Details for: ACADS

Gene ID: 35

Symbol: ACADS

Ensembl ID: ENSG00000122971

Description: acyl-CoA dehydrogenase short chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.38
    Marker Score: 11414
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.33
    Marker Score: 7327
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.04
    Marker Score: 3150
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.61
    Marker Score: 2669
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.47
    Marker Score: 5792
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.47
    Marker Score: 3493
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.22
    Marker Score: 459.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.13
    Marker Score: 851
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.12
    Marker Score: 1117.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.07
    Marker Score: 1023
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.05
    Marker Score: 304
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.02
    Marker Score: 247
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.01
    Marker Score: 557
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71732
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47957
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.98
    Marker Score: 360
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.98
    Marker Score: 6262
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.92
    Marker Score: 228
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.92
    Marker Score: 3253
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9
    Marker Score: 3900
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.89
    Marker Score: 1114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13895
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.88
    Marker Score: 4745
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1211
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.84
    Marker Score: 1781
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.84
    Marker Score: 892
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 873
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.84
    Marker Score: 3237
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1352
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1852
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.79
    Marker Score: 1255
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.79
    Marker Score: 5062
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.77
    Marker Score: 830
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7
    Marker Score: 1590
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.69
    Marker Score: 337
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.69
    Marker Score: 17768
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 460
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 606
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.66
    Marker Score: 3992
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.65
    Marker Score: 365
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.65
    Marker Score: 1747
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.65
    Marker Score: 271
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.64
    Marker Score: 320
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.64
    Marker Score: 940
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1201
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.62
    Marker Score: 2032
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 556
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.59
    Marker Score: 401
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.58
    Marker Score: 387
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.57
    Marker Score: 1587
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.57
    Marker Score: 1008
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 261
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.56
    Marker Score: 566
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 402
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.54
    Marker Score: 156
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.54
    Marker Score: 867
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1257
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 370
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.53
    Marker Score: 657
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.53
    Marker Score: 151
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 122
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3092
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.51
    Marker Score: 209.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5
    Marker Score: 2038
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.49
    Marker Score: 11021
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 437
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.49
    Marker Score: 1202
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.49
    Marker Score: 160
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.48
    Marker Score: 132
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.48
    Marker Score: 182
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.48
    Marker Score: 111
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.48
    Marker Score: 110
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.48
    Marker Score: 263
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.47
    Marker Score: 106
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.47
    Marker Score: 3025
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.47
    Marker Score: 112

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Other Information

**Key characteristics:** - ACADS is a protein of the mitochondrial matrix. - It is a single-pass protein, meaning that it can only enter the mitochondria from the cytoplasm. - It is a key enzyme in the beta oxidation of fatty acids. - It is highly expressed in enterocytes, colon epithelial cells, and kidney collecting duct intercalated cells. **Pathways and functions:** - ACADS is involved in the beta oxidation of fatty acids. - This process is important for the metabolism of fatty acids in the mitochondria of cells. - The reaction catalyzed by ACADS involves the transfer of a fatty acid from the acyl-CoA molecule to a coenzyme A. - This reaction is part of the citric acid cycle, which is a central metabolic pathway in the mitochondria. - The product of the beta oxidation of fatty acids, acetyl-CoA, can be used by other metabolic pathways, such as the citric acid cycle and the pentose phosphate pathway. **Clinical significance:** - Mutations in the ACADS gene have been linked to a number of human diseases, including obesity, diabetes, and liver disease. - These diseases are characterized by an increased intake of fatty acids and a decreased use of glucose. - ACADS is a potential therapeutic target for these diseases.

Genular Protein ID: 1689682434

Symbol: ACADS_HUMAN

Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P16219 P78331

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 27 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2565344

Title: Molecular cloning and nucleotide sequence of complementary DNAs encoding human short chain acyl-coenzyme A dehydrogenase and the study of the molecular basis of human short chain acyl-coenzyme A dehydrogenase deficiency.

PubMed ID: 2565344

DOI: 10.1172/jci114058

PubMed ID: 9383286

Title: Structural organization of the human short-chain acyl-CoA dehydrogenase gene.

PubMed ID: 9383286

DOI: 10.1007/s003359900612

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21237683

Title: Identification and characterization of new long chain acyl-CoA dehydrogenases.

PubMed ID: 21237683

DOI: 10.1016/j.ymgme.2010.12.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1692038

Title: Identification of two variant short chain acyl-coenzyme A dehydrogenase alleles, each containing a different point mutation in a patient with short chain acyl-coenzyme A dehydrogenase deficiency.

PubMed ID: 1692038

DOI: 10.1172/jci114607

PubMed ID: 9499414

Title: Identification of four new mutations in the short-chain acyl-CoA dehydrogenase (SCAD) gene in two patients: one of the variant alleles, 511C-->T, is present at an unexpectedly high frequency in the general population, as was the case for 625G-->A, together conferring susceptibility to ethylmalonic aciduria.

PubMed ID: 9499414

DOI: 10.1093/hmg/7.4.619

PubMed ID: 11134486

Title: Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency.

PubMed ID: 11134486

DOI: 10.1203/00006450-200101000-00008

Sequence Information:

  • Length: 412
  • Mass: 44297
  • Checksum: 3E946ADFC3DA3C0E
  • Sequence:
    • MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE KELFPIAAQV 
DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI AMEEISRGCA STGVIMSVNN 
SLYLGPILKF GSKEQKQAWV TPFTSGDKIG CFALSEPGNG SDAGAASTTA RAEGDSWVLN 
GTKAWITNAW EASAAVVFAS TDRALQNKGI SAFLVPMPTP GLTLGKKEDK LGIRGSSTAN 
LIFEDCRIPK DSILGEPGMG FKIAMQTLDM GRIGIASQAL GIAQTALDCA VNYAENRMAF 
GAPLTKLQVI QFKLADMALA LESARLLTWR AAMLKDNKKP FIKEAAMAKL AASEAATAIS 
HQAIQILGGM GYVTEMPAER HYRDARITEI YEGTSEIQRL VIAGHLLRSY RS

Genular Protein ID: 140606007

Symbol: B4DUH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUH1

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 1 Pfam 4 RefSeq 1 SUPFAM 2

Sequence Information:

  • Length: 405
  • Mass: 43631
  • Checksum: F82DC5F0E93C6C53
  • Sequence:
    • MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE KELFPIAAQV 
DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI AMEEISRGCA STGVIMSVNN 
SLYLGPILKF GSKEQKQAWV TPFTSGDKIG CFALSEPGPS LLGPTGPIFA LGQVGCPCPS 
SAATEACTFP RSRQRVSRPE LPREGISAFL VPMPTPGLTL GKKEDKLGIR GSSTANLIFE 
DCRIPKDSIL GEPGMGFKIA MQTLDMGRIG IASQALGIAQ TALDCAVSYA ENRMAFGAPL 
TKLQVIQFKL ADMALALESA RLLTWRAAML KDNKKPFIKE AAMAASEAAT AISHQAIQIL 
GGMGYVTEMP AERHYRDARI TEIYEGTSEI QRLVIAGHLL RSHRS

Genular Protein ID: 3995396785

Symbol: E9PE82_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PE82

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 408
  • Mass: 44012
  • Checksum: 9C0DA2EA8B24E6A1
  • Sequence:
    • MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE KELFPIAAQV 
DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI AMEEISRGCA STGVIMSVNN 
SLYLGPILKF GSKEQKQAWV TPFTSGDKIG CFALSEPGPS LLGPTGPIFA LGQVGCPCPS 
SAATEACTFP RSRQRVSRPE LLREGISAFL VPMPTPGLTL GKKEDKLGIR GSSTANLIFE 
DCRIPKDSIL GEPGMGFKIA MQTLDMGRIG IASQALGIAQ TALDCAVNYA ENRMAFGAPL 
TKLQVIQFKL ADMALALESA RLLTWRAAML KDNKKPFIKE AAMAKLAASE AATAISHQAI 
QILGGMGYVT EMPAERHYRD ARITEIYEGT SEIQRLVIAG HLLRSYRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.