APOE | ENSG00000130203 | NCBI 348

Details for: APOE

Gene ID: 348

Symbol: APOE

Ensembl ID: ENSG00000130203

Description: apolipoprotein E

Associated with

Amyloid fiber formation
(R-HSA-977225)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Chylomicron assembly
(R-HSA-8963888)
Chylomicron clearance
(R-HSA-8964026)
Chylomicron remodeling
(R-HSA-8963901)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdl remodeling
(R-HSA-8964058)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear signaling by erbb4
(R-HSA-1251985)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Retinoid metabolism and transport
(R-HSA-975634)
Rna polymerase ii transcription
(R-HSA-73857)
Scavenging by class a receptors
(R-HSA-3000480)
Sensory perception
(R-HSA-9709957)
Signaling by erbb4
(R-HSA-1236394)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)
Visual phototransduction
(R-HSA-2187338)
Amyloid-beta binding
(GO:0001540)
Antioxidant activity
(GO:0016209)
Cholesterol catabolic process
(GO:0006707)
Cholesterol efflux
(GO:0033344)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transfer activity
(GO:0120020)
Cytoskeleton organization
(GO:0007010)
Enzyme binding
(GO:0019899)
Gene expression
(GO:0010467)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Intracellular calcium ion homeostasis
(GO:0006874)
Lipid binding
(GO:0008289)
Lipid transporter activity
(GO:0005319)
Lipid transport involved in lipid storage
(GO:0010877)
Lipoprotein particle binding
(GO:0071813)
Long-chain fatty acid transport
(GO:0015909)
Long-term memory
(GO:0007616)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Melanosome organization
(GO:0032438)
Metal chelating activity
(GO:0046911)
Negative regulation of blood coagulation
(GO:0030195)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of platelet activation
(GO:0010544)
Neuron projection development
(GO:0031175)
Phosphatidylcholine-sterol o-acyltransferase activator activity
(GO:0060228)
Phospholipid binding
(GO:0005543)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of low-density lipoprotein particle receptor catabolic process
(GO:0032805)
Positive regulation of neuron projection development
(GO:0010976)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Protein import
(GO:0017038)
Receptor-mediated endocytosis
(GO:0006898)
Receptor ligand activity
(GO:0048018)
Regulation of axon extension
(GO:0030516)
Regulation of cdc42 protein signal transduction
(GO:0032489)
Response to dietary excess
(GO:0002021)
Response to reactive oxygen species
(GO:0000302)
Signaling receptor binding
(GO:0005102)
Structural molecule activity
(GO:0005198)
Synaptic transmission, cholinergic
(GO:0007271)
Tau protein binding
(GO:0048156)
Triglyceride metabolic process
(GO:0006641)
Very-low-density lipoprotein particle receptor binding
(GO:0070326)
Virion assembly
(GO:0019068)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.6
Cell Significance Index: 3
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.7
Cell Significance Index: 2
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 1
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 1
Cell Significance Index: 1
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 1
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Leydig cell (CL0000178)
Fold Change: 1
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 1
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1
Cell Significance Index: 1
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 1
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature T cell (CL0002419)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: melanocyte (CL0000148)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: macrophage (CL0000235)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microglial cell (CL0000129)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stromal cell (CL0000499)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** APOE is a 299-amino acid protein that is synthesized in various cell types, including hepatoblasts, cortical cells of the adrenal gland, enterocytes, and astrocytes. It has a unique structure, consisting of two A and two B domains, which are responsible for its ability to bind lipids and interact with cell surface receptors. APOE is highly conserved across species, suggesting its essential role in lipid metabolism and transport. **Pathways and Functions** APOE is involved in several key pathways, including: 1. **Cholesterol Efflux**: APOE facilitates the transfer of cholesterol from peripheral tissues to the liver, where it is excreted into bile. 2. **Antioxidant Activity**: APOE has antioxidant properties, which help protect against oxidative stress and inflammation. 3. **Lipid Transport**: APOE is a component of lipoproteins, which transport lipids, including cholesterol, triglycerides, and phospholipids, throughout the body. 4. **Axon Extension**: APOE is involved in the regulation of axon extension, a process essential for neuronal development and function. 5. **Gene Expression Regulation**: APOE regulates gene expression through interaction with transcription factors, such as Ap-2, and influences the expression of genes involved in lipid metabolism and transport. **Clinical Significance** APOE is a significant factor in the development of several diseases, including: 1. **Atherosclerosis**: Elevated levels of LDL cholesterol, facilitated by APOE, contribute to the development of atherosclerosis. 2. **Alzheimer's Disease**: The ε4 isoform of APOE is associated with an increased risk of Alzheimer's disease, suggesting a role in amyloid-β clearance and deposition. 3. **Cardiovascular Disease**: APOE influences lipid metabolism and transport, which are critical factors in the development of cardiovascular disease. 4. **Neurodegenerative Disorders**: APOE's role in axon extension and gene expression regulation may also contribute to the pathogenesis of neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. In conclusion, APOE is a multifunctional protein that plays a crucial role in lipid metabolism, transport, and clearance. Its dysregulation is associated with several diseases, highlighting the importance of understanding its functions and mechanisms of action.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.