APOC3 | ENSG00000110245 | NCBI 345

Details for: APOC3

Gene ID: 345

Symbol: APOC3

Ensembl ID: ENSG00000110245

Description: apolipoprotein C3

Associated with

Chylomicron assembly
(R-HSA-8963888)
Chylomicron remodeling
(R-HSA-8963901)
Hdl remodeling
(R-HSA-8964058)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Retinoid metabolism and transport
(R-HSA-975634)
Sensory perception
(R-HSA-9709957)
Transport of small molecules
(R-HSA-382551)
Visual phototransduction
(R-HSA-2187338)
Cholesterol binding
(GO:0015485)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Chylomicron
(GO:0042627)
Chylomicron remnant clearance
(GO:0034382)
Collagen-containing extracellular matrix
(GO:0062023)
Early endosome
(GO:0005769)
Enzyme regulator activity
(GO:0030234)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
High-density lipoprotein particle receptor binding
(GO:0070653)
High-density lipoprotein particle remodeling
(GO:0034375)
Intermediate-density lipoprotein particle
(GO:0034363)
Lipase inhibitor activity
(GO:0055102)
Lipoprotein metabolic process
(GO:0042157)
Negative regulation of cholesterol import
(GO:0060621)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Negative regulation of high-density lipoprotein particle clearance
(GO:0010987)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of lipid metabolic process
(GO:0045833)
Negative regulation of lipoprotein lipase activity
(GO:0051005)
Negative regulation of low-density lipoprotein particle clearance
(GO:0010989)
Negative regulation of receptor-mediated endocytosis
(GO:0048261)
Negative regulation of triglyceride catabolic process
(GO:0010897)
Negative regulation of very-low-density lipoprotein particle clearance
(GO:0010916)
Negative regulation of very-low-density lipoprotein particle remodeling
(GO:0010903)
Phospholipid binding
(GO:0005543)
Phospholipid efflux
(GO:0033700)
Protein binding
(GO:0005515)
Regulation of cdc42 protein signal transduction
(GO:0032489)
Reverse cholesterol transport
(GO:0043691)
Spherical high-density lipoprotein particle
(GO:0034366)
Triglyceride catabolic process
(GO:0019433)
Triglyceride homeostasis
(GO:0070328)
Triglyceride metabolic process
(GO:0006641)
Very-low-density lipoprotein particle
(GO:0034361)
Very-low-density lipoprotein particle assembly
(GO:0034379)

Other Information

Proteins

Apolipoprotein C-III

Genular Protein ID: 393228631

Symbol: APOC3_HUMAN

Name: Apolipoprotein C-III

UniProtKB Accession Codes:

P02656 Q08E83 Q6Q786

Database IDs:

Citations:

PubMed ID: 6439535

Title: Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes.

PubMed ID: 6439535

DOI: 10.1089/dna.1.1984.3.449

PubMed ID: 6548954

Title: Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII.

PubMed ID: 6548954

DOI: 10.1089/dna.1984.3.359

PubMed ID: 2989400

Title: Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles.

PubMed ID: 2989400

PubMed ID: 6328445

Title: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance.

PubMed ID: 6328445

DOI: 10.1093/nar/12.9.3917

PubMed ID: 15108119

Title: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.

PubMed ID: 15108119

DOI: 10.1007/s00439-004-1106-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3949020

Title: Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects.

PubMed ID: 3949020

DOI: 10.1016/0014-5793(86)80300-3

PubMed ID: 4846755

Title: The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins.

PubMed ID: 4846755

DOI: 10.1016/s0021-9258(19)42416-2

PubMed ID: 18201179

Title: An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?

PubMed ID: 18201179

DOI: 10.1111/j.1742-1241.2007.01678.x

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22510806

Title: Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production.

PubMed ID: 22510806

DOI: 10.1097/mol.0b013e328352dc70

PubMed ID: 23527852

Title: Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera.

PubMed ID: 23527852

DOI: 10.1021/pr400136p

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18408013

Title: Structure and dynamics of human apolipoprotein CIII.

PubMed ID: 18408013

DOI: 10.1074/jbc.m800756200

PubMed ID: 3123586

Title: Molecular cloning of a human apoC-III variant: Thr 74-->Ala 74 mutation prevents O-glycosylation.

PubMed ID: 3123586

PubMed ID: 2022742

Title: Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia.

PubMed ID: 2022742

DOI: 10.1172/jci115190

Sequence Information:

Length: 99
Mass: 10852
Checksum: D4E806339FAE4DA7
Sequence:

MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV QESQVAQQAR 
GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APOC3

Associated with

Other Information

Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes. PubMed ID: 6439535

Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII. PubMed ID: 6548954

Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles. PubMed ID: 2989400

Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. PubMed ID: 6328445

The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. PubMed ID: 15108119

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects. PubMed ID: 3949020

The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins. PubMed ID: 4846755

An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor? PubMed ID: 18201179

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Initial characterization of the human central proteome. PubMed ID: 21269460

Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production. PubMed ID: 22510806

Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera. PubMed ID: 23527852

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure and dynamics of human apolipoprotein CIII. PubMed ID: 18408013

Molecular cloning of a human apoC-III variant: Thr 74--&gt;Ala 74 mutation prevents O-glycosylation. PubMed ID: 3123586

Apolipoprotein C-III(Lys-58--&gt;Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. PubMed ID: 2022742