Details for: AQP8

Gene ID: 343

Symbol: AQP8

Ensembl ID: ENSG00000103375

Description: aquaporin 8

Associated with

Other Information

Genular Protein ID: 4093251244

Symbol: AQP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94778 Q8IUU3 Q9UIA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9806845

Title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.

PubMed ID: 9806845

DOI: 10.1006/geno.1998.5552

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15948717

Title: Purification and functional characterization of aquaporin-8.

PubMed ID: 15948717

DOI: 10.1042/bc20050026

PubMed ID: 18948439

Title: Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.

PubMed ID: 18948439

DOI: 10.1152/ajpgi.90410.2008

PubMed ID: 20144166

Title: Expression of aquaporin 8 is diversely regulated by osmotic stress in amnion epithelial cells.

PubMed ID: 20144166

DOI: 10.1111/j.1447-0756.2009.01061.x

PubMed ID: 22622463

Title: Mitochondrial aquaporin-8 in renal proximal tubule cells: evidence for a role in the response to metabolic acidosis.

PubMed ID: 22622463

DOI: 10.1152/ajprenal.00226.2012

PubMed ID: 28042826

Title: Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.

PubMed ID: 28042826

DOI: 10.3390/ijms18010066

PubMed ID: 23541115

Title: Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

PubMed ID: 23541115

DOI: 10.1089/ars.2013.5330

PubMed ID: 26972385

Title: Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

PubMed ID: 26972385

DOI: 10.1089/ars.2016.6636

PubMed ID: 29732408

Title: A persulfidation-based mechanism controls aquaporin-8 conductance.

PubMed ID: 29732408

DOI: 10.1126/sciadv.aar5770

PubMed ID: 30579780

Title: Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis.

PubMed ID: 30579780

DOI: 10.1016/j.freeradbiomed.2018.12.016

PubMed ID: 34292591

Title: Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene.

PubMed ID: 34292591

DOI: 10.1002/bit.27901

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 261
  • Mass: 27381
  • Checksum: B5328B07A2049B3B
  • Sequence:
    • MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF IGCLSVIENG 
TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM LIGGLNLVML LPYWVSQLLG 
GMLGAALAKA VSPEERFWNA SGAAFVTVQE QGQVAGALVA EIILTTLLAL AVCMGAINEK 
TKGPLAPFSI GFAVTVDILA GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL 
VGLLIRCFIG DGKTRLILKA R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.