Details for: AQP8

Gene ID: 343

Symbol: AQP8

Ensembl ID: ENSG00000103375

Description: aquaporin 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.59
    Marker Score: 1824
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.31
    Marker Score: 4885
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.61
    Marker Score: 5042
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 391
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.76
    Marker Score: 1564.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1416
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.7
    Marker Score: 2069
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.7
    Marker Score: 393
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10423
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.58
    Marker Score: 894
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1076
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.47
    Marker Score: 468
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 230
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.33
    Marker Score: 101
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.32
    Marker Score: 170
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 321
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.24
    Marker Score: 2009.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.24
    Marker Score: 1572
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.2
    Marker Score: 173
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2
    Marker Score: 76
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 427
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.18
    Marker Score: 78.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 175
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 111
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 375
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.08
    Marker Score: 83
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 801
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.08
    Marker Score: 670
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.08
    Marker Score: 366
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.07
    Marker Score: 168
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.07
    Marker Score: 1003
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 102
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.06
    Marker Score: 177
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.06
    Marker Score: 686
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.06
    Marker Score: 3618
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.06
    Marker Score: 1165
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.06
    Marker Score: 252
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.06
    Marker Score: 224
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.06
    Marker Score: 99
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.06
    Marker Score: 2129
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.05
    Marker Score: 497
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 23

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Other Information

## Summary AQP8 is a water channel protein that is expressed in various cell types in the human body. It is involved in a variety of cellular processes, including aquaporin-mediated transport, B cell differentiation, cellular responses to stimuli, cellular responses to stress, and detoxification of reactive oxygen species. ## Key characteristics * AQP8 is a water channel protein that is found in the plasma membrane of cells. * It is a member of the Aquaporin family of water channels. * AQP8 is expressed in a variety of cell types, including acinar cell, pancreatic acinar cell, colon epithelial cell, enterocyte of epithelium of small intestine, cerebral cortex GABAergic interneuron, forebrain radial glial cell, tuft cell of colon, absorptive cell, BEST4+ intestinal epithelial cell. * AQP8 is a highly conserved protein, with a sequence that is found in vertebrates. ## Pathways and functions AQP8 is involved in a variety of cellular processes, including: * **Aquaporin-mediated transport:** AQP8 is a key protein for aquaporin-mediated transport, which is the movement of water across cell membranes. This process is important for a variety of cellular functions, including maintaining the water balance of cells, transporting nutrients and waste products, and facilitating the transport of ions. * **B cell differentiation:** AQP8 is expressed in high levels in the developing immune system, including B cells. This suggests that AQP8 is involved in the differentiation of B cells. * **Cellular responses to stimuli:** AQP8 is also expressed in cells that respond to stimuli, such as inflammatory cells and neurons. This suggests that AQP8 is involved in the regulation of inflammatory responses. * **Cellular responses to stress:** AQP8 is also involved in the regulation of cellular responses to stress, such as heat shock and cold shock. This suggests that AQP8 is involved in the protection of cells from stress. * **Detoxification of reactive oxygen species:** AQP8 is a key protein for the detoxification of reactive oxygen species (ROS), which are produced in large amounts during oxidative stress. This suggests that AQP8 is involved in the protection of cells from damage caused by ROS. ## Clinical significance Mutations in AQP8 have been linked to a number of human diseases, including kidney disease, diabetes, and cancer. This suggests that AQP8 is an important protein for human health. Further research is needed to understand the role of AQP8 in human disease and to develop treatments for these diseases.

Genular Protein ID: 4093251244

Symbol: AQP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94778 Q8IUU3 Q9UIA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9806845

Title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.

PubMed ID: 9806845

DOI: 10.1006/geno.1998.5552

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15948717

Title: Purification and functional characterization of aquaporin-8.

PubMed ID: 15948717

DOI: 10.1042/bc20050026

PubMed ID: 18948439

Title: Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.

PubMed ID: 18948439

DOI: 10.1152/ajpgi.90410.2008

PubMed ID: 20144166

Title: Expression of aquaporin 8 is diversely regulated by osmotic stress in amnion epithelial cells.

PubMed ID: 20144166

DOI: 10.1111/j.1447-0756.2009.01061.x

PubMed ID: 22622463

Title: Mitochondrial aquaporin-8 in renal proximal tubule cells: evidence for a role in the response to metabolic acidosis.

PubMed ID: 22622463

DOI: 10.1152/ajprenal.00226.2012

PubMed ID: 28042826

Title: Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.

PubMed ID: 28042826

DOI: 10.3390/ijms18010066

PubMed ID: 23541115

Title: Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

PubMed ID: 23541115

DOI: 10.1089/ars.2013.5330

PubMed ID: 26972385

Title: Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

PubMed ID: 26972385

DOI: 10.1089/ars.2016.6636

PubMed ID: 29732408

Title: A persulfidation-based mechanism controls aquaporin-8 conductance.

PubMed ID: 29732408

DOI: 10.1126/sciadv.aar5770

PubMed ID: 30579780

Title: Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis.

PubMed ID: 30579780

DOI: 10.1016/j.freeradbiomed.2018.12.016

PubMed ID: 34292591

Title: Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene.

PubMed ID: 34292591

DOI: 10.1002/bit.27901

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 261
  • Mass: 27381
  • Checksum: B5328B07A2049B3B
  • Sequence:
    • MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF IGCLSVIENG 
TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM LIGGLNLVML LPYWVSQLLG 
GMLGAALAKA VSPEERFWNA SGAAFVTVQE QGQVAGALVA EIILTTLLAL AVCMGAINEK 
TKGPLAPFSI GFAVTVDILA GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL 
VGLLIRCFIG DGKTRLILKA R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.