Details for: piwi

Gene ID: 34521

Symbol: piwi

Ensembl ID: FBgn0004872

Description: P-element induced wimpy testis

Associated with

Other Information

Genular Protein ID: 2544036293

Symbol: PIWI_DROME

Name: Protein piwi

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9851978

Title: A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.

PubMed ID: 9851978

DOI: 10.1101/gad.12.23.3715

PubMed ID: 22997235

Title: Long-term and short-term evolutionary impacts of transposable elements on Drosophila.

PubMed ID: 22997235

DOI: 10.1534/genetics.112.145714

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 9199372

Title: A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary.

PubMed ID: 9199372

DOI: 10.1242/dev.124.12.2463

PubMed ID: 10631171

Title: piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.

PubMed ID: 10631171

DOI: 10.1242/dev.127.3.503

PubMed ID: 15817569

Title: Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline.

PubMed ID: 15817569

DOI: 10.1093/nar/gki323

PubMed ID: 16949822

Title: The role of PIWI and the miRNA machinery in Drosophila germline determination.

PubMed ID: 16949822

DOI: 10.1016/j.cub.2006.08.051

PubMed ID: 16882972

Title: Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome.

PubMed ID: 16882972

DOI: 10.1101/gad.1454806

PubMed ID: 17346786

Title: Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

PubMed ID: 17346786

DOI: 10.1016/j.cell.2007.01.043

PubMed ID: 17875665

Title: Drosophila PIWI associates with chromatin and interacts directly with HP1a.

PubMed ID: 17875665

DOI: 10.1101/gad.1564307

PubMed ID: 17952056

Title: An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster.

PubMed ID: 17952056

DOI: 10.1038/nature06263

PubMed ID: 19395009

Title: Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.

PubMed ID: 19395009

DOI: 10.1016/j.cell.2009.04.027

PubMed ID: 19812547

Title: A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila.

PubMed ID: 19812547

DOI: 10.1038/nature08501

PubMed ID: 19377467

Title: Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.

PubMed ID: 19377467

DOI: 10.1038/ncb1872

PubMed ID: 20966047

Title: Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila.

PubMed ID: 20966047

DOI: 10.1101/gad.1989510

PubMed ID: 21447556

Title: PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.

PubMed ID: 21447556

DOI: 10.1242/dev.059287

PubMed ID: 21831924

Title: Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

PubMed ID: 21831924

DOI: 10.1242/dev.069187

PubMed ID: 21186352

Title: Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.

PubMed ID: 21186352

DOI: 10.1038/ng.743

PubMed ID: 22065765

Title: Separation of stem cell maintenance and transposon silencing functions of Piwi protein.

PubMed ID: 22065765

DOI: 10.1073/pnas.1106676108

PubMed ID: 23159368

Title: Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.

PubMed ID: 23159368

DOI: 10.1016/j.cell.2012.10.040

PubMed ID: 23434410

Title: A major epigenetic programming mechanism guided by piRNAs.

PubMed ID: 23434410

DOI: 10.1016/j.devcel.2013.01.023

PubMed ID: 23392610

Title: Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state.

PubMed ID: 23392610

DOI: 10.1101/gad.209841.112

PubMed ID: 23392609

Title: Multiple roles for Piwi in silencing Drosophila transposons.

PubMed ID: 23392609

DOI: 10.1101/gad.209767.112

PubMed ID: 23913921

Title: DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.

PubMed ID: 23913921

DOI: 10.1101/gad.221515.113

PubMed ID: 23913922

Title: Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex.

PubMed ID: 23913922

DOI: 10.1101/gad.221150.113

PubMed ID: 23297219

Title: Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.

PubMed ID: 23297219

DOI: 10.1073/pnas.1213283110

PubMed ID: 24906153

Title: The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila.

PubMed ID: 24906153

DOI: 10.1016/j.cell.2014.04.031

PubMed ID: 26472911

Title: Panoramix enforces piRNA-dependent cotranscriptional silencing.

PubMed ID: 26472911

DOI: 10.1126/science.aab0700

PubMed ID: 26494711

Title: Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.

PubMed ID: 26494711

DOI: 10.1101/gad.271908.115

PubMed ID: 26808625

Title: Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila.

PubMed ID: 26808625

DOI: 10.1371/journal.pgen.1005813

PubMed ID: 28472469

Title: Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells.

PubMed ID: 28472469

DOI: 10.1093/nar/gkx355

PubMed ID: 29735528

Title: A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila.

PubMed ID: 29735528

DOI: 10.1074/jbc.ac118.003264

PubMed ID: 31368590

Title: Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.

PubMed ID: 31368590

DOI: 10.15252/embj.2019102870

PubMed ID: 31384064

Title: The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

PubMed ID: 31384064

DOI: 10.1038/s41594-019-0270-6

PubMed ID: 29531043

Title: Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi.

PubMed ID: 29531043

DOI: 10.1073/pnas.1717116115

Sequence Information:

  • Length: 843
  • Mass: 97177
  • Checksum: 9B4A95E688E9D9B7
  • Sequence:
  • MADDQGRGRR RPLNEDDSST SRGSGDGPRV KVFRGSSSGD PRADPRIEAS RERRALEEAP 
    RREGGPTERK PWGDQYDYLN TRPAELVSKK GTDGVPVMLQ TNFFRLKTKP EWRIVHYHVE 
    FEPSIENPRV RMGVLSNHAN LLGSGYLFDG LQLFTTRKFE QEITVLSGKS KLDIEYKISI 
    KFVGFISCAE PRFLQVLNLI LRRSMKGLNL ELVGRNLFDP RAKIEIREFK MELWPGYETS 
    IRQHEKDILL GTEITHKVMR TETIYDIMRR CSHNPARHQD EVRVNVLDLI VLTDYNNRTY 
    RINDVDFGQT PKSTFSCKGR DISFVEYYLT KYNIRIRDHN QPLLISKNRD KALKTNASEL 
    VVLIPELCRV TGLNAEMRSN FQLMRAMSSY TRMNPKQRTD RLRAFNHRLQ NTPESVKVLR 
    DWNMELDKNV TEVQGRIIGQ QNIVFHNGKV PAGENADWQR HFRDQRMLTT PSDGLDRWAV 
    IAPQRNSHEL RTLLDSLYRA ASGMGLRIRS PQEFIIYDDR TGTYVRAMDD CVRSDPKLIL 
    CLVPNDNAER YSSIKKRGYV DRAVPTQVVT LKTTKNRSLM SIATKIAIQL NCKLGYTPWM 
    IELPLSGLMT IGFDIAKSTR DRKRAYGALI ASMDLQQNST YFSTVTECSA FDVLANTLWP 
    MIAKALRQYQ HEHRKLPSRI VFYRDGVSSG SLKQLFEFEV KDIIEKLKTE YARVQLSPPQ 
    LAYIVVTRSM NTRFFLNGQN PPPGTIVDDV ITLPERYDFY LVSQQVRQGT VSPTSYNVLY 
    SSMGLSPEKM QKLTYKMCHL YYNWSGTTRV PAVCQYAKKL ATLVGTNLHS IPQNALEKKF 
    YYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.