Details for: APOC1

Gene ID: 341

Symbol: APOC1

Ensembl ID: ENSG00000130208

Description: apolipoprotein C1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.94
    Marker Score: 29272
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.7
    Marker Score: 83404
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.61
    Marker Score: 19432
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.59
    Marker Score: 3858
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.58
    Marker Score: 21739
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.31
    Marker Score: 3539
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.23
    Marker Score: 2016
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.05
    Marker Score: 77986
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.53
    Marker Score: 16512
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.36
    Marker Score: 10182
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.23
    Marker Score: 2227
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.16
    Marker Score: 2318.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.14
    Marker Score: 3437
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.13
    Marker Score: 13672
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.12
    Marker Score: 2288
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2
    Marker Score: 834
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.98
    Marker Score: 1346
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.89
    Marker Score: 3133
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.82
    Marker Score: 7850
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.73
    Marker Score: 3296
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.71
    Marker Score: 2143
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.68
    Marker Score: 838
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.66
    Marker Score: 2391
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.66
    Marker Score: 8740
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.65
    Marker Score: 1129
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.63
    Marker Score: 2263
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.58
    Marker Score: 346
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.58
    Marker Score: 594
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.51
    Marker Score: 384
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.44
    Marker Score: 16233
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.38
    Marker Score: 46897
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.37
    Marker Score: 1572
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.34
    Marker Score: 485.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.31
    Marker Score: 623
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.27
    Marker Score: 3313
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.26
    Marker Score: 346
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.26
    Marker Score: 1804
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.25
    Marker Score: 3249
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.24
    Marker Score: 659.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.19
    Marker Score: 1435
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.16
    Marker Score: 829
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 865
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.13
    Marker Score: 972
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.13
    Marker Score: 18109
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.11
    Marker Score: 2831
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.1
    Marker Score: 14783
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.09
    Marker Score: 1538
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.08
    Marker Score: 323
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2519.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.07
    Marker Score: 522
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.03
    Marker Score: 385
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.02
    Marker Score: 1478
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.01
    Marker Score: 9953
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71750
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1
    Marker Score: 549
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.97
    Marker Score: 284
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.96
    Marker Score: 1394
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.93
    Marker Score: 681
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.92
    Marker Score: 456
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.92
    Marker Score: 1021
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5192
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.9
    Marker Score: 387
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.88
    Marker Score: 922
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.88
    Marker Score: 1090
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.85
    Marker Score: 352
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.83
    Marker Score: 1143
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 634
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.82
    Marker Score: 1501
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.82
    Marker Score: 254
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.81
    Marker Score: 403
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8
    Marker Score: 228
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1285
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.79
    Marker Score: 4675.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.78
    Marker Score: 175
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3028
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.77
    Marker Score: 902
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3217.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1254
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.76
    Marker Score: 1178
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.76
    Marker Score: 523
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.75
    Marker Score: 239
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.74
    Marker Score: 524
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1150
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.72
    Marker Score: 328
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.71
    Marker Score: 2620
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7
    Marker Score: 7036
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.7
    Marker Score: 1930
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.7
    Marker Score: 183

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Other Information

**Key characteristics:** - APOC1 is a large protein with a molecular weight of approximately 120 kDa. - It is a glycoprotein with a unique structure that allows it to interact with both cholesterol and fatty acids. - APOC1 is a key regulator of the reverse cholesterol transport (RCT) pathway, which is responsible for the removal of cholesterol from the bloodstream and its return to the liver for processing. - APOC1 also plays a role in the regulation of lipid metabolism, including the assembly and clearance of very-low-density lipoprotein (VLDL) particles. **Pathways and functions:** - APOC1 is involved in the regulation of cholesterol transport and efflux from the bloodstream into cells. - It is a key regulator of the reverse cholesterol transport (RCT) pathway, which is responsible for the removal of cholesterol from the bloodstream and its return to the liver for processing. - APOC1 also plays a role in the regulation of lipid metabolism, including the assembly and clearance of VLDL particles. - It is also involved in the assembly and clearance of high-density lipoprotein (HDL) particles, which are responsible for transporting cholesterol away from cells. **Clinical significance:** - Mutations in the APOC1 gene have been linked to several human diseases, including hyperlipidemia, atherosclerosis, and cardiovascular disease. - APOC1 is a potential therapeutic target for these diseases, as it can be used to inhibit the activity of the enzyme that is responsible for the production of APOC1. - By inhibiting APOC1, it is possible to reduce cholesterol levels and improve cardiovascular health.

Genular Protein ID: 2135632176

Symbol: APOC1_HUMAN

Name: Apolipoprotein C-I

UniProtKB Accession Codes:

P02654 B2R526 Q6IB97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6328444

Title: Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

PubMed ID: 6328444

DOI: 10.1093/nar/12.9.3909

PubMed ID: 2835369

Title: Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

PubMed ID: 2835369

DOI: 10.1016/s0021-9258(18)68638-7

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985493

Title: Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19.

PubMed ID: 2985493

DOI: 10.1007/bf00291654

PubMed ID: 166984

Title: The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

PubMed ID: 166984

DOI: 10.1016/s0021-9258(19)41998-4

PubMed ID: 4369340

Title: The primary structure of apolipoprotein-serine.

PubMed ID: 4369340

DOI: 10.1016/s0021-9258(19)42365-x

PubMed ID: 2897845

Title: Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene.

PubMed ID: 2897845

DOI: 10.1016/s0006-291x(88)80424-8

PubMed ID: 17339654

Title: Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.

PubMed ID: 17339654

DOI: 10.1194/jlr.m700024-jlr200

PubMed ID: 28757862

Title: Proteogenomic Review of the Changes in Primate apoC-I during Evolution.

PubMed ID: 28757862

DOI: 10.1007/s11515-013-1278-7

PubMed ID: 25160599

Title: Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.

PubMed ID: 25160599

DOI: 10.1016/j.cbd.2014.08.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Title: MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a protein peak corresponding to ApoC1 and LuzP6.

DOI: 10.4236/ojmn.2018.83021

PubMed ID: 7779782

Title: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy.

PubMed ID: 7779782

DOI: 10.1021/bi00022a013

PubMed ID: 9300485

Title: Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy.

PubMed ID: 9300485

DOI: 10.1002/pro.5560060906

PubMed ID: 10545169

Title: Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy.

PubMed ID: 10545169

DOI: 10.1021/bi982966h

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 16981907

Title: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry.

PubMed ID: 16981907

DOI: 10.1111/j.1742-4658.2006.05473.x

Sequence Information:

  • Length: 83
  • Mass: 9332
  • Checksum: 4A3614626624AE6A
  • Sequence:
    • MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL 
SAKMREWFSE TFQKVKEKLK IDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.