Details for: Sos

Gene ID: 34790

Symbol: Sos

Ensembl ID: FBgn0001965

Description: Son of sevenless

Associated with

  • Axon midline choice point recognition
    (GO:0016199)
  • Cytosol
    (GO:0005829)
  • Defense response to virus
    (GO:0051607)
  • Epidermal growth factor receptor signaling pathway
    (GO:0007173)
  • Epithelial cell migration, open tracheal system
    (GO:0007427)
  • Extrinsic component of cytoplasmic side of plasma membrane
    (GO:0031234)
  • Fibroblast growth factor receptor signaling pathway
    (GO:0008543)
  • Guanyl-nucleotide exchange factor activity
    (GO:0005085)
  • Imaginal disc-derived leg morphogenesis
    (GO:0007480)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Photoreceptor cell fate determination
    (GO:0043703)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cell size
    (GO:0045793)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of rac protein signal transduction
    (GO:0035022)
  • Positive regulation of ras protein signal transduction
    (GO:0046579)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • R7 cell fate commitment
    (GO:0007465)
  • Ras protein signal transduction
    (GO:0007265)
  • Rhabdomere microvillus membrane
    (GO:0035997)
  • Sevenless signaling pathway
    (GO:0045500)
  • Small gtpase-mediated signal transduction
    (GO:0007264)
  • Torso signaling pathway
    (GO:0008293)
  • Tracheal outgrowth, open tracheal system
    (GO:0007426)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)

Other Information

Genular Protein ID: 602259200

Symbol: SOS_DROME

Name: Protein son of sevenless

UniProtKB Accession Codes:

P26675 Q6AWF4 Q8I067 Q8I0F7 Q8ITK2 Q95TI8 Q969D6 Q9VJV9

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 4 CTD 1 DIP 1 EMBL 25 EnsemblMetazoa 1 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 23 Gene3D 6 Genevisible 1 GenomeRNAi 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PaxDb 1 Pfam 4 PhylomeDB 1 Proteomes 1 Reactome 33 RefSeq 1 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1736363

Title: The Son of sevenless gene product: a putative activator of Ras.

PubMed ID: 1736363

DOI: 10.1126/science.1736363

PubMed ID: 1934068

Title: Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

PubMed ID: 1934068

DOI: 10.1016/0092-8674(91)90065-7

PubMed ID: 10471707

Title: An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region.

PubMed ID: 10471707

DOI: 10.1093/genetics/153.1.179

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12618399

Title: Evidence of a high rate of selective sweeps in African Drosophila melanogaster.

PubMed ID: 12618399

DOI: 10.1093/genetics/163.2.599

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 7773779

Title: NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.

PubMed ID: 7773779

DOI: 10.1038/nsb1294-898

Sequence Information:

  • Length: 1596
  • Mass: 177934
  • Checksum: 08DB85B59213B964
  • Sequence:
    • MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA GLQDCDGYDF 
TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK LCLRLLAMLC AKPLPHSVQD 
VEEKVNKSFP APIDQWALNE AKEVINSKKR KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL 
VAVLEYISAD ILKMAGDYVI KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL 
PAQRASATYE ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE 
VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ ASRDALNNLL 
SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY IKHLKDLSSS QDDIESFEQV 
QGLLHPLHCD LEKVMASLSK ERQVPVSGRV RRQLAIERTR ELQMKVEHWE DKDVGQNCNE 
FIREDSLSKL GSGKRIWSER KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR 
VDINDRPDSD DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL 
QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI ERLTYHIYAD 
PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT GTAGAGGMGG VGGDKEHKNS 
HREDWKRYRK EYVQPVQFRV LNVLRHWVDH HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW 
VDSVLKIVQR KNEQEKSNKK IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL 
EFEMYKNVKP SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI 
MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL EECRELSDDH 
LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT ELINFSKRRK VAEIIGEIQQ 
YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK QMSDYLYNES LRIEPRGCKT VPKFPRKWPH 
IPLKSPGIKP RRQNQTNSSS KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT 
AAAANAGSGT LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA 
PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS DTEAPPSPLP 
KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS GGEEFCAGGF YFNSAHQGQP 
GAVPISPHVN VPMATNMEYR AVPPPLPPRR KERTESCADM AQKRQAPDAP TLPPRDGELS 
PPPIPPRLNH STGISYLRQS HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN 
QAAAGPISTT LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST 
SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS SPKEFFPIAT 
SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.