Details for: APOD

Gene ID: 347

Symbol: APOD

Ensembl ID: ENSG00000189058

Description: apolipoprotein D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.04
    Marker Score: 4635
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.94
    Marker Score: 134114
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.36
    Marker Score: 8040
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.29
    Marker Score: 1875
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.18
    Marker Score: 1324
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.97
    Marker Score: 1279
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.97
    Marker Score: 12796
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.84
    Marker Score: 3273
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.47
    Marker Score: 2109
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.46
    Marker Score: 612
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.44
    Marker Score: 612
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.39
    Marker Score: 1182
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.36
    Marker Score: 542
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.35
    Marker Score: 26489
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.3
    Marker Score: 6030
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.02
    Marker Score: 4428
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.99
    Marker Score: 703
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.8
    Marker Score: 2225.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.78
    Marker Score: 1122
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.73
    Marker Score: 427
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.69
    Marker Score: 14696.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.67
    Marker Score: 434
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.48
    Marker Score: 2507
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168110
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.44
    Marker Score: 700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.43
    Marker Score: 2718
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.41
    Marker Score: 1365
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.34
    Marker Score: 1848
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.34
    Marker Score: 546
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.3
    Marker Score: 330
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.28
    Marker Score: 5359
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.28
    Marker Score: 915
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.27
    Marker Score: 400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.26
    Marker Score: 915
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.21
    Marker Score: 292
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.2
    Marker Score: 425
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4784
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.14
    Marker Score: 4380.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.12
    Marker Score: 380
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.07
    Marker Score: 1647.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.05
    Marker Score: 381.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.04
    Marker Score: 525
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.96
    Marker Score: 534
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.94
    Marker Score: 863
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.93
    Marker Score: 20690
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5250
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.92
    Marker Score: 3161
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.9
    Marker Score: 1297
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.88
    Marker Score: 1035
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.87
    Marker Score: 354
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.86
    Marker Score: 1077
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.83
    Marker Score: 1030
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.81
    Marker Score: 199
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.8
    Marker Score: 936
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.75
    Marker Score: 3936
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 441
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.72
    Marker Score: 1311
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.72
    Marker Score: 1270
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1608
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1274
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.64
    Marker Score: 165
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.62
    Marker Score: 386
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.61
    Marker Score: 316
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.61
    Marker Score: 252
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.61
    Marker Score: 4522
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.6
    Marker Score: 5148
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.6
    Marker Score: 172
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.59
    Marker Score: 3528
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.57
    Marker Score: 283
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.56
    Marker Score: 922
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8661
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.55
    Marker Score: 1102
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 249.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1093
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.53
    Marker Score: 307
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.52
    Marker Score: 354
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.52
    Marker Score: 548
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.51
    Marker Score: 3311
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.51
    Marker Score: 31289
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.51
    Marker Score: 151

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Other Information

**Key characteristics:** * APOD is a glycoprotein that is expressed in high levels in plasma and other body fluids. * It is a key component of low-density lipoprotein (LDL), the "bad" cholesterol. * APOD is involved in the transport of cholesterol from the liver to peripheral tissues. * It also plays a role in the metabolism of other lipids, including those derived from cholesterol. **Pathways and functions:** * APOD is involved in the regulation of cholesterol transport and efflux in the body. * It binds to apolipoprotein B, which is a protein that is found on the surface of LDL particles. * This binding complex is then transported to the liver, where it is converted into a form that can be taken up by cells. * APOD also plays a role in the metabolism of other lipids, including those derived from cholesterol. * It is involved in the regulation of inflammation and cell growth. **Clinical significance:** * Mutations in the APOD gene have been linked to a number of diseases, including atherosclerosis, heart disease, and stroke. * These mutations can lead to the accumulation of cholesterol in the blood, which can damage blood vessels and lead to the development of these diseases. * APOD is a potential target for the treatment of these diseases. **Additional information:** * APOD is a protein that is expressed in high levels in skeletal muscle, fibroblasts, and endothelial cells. * It is a key component of low-density lipoprotein (LDL), the "bad" cholesterol. * APOD is involved in the transport of cholesterol from the liver to peripheral tissues. * It also plays a role in the metabolism of other lipids, including those derived from cholesterol. * Mutations in the APOD gene have been linked to a number of diseases, including atherosclerosis, heart disease, and stroke.

Genular Protein ID: 1287761366

Symbol: APOD_HUMAN

Name: Apolipoprotein D

UniProtKB Accession Codes:

P05090 B2R579 D3DNW6 Q6IBG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3453108

Title: Cloning and expression of human apolipoprotein D cDNA.

PubMed ID: 3453108

DOI: 10.1016/s0021-9258(18)66599-8

PubMed ID: 2439269

Title: Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily.

PubMed ID: 2439269

DOI: 10.1089/dna.1987.6.199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7918467

Title: Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.

PubMed ID: 7918467

DOI: 10.1021/bi00207a011

PubMed ID: 8549691

Title: The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily.

PubMed ID: 8549691

DOI: 10.1016/s0014-4835(05)80145-9

PubMed ID: 2244881

Title: Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease.

PubMed ID: 2244881

DOI: 10.1042/bj2710803

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2083249

Title: Is apolipoprotein D a mammalian bilin-binding protein?

PubMed ID: 2083249

PubMed ID: 7613477

Title: Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.

PubMed ID: 7613477

DOI: 10.1002/pro.5560040419

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 189
  • Mass: 21276
  • Checksum: 0EAA6DE03D5E71A8
  • Sequence:
    • MVMLLLLLSA LAGLFGAAEG QAFHLGKCPN PPVQENFDVN KYLGRWYEIE KIPTTFENGR 
CIQANYSLME NGKIKVLNQE LRADGTVNQI EGEATPVNLT EPAKLEVKFS WFMPSAPYWI 
LATDYENYAL VYSCTCIIQL FHVDFAWILA RNPNLPPETV DSLKNILTSN NIDVKKMTVT 
DQVNCPKLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.