Sirt1 | FBgn0024291 | NCBI 34708

Details for: Sirt1

Gene ID: 34708

Symbol: Sirt1

Ensembl ID: FBgn0024291

Description: Sirtuin 1

Associated with

Epigenetic regulation of gene expression
(R-DME-212165)
Foxo-mediated transcription
(R-DME-9614085)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Negative epigenetic regulation of rrna expression
(R-DME-5250941)
Regulation of foxo transcriptional activity by acetylation
(R-DME-9617629)
Rna polymerase ii transcription
(R-DME-73857)
Sirt1 negatively regulates rrna expression
(R-DME-427359)
Behavioral response to ethanol
(GO:0048149)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Determination of adult lifespan
(GO:0008340)
Heterochromatin formation
(GO:0031507)
Histone deacetylase activity
(GO:0004407)
Lateral inhibition
(GO:0046331)
Nad+ binding
(GO:0070403)
Nad-dependent histone deacetylase activity
(GO:0017136)
Negative regulation of dna-templated transcription
(GO:0045892)
Nuclear inner membrane
(GO:0005637)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Peptidyl-lysine deacetylation
(GO:0034983)
Positive regulation of feeding behavior
(GO:2000253)
Positive regulation of notch signaling pathway
(GO:0045747)
Protein deacetylation
(GO:0006476)
Protein lysine deacetylase activity
(GO:0033558)
Rdna heterochromatin
(GO:0033553)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of response to ethanol
(GO:1901416)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)

Other Information

Proteins

SIRT1_DROME

Genular Protein ID: 2822647154

Symbol: SIRT1_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VK34 D5SHQ6 O96505

Database IDs:

Citations:

PubMed ID: 12663533

Title: The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

PubMed ID: 12663533

DOI: 10.1093/genetics/163.3.931

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 11281647

Title: dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster.

PubMed ID: 11281647

DOI: 10.1006/excr.2001.5162

PubMed ID: 12086602

Title: Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination.

PubMed ID: 12086602

DOI: 10.1016/s0092-8674(02)00732-8

PubMed ID: 15498488

Title: SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

PubMed ID: 15498488

DOI: 10.1016/j.cub.2004.09.060

PubMed ID: 15520384

Title: Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

PubMed ID: 15520384

DOI: 10.1073/pnas.0404184101

PubMed ID: 17159295

Title: Involvement of Drosophila Sir2-like genes in the regulation of life span.

PubMed ID: 17159295

DOI: 10.1266/ggs.81.341

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

Length: 823
Mass: 91837
Checksum: 3DD1EBA975A263D3
Sequence:

MMENYEEIRL GHIRSKDLGN QVPDTTQFYP PTKFDFGAEI LASTSTEAEA EAEATATTTE 
PATSELAGKA NGEIKTKTLA AREEQEIGAN LEHKTKNPTK SMGEDEDDEE EEEEDDEEEE 
EDDEEGITGT SNEDEDSSSN CSSSVEPDWK LRWLQREFYT GRVPRQVIAS IMPHFATGLA 
GDTDDSVLWD YLAHLLNEPK RRNKLASVNT FDDVISLVKK SQKIIVLTGA GVSVSCGIPD 
FRSTNGIYAR LAHDFPDLPD PQAMFDINYF KRDPRPFYKF AREIYPGEFQ PSPCHRFIKM 
LETKGKLLRN YTQNIDTLER VAGIQRVIEC HGSFSTASCT KCRFKCNADA LRADIFAQRI 
PVCPQCQPNK EQSVDASVAV TEEELRQLVE NGIMKPDIVF FGEGLPDEYH TVMATDKDVC 
DLLIVIGSSL KVRPVAHIPS SIPATVPQIL INREQLHHLK FDVELLGDSD VIINQICHRL 
SDNDDCWRQL CCDESVLTES KELMPPEHSN HHLHHHLLHH RHCSSESERQ SQLDTDTQSI 
KSNSSADYIL GSAGTCSDSG FESSTFSCGK RSTAAEAAAI ERIKTDILVE LNETTALSCD 
RLGLEGPQTT VESYRHLSID SSKDSGIEQC DNEATPSYVR PSNLVQETKT VAPSLTPIPQ 
QRGKRQTAAE RLQPGTFYSH TNNYSYVFPG AQVFWDNDYS DDDDEEEERS HNRHSDLFGN 
VGHNYKDDDE DACDLNAVPL SPLLPPSLEA HIVTDIVNGS NEPLPNSSPG QKRTACIIEQ 
QPTPAIETEI PPLKKRRPSE ENKQQTQIER SEESPPPGQL AAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sirt1

Associated with

Other Information

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. PubMed ID: 12663533

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. PubMed ID: 11281647

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. PubMed ID: 12086602

SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. PubMed ID: 15498488

Sir2 mediates longevity in the fly through a pathway related to calorie restriction. PubMed ID: 15520384

Involvement of Drosophila Sir2-like genes in the regulation of life span. PubMed ID: 17159295

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897