Details for: AQP8

Gene ID: 343

Symbol: AQP8

Ensembl ID: ENSG00000103375

Description: aquaporin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 24.0337
    Cell Significance Index: 12.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.8350
    Cell Significance Index: -1.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5004
    Cell Significance Index: 48.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0059
    Cell Significance Index: 45.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8808
    Cell Significance Index: 150.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4003
    Cell Significance Index: 5.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3325
    Cell Significance Index: 8.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2921
    Cell Significance Index: 4.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2718
    Cell Significance Index: 4.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2318
    Cell Significance Index: 44.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1772
    Cell Significance Index: 2.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1592
    Cell Significance Index: 2.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1475
    Cell Significance Index: 14.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1395
    Cell Significance Index: 2.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0740
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0709
    Cell Significance Index: 44.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0514
    Cell Significance Index: 3.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0434
    Cell Significance Index: 0.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0406
    Cell Significance Index: 0.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0377
    Cell Significance Index: 7.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0361
    Cell Significance Index: 0.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0222
    Cell Significance Index: 4.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0221
    Cell Significance Index: 7.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0190
    Cell Significance Index: 13.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0172
    Cell Significance Index: 1.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0163
    Cell Significance Index: 1.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0116
    Cell Significance Index: 0.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0102
    Cell Significance Index: 0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0043
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0032
    Cell Significance Index: 1.4100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0009
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0007
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0007
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0007
    Cell Significance Index: 1.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0007
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0030
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0037
    Cell Significance Index: -1.0600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0065
    Cell Significance Index: -0.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0082
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0110
    Cell Significance Index: -1.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0113
    Cell Significance Index: -0.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0113
    Cell Significance Index: -0.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0122
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0130
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0131
    Cell Significance Index: -1.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0146
    Cell Significance Index: -1.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0162
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0162
    Cell Significance Index: -1.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0170
    Cell Significance Index: -0.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0173
    Cell Significance Index: -0.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0177
    Cell Significance Index: -0.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0192
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0198
    Cell Significance Index: -0.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0206
    Cell Significance Index: -0.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0218
    Cell Significance Index: -1.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0225
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0226
    Cell Significance Index: -0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0242
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0245
    Cell Significance Index: -0.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0259
    Cell Significance Index: -1.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0268
    Cell Significance Index: -0.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0282
    Cell Significance Index: -1.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0322
    Cell Significance Index: -0.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0323
    Cell Significance Index: -0.9300
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0324
    Cell Significance Index: -0.1900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0340
    Cell Significance Index: -1.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0344
    Cell Significance Index: -0.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0349
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0372
    Cell Significance Index: -1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0373
    Cell Significance Index: -1.3100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0377
    Cell Significance Index: -0.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0377
    Cell Significance Index: -0.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0405
    Cell Significance Index: -0.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0415
    Cell Significance Index: -1.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0417
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0425
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0425
    Cell Significance Index: -0.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0460
    Cell Significance Index: -1.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0478
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AQP8 is a type II transmembrane protein, composed of six transmembrane helices and two extracellular loops. It is expressed in various tissues, including the pancreas, colon, and brain, where it plays a crucial role in maintaining cellular homeostasis. AQP8 is a water channel protein, allowing the transport of water and small molecules, such as urea and hydrogen peroxide, across cell membranes. Its expression is regulated by various factors, including hormones, growth factors, and stress signals. **Pathways and Functions:** AQP8 is involved in several cellular pathways, including: 1. **Ammonium transport:** AQP8 mediates the transport of ammonium across cell membranes, playing a crucial role in maintaining cellular pH and osmoregulation. 2. **Detoxification:** AQP8 helps to detoxify reactive oxygen species (ROS) by transporting hydrogen peroxide and other ROS across cell membranes. 3. **Transepithelial water transport:** AQP8 is involved in the transport of water across epithelial cell membranes, regulating water balance and electrolyte homeostasis. 4. **Cellular responses to stimuli:** AQP8 is sensitive to various stimuli, including hormones, growth factors, and stress signals, allowing it to regulate cellular responses to changes in the cellular microenvironment. **Clinical Significance:** Dysregulation of AQP8 expression and function has been implicated in various diseases and disorders, including: 1. **Pancreatitis:** AQP8 is overexpressed in pancreatitis, where it contributes to the formation of pancreatic fluid and the development of acute pancreatitis. 2. **Colorectal cancer:** AQP8 is overexpressed in colorectal cancer cells, where it facilitates the transport of ions and small molecules, contributing to tumor growth and metastasis. 3. **Neurodegenerative diseases:** AQP8 is involved in the transport of ions and small molecules across blood-brain barrier, where its dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Kidney disease:** AQP8 is involved in the transport of ions and small molecules in the kidneys, where its dysregulation may contribute to kidney disease and dysfunction. In conclusion, AQP8 is a multifaceted protein involved in various cellular processes, including detoxification, transepithelial water transport, and cellular responses to stimuli. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of AQP8 in human health and disease.

Genular Protein ID: 4093251244

Symbol: AQP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94778 Q8IUU3 Q9UIA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9806845

Title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.

PubMed ID: 9806845

DOI: 10.1006/geno.1998.5552

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15948717

Title: Purification and functional characterization of aquaporin-8.

PubMed ID: 15948717

DOI: 10.1042/bc20050026

PubMed ID: 18948439

Title: Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.

PubMed ID: 18948439

DOI: 10.1152/ajpgi.90410.2008

PubMed ID: 20144166

Title: Expression of aquaporin 8 is diversely regulated by osmotic stress in amnion epithelial cells.

PubMed ID: 20144166

DOI: 10.1111/j.1447-0756.2009.01061.x

PubMed ID: 22622463

Title: Mitochondrial aquaporin-8 in renal proximal tubule cells: evidence for a role in the response to metabolic acidosis.

PubMed ID: 22622463

DOI: 10.1152/ajprenal.00226.2012

PubMed ID: 28042826

Title: Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.

PubMed ID: 28042826

DOI: 10.3390/ijms18010066

PubMed ID: 23541115

Title: Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

PubMed ID: 23541115

DOI: 10.1089/ars.2013.5330

PubMed ID: 26972385

Title: Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

PubMed ID: 26972385

DOI: 10.1089/ars.2016.6636

PubMed ID: 29732408

Title: A persulfidation-based mechanism controls aquaporin-8 conductance.

PubMed ID: 29732408

DOI: 10.1126/sciadv.aar5770

PubMed ID: 30579780

Title: Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis.

PubMed ID: 30579780

DOI: 10.1016/j.freeradbiomed.2018.12.016

PubMed ID: 34292591

Title: Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene.

PubMed ID: 34292591

DOI: 10.1002/bit.27901

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 261
  • Mass: 27381
  • Checksum: B5328B07A2049B3B
  • Sequence:
    • MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF IGCLSVIENG 
TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM LIGGLNLVML LPYWVSQLLG 
GMLGAALAKA VSPEERFWNA SGAAFVTVQE QGQVAGALVA EIILTTLLAL AVCMGAINEK 
TKGPLAPFSI GFAVTVDILA GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL 
VGLLIRCFIG DGKTRLILKA R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.