Details for: Su H

Gene ID: 34881

Symbol: Su H

Ensembl ID: FBgn0004837

Description: Suppressor of Hairless

Associated with

  • Asymmetric cell division
    (GO:0008356)
  • Cell fate determination
    (GO:0001709)
  • Crystal cell differentiation
    (GO:0042688)
  • Csl-notch-mastermind transcription factor complex
    (GO:1990433)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Dorsal/ventral lineage restriction, imaginal disc
    (GO:0007451)
  • Hemopoiesis
    (GO:0030097)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Imaginal disc-derived leg morphogenesis
    (GO:0007480)
  • Imaginal disc-derived wing vein morphogenesis
    (GO:0008586)
  • Long-term memory
    (GO:0007616)
  • Negative regulation of compound eye cone cell fate specification
    (GO:0042683)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Polytene chromosome
    (GO:0005700)
  • Positive regulation of g1/s transition of mitotic cell cycle
    (GO:1900087)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Rna polymerase ii transcription repressor complex
    (GO:0090571)
  • Sensory organ precursor cell fate determination
    (GO:0016360)
  • Transcription repressor complex
    (GO:0017053)
  • Wing disc dorsal/ventral pattern formation
    (GO:0048190)

Other Information

Genular Protein ID: 3833041748

Symbol: SUH_DROME

Name: Suppressor of hairless protein

UniProtKB Accession Codes:

P28159 Q3S1M8 Q9TVK8 Q9TVY7 Q9TW34 Q9U8F9 Q9V446

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 EMBL 25 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 1 GO 31 Gene3D 3 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRO 1 PaxDb 1 Pfam 3 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1744127

Title: The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.

PubMed ID: 1744127

DOI: 10.1016/s0021-9258(18)54501-4

PubMed ID: 1617730

Title: Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates.

PubMed ID: 1617730

DOI: 10.1016/0092-8674(92)90641-o

PubMed ID: 10471707

Title: An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region.

PubMed ID: 10471707

DOI: 10.1093/genetics/153.1.179

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 10388820

Title: Selective sweep at the Drosophila melanogaster Suppressor of Hairless locus and its association with the In(2L)t inversion polymorphism.

PubMed ID: 10388820

DOI: 10.1093/genetics/152.3.1017

PubMed ID: 1617729

Title: The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.

PubMed ID: 1617729

DOI: 10.1016/0092-8674(92)90640-x

PubMed ID: 7813798

Title: The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo.

PubMed ID: 7813798

DOI: 10.1006/dbio.1994.1359

PubMed ID: 7958912

Title: Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

PubMed ID: 7958912

DOI: 10.1101/gad.8.20.2491

PubMed ID: 8674407

Title: Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling.

PubMed ID: 8674407

DOI: 10.1242/dev.122.6.1673

PubMed ID: 10673509

Title: Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.

PubMed ID: 10673509

PubMed ID: 12642500

Title: A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.

PubMed ID: 12642500

DOI: 10.1242/dev.00426

PubMed ID: 21262215

Title: The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.

PubMed ID: 21262215

DOI: 10.1016/j.ydbio.2011.01.019

PubMed ID: 21765394

Title: Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.

PubMed ID: 21765394

DOI: 10.1038/emboj.2011.218

Sequence Information:

  • Length: 594
  • Mass: 66924
  • Checksum: 145144F336CD8F4C
  • Sequence:
    • MKSYSQFNLN AAAPPAIAYE TTVVNPNGSP LDPHQQQQQQ SQDMPHFGLP GPQPPSSQQQ 
QQQLQVHHQQ QQQQQQQQQQ QQHQQQMQMS LLPGPYRPHI EEKKLTRDAM EKYMRERNDM 
VIVILHAKVA QKSYGNEKRF FCPPPCIYLF GSGWRRRYEE MLQQGEGEQG AQLCAFIGIG 
SSDQDMQQLD LNGKQYCAAK TLFISDSDKR KHFMLSVKMF YGNGHDIGVF NSKRIKVISK 
PSKKKQSLKN ADLCIASGTN VALFNRLRSQ TVSTRYLHVE NGHFHASSTQ WGAFTIHLLD 
DNESESEEFQ VRDGYIHYGA TVKLVCSVTG MALPRLIIRK VDKQMALLEA DDPVSQLHKC 
AFYMKDTDRM YLCLSQEKII QFQATPCPKE PNKEMINDGA CWTIISTDKA EYQFYEGMGP 
VASPVTPVPI VNSLNLNGGG DVAMLELSGD NFTPHLQVWF GDVEAETMYR CTETLLCVVP 
EISQFRGEWL WVRQPTQVPI SLVRNDGIIY ATGLTFTYTP EPGPRPHCNT QAEDVMRARQ 
NNNNNNITSI SNNNNSNNAG SPAAGGGLQQ QQQQHQALPS ISEVQWNSHG SGLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.