Details for: fzy

Gene ID: 34968

Symbol: fzy

Ensembl ID: FBgn0001086

Description: fizzy

Associated with

  • Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
    (R-DME-176814)
  • Adaptive immune system
    (R-DME-1280218)
  • Antigen processing: ubiquitination & proteasome degradation
    (R-DME-983168)
  • Apc-cdc20 mediated degradation of nek2a
    (R-DME-179409)
  • Apc/c-mediated degradation of cell cycle proteins
    (R-DME-174143)
  • Apc/c:cdc20 mediated degradation of cyclin b
    (R-DME-174048)
  • Apc/c:cdc20 mediated degradation of mitotic proteins
    (R-DME-176409)
  • Apc/c:cdc20 mediated degradation of securin
    (R-DME-174154)
  • Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
    (R-DME-174178)
  • Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
    (R-DME-179419)
  • Cdc20:phospho-apc/c mediated degradation of cyclin a
    (R-DME-174184)
  • Cell cycle
    (R-DME-1640170)
  • Cell cycle, mitotic
    (R-DME-69278)
  • Cell cycle checkpoints
    (R-DME-69620)
  • Class i mhc mediated antigen processing & presentation
    (R-DME-983169)
  • Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
    (R-DME-176407)
  • Immune system
    (R-DME-168256)
  • Inactivation of apc/c via direct inhibition of the apc/c complex
    (R-DME-141430)
  • Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
    (R-DME-141405)
  • Mitotic anaphase
    (R-DME-68882)
  • Mitotic metaphase and anaphase
    (R-DME-2555396)
  • Mitotic spindle checkpoint
    (R-DME-69618)
  • M phase
    (R-DME-68886)
  • Phosphorylation of emi1
    (R-DME-176417)
  • Regulation of apc/c activators between g1/s and early anaphase
    (R-DME-176408)
  • Regulation of mitotic cell cycle
    (R-DME-453276)
  • Scf-beta-trcp mediated degradation of emi1
    (R-DME-174113)
  • Separation of sister chromatids
    (R-DME-2467813)
  • Anaphase-promoting complex
    (GO:0005680)
  • Anaphase-promoting complex-dependent catabolic process
    (GO:0031145)
  • Anaphase-promoting complex binding
    (GO:0010997)
  • Centrosome
    (GO:0005813)
  • Female meiosis i
    (GO:0007144)
  • Female meiosis ii
    (GO:0007147)
  • Germ-line stem cell population maintenance
    (GO:0030718)
  • Kinetochore
    (GO:0000776)
  • Mitotic cell cycle
    (GO:0000278)
  • Negative regulation of programmed necrotic cell death
    (GO:0062099)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Positive regulation of anaphase-promoting complex-dependent catabolic process
    (GO:1905786)
  • Positive regulation of ubiquitin protein ligase activity
    (GO:1904668)
  • Protein catabolic process
    (GO:0030163)
  • Spindle
    (GO:0005819)
  • Ubiquitin-protein transferase activator activity
    (GO:0097027)
  • Ubiquitin ligase activator activity
    (GO:1990757)

Other Information

Genular Protein ID: 3989938867

Symbol: Q24044_DROME

Name: N/A

UniProtKB Accession Codes:

Q24044

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 EMBL 8 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 16 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 Proteomes 2 Reactome 14 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7730407

Title: The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

PubMed ID: 7730407

DOI: 10.1083/jcb.129.3.725

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

Sequence Information:

  • Length: 526
  • Mass: 57081
  • Checksum: 9948BC4F1B947ED9
  • Sequence:
    • MSQFNFVSDL QNALIMDGET RGPAPRWKKK LEASLNGSVN TTRSVLSVSY NTSFSGVQAP 
TKTPGKSSEG KTKKSNTTPS KTPGGGDRFI PNRAATNFEL AHFLVNKDSG DKSDEENDKA 
TSSNSNESNV QASAHKGDRQ KLISEVAQVG DSKGGRILCY QNKAPAAPET HNNPLKVVYS 
IKTPISTKSG SRYIPTTSER ILDAPDFIND YYLNLMDWSA DNIVAVALGS CVYLWNAQTG 
NIEQLTEFEE GDYAGSLSWI QEGQILAIGN STGAVELWDC SKVKRLRVMD GHSARVGSLA 
WNSFLVSSGS RDGTIVHHDV RAREHKLSTL SGHTQEVCGL KWSTDFKYLA SGGNDNLVNV 
WSAASGGVGT ATDPLHKFND HQAAVRALAW CPWQPSTLAS GGGTADRCIK FWNVNNGTLM 
KSVDSKSQVC SLLFSRHYKE LISAHGFANN QLTIWKYPTM VKQADLTGHT SRVLQMAMSP 
DGSTVISAGA DETLRLWNCF APDPLASKKA VSTSKGKQSV FRQSIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.