Details for: APOC2

Gene ID: 344

Symbol: APOC2

Ensembl ID: ENSG00000234906

Description: apolipoprotein C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 5.9516
    Cell Significance Index: 15.7000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.5367
    Cell Significance Index: 13.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7824
    Cell Significance Index: 89.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8018
    Cell Significance Index: 81.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6911
    Cell Significance Index: 321.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3563
    Cell Significance Index: 81.4300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2485
    Cell Significance Index: 7.1900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8902
    Cell Significance Index: 8.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7358
    Cell Significance Index: 80.0300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4524
    Cell Significance Index: 6.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4505
    Cell Significance Index: 406.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4200
    Cell Significance Index: 41.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4037
    Cell Significance Index: 11.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3851
    Cell Significance Index: 26.6400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.3571
    Cell Significance Index: 3.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3568
    Cell Significance Index: 6.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3265
    Cell Significance Index: 2.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2692
    Cell Significance Index: 43.7800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.2290
    Cell Significance Index: 2.7500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2265
    Cell Significance Index: 2.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1939
    Cell Significance Index: 4.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0903
    Cell Significance Index: 1.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0794
    Cell Significance Index: 1.6900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0440
    Cell Significance Index: 0.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0332
    Cell Significance Index: 0.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0134
    Cell Significance Index: 0.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0070
    Cell Significance Index: -1.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0083
    Cell Significance Index: -1.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0163
    Cell Significance Index: -0.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0165
    Cell Significance Index: -4.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0181
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0194
    Cell Significance Index: -2.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0217
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0239
    Cell Significance Index: -4.0800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0252
    Cell Significance Index: -0.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0265
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0291
    Cell Significance Index: -3.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0307
    Cell Significance Index: -3.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0356
    Cell Significance Index: -4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0388
    Cell Significance Index: -4.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0457
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0590
    Cell Significance Index: -4.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0619
    Cell Significance Index: -4.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0629
    Cell Significance Index: -4.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0656
    Cell Significance Index: -4.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0657
    Cell Significance Index: -3.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0683
    Cell Significance Index: -8.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0710
    Cell Significance Index: -4.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0802
    Cell Significance Index: -4.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0858
    Cell Significance Index: -1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0874
    Cell Significance Index: -4.5900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0902
    Cell Significance Index: -1.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0992
    Cell Significance Index: -4.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1033
    Cell Significance Index: -3.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1046
    Cell Significance Index: -1.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1102
    Cell Significance Index: -2.6700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1102
    Cell Significance Index: -1.1300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1112
    Cell Significance Index: -0.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1146
    Cell Significance Index: -3.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1158
    Cell Significance Index: -4.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1251
    Cell Significance Index: -4.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1290
    Cell Significance Index: -4.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1308
    Cell Significance Index: -6.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1345
    Cell Significance Index: -2.7900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1415
    Cell Significance Index: -1.4500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1417
    Cell Significance Index: -2.0300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1424
    Cell Significance Index: -0.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1426
    Cell Significance Index: -2.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1483
    Cell Significance Index: -1.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1539
    Cell Significance Index: -3.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1549
    Cell Significance Index: -4.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1557
    Cell Significance Index: -4.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1578
    Cell Significance Index: -2.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1608
    Cell Significance Index: -4.0100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1622
    Cell Significance Index: -1.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1630
    Cell Significance Index: -4.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1766
    Cell Significance Index: -4.5000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1784
    Cell Significance Index: -1.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1791
    Cell Significance Index: -5.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1800
    Cell Significance Index: -3.8900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1803
    Cell Significance Index: -2.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1840
    Cell Significance Index: -4.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1868
    Cell Significance Index: -2.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1873
    Cell Significance Index: -5.0000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1890
    Cell Significance Index: -1.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1893
    Cell Significance Index: -3.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1897
    Cell Significance Index: -4.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1899
    Cell Significance Index: -4.0300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1952
    Cell Significance Index: -2.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOC2 is a 38-amino acid protein that belongs to the apolipoprotein C family. It is highly conserved across species, with a high degree of sequence similarity to other apolipoproteins. APOC2 is characterized by its ability to bind to lipoproteins, particularly very-low-density lipoproteins (VLDL) and chylomicrons, and to regulate their metabolism. APOC2 also possesses phospholipase activator activity, which enables it to activate phospholipases involved in lipid catabolism. **Pathways and Functions:** APOC2 plays a crucial role in various lipid metabolism pathways, including: 1. **Cholesterol efflux:** APOC2 facilitates the transfer of cholesterol from VLDL and chylomicrons to high-density lipoprotein (HDL) particles, promoting reverse cholesterol transport. 2. **Lipid catabolism:** APOC2 activates phospholipases involved in the breakdown of triglycerides and phospholipids, leading to the production of fatty acids and glycerol. 3. **Lipoprotein assembly and remodeling:** APOC2 regulates the assembly and remodeling of lipoproteins, including VLDL, chylomicrons, and HDL particles. 4. **Immune regulation:** APOC2 modulates immune responses by regulating the activity of immune cells, such as macrophages and T cells. **Clinical Significance:** APOC2 has been implicated in various lipid metabolism disorders, including: 1. **Hypertriglyceridemia:** APOC2 deficiency or dysfunction has been linked to hypertriglyceridemia, a condition characterized by elevated levels of triglycerides in the blood. 2. **Hypercholesterolemia:** APOC2 has been shown to play a role in regulating cholesterol levels in the blood, and its dysfunction may contribute to hypercholesterolemia. 3. **Atherosclerosis:** APOC2 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. In addition to its role in lipid metabolism, APOC2 has also been implicated in immune-related diseases, including: 1. **Multiple sclerosis:** APOC2 has been shown to play a role in the regulation of immune responses in multiple sclerosis, a chronic autoimmune disease. 2. **Rheumatoid arthritis:** APOC2 has been implicated in the development of rheumatoid arthritis, a chronic inflammatory disease. **Conclusion:** In conclusion, APOC2 plays a crucial role in lipid metabolism and immune function, and its dysfunction has been implicated in various diseases, including lipid metabolism disorders and immune-related diseases. Further research is needed to fully elucidate the mechanisms by which APOC2 regulates lipid metabolism and immune responses, and to explore its potential as a therapeutic target for the treatment of these diseases.

Genular Protein ID: 4057470403

Symbol: APOC2_HUMAN

Name: Apolipoprotein C-II

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3030808

Title: The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization.

PubMed ID: 3030808

DOI: 10.1016/0014-5793(87)81495-3

PubMed ID: 6593704

Title: Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.

PubMed ID: 6593704

DOI: 10.1073/pnas.81.20.6354

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 3558370

Title: The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

PubMed ID: 3558370

DOI: 10.1016/s0021-9258(18)61264-5

PubMed ID: 2415514

Title: The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.

PubMed ID: 2415514

DOI: 10.1016/s0021-9258(18)95724-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6546757

Title: The isolation and characterization of cDNA clones for human apolipoprotein CII.

PubMed ID: 6546757

DOI: 10.1016/s0021-9258(17)43060-2

PubMed ID: 3014272

Title: Isolation of cDNA and genomic clones for apolipoprotein C-II.

PubMed ID: 3014272

DOI: 10.1016/0076-6879(86)28106-9

PubMed ID: 6706938

Title: Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects.

PubMed ID: 6706938

DOI: 10.1016/s0021-9258(17)43660-x

PubMed ID: 194244

Title: Primary structure of very low density apolipoprotein C-II of human plasma.

PubMed ID: 194244

DOI: 10.1073/pnas.74.5.1942

PubMed ID: 3525527

Title: Human preproapolipoprotein C-II. Analysis of major plasma isoforms.

PubMed ID: 3525527

DOI: 10.1016/s0021-9258(18)67554-4

PubMed ID: 11310852

Title: Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells.

PubMed ID: 11310852

PubMed ID: 6772077

Title: Phospholipid binding studies with synthetic apolipoprotein fragments.

PubMed ID: 6772077

DOI: 10.1111/j.1749-6632.1980.tb21300.x

PubMed ID: 2209608

Title: Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.

PubMed ID: 2209608

DOI: 10.1111/j.1432-1033.1990.tb19255.x

PubMed ID: 22304839

Title: A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease.

PubMed ID: 22304839

DOI: 10.1016/j.metabol.2011.12.002

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1555583

Title: Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.

PubMed ID: 1555583

DOI: 10.1111/j.1432-1033.1992.tb16772.x

PubMed ID: 8112221

Title: A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII.

PubMed ID: 8112221

DOI: 10.1007/bf00213558

PubMed ID: 3944271

Title: A variant primary structure of apolipoprotein C-II in individuals of African descent.

PubMed ID: 3944271

DOI: 10.1172/jci112342

PubMed ID: 8490626

Title: Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia.

PubMed ID: 8490626

DOI: 10.1093/hmg/2.1.69

PubMed ID: 1782747

Title: An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia.

PubMed ID: 1782747

PubMed ID: 7923858

Title: The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred.

PubMed ID: 7923858

DOI: 10.1111/j.1399-0004.1994.tb04033.x

PubMed ID: 8323539

Title: A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama).

PubMed ID: 8323539

DOI: 10.1006/bbrc.1993.1749

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

  • Length: 101
  • Mass: 11284
  • Checksum: 51CB86FEDB174D84
  • Sequence:
  • MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES AKTAAQNLYE 
    KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.