Details for: loqs

Gene ID: 34751

Symbol: loqs

Ensembl ID: FBgn0032515

Description: loquacious

Associated with

Other Information

Genular Protein ID: 2902261833

Symbol: LOQS_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15985611

Title: Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila.

PubMed ID: 15985611

DOI: 10.1101/gad.1334005

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 19644447

Title: Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences.

PubMed ID: 19644447

DOI: 10.1038/emboj.2009.220

PubMed ID: 15918769

Title: Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells.

PubMed ID: 15918769

DOI: 10.1371/journal.pbio.0030235

PubMed ID: 15918770

Title: Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

PubMed ID: 15918770

DOI: 10.1371/journal.pbio.0030236

PubMed ID: 17320391

Title: The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells.

PubMed ID: 17320391

DOI: 10.1016/j.cub.2007.01.060

PubMed ID: 17666393

Title: Functional anatomy of the Drosophila microRNA-generating enzyme.

PubMed ID: 17666393

DOI: 10.1074/jbc.m705208200

PubMed ID: 17928574

Title: Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes.

PubMed ID: 17928574

DOI: 10.1261/rna.723707

PubMed ID: 19451544

Title: Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.

PubMed ID: 19451544

DOI: 10.1261/rna.1541209

PubMed ID: 19635780

Title: Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

PubMed ID: 19635780

DOI: 10.1261/rna.1611309

PubMed ID: 21245036

Title: Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.

PubMed ID: 21245036

DOI: 10.1093/nar/gkq1324

PubMed ID: 23063653

Title: Dicer partner proteins tune the length of mature miRNAs in flies and mammals.

PubMed ID: 23063653

DOI: 10.1016/j.cell.2012.09.027

PubMed ID: 25891075

Title: Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.

PubMed ID: 25891075

DOI: 10.1016/j.molcel.2015.03.012

PubMed ID: 27184838

Title: The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site.

PubMed ID: 27184838

DOI: 10.1016/j.celrep.2016.04.059

PubMed ID: 28874570

Title: Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA.

PubMed ID: 28874570

DOI: 10.1073/pnas.1707063114

PubMed ID: 29550490

Title: Loquacious-PD removes phosphate inhibition of Dicer-2 processing of hairpin RNAs into siRNAs.

PubMed ID: 29550490

DOI: 10.1016/j.bbrc.2018.03.108

PubMed ID: 29373753

Title: Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem.

PubMed ID: 29373753

DOI: 10.1093/nar/gky043

PubMed ID: 34590626

Title: Loquacious-PD regulates the terminus-dependent molecular recognition of Dicer-2 toward double-stranded RNA.

PubMed ID: 34590626

DOI: 10.1039/d1cc03843e

PubMed ID: 36057690

Title: Low dose rate gamma-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious.

PubMed ID: 36057690

DOI: 10.1038/s42003-022-03885-w

PubMed ID: 36175493

Title:

PubMed ID: 36175493

DOI: 10.1038/s42003-022-03984-8

PubMed ID: 26769856

Title: Structural and functional insights into the fly microRNA biogenesis factor Loquacious.

PubMed ID: 26769856

DOI: 10.1261/rna.055426.115

PubMed ID: 29040648

Title: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.

PubMed ID: 29040648

DOI: 10.1093/nar/gkx886

PubMed ID: 36182693

Title: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB.

PubMed ID: 36182693

DOI: 10.1016/j.molcel.2022.09.002

PubMed ID: 35768513

Title: Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD.

PubMed ID: 35768513

DOI: 10.1038/s41586-022-04911-x

Sequence Information:

  • Length: 465
  • Mass: 50085
  • Checksum: B69684E6B912F929
  • Sequence:
  • MDQENFHGSS LPQQLQNLHI QPQQASPNPV QTGFAPRRHY NNLVGLGNGN AVSGSPVKGA 
    PLGQRHVKLK KEKISAQVAQ LSQPGQLQLS DVGDPALAGG SGLQGGVGLM GVILPSDEAL 
    KFVSETDANG LAMKTPVSIL QELLSRRGIT PGYELVQIEG AIHEPTFRFR VSFKDKDTPF 
    TAMGAGRSKK EAKHAAARAL IDKLIGAQLP ESPSSSAGPS VTGLTVAGSG GDGNANATGG 
    GDASDKTVGN PIGWLQEMCM QRRWPPPSYE TETEVGLPHE RLFTIACSIL NYREMGKGKS 
    KKIAKRLAAH RMWMRLQETP IDSGKISDSI CGELEGEPRS SENYYGELKD ISVPTLTTQH 
    SNKVSQFHKT LKNATGKKLL KLQKTCLKNN KIDYIKLLGE IATENQFEVT YVDIEEKTFS 
    GQFQCLVQLS TLPVGVCHGS GPTAADAQRH AAQNALEYLK IMTKK

Genular Protein ID: 1945930648

Symbol: X2JAB1_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 418
  • Mass: 44745
  • Checksum: 9A669E2F6AEE1A4E
  • Sequence:
  • MDQENFHGSS LPQQLQNLHI QPQQASPNPV QTGFAPRRHY NNLVGLGNGN AVSGSPVKGA 
    PLGQRHVKLK KEKISAQVAQ LSQPGQLQLS DVGDPALAGG SGLQGGVGLM GVILPSDEAL 
    KFVSETDANG LAMKTPVSIL QELLSRRGIT PGYELVQIEG AIHEPTFRFR VSFKDKDTPF 
    TAMGAGRSKK EAKHAAARAL IDKLIGAQLP ESPSSSAGPS VTGLTVAGSG GDGNANATGG 
    GDASDKTVGN PIGWLQEMCM QRRWPPPSYE TETEVGLPHE RLFTIACSIL NYREMGKGKS 
    KKIAKRLAAH RMWMRLQETP IDSGKISDSI CGELEGETCL KNNKIDYIKL LGEIATENQF 
    EVTYVDIEEK TFSGQFQCLV QLSTLPVGVC HGSGPTAADA QRHAAQNALE YLKIMTKK

Genular Protein ID: 236861831

Symbol: X2J5X6_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 29040648

Title: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.

PubMed ID: 29040648

DOI: 10.1093/nar/gkx886

Sequence Information:

  • Length: 464
  • Mass: 49957
  • Checksum: B1EF94E83AC28FAA
  • Sequence:
  • MDQENFHGSS LPQQLQNLHI QPQQASPNPV QTGFAPRRHY NNLVGLGNGN AVSGSPVKGA 
    PLGQRHVKLK KEKISAQVAQ LSQPGQLQLS DVGDPALAGG SGLQGGVGLM GVILPSDEAL 
    KFVSETDANG LAMKTPVSIL QELLSRRGIT PGYELVQIEG AIHEPTFRFR VSFKDKDTPF 
    TAMGAGRSKK EAKHAAARAL IDKLIGAQLP ESPSSSAGPS VTGLTVAGSG GDGNANATGG 
    GDASDKTVGN PIGWLQEMCM QRRWPPPSYE TETEVGLPHE RLFTIACSIL NYREMGKGKS 
    KKIAKRLAAH RMWMRLQETP IDSGKISDSI CGELEGEPRS SENYYGELKD ISVPTLTTQH 
    SNKVSQFHKT LKNATGKKLL KLQTCLKNNK IDYIKLLGEI ATENQFEVTY VDIEEKTFSG 
    QFQCLVQLST LPVGVCHGSG PTAADAQRHA AQNALEYLKI MTKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.