Details for: APOC2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: liver dendritic cell (CL2000055)
Fold Change: 5.9516
Cell Significance Index: 15.7000 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 3.5367
Cell Significance Index: 13.3200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.7824
Cell Significance Index: 89.1200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8018
Cell Significance Index: 81.6700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.6911
Cell Significance Index: 321.8200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3563
Cell Significance Index: 81.4300 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.2485
Cell Significance Index: 7.1900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.8902
Cell Significance Index: 8.9800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7358
Cell Significance Index: 80.0300 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.4524
Cell Significance Index: 6.3500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4505
Cell Significance Index: 406.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4200
Cell Significance Index: 41.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4037
Cell Significance Index: 11.6300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3851
Cell Significance Index: 26.6400 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.3571
Cell Significance Index: 3.4000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.3568
Cell Significance Index: 6.0100 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.3265
Cell Significance Index: 2.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2692
Cell Significance Index: 43.7800 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.2290
Cell Significance Index: 2.7500 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.2265
Cell Significance Index: 2.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1939
Cell Significance Index: 4.2000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.0903
Cell Significance Index: 1.4900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0794
Cell Significance Index: 1.6900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0440
Cell Significance Index: 0.7400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0332
Cell Significance Index: 0.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0176
Cell Significance Index: 0.6200 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0134
Cell Significance Index: 0.1700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0053
Cell Significance Index: 0.0600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0029
Cell Significance Index: -1.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0039
Cell Significance Index: -2.8900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0045
Cell Significance Index: -0.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0049
Cell Significance Index: -2.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0054
Cell Significance Index: -4.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0070
Cell Significance Index: -1.4000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0076
Cell Significance Index: -4.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0083
Cell Significance Index: -1.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0096
Cell Significance Index: -0.2400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0146
Cell Significance Index: -0.3900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0156
Cell Significance Index: -1.5900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0163
Cell Significance Index: -0.6700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0165
Cell Significance Index: -4.7600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0181
Cell Significance Index: -1.1100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0194
Cell Significance Index: -2.2200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0217
Cell Significance Index: -0.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0239
Cell Significance Index: -4.0800 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0252
Cell Significance Index: -0.3500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0265
Cell Significance Index: -0.4000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0291
Cell Significance Index: -3.9900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0307
Cell Significance Index: -3.7800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0356
Cell Significance Index: -4.6000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0388
Cell Significance Index: -4.5800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0457
Cell Significance Index: -0.7800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0590
Cell Significance Index: -4.5300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0619
Cell Significance Index: -4.9000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0629
Cell Significance Index: -4.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0656
Cell Significance Index: -4.0200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0657
Cell Significance Index: -3.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0683
Cell Significance Index: -8.7500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0710
Cell Significance Index: -4.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0802
Cell Significance Index: -4.5000 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0858
Cell Significance Index: -1.7500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0874
Cell Significance Index: -4.5900 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0902
Cell Significance Index: -1.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0992
Cell Significance Index: -4.3900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1033
Cell Significance Index: -3.6200 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1046
Cell Significance Index: -1.3900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1102
Cell Significance Index: -2.6700 - Cell Name: osteoclast (CL0000092)
Fold Change: -0.1102
Cell Significance Index: -1.1300 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1112
Cell Significance Index: -0.9800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1146
Cell Significance Index: -3.0700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1158
Cell Significance Index: -4.3900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1251
Cell Significance Index: -4.1000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1290
Cell Significance Index: -4.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1308
Cell Significance Index: -6.1000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1345
Cell Significance Index: -2.7900 - Cell Name: macrophage (CL0000235)
Fold Change: -0.1415
Cell Significance Index: -1.4500 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1417
Cell Significance Index: -2.0300 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.1424
Cell Significance Index: -0.8800 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1426
Cell Significance Index: -2.0900 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1483
Cell Significance Index: -1.9400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1539
Cell Significance Index: -3.6900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1549
Cell Significance Index: -4.4400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1557
Cell Significance Index: -4.1000 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.1578
Cell Significance Index: -2.6800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1608
Cell Significance Index: -4.0100 - Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.1622
Cell Significance Index: -1.6000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1630
Cell Significance Index: -4.1700 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1766
Cell Significance Index: -4.5000 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.1784
Cell Significance Index: -1.8400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1791
Cell Significance Index: -5.2600 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1800
Cell Significance Index: -3.8900 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.1803
Cell Significance Index: -2.1200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1840
Cell Significance Index: -4.2500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1868
Cell Significance Index: -2.1200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1873
Cell Significance Index: -5.0000 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.1890
Cell Significance Index: -1.7300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1893
Cell Significance Index: -3.9500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1897
Cell Significance Index: -4.7400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1899
Cell Significance Index: -4.0300 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1952
Cell Significance Index: -2.2100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4057470403
Symbol: APOC2_HUMAN
Name: Apolipoprotein C-II
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3030808
Title: The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization.
PubMed ID: 3030808
PubMed ID: 6593704
Title: Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.
PubMed ID: 6593704
PubMed ID: 6328445
Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.
PubMed ID: 6328445
PubMed ID: 3558370
Title: The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.
PubMed ID: 3558370
PubMed ID: 2415514
Title: The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.
PubMed ID: 2415514
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6546757
Title: The isolation and characterization of cDNA clones for human apolipoprotein CII.
PubMed ID: 6546757
PubMed ID: 3014272
Title: Isolation of cDNA and genomic clones for apolipoprotein C-II.
PubMed ID: 3014272
PubMed ID: 6706938
Title: Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects.
PubMed ID: 6706938
PubMed ID: 194244
Title: Primary structure of very low density apolipoprotein C-II of human plasma.
PubMed ID: 194244
PubMed ID: 3525527
Title: Human preproapolipoprotein C-II. Analysis of major plasma isoforms.
PubMed ID: 3525527
PubMed ID: 11310852
Title: Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells.
PubMed ID: 11310852
PubMed ID: 6772077
Title: Phospholipid binding studies with synthetic apolipoprotein fragments.
PubMed ID: 6772077
PubMed ID: 2209608
Title: Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.
PubMed ID: 2209608
PubMed ID: 22304839
Title: A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease.
PubMed ID: 22304839
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 1555583
Title: Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.
PubMed ID: 1555583
PubMed ID: 8112221
Title: A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII.
PubMed ID: 8112221
DOI: 10.1007/bf00213558
PubMed ID: 3944271
Title: A variant primary structure of apolipoprotein C-II in individuals of African descent.
PubMed ID: 3944271
DOI: 10.1172/jci112342
PubMed ID: 8490626
Title: Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia.
PubMed ID: 8490626
DOI: 10.1093/hmg/2.1.69
PubMed ID: 1782747
Title: An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia.
PubMed ID: 1782747
PubMed ID: 7923858
Title: The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred.
PubMed ID: 7923858
PubMed ID: 8323539
Title: A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama).
PubMed ID: 8323539
PubMed ID: 10391210
Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
PubMed ID: 10391210
DOI: 10.1038/10297
Sequence Information:
- Length: 101
- Mass: 11284
- Checksum: 51CB86FEDB174D84
- Sequence:
MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES AKTAAQNLYE KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE E
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.