APOC2 | ENSG00000234906 | NCBI 344

Details for: APOC2

Gene ID: 344

Symbol: APOC2

Ensembl ID: ENSG00000234906

Description: apolipoprotein C2

Associated with

Assembly of active lpl and lipc lipase complexes
(R-HSA-8963889)
Chylomicron assembly
(R-HSA-8963888)
Hdl remodeling
(R-HSA-8964058)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Retinoid metabolism and transport
(R-HSA-975634)
Sensory perception
(R-HSA-9709957)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Visual phototransduction
(R-HSA-2187338)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Chylomicron
(GO:0042627)
Chylomicron remnant clearance
(GO:0034382)
Chylomicron remodeling
(GO:0034371)
Early endosome
(GO:0005769)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
High-density lipoprotein particle clearance
(GO:0034384)
Intermediate-density lipoprotein particle
(GO:0034363)
Lipase inhibitor activity
(GO:0055102)
Lipid binding
(GO:0008289)
Lipid catabolic process
(GO:0016042)
Lipoprotein lipase activator activity
(GO:0060230)
Low-density lipoprotein particle
(GO:0034362)
Molecular function activator activity
(GO:0140677)
Negative regulation of cholesterol transport
(GO:0032375)
Negative regulation of lipid metabolic process
(GO:0045833)
Negative regulation of receptor-mediated endocytosis
(GO:0048261)
Negative regulation of very-low-density lipoprotein particle clearance
(GO:0010916)
Phospholipase activator activity
(GO:0016004)
Phospholipase binding
(GO:0043274)
Phospholipid efflux
(GO:0033700)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of phospholipase activity
(GO:0010518)
Positive regulation of phospholipid catabolic process
(GO:0060697)
Positive regulation of triglyceride catabolic process
(GO:0010898)
Positive regulation of very-low-density lipoprotein particle remodeling
(GO:0010902)
Protein binding
(GO:0005515)
Reverse cholesterol transport
(GO:0043691)
Spherical high-density lipoprotein particle
(GO:0034366)
Triglyceride-rich lipoprotein particle remodeling
(GO:0034370)
Triglyceride homeostasis
(GO:0070328)
Very-low-density lipoprotein particle
(GO:0034361)
Very-low-density lipoprotein particle remodeling
(GO:0034372)

Other Information

Proteins

Apolipoprotein C-II

Genular Protein ID: 4057470403

Symbol: APOC2_HUMAN

Name: Apolipoprotein C-II

UniProtKB Accession Codes:

P02655 C0JYY4 Q9BS39 Q9UDE3 Q9UNK3

Database IDs:

Citations:

PubMed ID: 3030808

Title: The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization.

PubMed ID: 3030808

DOI: 10.1016/0014-5793(87)81495-3

PubMed ID: 6593704

Title: Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.

PubMed ID: 6593704

DOI: 10.1073/pnas.81.20.6354

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 3558370

Title: The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

PubMed ID: 3558370

DOI: 10.1016/s0021-9258(18)61264-5

PubMed ID: 2415514

Title: The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.

PubMed ID: 2415514

DOI: 10.1016/s0021-9258(18)95724-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6546757

Title: The isolation and characterization of cDNA clones for human apolipoprotein CII.

PubMed ID: 6546757

DOI: 10.1016/s0021-9258(17)43060-2

PubMed ID: 3014272

Title: Isolation of cDNA and genomic clones for apolipoprotein C-II.

PubMed ID: 3014272

DOI: 10.1016/0076-6879(86)28106-9

PubMed ID: 6706938

Title: Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects.

PubMed ID: 6706938

DOI: 10.1016/s0021-9258(17)43660-x

PubMed ID: 194244

Title: Primary structure of very low density apolipoprotein C-II of human plasma.

PubMed ID: 194244

DOI: 10.1073/pnas.74.5.1942

PubMed ID: 3525527

Title: Human preproapolipoprotein C-II. Analysis of major plasma isoforms.

PubMed ID: 3525527

DOI: 10.1016/s0021-9258(18)67554-4

PubMed ID: 11310852

Title: Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells.

PubMed ID: 11310852

PubMed ID: 6772077

Title: Phospholipid binding studies with synthetic apolipoprotein fragments.

PubMed ID: 6772077

DOI: 10.1111/j.1749-6632.1980.tb21300.x

PubMed ID: 2209608

Title: Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.

PubMed ID: 2209608

DOI: 10.1111/j.1432-1033.1990.tb19255.x

PubMed ID: 22304839

Title: A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease.

PubMed ID: 22304839

DOI: 10.1016/j.metabol.2011.12.002

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1555583

Title: Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.

PubMed ID: 1555583

DOI: 10.1111/j.1432-1033.1992.tb16772.x

PubMed ID: 8112221

Title: A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII.

PubMed ID: 8112221

DOI: 10.1007/bf00213558

PubMed ID: 3944271

Title: A variant primary structure of apolipoprotein C-II in individuals of African descent.

PubMed ID: 3944271

DOI: 10.1172/jci112342

PubMed ID: 8490626

Title: Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia.

PubMed ID: 8490626

DOI: 10.1093/hmg/2.1.69

PubMed ID: 1782747

Title: An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia.

PubMed ID: 1782747

PubMed ID: 7923858

Title: The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred.

PubMed ID: 7923858

DOI: 10.1111/j.1399-0004.1994.tb04033.x

PubMed ID: 8323539

Title: A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama).

PubMed ID: 8323539

DOI: 10.1006/bbrc.1993.1749

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

Length: 101
Mass: 11284
Checksum: 51CB86FEDB174D84
Sequence:

MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES AKTAAQNLYE 
KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOC2

Associated with

Other Information

The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization. PubMed ID: 3030808

Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II. PubMed ID: 6593704

Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. PubMed ID: 6328445

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron. PubMed ID: 3558370

The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes. PubMed ID: 2415514

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The isolation and characterization of cDNA clones for human apolipoprotein CII. PubMed ID: 6546757

Isolation of cDNA and genomic clones for apolipoprotein C-II. PubMed ID: 3014272

Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects. PubMed ID: 6706938

Primary structure of very low density apolipoprotein C-II of human plasma. PubMed ID: 194244

Human preproapolipoprotein C-II. Analysis of major plasma isoforms. PubMed ID: 3525527

Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells. PubMed ID: 11310852

Phospholipid binding studies with synthetic apolipoprotein fragments. PubMed ID: 6772077

Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. PubMed ID: 2209608

A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease. PubMed ID: 22304839

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. PubMed ID: 1555583

A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII. PubMed ID: 8112221

A variant primary structure of apolipoprotein C-II in individuals of African descent. PubMed ID: 3944271

Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. PubMed ID: 8490626

An apolipoprotein CII mutation, CII Lys-19--&gt;Thr identified in patients with hyperlipidemia. PubMed ID: 1782747

The apolipoprotein C-II variant apoC-II Lys-19--&gt;Thr is not associated with dyslipidemia in an affected kindred. PubMed ID: 7923858

A missense mutation (Trp 26--&gt;Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama). PubMed ID: 8323539

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210