.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0410
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0520
    Cell Significance Index: -6.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0528
    Cell Significance Index: -18.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0626
    Cell Significance Index: -28.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0968
    Cell Significance Index: -19.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1171
    Cell Significance Index: -5.3100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.1179
    Cell Significance Index: -0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1363
    Cell Significance Index: -3.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1395
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1444
    Cell Significance Index: -30.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1525
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1551
    Cell Significance Index: -26.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1608
    Cell Significance Index: -4.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1708
    Cell Significance Index: -24.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1938
    Cell Significance Index: -22.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1994
    Cell Significance Index: -10.4700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2009
    Cell Significance Index: -1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2042
    Cell Significance Index: -10.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2145
    Cell Significance Index: -15.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2176
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2211
    Cell Significance Index: -25.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2248
    Cell Significance Index: -7.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2290
    Cell Significance Index: -23.8400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2328
    Cell Significance Index: -0.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2902
    Cell Significance Index: -17.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2976
    Cell Significance Index: -7.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3264
    Cell Significance Index: -20.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3330
    Cell Significance Index: -26.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3331
    Cell Significance Index: -4.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3532
    Cell Significance Index: -14.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3758
    Cell Significance Index: -28.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3763
    Cell Significance Index: -25.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4047
    Cell Significance Index: -20.4500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.4120
    Cell Significance Index: -3.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4425
    Cell Significance Index: -28.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4600
    Cell Significance Index: -25.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4633
    Cell Significance Index: -16.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4761
    Cell Significance Index: -24.8000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.4806
    Cell Significance Index: -1.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5171
    Cell Significance Index: -7.4100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5294
    Cell Significance Index: -5.0300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.5617
    Cell Significance Index: -5.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5639
    Cell Significance Index: -7.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5776
    Cell Significance Index: -26.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOC1 is a small, secreted protein that belongs to the apolipoprotein family. It is composed of 108 amino acids and is characterized by its ability to bind phospholipids, fatty acids, and cholesterol. APOC1's lipid-binding properties enable it to participate in various lipid metabolic processes, including cholesterol efflux, fatty acid biosynthesis, and lipoprotein assembly and clearance. The gene is highly conserved across species, suggesting its evolutionary importance in lipid metabolism. **Pathways and Functions:** APOC1 is involved in several key lipid metabolic pathways, including: 1. **Cholesterol Efflux:** APOC1 facilitates the transfer of cholesterol from peripheral tissues to the liver, promoting cholesterol efflux and reducing the risk of atherosclerosis. 2. **Fatty Acid Biosynthesis:** APOC1 inhibits fatty acid biosynthesis by regulating the activity of key enzymes, such as acetyl-CoA carboxylase and fatty acid synthase. 3. **Lipoprotein Assembly and Clearance:** APOC1 participates in the assembly and clearance of plasma lipoproteins, including high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL). 4. **Phospholipid Metabolism:** APOC1 regulates phospholipid metabolism by inhibiting phospholipase activity and promoting phosphatidylcholine synthesis. 5. **Signal Transduction:** APOC1 interacts with nuclear receptors, such as NR1H2 and NR1H3, to regulate gene expression linked to lipid transport and metabolism. **Clinical Significance:** Dysregulation of APOC1 has been implicated in various metabolic disorders, including: 1. **Atherosclerosis:** Reduced APOC1 expression has been linked to increased risk of atherosclerosis and cardiovascular disease. 2. **Hyperlipidemia:** APOC1's role in lipid metabolism makes it a potential therapeutic target for the treatment of hyperlipidemia and dyslipidemia. 3. **Type 2 Diabetes:** APOC1's involvement in fatty acid biosynthesis and lipoprotein metabolism suggests its potential role in the pathogenesis of type 2 diabetes. In conclusion, APOC1 is a crucial regulator of lipid metabolism, and its dysregulation can have significant consequences for human health. Further research is needed to fully elucidate the mechanisms by which APOC1 influences lipid metabolism and to explore its therapeutic potential in metabolic disorders.

Genular Protein ID: 2135632176

Symbol: APOC1_HUMAN

Name: Apolipoprotein C-I

UniProtKB Accession Codes:

P02654 B2R526 Q6IB97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6328444

Title: Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

PubMed ID: 6328444

DOI: 10.1093/nar/12.9.3909

PubMed ID: 2835369

Title: Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

PubMed ID: 2835369

DOI: 10.1016/s0021-9258(18)68638-7

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985493

Title: Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

PubMed ID: 2985493

DOI: 10.1007/bf00291654

PubMed ID: 166984

Title: The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

PubMed ID: 166984

DOI: 10.1016/s0021-9258(19)41998-4

PubMed ID: 4369340

Title: The primary structure of apolipoprotein-serine.

PubMed ID: 4369340

DOI: 10.1016/s0021-9258(19)42365-x

PubMed ID: 2897845

Title: Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene.

PubMed ID: 2897845

DOI: 10.1016/s0006-291x(88)80424-8

PubMed ID: 17339654

Title: Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.

PubMed ID: 17339654

DOI: 10.1194/jlr.m700024-jlr200

PubMed ID: 28757862

Title: Proteogenomic Review of the Changes in Primate apoC-I during Evolution.

PubMed ID: 28757862

DOI: 10.1007/s11515-013-1278-7

PubMed ID: 25160599

Title: Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.

PubMed ID: 25160599

DOI: 10.1016/j.cbd.2014.08.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Title: MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a protein peak corresponding to ApoC1 and LuzP6.

DOI: 10.4236/ojmn.2018.83021

PubMed ID: 7779782

Title: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy.

PubMed ID: 7779782

DOI: 10.1021/bi00022a013

PubMed ID: 9300485

Title: Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy.

PubMed ID: 9300485

DOI: 10.1002/pro.5560060906

PubMed ID: 10545169

Title: Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy.

PubMed ID: 10545169

DOI: 10.1021/bi982966h

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 16981907

Title: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry.

PubMed ID: 16981907

DOI: 10.1111/j.1742-4658.2006.05473.x

Sequence Information:

  • Length: 83
  • Mass: 9332
  • Checksum: 4A3614626624AE6A
  • Sequence:
    • MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL 
SAKMREWFSE TFQKVKEKLK IDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.