Details for: PolG1

Gene ID: 34792

Symbol: PolG1

Ensembl ID: FBgn0004406

Description: DNA polymerase gamma subunit 1

Associated with

Other Information

Genular Protein ID: 2399669764

Symbol: DPOG1_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8884268

Title: Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma.

PubMed ID: 8884268

DOI: 10.1006/geno.1996.0490

PubMed ID: 8798543

Title: Catalytic subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, bacterial overexpression, and biochemical characterization.

PubMed ID: 8798543

DOI: 10.1074/jbc.271.38.23389

PubMed ID: 10471707

Title: An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region.

PubMed ID: 10471707

DOI: 10.1093/genetics/153.1.179

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 3095323

Title: A mitochondrial DNA polymerase from embryos of Drosophila melanogaster. Purification, subunit structure, and partial characterization.

PubMed ID: 3095323

DOI: 10.1016/s0021-9258(18)66938-8

PubMed ID: 2671990

Title: Mismatch-specific 3'----5' exonuclease associated with the mitochondrial DNA polymerase from Drosophila embryos.

PubMed ID: 2671990

DOI: 10.1073/pnas.86.17.6469

PubMed ID: 7499423

Title: Subunit structure of mitochondrial DNA polymerase from Drosophila embryos. Physical and immunological studies.

PubMed ID: 7499423

DOI: 10.1074/jbc.270.48.28932

PubMed ID: 9153213

Title: Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme.

PubMed ID: 9153213

DOI: 10.1074/jbc.272.21.13640

PubMed ID: 10930405

Title: Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase.

PubMed ID: 10930405

DOI: 10.1074/jbc.m003024200

PubMed ID: 11917141

Title: The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster.

PubMed ID: 11917141

DOI: 10.1073/pnas.072664899

PubMed ID: 15537632

Title: Mutations in the spacer region of Drosophila mitochondrial DNA polymerase affect DNA binding, processivity, and the balance between Pol and Exo function.

PubMed ID: 15537632

DOI: 10.1074/jbc.m411447200

PubMed ID: 19924234

Title: Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.

PubMed ID: 19924234

DOI: 10.1371/journal.pone.0007874

PubMed ID: 26554610

Title: Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

PubMed ID: 26554610

DOI: 10.1038/ncomms9808

PubMed ID: 28318978

Title: The mitochondrial DNA polymerase promotes elimination of paternal mitochondrial genomes.

PubMed ID: 28318978

DOI: 10.1016/j.cub.2017.02.014

PubMed ID: 28430993

Title: A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.

PubMed ID: 28430993

DOI: 10.1093/hmg/ddx146

Sequence Information:

  • Length: 1145
  • Mass: 129828
  • Checksum: 186AD02B63827707
  • Sequence:
  • MQFHLIRKYA SKVSREHYAS SSVKIFRRVK PPQKVNKPKK PENVENGPTE YAENLVKVQM 
    ISRNLHAQLF PQAPRSISEQ QVASAKVYKD ELRRHGVDIE SSAPVSDVQL KLPALRGANI 
    EEHFHNIAKE QVQPYEELLL PLVQCEQLPK RPKRWAFHTG WTAYDPEDGT ATPVDHPLEK 
    GLVFDVEVCV SEGQAPVLAT AVSTKRWYSW VSSKLTKHRL SVEKLEPLDV DTDSERPHYT 
    TDELIPLGTT GPGLVVGHNV SYDRARLKEQ YLTEDTGTRF VDTMSLHMCV SGVTSYQRAM 
    LKSKKEPAAE DLGWLEQSSL NSLVEVHRLY CGGDTLSKEP RNIFVEGTLE QVRQSFQSLT 
    NYCASDVEAT HRILRVLYPL YAERFPHPAS LAGMLEMGSA YLPVNSNWER YIREAQLTYE 
    DLSIEAKYHL GRRAEEACSL LLDDQYRQNL WLWDEDWSVQ ELKLKQPPKR KPLPTVELKD 
    SGNTPEERRL QAKFQHLYDQ QALLPARRPL LPGYPLWYRK LCRKPPAKRA DEILEDDEEP 
    WSPGASEIST GMQIAPKLLS LCWEGYPLHY EREQGWGFLV PFRSDSEGVD RLPMEQLLAH 
    CPVPEFARLS ASKAESDMAF DMLPGQVEQH LGKREHYKKL SQKQQRLETQ YQGSGVWCNK 
    VLDDCCFFLK LPHKNGPSFR VGNPLSKDFL NKFAENVLSS GDPSCQAAAR VIDIARMMSY 
    WRNNRDRIMG QMVVWLDSQQ LPNEFTGEKC QPIAYGAICP QVVACGTLTR RAMEPTWMTA 
    SNSRPDRLGS ELRSMVQAPP GYRLVGADVD SQELWIASVL GDAYACGEHG ATPLGWMTLS 
    GSKSNGSDMH SITAKAVGIS RDHAKVINYA RIYGAGQLFA ETLLRQFNPT FSASEAKAKA 
    MKMFSITKGK RVYRLREEFH DELEDRAYSS YEASRLAIQR NRTLAEVFHR PNWQGGTESA 
    MFNRLEEIAT GSQPRTPFLG GRLSRALEAD TGPEQEQRFL PTRINWVVQS GAVDFLHLML 
    VSMRWLMGSH VRFCLSFHDE LRYLVKEELS PKAALAMHIT NLMTRSFCVS RIGLQDLPMS 
    VAFFSSVEVD TVLRKECTMD CKTPSNPHGL RIGYGIQPGQ SLSVAEAIEK AGGNDVSQWD 
    WIKKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.