Details for: APOE

Gene ID: 348

Symbol: APOE

Ensembl ID: ENSG00000130203

Description: apolipoprotein E

Associated with

Other Information

Genular Protein ID: 3969851902

Symbol: APOE_HUMAN

Name: N/A

UniProtKB Accession Codes:

P02649 B2RC15 C0JYY5 Q9P2S4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 2 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 EMBL 9 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 43 PDBsum 28 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 12 RefSeq 5 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6325438

Title: Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

PubMed ID: 6325438

DOI: 10.1016/s0021-9258(18)91039-2

PubMed ID: 6327682

Title: Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.

PubMed ID: 6327682

DOI: 10.1016/s0021-9258(20)82169-3

PubMed ID: 2987927

Title: Nucleotide sequence and structure of the human apolipoprotein E gene.

PubMed ID: 2987927

DOI: 10.1073/pnas.82.10.3445

PubMed ID: 3243553

Title: Genotyping and sequence analysis of apolipoprotein E isoforms.

PubMed ID: 3243553

DOI: 10.1016/0888-7543(88)90130-9

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 11042151

Title: Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.

PubMed ID: 11042151

DOI: 10.1101/gr.146900

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6897404

Title: Identification and DNA sequence of a human apolipoprotein E cDNA clone.

PubMed ID: 6897404

DOI: 10.1016/s0021-9258(18)33328-3

PubMed ID: 7068630

Title: Human apolipoprotein E. The complete amino acid sequence.

PubMed ID: 7068630

DOI: 10.1016/s0021-9258(18)34702-1

PubMed ID: 6860692

Title: Cholesteryl ester and apolipoprotein E transfer between human high density lipoproteins and chylomicrons.

PubMed ID: 6860692

DOI: 10.1016/0005-2760(83)90047-4

PubMed ID: 3947350

Title: Binding of a high reactive heparin to human apolipoprotein E: identification of two heparin-binding domains.

PubMed ID: 3947350

DOI: 10.1016/s0006-291x(86)80489-2

PubMed ID: 3115992

Title: Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

PubMed ID: 3115992

DOI: 10.1016/s0021-9258(18)47945-8

PubMed ID: 30448281

Title: Soluble LR11 competes with amyloid beta in binding to cerebrospinal fluid-high-density lipoprotein.

PubMed ID: 30448281

DOI: 10.1016/j.cca.2018.11.024

PubMed ID: 2831187

Title: Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.

PubMed ID: 2831187

DOI: 10.1016/s0021-9258(18)68957-4

PubMed ID: 2498325

Title: Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.

PubMed ID: 2498325

DOI: 10.1016/s0021-9258(18)81907-x

PubMed ID: 2762297

Title: Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

PubMed ID: 2762297

DOI: 10.1073/pnas.86.15.5810

PubMed ID: 2280190

Title: Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

PubMed ID: 2280190

PubMed ID: 1911868

Title: Effects of exogenous apo E-3 and of cholesterol-enriched meals on the cellular metabolism of human chylomicrons and their remnants.

PubMed ID: 1911868

DOI: 10.1016/0005-2760(91)90138-8

PubMed ID: 1917954

Title: Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway.

PubMed ID: 1917954

DOI: 10.1016/s0021-9258(18)55263-7

PubMed ID: 8340399

Title: Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization.

PubMed ID: 8340399

DOI: 10.1016/s0021-9258(18)82318-3

PubMed ID: 8367470

Title: Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

PubMed ID: 8367470

DOI: 10.1073/pnas.90.17.8098

PubMed ID: 7891887

Title: Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

PubMed ID: 7891887

DOI: 10.1016/0304-3940(94)90204-6

PubMed ID: 7972031

Title: Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

PubMed ID: 7972031

DOI: 10.1073/pnas.91.23.11183

PubMed ID: 7768901

Title: Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin.

PubMed ID: 7768901

DOI: 10.1074/jbc.270.22.13070

PubMed ID: 8939961

Title: Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.

PubMed ID: 8939961

DOI: 10.1074/jbc.271.47.30121

PubMed ID: 9395455

Title: Heparan sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins.

PubMed ID: 9395455

DOI: 10.1074/jbc.272.50.31285

PubMed ID: 9488694

Title: The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of ApoE. Implications for hepatic lipoprotein metabolism.

PubMed ID: 9488694

DOI: 10.1074/jbc.273.10.5645

PubMed ID: 10027417

Title: Specific regional transcription of apolipoprotein E in human brain neurons.

PubMed ID: 10027417

DOI: 10.1016/s0002-9440(10)65305-9

PubMed ID: 10452964

Title: Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.

PubMed ID: 10452964

DOI: 10.1016/s0925-4439(99)00047-2

PubMed ID: 11447277

Title: Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.

PubMed ID: 11447277

DOI: 10.1073/pnas.151254698

PubMed ID: 12950167

Title: Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.

PubMed ID: 12950167

DOI: 10.1021/bi027093c

PubMed ID: 14754908

Title: Molecular interactions between apoE and ABCA1: impact on apoE lipidation.

PubMed ID: 14754908

DOI: 10.1194/jlr.m300418-jlr200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20030366

Title: Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.

PubMed ID: 20030366

DOI: 10.1021/bi9017208

PubMed ID: 20511397

Title: Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290.

PubMed ID: 20511397

DOI: 10.1074/mcp.m900430-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23676495

Title: Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.

PubMed ID: 23676495

DOI: 10.1172/jci67398

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 23620513

Title: ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions.

PubMed ID: 23620513

DOI: 10.1073/pnas.1220484110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25122793

Title: Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.

PubMed ID: 25122793

DOI: 10.1128/jvi.01660-14

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 26387950

Title: Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.

PubMed ID: 26387950

DOI: 10.1016/j.celrep.2015.08.057

PubMed ID: 28111074

Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion.

PubMed ID: 28111074

DOI: 10.1016/j.cell.2016.12.044

PubMed ID: 29695434

Title: Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy.

PubMed ID: 29695434

DOI: 10.1128/jvi.00211-18

PubMed ID: 30333625

Title: LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.

PubMed ID: 30333625

DOI: 10.1038/s41586-018-0615-z

PubMed ID: 2063194

Title: Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.

PubMed ID: 2063194

DOI: 10.1126/science.2063194

PubMed ID: 8071364

Title: Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.

PubMed ID: 8071364

DOI: 10.1016/s0021-9258(17)31797-0

PubMed ID: 7994571

Title: Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.

PubMed ID: 7994571

DOI: 10.1016/s0969-2126(00)00072-1

PubMed ID: 8756331

Title: Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.

PubMed ID: 8756331

DOI: 10.1038/nsb0896-718

PubMed ID: 10850798

Title: Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.

PubMed ID: 10850798

DOI: 10.1110/ps.9.5.886

PubMed ID: 11258893

Title: Interaction of the N-terminal domain of apolipoprotein E4 with heparin.

PubMed ID: 11258893

DOI: 10.1021/bi002417n

PubMed ID: 20303980

Title: Structure of the minimal interface between ApoE and LRP.

PubMed ID: 20303980

DOI: 10.1016/j.jmb.2010.03.022

PubMed ID: 2738044

Title: Identification of human apolipoprotein E variant gene: apolipoprotein E7 (Glu244,245----Lys244,245).

PubMed ID: 2738044

DOI: 10.1093/oxfordjournals.jbchem.a122618

PubMed ID: 2760009

Title: Molecular cloning of a human apolipoprotein E variant: E5 (Glu-3-->Lys).

PubMed ID: 2760009

DOI: 10.1093/oxfordjournals.jbchem.a122692

PubMed ID: 2556398

Title: Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127.

PubMed ID: 2556398

DOI: 10.1016/s0021-9258(19)30067-5

PubMed ID: 2101409

Title: Identification and characterization of a new variant of apolipoprotein E (apo E-Kochi).

PubMed ID: 2101409

DOI: 10.2169/internalmedicine1962.29.587

PubMed ID: 2341812

Title: Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.

PubMed ID: 2341812

PubMed ID: 1674745

Title: Apolipoprotein E-4 Philadelphia (Glu-13-->Lys,Arg-145-->Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.

PubMed ID: 1674745

DOI: 10.1016/s0021-9258(18)99249-5

PubMed ID: 1713245

Title: Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects.

PubMed ID: 1713245

PubMed ID: 1530612

Title: Site-directed mutagenesis of an apolipoprotein E mutant, apo E5(Glu3----Lys) and its binding to low density lipoprotein receptors.

PubMed ID: 1530612

DOI: 10.1016/0006-291x(92)91321-g

PubMed ID: 1361196

Title: Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene.

PubMed ID: 1361196

PubMed ID: 8488843

Title: Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.

PubMed ID: 8488843

PubMed ID: 8125051

Title: Characterization of the gene for apolipoprotein E5-Frankfurt (Gln81->Lys, Cys112->Arg) by polymerase chain reaction, restriction isotyping, and temperature gradient gel electrophoresis.

PubMed ID: 8125051

DOI: 10.1002/elps.11501401164

PubMed ID: 8468528

Title: Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.

PubMed ID: 8468528

PubMed ID: 8346443

Title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

PubMed ID: 8346443

DOI: 10.1126/science.8346443

PubMed ID: 8287539

Title: Common and rare genotypes of human apolipoprotein E determined by specific restriction profiles of polymerase chain reaction-amplified DNA.

PubMed ID: 8287539

PubMed ID: 7635945

Title: Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).

PubMed ID: 7635945

DOI: 10.1172/jci118096

PubMed ID: 8664327

Title: Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 --> Gln) in a hyperlipidemic patient with xanthomatosis.

PubMed ID: 8664327

DOI: 10.1016/0005-2760(96)00014-8

PubMed ID: 9176854

Title: Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy.

PubMed ID: 9176854

DOI: 10.1681/asn.v85820

PubMed ID: 9360638

Title: Apolipoprotein E R112; R251G: a carboxy-terminal variant found in patients with hyperlipidemia and coronary heart disease.

PubMed ID: 9360638

DOI: 10.1016/s1383-5726(97)00009-5

PubMed ID: 10432380

Title: A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy.

PubMed ID: 10432380

DOI: 10.1046/j.1523-1755.1999.00572.x

PubMed ID: 10903326

Title: Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice.

PubMed ID: 10903326

DOI: 10.1074/jbc.m005906200

PubMed ID: 11095479

Title: Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].

PubMed ID: 11095479

DOI: 10.1210/jcem.85.11.6981

PubMed ID: 12864777

Title: Apolipoprotein E3Basel: new insights into a highly conserved protein region.

PubMed ID: 12864777

DOI: 10.1046/j.1365-2362.2003.01180.x

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 16094309

Title: Variable expressivity of the clinical and biochemical phenotype associated with the apolipoprotein E p.Leu149del mutation.

PubMed ID: 16094309

DOI: 10.1038/sj.ejhg.5201480

PubMed ID: 18077821

Title: APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy.

PubMed ID: 18077821

DOI: 10.1056/nejmc072088

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 22481068

Title: Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.

PubMed ID: 22481068

DOI: 10.1016/j.atherosclerosis.2012.03.011

PubMed ID: 24267230

Title: APOE p.Leu167del mutation in familial hypercholesterolemia.

PubMed ID: 24267230

DOI: 10.1016/j.atherosclerosis.2013.09.007

PubMed ID: 22949395

Title: Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation.

PubMed ID: 22949395

DOI: 10.1002/humu.22215

PubMed ID: 26802169

Title: Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France.

PubMed ID: 26802169

DOI: 10.1194/jlr.p055699

PubMed ID: 7833947

Title: Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels.

PubMed ID: 7833947

DOI: 10.1002/humu.1380040303

PubMed ID: 25173806

Title: Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

PubMed ID: 25173806

DOI: 10.1016/j.nbd.2014.08.025

PubMed ID: 29516132

Title: Cell-specific production, secretion, and function of apolipoprotein E.

PubMed ID: 29516132

DOI: 10.1007/s00109-018-1632-y

PubMed ID: 33450186

Title: ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.

PubMed ID: 33450186

DOI: 10.1016/j.stem.2020.12.018

Sequence Information:

  • Length: 317
  • Mass: 36154
  • Checksum: 91AFC04210A30689
  • Sequence:
    • MKVLWAALLV TFLAGCQAKV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT 
LSEQVQEELL SSQVTQELRA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA 
RLGADMEDVC GRLVQYRGEV QAMLGQSTEE LRVRLASHLR KLRKRLLRDA DDLQKRLAVY 
QAGAREGAER GLSAIRERLG PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEMG 
SRTRDRLDEV KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK 
VQAAVGTSAA PVPSDNH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.