Details for: APOC4

Gene ID: 346

Symbol: APOC4

Ensembl ID: ENSG00000267467

Description: apolipoprotein C4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 7.1896
    Cell Significance Index: 120.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 6.9837
    Cell Significance Index: 72.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.6346
    Cell Significance Index: 41.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6616
    Cell Significance Index: 16.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.5918
    Cell Significance Index: 7.7400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.5193
    Cell Significance Index: 4.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4916
    Cell Significance Index: 7.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3318
    Cell Significance Index: 8.8900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.1877
    Cell Significance Index: 2.1600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1835
    Cell Significance Index: 1.8100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1776
    Cell Significance Index: 2.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1592
    Cell Significance Index: 2.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0930
    Cell Significance Index: 1.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0789
    Cell Significance Index: 1.1300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0403
    Cell Significance Index: 0.5900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0148
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0123
    Cell Significance Index: 1.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0084
    Cell Significance Index: 0.1800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0047
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0016
    Cell Significance Index: 0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0026
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0057
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0060
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0086
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0090
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0107
    Cell Significance Index: -0.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0109
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0125
    Cell Significance Index: -0.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0134
    Cell Significance Index: -0.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0137
    Cell Significance Index: -0.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0150
    Cell Significance Index: -0.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0166
    Cell Significance Index: -0.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0179
    Cell Significance Index: -1.1000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0201
    Cell Significance Index: -0.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0217
    Cell Significance Index: -1.1300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0233
    Cell Significance Index: -0.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0262
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0281
    Cell Significance Index: -0.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0288
    Cell Significance Index: -0.6300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0293
    Cell Significance Index: -0.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0295
    Cell Significance Index: -0.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0305
    Cell Significance Index: -0.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0309
    Cell Significance Index: -0.8900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0312
    Cell Significance Index: -0.3900
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0320
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0333
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0338
    Cell Significance Index: -0.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0362
    Cell Significance Index: -0.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0372
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0372
    Cell Significance Index: -0.2300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0373
    Cell Significance Index: -0.2200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0395
    Cell Significance Index: -0.3600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0400
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0403
    Cell Significance Index: -0.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0404
    Cell Significance Index: -0.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0408
    Cell Significance Index: -0.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0419
    Cell Significance Index: -0.8900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0420
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0421
    Cell Significance Index: -0.8500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0425
    Cell Significance Index: -0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0425
    Cell Significance Index: -1.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0434
    Cell Significance Index: -0.6400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0439
    Cell Significance Index: -0.5300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0440
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0443
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0460
    Cell Significance Index: -1.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0464
    Cell Significance Index: -0.7700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0481
    Cell Significance Index: -0.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0489
    Cell Significance Index: -0.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0491
    Cell Significance Index: -0.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0501
    Cell Significance Index: -0.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0511
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0517
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0518
    Cell Significance Index: -0.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0518
    Cell Significance Index: -0.8800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0519
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0519
    Cell Significance Index: -0.9000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0530
    Cell Significance Index: -0.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0541
    Cell Significance Index: -1.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0549
    Cell Significance Index: -1.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0566
    Cell Significance Index: -0.6600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0569
    Cell Significance Index: -0.5900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0578
    Cell Significance Index: -0.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0580
    Cell Significance Index: -1.3900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0582
    Cell Significance Index: -0.6000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0595
    Cell Significance Index: -0.8900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0597
    Cell Significance Index: -0.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0598
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0608
    Cell Significance Index: -0.4800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0612
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOC4 is a small, secreted protein that belongs to the apolipoprotein family. It is primarily expressed in cells involved in lipid metabolism, including endothelial cells, T cells, plasma cells, and goblet cells. APOC4 is known to interact with various lipoproteins, including high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL), and has been implicated in the regulation of triglyceride homeostasis. **Pathways and Functions:** APOC4 is involved in several key pathways, including: 1. **Lipid Transport:** APOC4 facilitates the transport of triglycerides and cholesterol from peripheral tissues to the liver for excretion. 2. **Triglyceride Homeostasis:** APOC4 regulates the balance of triglycerides in the bloodstream by promoting the clearance of triglyceride-rich lipoproteins. 3. **Lipid Efflux:** APOC4 has been shown to enhance the efflux of cholesterol from cells to HDL, promoting the formation of HDL particles. 4. **Nr1h2 and Nr1h3-mediated Signaling:** APOC4 interacts with nuclear receptors Nr1h2 and Nr1h3, which regulate gene expression linked to cholesterol transport and efflux. **Clinical Significance:** The clinical significance of APOC4 is multifaceted: 1. **Atherosclerosis:** Elevated levels of APOC4 have been linked to increased risk of atherosclerosis, a condition characterized by the buildup of plaque in arterial walls. 2. **Metabolic Syndrome:** APOC4 has been implicated in the regulation of triglyceride homeostasis, and its dysregulation has been linked to metabolic syndrome, a cluster of conditions that increase the risk of cardiovascular disease. 3. **Neurological Disorders:** APOC4 has been shown to play a role in the regulation of GABAergic neurotransmission, and its dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. **Conclusion:** APOC4 is a critical gene that plays a multifaceted role in lipid metabolism. Its dysregulation has been linked to various human diseases, including atherosclerosis, metabolic syndrome, and neurological disorders. Further research is needed to fully elucidate the mechanisms of APOC4 and its clinical significance, but it is clear that this gene holds great promise for the development of novel therapeutic strategies for lipid-related diseases.

Genular Protein ID: 630014918

Symbol: APOC4_HUMAN

Name: Apolipoprotein C-IV

UniProtKB Accession Codes:

P55056 B3KWY6 Q53YY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530039

Title: Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus.

PubMed ID: 8530039

DOI: 10.1006/geno.1995.1144

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 10996355

Title: DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile.

PubMed ID: 10996355

DOI: 10.1016/s0021-9150(99)00459-1

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 127
  • Mass: 14553
  • Checksum: D7C7F6F2CD922775
  • Sequence:
    • MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET 
VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV 
CGDKDQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.