numb | FBgn0002973 | NCBI 34263

Details for: numb

Gene ID: 34263

Symbol: numb

Ensembl ID: FBgn0002973

Description: numb

Associated with

Asymmetric neuroblast division
(GO:0055059)
Basal part of cell
(GO:0045178)
Cell cortex
(GO:0005938)
Centrosome localization
(GO:0051642)
Cytoplasm
(GO:0005737)
Embryonic heart tube development
(GO:0035050)
Enteroendocrine cell differentiation
(GO:0035883)
Glial cell migration
(GO:0008347)
Malpighian tubule tip cell differentiation
(GO:0061382)
Muscle cell fate specification
(GO:0042694)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of receptor recycling
(GO:0001920)
Neuroblast development
(GO:0014019)
Neuroblast proliferation
(GO:0007405)
Notch binding
(GO:0005112)
Pericardial nephrocyte differentiation
(GO:0061320)
Positive regulation of endocytosis
(GO:0045807)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of asymmetric cell division
(GO:0009786)
Regulation of nervous system development
(GO:0051960)
Regulation of neuroblast proliferation
(GO:1902692)
Regulation of neurogenesis
(GO:0050767)
Sensory organ precursor cell division
(GO:0045035)
Sensory organ precursor cell fate determination
(GO:0016360)

Other Information

Proteins

Protein numb

Genular Protein ID: 4122523637

Symbol: NUMB_DROME

Name: Protein numb

UniProtKB Accession Codes:

P16554 B8A413 B8A419 Q8IPE9 Q961A6 Q9VLB8

Database IDs:

Citations:

PubMed ID: 2752427

Title: Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.

PubMed ID: 2752427

DOI: 10.1016/0092-8674(89)90849-0

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 18342578

Title: The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.

PubMed ID: 18342578

DOI: 10.1016/j.devcel.2008.03.004

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 24550111

Title: Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors.

PubMed ID: 24550111

DOI: 10.1242/dev.106534

PubMed ID: 26481050

Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

PubMed ID: 26481050

DOI: 10.1016/j.devcel.2015.09.016

PubMed ID: 28899667

Title: bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression.

PubMed ID: 28899667

DOI: 10.1016/j.ydbio.2017.09.011

PubMed ID: 9846878

Title: Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.

PubMed ID: 9846878

DOI: 10.1038/4185

PubMed ID: 10747019

Title: Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.

PubMed ID: 10747019

DOI: 10.1093/emboj/19.7.1505

Sequence Information:

Length: 556
Mass: 60614
Checksum: 91B26959B5DE8405
Sequence:

MGNSSSHTHE PLERGFTRGK FGDVKNGKSA SFRFSKKSPK KMDRLRRSFR DSFRRRKDRV 
PESSKPHQWQ ADEEAVRSAT CSFSVKYLGC VEVFESRGMQ VCEEALKVLR QSRRRPVRGL 
LHVSGDGLRV VDDETKGLIV DQTIEKVSFC APDRNHERGF SYICRDGTTR RWMCHGFLAC 
KDSGERLSHA VGCAFAVCLE RKQRRDKECG VTMTFDTKNS TFTRTGSFRQ QTLTERLAMA 
TVGTNERSVD GPGSAMPGPP AATVKPFNPF AIERPHATPN MLERQSSFRL STIGSQSPFK 
RQMSLRINDL PSNADRQRAF LTAAAGNPMQ TPLRSVSPIA EVSPAKSAGA DPLSAAAVAA 
DSVSQLCQEL SQGLSLLTQT DALLAAGEDL NFNNNRSINQ NIIAAEKQVQ HVHSYAPPTA 
QVTPRVASTT PTYQTLHSQS PSRSEQSIET STELPNAEQW LGHVVRSTSP AAPKRPTYLA 
NVGRAQTLAS GTGAAVGGGG PDDPFDAEWV ANVAAAKQLS PDLPIPSTAR SPLARHSTNP 
FISPPKAPAQ SFQVQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: numb

Associated with

Other Information

Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. PubMed ID: 2752427

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. PubMed ID: 18342578

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors. PubMed ID: 24550111

Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs. PubMed ID: 26481050

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression. PubMed ID: 28899667

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. PubMed ID: 9846878

Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb. PubMed ID: 10747019