Cdk1 | FBgn0004106 | NCBI 34411

Details for: Cdk1

Gene ID: 34411

Symbol: Cdk1

Ensembl ID: FBgn0004106

Description: Cyclin-dependent kinase 1

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-DME-176814)
Antiviral mechanism by ifn-stimulated genes
(R-DME-1169410)
Apc/c-mediated degradation of cell cycle proteins
(R-DME-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-DME-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-DME-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-DME-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-DME-174184)
Cell cycle
(R-DME-1640170)
Cell cycle, mitotic
(R-DME-69278)
Cell cycle checkpoints
(R-DME-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-DME-75035)
Cyclin a/b1/b2 associated events during g2/m transition
(R-DME-69273)
Cytokine signaling in immune system
(R-DME-1280215)
Depolymerization of the nuclear lamina
(R-DME-4419969)
G2/m checkpoints
(R-DME-69481)
G2/m dna damage checkpoint
(R-DME-69473)
G2/m dna replication checkpoint
(R-DME-69478)
G2/m transition
(R-DME-69275)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Immune system
(R-DME-168256)
Interferon signaling
(R-DME-913531)
Mapk1/mapk3 signaling
(R-DME-5684996)
Mapk3 (erk1) activation
(R-DME-110056)
Mapk family signaling cascades
(R-DME-5683057)
Mitotic g2-g2/m phases
(R-DME-453274)
Mitotic prometaphase
(R-DME-68877)
Mitotic prophase
(R-DME-68875)
M phase
(R-DME-68886)
Nuclear envelope breakdown
(R-DME-2980766)
Nuclear pore complex (npc) disassembly
(R-DME-3301854)
Phosphorylation of emi1
(R-DME-176417)
Phosphorylation of the apc/c
(R-DME-176412)
Pkr-mediated signaling
(R-DME-9833482)
Raf-independent mapk1/3 activation
(R-DME-112409)
Regulation of apc/c activators between g1/s and early anaphase
(R-DME-176408)
Regulation of mitotic cell cycle
(R-DME-453276)
Regulation of plk1 activity at g2/m transition
(R-DME-2565942)
Resolution of sister chromatid cohesion
(R-DME-2500257)
Rna polymerase ii transcription
(R-DME-73857)
Signal transduction
(R-DME-162582)
Tp53 regulates transcription of cell cycle genes
(R-DME-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-DME-6804114)
Transcriptional regulation by runx2
(R-DME-8878166)
Transcriptional regulation by tp53
(R-DME-3700989)
Asymmetric neuroblast division
(GO:0055059)
Atp binding
(GO:0005524)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Embryonic development via the syncytial blastoderm
(GO:0001700)
Follicle cell of egg chamber development
(GO:0030707)
Fusome
(GO:0045169)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Germarium-derived cystoblast division
(GO:0048142)
Male meiotic nuclear division
(GO:0007140)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic g2/m transition checkpoint
(GO:0044818)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of dna-templated dna replication initiation
(GO:0030174)
Regulation of mitotic cell cycle phase transition
(GO:1901990)
Regulation of protein localization
(GO:0032880)
Spermatogonial cell division
(GO:0007284)

Other Information

Proteins

Cyclin-dependent kinase 1

Genular Protein ID: 352956280

Symbol: CDK1_DROME

Name: Cyclin-dependent kinase 1

UniProtKB Accession Codes:

P23572 A0ANT1 Q86FT5 Q86FT6 Q86FT7 Q86FT8 Q86FT9 Q9TX68 Q9TX69 Q9TX70 Q9TX71 Q9TX72 Q9TX73 Q9TX74 Q9VKX5

Database IDs:

Citations:

PubMed ID: 2120045

Title: Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.

PubMed ID: 2120045

DOI: 10.1002/j.1460-2075.1990.tb07568.x

PubMed ID: 2120044

Title: Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string.

PubMed ID: 2120044

DOI: 10.1002/j.1460-2075.1990.tb07567.x

PubMed ID: 8223248

Title: Genetic analysis of the Drosophila cdc2 homolog.

PubMed ID: 8223248

DOI: 10.1242/dev.117.1.219

PubMed ID: 16951084

Title: Widespread adaptive evolution of Drosophila genes with sex-biased expression.

PubMed ID: 16951084

DOI: 10.1534/genetics.106.058008

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8405984

Title: A developmental and molecular analysis of cdc2 mutations in Drosophila melanogaster.

PubMed ID: 8405984

DOI: 10.1139/g93-091

PubMed ID: 15581871

Title: Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage.

PubMed ID: 15581871

DOI: 10.1016/j.ydbio.2004.08.043

PubMed ID: 17431409

Title: The Drosophila mitotic inhibitor Fruehstart specifically binds to the hydrophobic patch of cyclins.

PubMed ID: 17431409

DOI: 10.1038/sj.embor.7400948

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 29746464

Title: Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition.

PubMed ID: 29746464

DOI: 10.1371/journal.pbio.2005687

Sequence Information:

Length: 297
Mass: 34439
Checksum: 952CF136D8AB64C0
Sequence:

MEDFEKIEKI GEGTYGVVYK GRNRLTGQIV AMKKIRLESD DEGVPSTAIR EISLLKELKH 
ENIVCLEDVL MEENRIYLIF EFLSMDLKKY MDSLPVDKHM ESELVRSYLY QITSAILFCH 
RRRVLHRDLK PQNLLIDKSG LIKVADFGLG RSFGIPVRIY THEIVTLWYR APEVLLGSPR 
YSCPVDIWSI GCIFAEMATR KPLFQGDSEI DQLFRMFRIL KTPTEDIWPG VTSLPDYKNT 
FPCWSTNQLT NQLKNLDANG IDLIQKMLIY DPVHRISAKD ILEHPYFNGF QSGLVRN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk1

Associated with

Other Information

Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. PubMed ID: 2120045

Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. PubMed ID: 2120044

Genetic analysis of the Drosophila cdc2 homolog. PubMed ID: 8223248

Widespread adaptive evolution of Drosophila genes with sex-biased expression. PubMed ID: 16951084

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

A developmental and molecular analysis of cdc2 mutations in Drosophila melanogaster. PubMed ID: 8405984

Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage. PubMed ID: 15581871

The Drosophila mitotic inhibitor Fruehstart specifically binds to the hydrophobic patch of cyclins. PubMed ID: 17431409

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PubMed ID: 29746464