Details for: l 2 gd1

Gene ID: 34543

Symbol: l 2 gd1

Ensembl ID: FBgn0261983

Description: lethal (2) giant discs 1

Associated with

Other Information

Genular Protein ID: 1795540111

Symbol: C2D1_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12648493

Title: The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development.

PubMed ID: 12648493

DOI: 10.1016/s0012-1606(02)00052-0

PubMed ID: 17088062

Title: Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis.

PubMed ID: 17088062

DOI: 10.1016/j.cub.2006.09.031

PubMed ID: 17084357

Title: The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila.

PubMed ID: 17084357

DOI: 10.1016/j.devcel.2006.09.014

PubMed ID: 17084358

Title: The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking.

PubMed ID: 17084358

DOI: 10.1016/j.devcel.2006.09.019

PubMed ID: 22389409

Title: The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4.

PubMed ID: 22389409

DOI: 10.1242/jcs.097261

PubMed ID: 23178945

Title: Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome.

PubMed ID: 23178945

DOI: 10.1242/jcs.116590

PubMed ID: 25804739

Title: Lgd regulates the activity of the BMP/Dpp signalling pathway during Drosophila oogenesis.

PubMed ID: 25804739

DOI: 10.1242/dev.112961

PubMed ID: 25647097

Title: Abscission is regulated by the ESCRT-III protein shrub in Drosophila germline stem cells.

PubMed ID: 25647097

DOI: 10.1371/journal.pgen.1004653

PubMed ID: 27452459

Title: Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.

PubMed ID: 27452459

DOI: 10.1016/j.celrep.2016.06.093

PubMed ID: 33349255

Title: Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery.

PubMed ID: 33349255

DOI: 10.1186/s12915-020-00933-x

PubMed ID: 28564595

Title: Structural Basis for Regulation of ESCRT-III Complexes by Lgd.

PubMed ID: 28564595

DOI: 10.1016/j.celrep.2017.05.026

PubMed ID: 30513301

Title: CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.

PubMed ID: 30513301

DOI: 10.1016/j.devcel.2018.11.012

Sequence Information:

  • Length: 816
  • Mass: 89038
  • Checksum: CD757E267DA491E5
  • Sequence:
  • MFSRKKPEPA KRRQHDLSQF GLTEIPDDFD PSAGYGEDDG GDSDLEAELA AITGGEGAKP 
    KPKPKAKLLP ASDLDKMIAD SLRDVSDDDD DDNLESDPDL LGELSGIGGL EEAEEEEPVA 
    QPPAASEEPV QTFLPTTTVD TLSIIKQRLE MYKQAEANAK TAGDSGKARR FGRGLKTLKD 
    LHRQAAAGKS INVDDIPPEV SVKPIGGQAP PVPAEESPAP STPASPPPVP SRAAPDPPTP 
    GTPVEPTTSV APTSPPNPLV TQMRSRQTDY KAAALQSKRS GDISTALQFL KVVKQFDVVI 
    KMCEDGQEVD LSDMPPPPAE FLEFLKKMQE EAAAEAVAEP TAAPEPTPVA PAPVLAAATN 
    MLEALQQRLE KYQSVEAAAK AENNSGKARR FGRIVKQYED AIKLYKAGKP VPYDELPVPP 
    GFGPLPTADA APVAPTPSLP TSPTSPPPTA STSAGGTPSS SSATTPTAPR KAPSPPKPKE 
    LTTRTSGNQQ KNNIAEQQMK LLLERQKEFK LAAIEAKKAG EIDQAKEYLK IFKGFDSLLN 
    AASSGLPVDL STLPVPPSQR DNLEASFAIV SAEECDPTDD ICEIGVRMEE QLAKQLMMCK 
    NTRDHHKAMG DVAGMNRFEN LALTVQKDLD LVRYSKRKNE PLPKFHYEKR SFNIVHCNTD 
    LTDSELEIVV VRGISYNVAN PKDVDTYVRV EFPLLNDESF KTKTNVIRDT SSPDYDERFK 
    VDIQRTNRQF QRIFKRHGVK FEIYSRGGFL RSDTLIGTVN VKLQPLETKC EIHDTYDLMD 
    GRKQVGGKLE VKIRVRNPIL TKQMEHITEK WLVLDA

Genular Protein ID: 1693074206

Symbol: M9NEZ0_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 834
  • Mass: 91037
  • Checksum: B61D365D0BB4AB13
  • Sequence:
  • MFSRKKPEPA KRRQHDLSQF GLTEIPDDFD PSAGYGEDDG GDSDLEAELA AITGGEGAKP 
    KPKPKAKLLP ASDLDKMIAD SLRDVSDDDD DDNLESDPDL LGELSGIGGL EEAEEEEPVA 
    QPPAASEEPV QTFLPTTTVD TLSIIKQRLE MYKQAEANAK TAGDSGKARR FGRGLKTLKD 
    LHRQAAAGKS INVDDIPPEV SVKPIGGQAP PVPAEESPAP STPASPPPVP SRAAPDPPTP 
    GTPVEPTTSV APTSPPNPLV TQMRSRQTDY KAAALQSKRS GDISTALQFL KVVKQFDVVI 
    KMCEDGQEVD LSDMPPPPAE FLEFLKKMQE EAAAEAVAEP TAAPEPTPVA PAPVLAAATN 
    MLEALQQRLE KYQSVEAAAK AENNSGKARR FGRIVKQYED AIKLYKAGKP VPYDELPVPP 
    GFGPLPTADA APVAPTPSLP TSPTSPPPTA STSAGGTPSS SSATTPTAPR KAPSPPKPKE 
    LTTRTSGNQQ KNNIAEQQMK LLLERQKEFK LAAIEAKKAG EIDQAKEYLK IFKGFDSLLN 
    AASSGLPVDL STLPVPPSQR DNLEASFAIV SAEECDPTDD ICEIGVRMEE QLAKQLMMCK 
    NTRDHHKAMG DVAGMNRFEN LALTVQKDLD LVRYSKRKNE PLPKFHYEKR SFNIVHCNTD 
    LTDSELEIVV VRGISYNVAN PKDVDTYVRV EFPLLNDESF KTKTNVIRDT SSPDYDERFK 
    VDIQRTNRQF QRIFKRHGVK FEIYSRGCSI DCCGLSRKLP LCCFRGFLRS DTLIGTVNVK 
    LQPLETKCEI HDTYDLMDGR KQVGGKLEVK IRVRNPILTK QMEHITEKWL VLDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.